Despite the commitment of the Paris agreement to pursue efforts to limit end-of-century global warming to 1.5°C above pre-industrial levels, few have studied mitigation pathways consistent with such ...a demanding goal. This paper uses a fully integrated engineering- economic model of the U.S. energy system, to explore the ability of the U.S. electricity sector to operate within a budget of 44 gigatons of CO2 (GtCO2) between 2016 and 2040 - almost 20 percent less than projected. Our modeling results suggest that carbon taxes coupled with strong energy-efficiency policies would produce synergistic effects that could meet deep decarbonization goals. Combining energy-efficiency initiatives with a $10/tCO2 tax rising to $27/tCO2 in 2040 (in $2013) would achieve the U.S. electric sector's carbon budget with a net savings to the U.S. economy. A $20/tCO2 tax rising to $53/tCO2 in 2040 would also stay below this budget, but it would cost more if not coupled with strong energy efficiency. U.S. regionswillwin or lose depending on their generationmix and how carbon tax revenues are recycled.
We have previously reported that the mouse gut microbiome contributes to pulmonary responses to ozone, a common asthma trigger, and that short-chain fatty acids, end products of bacterial ...fermentation, likely contribute to this role of the microbiome. A growing body of evidence indicates that there are sex-related differences in gut microbiota and these differences can have important functional consequences. The purpose of this study was to determine whether there are sex-related differences in the impact of the gut microbiota on pulmonary responses to ozone. After acute exposure to ozone, male mice developed greater airway hyperresponsiveness than female mice. This difference was abolished after antibiotic ablation of the gut microbiome. Moreover, weanling female pups housed in cages conditioned by adult male mice developed greater ozone-induced airway hyperresponsiveness than weanling female pups raised in cages conditioned by adult females. Finally, ad libitum oral administration via drinking water of the short-chain fatty acid propionate resulted in augmented ozone-induced airway hyperresponsiveness in male, but not female, mice. Overall, these data are consistent with the hypothesis that the microbiome contributes to sex differences in ozone-induced airway hyperresponsiveness, likely as a result of sex differences in the response to short-chain fatty acids.
Gaia Data Release 3 Montegriffo, P.; De Angeli, F.; Andrae, R. ...
Astronomy and astrophysics (Berlin),
06/2023, Letnik:
674
Journal Article
Recenzirano
Odprti dostop
Context.Gaia
Data Release 3 contains astrometry and photometry results for about 1.8 billion sources based on observations collected by the European Space Agency (ESA)
Gaia
satellite during the first ...34 months of its operational phase (the same period covered by
Gaia
early Data Release 3;
Gaia
EDR3). Low-resolution spectra for 220 million sources are one of the important new data products included in this release.
Aims.
In this paper, we focus on the external calibration of low-resolution spectroscopic content, describing the input data, algorithms, data processing, and the validation of the results. Particular attention is given to the quality of the data and to a number of features that users may need to take into account to make the best use of the catalogue.
Methods.
We calibrated an instrument model to relate mean
Gaia
spectra to the corresponding spectral energy distributions (SEDs) using an extended set of calibrators: this includes modelling of the instrument dispersion relation, transmission, and line spread functions. Optimisation of the model is achieved through total least-squares regression, accounting for errors in
Gaia
and external spectra.
Results.
The resulting instrument model can be used for forward modelling of
Gaia
spectra or for inverse modelling of externally calibrated spectra in absolute flux units.
Conclusions.
The absolute calibration derived in this paper provides an essential ingredient for users of
BP
/
RP
spectra. It allows users to connect
BP
/
RP
spectra to absolute fluxes and physical wavelengths.
•Suicidality in eating disorders (ED) is linked to low interoceptive awareness (IA).•Low body trust predicted the presence of suicidal ideation in an ED sample.•No dimensions of IA were associated ...with severity of suicidal ideation.
Previous research has demonstrated that both suicidal ideation (SI) and eating disorders (EDs) are associated with poor interoceptive awareness (IA). Suicidality research has demonstrated that the IA dimension of lower body trust is associated with SI, suicide plans, and suicide attempts. Similarly, in ED samples, recent research supports that low body trust has been the most robust dimension of IA associated with eating pathology. However, to date, research is lacking in how dimensions of IA may be associated with SI in an ED sample, above and beyond the impact of eating pathology on SI. Thus, in a clinical ED sample, the present study sought to determine which IA dimensions predict the presence and severity of SI, above and beyond ED symptoms. Participants (N = 102) completed a clinical interview assessing SI and self-report assessments including the Multidimensional Assessment of Interoceptive Awareness (MAIA). Results demonstrated that patients with current SI reported greater ED psychopathology, lower MAIA Attention Regulation, MAIA Self-Regulation, and MAIA Trusting scores compared to patients without SI. Higher ED psychopathology and lower MAIA Attention Regulation, Self-Regulation, and Trusting subscale scores were all significantly associated with the presence of SI. However, only low MAIA Trusting scores predicted the presence of SI, above and beyond covariates (age, depression, and eating pathology). No MAIA subscales were correlated with the severity of SI. Consistent with previous research, results suggest low MAIA Trusting scores may be associated with SI in ED samples and highlight the need for future research on mechanisms of these associations.
The Tommy Creek Domain is a complex, yet little studied, terrane in the Eastern Subprovince of the Mount Isa Province, northwest Queensland Australia. In this study, we take advantage of modern ...low-cost and rapid geochronology techniques to undertake an iterative dating approach integrated with detailed fieldwork to define the ages and extents of numerous lithologies and units of the Tommy Creek Domain. This includes some units not previously identified, lithologies previously grouped together based on field observations but now shown to have multiple distinct ages and dates not commonly represented in Mount Isan time-space plots. We identify an episode of felsic magmatism at ca 1640 Ma, and multimodal intrusions (ca 1615 Ma) immediately preceding the onset of the Isan Orogeny. A major rock package of the Tommy Creek Domain, the Milo beds, are characterised here as the youngest pre-Isan Orogeny sedimentary unit in the Eastern Subprovince (1660-1620 Ma), confirming that sedimentation and possibly rifting continued after deposition of the Soldiers Cap, Mount Albert and Kuridala groups (ca 1690-1650 Ma) before the onset of the Isan Orogeny (ca 1600 Ma). The Milo beds are thus age equivalent to the Mount Isa and McNamara groups of the Western Succession. There is evidence of a compositional shift in sedimentation coincident with the ca 1640 Ma Riversleigh Inversion event, previously only observed in the Western Subprovince in the Lawn Hill Platform. The application of geochronology as part of the mapping workflow can assist with differentiating geological units in terranes where field evidence is ambiguous and can aid in the focusing of objectives for field campaigns to enable the best possible interpretations to be made.
KEY POINTS
New ages constrain the Milo beds in the Tommy Creek Domain as the youngest stratigraphy in the Eastern Subprovince of the Mount Isa Province.
The Milo beds are age equivalents of the McNamara and Mount Isa groups of the Western Subprovince of the inlier.
Recognition of felsic and mafic intrusions with ca 1640 Ma and ca 1615 Ma ages.
Evidence for Riversleigh Inversion event ca 1640 in the Eastern Subprovince.
Enterobacterial repetitive intergenic consensus (ERIC) sequence analysis is a powerful tool for epidemiological analysis of bacterial species. This study aimed to determine the genetic relatedness or ...variability in carbapenem-resistant isolates by species using this technique.
A total of 111 non-duplicated carbapenem-resistant (CR) Gram-negative bacilli isolates from a three-year collection period (2012-2014) were investigated by enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) in four selected hospital laboratories in Ghana. The isolates were also screened for carbapenemase and extended spectrum β-lactamase genes by PCR.
A proportion of 23.4% (26/111) of the genomic DNA extracts were carriers of PCR-positive carbapenemase genes, including 14.4% blaNDM-1, 7.2% blaVIM-1 and 1.8% blaOXA-48. The highest prevalence of carbapenemase genes was from non-fermenters, Acinetobacter baumannii and Pseudomonas aeruginosa. For the ESBL genes tested, 96.4% (107/111) of the CR isolates co-harboured both TEM-1 and SHV-1 genes. The ERIC-PCR gel analysis exhibited 1 to 8 bands ranging from 50 to 800 bp. Band patterns of 93 complex dissimilarities were visually distinguished from the 111 CR isolates studied, while the remaining 18 showed band similarities in pairs.
Overall, ERIC-PCR fingerprints have shown a high level of diversity among the species of Gram-negative bacterial pathogens and specimen collection sites in this study. ERIC-PCR optimisation assays may serve as a suitable genotyping tool for the assessment of genetic diversity or close relatedness of isolates that are found in clinical settings.
Inhaled hypertonic saline (HS) has been shown to increase mucociliary clearance (MCC) and improve clinical outcomes in adults and adolescents with cystic fibrosis (CF). However, in younger children ...with CF, a large study failed to demonstrate clinical benefits. This discrepancy could reflect pharmacodynamic differences in the MCC response to HS in different populations. We previously demonstrated the absence of a sustained effect of HS on MCC in healthy adults and in this study sought to characterize the durability of the MCC response to HS in adults with CF.
At two study sites, MCC was measured in CF adults using gamma scintigraphy during three separate visits: at baseline, 15 min, and 4 h after a single dose of HS (7% NaCl, 4 mL). Particle clearance rates at these visits were used to assess the durability of the MCC response to HS.
The average 90-minute clearance rate measured 4 h after HS was significantly increased (21.81% ± 12.8) when compared to baseline (13.77% ± 8.7, p = .048) and showed no apparent slowing relative to the rate measured 15 min after HS. While not all subjects responded to HS, the acute response strongly predicted the sustained effect in these subjects (r = 0.896, p < .0001).
These results suggest that, in contrast to healthy adults, a single dose of HS has a prolonged effect on MCC in adults with CF, which lasts at least 4 h. This may explain its clinical efficacy in this population.
Domestication of barley and other cereals was accompanied by an increase in seed size which has been ascribed to human selection, large seeds being preferred by early farmers or favoured by ...cultivation practices such as deep sowing. An alternative suggestion is that the increase in seed size was an indirect consequence of selection for plants with more vigorous growth. To begin to address the latter hypothesis we studied the diversity of HvWAK1, a wall-associated kinase gene involved in root proliferation, in 220 wild barley accessions and 200 domesticated landraces. A 3655-bp sequence comprising the gene and upstream region contained 69 single nucleotide polymorphisms (SNPs), one indel and four short tandem repeats. A network of 50 haplotypes revealed a complex evolutionary relationship, but with landraces largely restricted to two parts of the topology. SNPs in the HvWAK1 coding region resulted in nonsynonymous substitutions at nine positions in the translation product, but none of these changes were predicted to have a significant effect on the protein structure. In contrast, the region upstream of the coding sequence contained five SNPs that were invariant in the domesticated population, fixation of these SNPs decreasing the likelihood that the upstream of a pair of TATA boxes and transcription start sites would be used to promote transcription of HvWAK1. The sequence diversity therefore suggests that the cis-regulatory region of HvWAK1 might have been subject to selection during barley domestication. The extent of root proliferation has been linked with traits such as above-ground biomass, so selection for particular cis-regulatory variants of HvWAK1 would be consistent with the hypothesis that seed size increases during domestication were the indirect consequence of selection for plants with increased growth vigour.
Non-invasive assessment of myocardial ischaemia is a cornerstone of the diagnosis of coronary artery disease. Measurement of myocardial blood flow (MBF) using positron emission tomography (PET) is ...the current reference standard for non-invasive quantification of myocardial ischaemia. Dynamic myocardial perfusion cardiovascular magnetic resonance (CMR) offers an alternative to PET and a recently developed method with automated inline perfusion mapping has shown good correlation of MBF values between CMR and PET. This study assessed the repeatability of myocardial perfusion mapping by CMR in healthy subjects.
Forty-two healthy subjects were recruited and underwent adenosine stress and rest perfusion CMR on two visits. Scans were repeated with a minimum interval of 7 days. Intrastudy rest and stress MBF repeatability were assessed with a 15-min interval between acquisitions. Interstudy rest and stress MBF and myocardial perfusion reserve (MPR) were measured for global myocardium and regionally for coronary territories and slices.
There was no significant difference in intrastudy repeated global rest MBF (0.65 ± 0.13 ml/g/min vs 0.62 ± 0.12 ml/g/min, p = 0.24, repeatability coefficient (RC) =24%) or stress (2.89 ± 0.56 ml/g/min vs 2.83 ± 0.64 ml/g/min, p = 0.41, RC = 29%) MBF. No significant difference was seen in interstudy repeatability for global rest MBF (0.64 ± 0.13 ml/g/min vs 0.64 ± 0.15 ml/g/min, p = 0.80, RC = 32%), stress MBF (2.71 ± 0.61 ml/g/min vs 2.55 ± 0.57 ml/g/min, p = 0.12, RC = 33%) or MPR (4.24 ± 0.69 vs 3.73 ± 0.76, p = 0.25, RC = 36%). Regional repeatability was good for stress (RC = 30-37%) and rest MBF (RC = 32-36%) but poorer for MPR (RC = 35-43%). Within subject coefficient of variation was 8% for rest and 11% for stress within the same study, and 11% for rest and 12% for stress between studies.
Fully automated, inline, myocardial perfusion mapping by CMR shows good repeatability that is similar to the published PET literature. Both rest and stress MBF show better repeatability than MPR, particularly in regional analysis.
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. We mapped FOP to chromosome 2q23-24 by linkage ...analysis and identified an identical heterozygous mutation (617G → A; R206H) in the glycine-serine (GS) activation domain of ACVR1, a BMP type I receptor, in all affected individuals examined. Protein modeling predicts destabilization of the GS domain, consistent with constitutive activation of ACVR1 as the underlying cause of the ectopic chondrogenesis, osteogenesis and joint fusions seen in FOP.NOTE: In the version of this article initially published, several contributing authors were listed collectively under the name The International FOP Research Consortium. In order to facilitate the electronic citation of author contributions, the authors have chosen to delete the Consortium name and replace it with the names of the individual consortium authors in alphabetical order. This error has been corrected in the HTML and PDF versions of the article.
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