Abstract
Currently, the use of food additives of plant origin is widely used in technologies of meat products, that allow not only to expand assortment, but also to increase biological value, improve ...the organoleptic characteristics of prepared food products. The purpose of this work was to develop a recipe for fried sausage products with original food additives. During the research, the main quality indicators of enriched fried sausages: organoleptic and physicochemical, were studied. The developed products have elastic consistency and spicy taste, that is characteristic for each sample with a brown color on the cut, as well as a pleasant aroma, that is specific to this type of product. Calculation of the production cost showed the feasibility of introducing the developed formulations into manufacturing process. The use of these sausages in diet will enrich it with micronutrients.
Vancomycin is a drug of choice for the infections caused by methicillin-resistant strains of staphylococci. Its use requires individualised dosing and renal function monitoring.
The aim of the study
...was to evaluate, using therapeutic drug monitoring (TDM), the frequency of reaching target trough serum concentrations (TSCs) and the frequency of renal function impairment in orthopaedic infection patients receiving vancomycin therapy.
Materials and methods
:
the authors carried out a retrospective analysis of vancomycin TSC test results of 457 patients admitted to a purulent osteology department in 2019–2021. The results were grouped according to the number of TSC determination performed as part of TDM (tests 1, 2, and 3). Each of the 3 groups was further divided into 4 subgroups according to the TSCs of vancomycin: ≤9.9 µg/ml (extremely low), 10–14.9 µg/ml (recommended for mild infections), 15–19.9 µg/ml (recommended for bone and joint infections), ≥20 µg/ml (potentially toxic). The results obtained in each group were analysed separately.
Results
:
according to the 1st TDM test, only 9.6% of patients achieved the TSCs of vancomycin recommended for bone and joint infections. Extremely low TSCs, insufficient for treatment of the infections, were found in 64.8% of patients. According to the 2nd and 3rd TSC determinations, dose corrections decreased the percentage of patients with extremely low TSCs to 49.9% and 41.2%, respectively. Potentially toxic TSCs of vancomycin were detected in 48 (10.5%) patients, but renal dysfunction was observed only in 8 (1.75%) of them. The authors exemplify the use of TDM to control the efficacy and safety of vancomycin in patients with pronounced signs of renal function impairment by two clinical cases.
Conclusion
:
with a standard dose of vancomycin, the concentrations recommended for bone and joint infections were reached only in every tenth patient. There was a large percentage of patients with extremely low serum concentrations of the medicinal product (64.8%), but it decreased after dose adjustments. Monitoring of vancomycin concentrations allows for individualised dosing, efficacy control and significant reduction of the risk of adverse kidney reactions.
The method of scanning electron microscopy in complex with energy dispersive spectrometric analysis is applied for the first time for studying the composition of materials used or medical purposes. ...Cartilage implants have been formed based on polyacrylamide hydrogels reinforced by bacterial and plant celluloses, and the dynamics of variation of compositions of implant and the boundary osteal regions of a joint, indicating the dependence of osteointegration on the cellulose origin, has been demonstrated. The systems of protein delivery based on porous vaterites CaCO
3
have been investigated, and one variant of delivery systems is represented by composite systems in which the CaCO
3
matrices of the core are coated with a shell consisting of several pairs of polyelectrolyte layers. The possibility of determining the structures of polyelectrolyte shells depending on the method of their formation has been demonstrated, and the position of the encapsulated protein in CaCO
3
cores has been determined.
The bactericidal properties of a number of promising ceramic coatings obtained by magnetron sputtering have been determined. The coatings considered in this work hold much promise for protecting ...against common causative agents of acute purulent inflammation and surgical complications. The prospects of using the synthesized coatings in medical devices are estimated.
Decreased adhesion of
Staphylococcus aureus
provides additional opportunities for the prevention and treatment of infectious diseases caused by bacteria, including drug-resistant strains. In this ...work, the interaction of
S. aureus
ATCC 29213 strain and epithelial eukaryotic cells was studied using optical microscopy. Low-molecular-mass organic compounds of the 5-arylpyrrolidine-2-carboxylate class were found to be capable of decreasing the adhesion of bacterial cells to Vero cells. Racemic methyl (2
S
*
,4
S
*
,5
R
*
)-4-(hydroxymethyl)-1-methyl-5-(2-fluoro-5-methoxyphenyl)pyrrolidine-2-carboxylate produced statistically significant inhibition of the adhesion of
S. aureus
type strains and was characterized by a lack of cytotoxicity against both the eukaryotic Vero cell line and the studied
S. aureus
strain.
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