iCyst: 1 year, 1000 and more simulations through an app Balduzzi, A.; Marchegiani, G.; Andrianello, S. ...
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... et al.,
July 2021, 2021-07-00, 20210701, Letnik:
21
Journal Article
Tecnorad set up a complete series of tests for both TLD and film dosimetry to verify the ability of its dosimetry service to meet the requirements stated in ICRP 60 and in the Italian Legislative ...Decree 230/95 of 1 mSv.y-1 for the public and for persons not exposed to radiation in their workplace. The service used GR-200A LiF:Mg,Cu,P TLDs and Kodak Type 2 film dosemeters packed in proprietary badges. The measurements of low doses, comparable with the background value, have been carried out during several wearing periods in the past year (1997) the results of which are presented. Values of LD (detection limit) less than 20 µSv (TLD system) and less than 80 µSv (film dosemeter system) have been determined. The requirement of a personal dosimetry system able to measure down to 80 µSv per month, also with high energy photon radiations, is fulfilled for both TLD and film methods.
To explore the prognostic significance of nutritional status in patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC).
Clinical data of non-consecutive patients submitted to surgery ...for PDAC from 2015 to 2018 at Pancreas Institute of Verona were prospectively collected. Nutritional Risk Screening 2002 (NRS) was performed to assess nutritional risk. Body composition was detected by Bioelectrical Impedance Analysis (BIA) the day before the scheduled surgery. Data were correlated to disease-free/overall survival (DFS/OS) using a Cox and logistic regression model. Kaplan-Meier curves were compared with Log-Rank.
The final cohort consisted of 73 patients (median follow-up 11 months). The majority were at risk of malnutrition (NRS≥3). At multivariate analysis, stage (HR 4.30, p=0.045), NRS (HR 6.51, p=0.017), fat-free mass (FFM) (HR 1.08, p=0.013) were significant independent predictors for OS. Particularly, patients with preoperative NRS≤3 had significantly longer 2-year OS than those with NRS>3 (94% vs 75%, p=0.02). Contrariwise, BMI did not affect OS. Twenty-four patients (32.9%) were treated with neoadjuvant therapy. NRS was significantly higher in this subset of patients (p=0.026), with a significant difference according to chemotherapy regimens (Folfirinox vs Gemcitabine/Nab-paclitaxel) (p=0.035). In patients treated with adjuvant chemotherapy (45.2%), FFM correlated with worse DSF and OS (p=0.039 and p=0.039, respectively).
Our analysis suggests that preoperative malnutrition has a detrimental impact on OS in resected PDAC. Preoperative nutritional screening and, possibly, targeted nutritional intervention may improve outcomes in resectable PDAC patients, particularly in those who are candidate to neoadjuvant therapy.
Nutritional derangements are common hallmarks of PDAC. Their early detection and management are usually overlooked in routine practice. The aim of this study was to explore the prognostic value of ...nutritional status in patients (pts) undergoing surgery for PDAC.
We prospectively studied 73 non-consecutive pts submitted to surgery for PDAC from November 2015 to January 2018 at General and Pancreatic Surgery Unit, Pancreas Institute, University Hospital of Verona. Nutritional Risk Screening (NRS) 2002 was used to evaluate the nutritional risk. Body composition was assessed using Bioelectrical Impedance Vector Analysis (BIVA) the day before the scheduled surgery. Clinical, pathological and nutritional data were correlated to disease-free/overall survival (DFS/OS) using a Cox and logistic regression model. Kaplan-Meier curves were compared with Log-Rank.
The median age was 65 years range 37-81, 41 pts were male (56.2%) and 32 were female (43.8%). Median follow-up was 11 months range 1-40. The majority (80.8%) were at risk of malnutrition (NRS-2002≥3), despite median BMI was 23.9kg/m2. At multivariate analysis, stage (HR 4.30, 95% CI 1.03-17.92, p=0.045), NRS-2002 (HR 6.51, 95% CI 1.39-30.38, p=0.017), fat-free mass (FFM) (HR 1.08, 95% CI 1.02-1.14, p=0.013) were significant independent predictors for OS. Particularly, pts with preoperative NRS-2002 ≤3 had significantly longer 2-year OS than those with NRS-2002 >3 (94% vs 75%, p=0.02). Twenty-four pts (32.9%) were treated with neoadjuvant therapy. NRS-2002 was significantly higher in this subset of pts (p=0.026), with a significant difference according to chemotherapy regimens (Folfirinox vs. Gemcitabine/Nab-paclitaxel) (p=0.035). In pts treated with adjuvant chemotherapy (n=33, 45.2%) FFM correlated with worse DSF and OS (p=0.039 and p=0.039, respectively).
Our analysis suggests that preoperative malnutrition has a detrimental impact on OS in PDAC. Therefore, preoperative nutritional screening and, possibly, targeted nutritional intervention may improve outcomes in resectable PDAC pts, particularly in those who are candidate to neoadjuvant therapy.
The authors.
Has not received any funding.
M. Milella: Honoraria (self): Pfizer, EUSA Pharma, AstraZeneca. All other authors have declared no conflicts of interest.
A detailed analysis of the coding sequences of myelin oligodendrocyte glycoprotei (MOG) gene was performed in multiple sclerosis (MS) patients and in control individuals and three new polymorphisms ...are described: T636C, nt 571+77C→T (IVS 4), and nt 710−44A→G (IVS 6). Screening studies demonstrated that T636C was present in three MS patients and in no control individual and that polymorphisms nt 571+77C→T (IVS 4), and nt 710−44A→G (IVS 6), were present with no significant frequency differences in MS patients and control individuals. No mutations were found after sequencing the coding sequences of the extracellular domain of MOG gene in 20 MS patients and 20 control individuals. Screening studies were also performed for known polymorphisms: G15A, Val142Leu, nt 571+68A→G (IVS 4), and 571+92C→G (IVS 4). Polymorphism Val 142 Leu, which is linked to nt 571+68A→G (IVS 4), resulted under-represented in MS patients.
PDF
