Abstract
The effects of dust–dust self-gravitational force and nonextensive characteristics of plasma species on the low frequency twisted waves owing to the helical wave structure in complex (dusty) ...plasmas are analyzed. The electrons and ions of the plasma are modelled by nonextensive
q
-distribution function while massive dust particles are Maxwellian distributed. The self-gravitational effects are incorporated in the Vlasov equation of kinetic theory where perturbed distribution function, electrostatic and gravitational potentials are expressed with Laguerre–Gauss functions. The governing equations of kinetic theory are solved together under paraxial approximations. The dispersion relations and damping rates of twisted dust-acoustic waves (TDAWs) are obtained for two situations; (a) super-extensivity (
q
< 1) and (b) sub-extensivity (
q
> 1). The effects of self-gravity, nonextensivity and twist parameter significantly modified the basic features of dust-acoustic waves. This study contributes to our understanding of the complex dynamics of TDAWs in interstellar dust clouds, considering the interplay of self-gravity, nonextensivity, and helical phase structures. The obtained theoretical and numerical results provide valuable insights into the behavior of these waves and offer a foundation for further investigations in this field. However, understanding of the topic can be enhanced through a combination of theoretical models, numerical simulations and observational data.
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•Synthetic or natural chalcones are currently a hot research topic for the treatment of AD which has affected millions of peoples throughout the world.•This present review highlights ...the design, synthesis, molecular binding studies importance of chalcones playing multiple roles in the AD treatments.•This review also provides the new idea of development of chalcone based anti-AD drugs in near future.
The complications of Alzheimer’s disease AD were deadly dangerous cause of neurodegenerative disorders connected with the decline of the cognitive functions and loss of memory. The common form of dementia is accounted as the sixth leading cause of the death affecting any stage of people in a lifetime. Synthetic natural chalcone analogs were currently a hot research topic for the treatment of (AD) which has affected millions of peoples throughout the world. The present aim was set to understand the important problems of the AD and its treatment based on natural derivatives of novel chalcones. One interesting strategy currently of searching for the treatment of AD is to find inhibitors for acetylcholinesterase (AChE) and using metal chelators to target amyloid-β (Aβ) peptides, and then metal-Aβ complexes for the AD pathogenesis. The present compressed review focuses and highlights the design and synthesis of new approaches for the construction of important chalcones playing multiple beneficiary roles in the AD treatments. These hallmarks of concurred research represent the immediate needs of development of novel therapeutic drugs for effective treatment of ADs by understanding the specific pharmacology targets.
The multidrug-resistant Staphylococcus aureus (MRSA) is one of the most prevalent human pathogens involved in many minor to major disease burdens throughout the world. Inhibition of biofilm formation ...is an attractive strategy to treat diseases associated with MRSA infection. In the present investigation, a series of functional group diverse (hetero)aryl fluorosulfonyl analogs were designed, synthesized and tested as antibacterial agents against Staphylococcal spp., and as anti-biofilm candidates. Compounds 8, 15, and 67 were found to possess potent in vitro antibacterial activity among this class of sulfonyl fluorides (MIC = 0.818 ± 0.42, 0.840 ± 0.37 and 0.811 ± 0.37 μg/mL respectively). The analogs 8, 15, 36, and 67 exhibited outstanding anti-biofilm properties compared to other available synthetic antibiotics. The efficacy of synthetic analogs displayed membrane-damaging effect and they are also validated by cellular content release assay. The insight physiological changes were explored by studying the intracellular redox activities through changing cyclic voltammetric (CV) method. The compounds 8, 15, 22, 32, 36, 51, and 67 were found to participate in the interfering in the electron transport chain (ETC) of MRSA. The analogs 8, 15, and 67 possess great potentiality for discovery and development of anti-staphylococcal drugs to treat the MRSA infections.
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Growing evidence points to a disruption of cortico-thalamo-cortical circuits in schizophrenia (SZ) and bipolar disorder (BD). Clues for a specific involvement of the thalamic reticular nucleus (TRN) ...come from its unique neuronal characteristics and neural connectivity, allowing it to shape the thalamo-cortical information flow. A direct involvement of the TRN in SZ and BD has not been tested thus far. We used a combination of human postmortem and rodent studies to test the hypothesis that neurons expressing parvalbumin (PV neurons), a main TRN neuronal population, and associated Wisteria floribunda agglutinin-labeled perineuronal nets (WFA/PNNs) are altered in SZ and BD, and that these changes may occur early in the course of the disease as a consequence of oxidative stress. In both disease groups, marked decreases of PV neurons (immunoreactive for PV) and WFA/PNNs were observed in the TRN, with no effects of duration of illness or age at onset. Similarly, in transgenic mice with redox dysregulation, numbers of PV neurons and WFA/PNN+PV neurons were decreased in transgenic compared with wild-type mice; these changes were present at postnatal day (P) 20 for PV neurons and P40 for WFA/PNN+PV neurons, accompanied by alterations of their firing properties. These results show profound abnormalities of PV neurons in the TRN of subjects with SZ and BD, and offer support for the hypothesis that oxidative stress may play a key role in impacting TRN PV neurons at early stages of these disorders. We put forth that these TRN abnormalities may contribute to disruptions of sleep spindles, focused attention and emotion processing in these disorders.
•The problem of over-fitting in Heart Failure (HF) detection is highlighted.•A hybrid decision support system (DSS) is developed to reduce the over-fitting and improve generalization.•The proposed ...DSS shows better generalization and lower over-fitting than conventional neural networks.•Simulation results validate effectiveness of the developed DSS over recently published work.
Available clinical methods for heart failure (HF) diagnosis are expensive and require a high-level of experts intervention. Recently, various machine learning models have been developed for the prediction of HF where most of them have an issue of over-fitting. Over-fitting occurs when machine learning based predictive models show better performance on the training data yet demonstrate a poor performance on the testing data and the other way around. Developing a machine learning model which is able to produce generalization capabilities (such that the model exhibits better performance on both the training and the testing data sets) could overall minimize the prediction errors. Hence, such prediction models could potentially be helpful to cardiologists for the effective diagnose of HF. This paper proposes a two-stage decision support system to overcome the over-fitting issue and to optimize the generalization factor. The first stage uses a mutual information based statistical model while the second stage uses a neural network. We applied our approach to the HF subset of publicly available Cleveland heart disease database. Our experimental results show that the proposed decision support system has optimized the generalization capabilities and has reduced the mean percent error (MPE) to 8.8% which is significantly less than the recently published studies. In addition, our model exhibits a 93.33% accuracy rate which is higher than twenty eight recently developed HF risk prediction models that achieved accuracy in the range of 57.85% to 92.31%. We can hope that our decision support system will be helpful to cardiologists if deployed in clinical setup.
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•Aryl fluorosulfates were synthesized directly from the phenols and SO2F2 in a simple method.•The compounds 9, 12, 14, 19, 25, 26, 35, 36 and 37 exhibited superior antibacterial ...activity.•Compounds 2, 4, 5, 15, 35, 36 and 37 were found to have better antifungal activity.•The SAR revealed that the antimicrobial activity depends upon the presence of –OSO2F group and slender effect of different substituent’s on the phenyl rings.
A series of aryl fluorosulfate analogues (1–37) were synthesized and tested for in vitro antibacterial and antifungal studies, and validated by docking studies. The compounds 9, 12, 14, 19, 25, 26, 35, 36 and 37 exhibited superior antibacterial potency against tested bacterial strains, while compounds 2, 4, 5, 15, 35, 36 and 37 were found to have better antifungal activity against tested fungal strains, compared to standard antibiotic gentamicin and ketoconazole respectively. Among all the synthesized 37 analogs, compounds 25, 26, 35, 36 and 37 displayed excellent anti-biofilm property against Staphylococcus aureus. The structure–activity relationship (SAR) revealed that the antimicrobial activity depends upon the presence of –OSO2F group and slender effect of different substituent’s on the phenyl rings. The electron donating (OCH3) groups in analogs increase the antibacterial activity, and interestingly the electron withdrawing (Cl, NO2, F and Br) groups increase the antifungal activity (except compound 35, 36 and 37). The mechanism of potent compounds showed membrane damage on bacteria confirmed by SEM. Compounds 35, 36 and 37 exhibited highest glide g-scores in molecular docking studies and validated the biocidal property.
In the present study, we explore the topological classifications at fixed points, global dynamics, Neimark-Sacker bifurcation and hybrid control in the two-dimensional discrete-time Leslie’s ...prey-predator model. It is proved that for all involved parameters a,b,c,d,h and α, discrete-time Leslie’s prey-predator model has boundary and interior fixed points: Ex0(ab,0),Exy+aαcd+bα,adcd+bα respectively. Then by linear stability theory, local dynamics with different topological classifications are investigated at fixed points: Ex0(ab,0),Exy+aαcd+bα,adcd+bα. Further for the discrete-time Leslie’s prey-predator model, existence of periodic points are also investigated. By bifurcation theory, it is also proved that if (a,b,c,d,h,α)∈NSBExy+aαcd+bα,adcd+bα then at interior fixed point: Exy+aαcd+bα,adcd+bα, discrete Leslie’s prey-predator model undergo Neimark-Sacker bifurcation and no other bifurcation occurs at it. Moreover, hybrid control strategy is applied to control Neimark-Sacker bifurcation. Boundedness and global dynamics of the discrete-time Leslie’s prey-predator model are also investigated. Finally, obtained results are numerically verified.
Dysregulated anabolic responses to nutrition/exercise may contribute to sarcopenia; however, these characteristics are poorly defined in female populations. We determined the effects of two feeding ...regimes in older women (66 ± 2.5 yr; n = 8/group): bolus whey protein (WP-20 g) or novel low-dose leucine-enriched essential amino acids (EAA) LEAA; 3 g (40% leucine). Using (13)C6phenylalanine infusions, we quantified muscle (MPS) and albumin (APS) protein synthesis at baseline and in response to both feeding (FED) and feeding plus exercise (FED-EX; 6 × 8 knee extensions at 75% 1-repetition maximum). We also quantified plasma insulin/AA concentrations, whole leg (LBF)/muscle microvascular blood flow (MBF), and muscle anabolic signaling by phosphoimmunoblotting. Plasma insulinemia and EAA/aemia were markedly greater after WP than LEAA (P < 0.001). Neither LEAA nor WP modified LBF in response to FED or FED-EX, whereas MBF increased to a similar extent in both groups only after FED-EX (P < 0.05). In response to FED, both WP and LEAA equally stimulated MPS 0-2 h (P < 0.05), abating thereafter (0-4 h, P > 0.05). In contrast, after FED-EX, MPS increased at 0-2 h and remained elevated at 0-4 h (P < 0.05) with both WP and LEAA. No anabolic signals quantifiably increased after FED, but p70 S6K1 Thr(389) increased after FED-EX (2 h, P < 0.05). APS increased similarly after WP and LEAA. Older women remain subtly responsive to nutrition ± exercise. Intriguingly though, bolus WP offers no trophic advantage over LEAA.
Achondroplasia is a genetic disorder known for short stature and skeletal abnormalities.
We present a case of narrowing of the foramen magnum from a large opisthion extending to the spinal canal.
...Foramen magnum stenosis and cervicomedullary stenosis are potentially life threatening neurological manifestations of achondroplasia.
Gram-negative members of the ESCAPE family are more difficult to treat, due to the presence of an additional barrier in the form of a lipopolysaccharide layer and the efficiency of efflux pumps to ...pump out the drugs from the cytoplasm. The development of alternative therapeutic strategies to tackle ESCAPE Gram-negative members is of extreme necessity to provide a solution to the cause of life-threatening infections. The present investigations demonstrated that compounds 17, 20, 25 and 26 possessing the presence of electron donating (OH and OCH
) groups on the phenyl rings are highly potent; whereas compounds 9, 10, 15, 16, 18, 33 and 36 showed moderate activity against Gram-negative bacteria. An excellent dose-dependent antibacterial activity was established compared to that of the standard antibiotic ampicillin. Significant anti-biofilm properties were measured quantitatively, showing optical density (O.D) values of 0.51 ± 015, 0.63 ± 0.20, 0.38 ± 0.07 and 0.62 ± 0.11 at 492 nm and the leakage of cellular components by the compounds, such as 17, 20, 25 and 26, increased the O.D. of respective treated samples compared to the control. In addition, the implication of experimental results is discussed in the light of the lack of survivability of planktonic bacteria and biofilm destruction
. These results revealed the great significance of the development of a new generation of synthetic materials with greater efficacy in anti-biofilm properties by targeting to lock the bio-film associated protein Bap in Gram-negative bacteria.
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