The reaction e+e−→ π+ π−π0η has been studied in the experiment with the SND detector at the VEPP-2000 e+ e− collider. The reaction proceeds via the four intermediate states: ωη, φη, a0ρ, and ...structureless π+π−π0η state, which may be, for example, ρ(1450) with ρ(1450) → ρ(770)η. The total e+e−→ π+π−π0η cross section and cross section for the four intermediate states have been measured and fitted in the vector meson dominance model.
To evaluate the effectiveness of the use of invasive intracranial pressure (ICP) monitoring on treatment outcomes in patients with severe traumatic brain injury (TBI).
We analyzed 50 case histories ...of patients with severe TBI who received treatment in the Krasnoyarsk Regional Clinical Hospital for the period 2021-2022. Comparisons were made between patients with and without invasive intraventricular ICP monitoring.
With the same initial condition of patients, ICP monitoring allows for a faster and more timely response to changes in the clinical condition, which significantly affects the clinical outcome.
The use of invasive ICP monitoring improves the outcome of treatment of patients with severe TBI and justifies the money spent on it.
The SND is a non-magnetic detector at the VEPP-2000 e+e− collider (BINP, Novosibirsk) designed for hadronic cross-section measurements in the center-of-mass energy range up to 2 GeV. The important ...part of the detector is a segmented electromagnetic calorimeter (EMC) with three layers of NaI(Tl) counters. The EMC signal shaping and digitizing electronics based on FADC allow one to obtain both the signal amplitude and the arrival time. We describe the EMC signal processing and how the EMC measured time is applied in event reconstruction and physics analysis.
A
bstract
The cross section of the process
e
+
e
−
→
π
+
π
−
has been measured in the Spherical Neutral Detector (SND) experiment at the VEPP-2000
e
+
e
−
collider VEPP-2000 in the energy region 525
...<
s
<
883 MeV. The measurement is based on data with an integrated luminosity of about 4.6 pb
−
1
. The systematic uncertainty of the cross section determination is 0.8% at
s
>
0
.
600 GeV. The
ρ
meson parameters are obtained as
m
ρ
= 775
.
3 ± 0
.
5 ± 0
.
6 MeV, Γ
ρ
= 145
.
6 ± 0
.
6 ± 0
.
8 MeV,
B
ρ
→
e
+
e−
×
B
ρ
→
π
+
π−
= (4
.
89 ± 0
.
02 ± 0
.
04) × 10
−
5
, and the parameters of the
e
+
e
−
→
ω
→
π
+
π
−
process, suppressed by
G
-parity, as
B
ω
→
e
+
e−
×
B
ω
→
π
+
π−
= (1
.
32 ± 0
.
06 ± 0
.
02) × 10
−
6
and and
ϕ
ρω
= 110
.
7 ± 1
.
5 ± 1
.
0 degrees.
Acyloxydiene-Fe(CO)3 complexes can act as enzyme-triggered CO-releasing molecules (ET-CORMs). Their biological activity strongly depends on the mother compound from which they are derived, i.e. ...cyclohexenone or cyclohexanedione, and on the position of the ester functionality they harbour. The present study addresses if the latter characteristic affects CO release, if cytotoxicity of ET-CORMs is mediated through iron release or inhibition of cell respiration and to what extent cyclohexenone and cyclohexanedione derived ET-CORMs differ in their ability to counteract TNF-α mediated inflammation. Irrespective of the formulation (DMSO or cyclodextrin), toxicity in HUVEC was significantly higher for ET-CORMs bearing the ester functionality at the outer (rac-4), as compared to the inner (rac-1) position of the cyclohexenone moiety. This was paralleled by an increased CO release from the former ET-CORM. Toxicity was not mediated via iron as EC50 values for rac-4 were significantly lower than for FeCl2 or FeCl3 and were not influenced by iron chelation. ATP depletion preceded toxicity suggesting impaired cell respiration as putative cause for cell death. In long-term HUVEC cultures inhibition of VCAM-1 expression by rac-1 waned in time, while for the cyclohexanedione derived rac-8 inhibition seems to increase. NFκB was inhibited by both rac-1 and rac-8 independent of IκBα degradation. Both ET-CORMs activated Nrf-2 and consequently induced the expression of HO-1. This study further provides a rational framework for designing acyloxydiene-Fe(CO)3 complexes as ET-CORMs with differential CO release and biological activities. We also provide a better understanding of how these complexes affect cell-biology in mechanistic terms.
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