The CLEO RICH detector Artuso, M.; Ayad, R.; Bukin, K. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
12/2005, Letnik:
554, Številka:
1
Journal Article
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We describe the design, construction and performance of a Ring Imaging Cherenkov Detector (RICH) constructed to identify charged particles in the CLEO experiment. Cherenkov radiation occurs in LiF ...crystals, both planar and ones with a novel “sawtooth”-shaped exit surface. Photons in the wavelength interval 135–165
nm are detected using multi-wire chambers filled with a mixture of methane gas and triethylamine vapor. Excellent
π
/
K
separation is demonstrated.
The activities of a zeolite-containing catalyst and catalysts containing a noble metal in intermolecular hydrogen transfer between С
6
hydrocarbons are compared. The zeolite-containing catalyst is ...ineffective in hydrogen transfer from cyclohexane to 1-hexene and in cyclohexene conversion at <400°С. Cyclohexene disproportionation at
Т
< 200°С takes place only over catalysts containing a noble metal. The cyclohexene conversion selectivity depends strongly on the support type. Using deuterated compounds, it has been demonstrated that intermolecular hydrogen transfer via the dehydrogenation–hydrogenation mechanism involves only the initial cyclohexene.
To evaluate the cost effectiveness of dolutegravir + abacavir/lamivudine (DTG + ABC/3TC) compared with raltegravir + abacavir/lamivudine (RAL + ABC/3TC) and ritonavir-boosted ...darunavir + abacavir/lamivudine (DRV/r + ABC/3TC) in HIV-1–infected treatment-naive patients in Russia.
A dynamic Markov model was developed with five response states and six CD4+-based health states. Efficacy estimated as probability of viral suppression (HIV RNA <50 copies/ml) at 48 weeks was obtained from a published network meta-analysis. Baseline cohort characteristics and health state utilities were informed using DTG phase 3 clinical trials. Health care resource use was obtained from literature and costed using published unit costs. Costs (presented in Russian rubles) included antiretroviral drug costs; HIV management costs such as routine care; costs of treating cardiovascular conditions, opportunistic infections, and drug-related adverse effects; and mortality costs. A patient lifetime analysis was conducted using the societal perspective. Outcomes were quality-adjusted life-years (QALYs), life-years, incremental cost per QALY ratio, and incremental cost per responder.
The viral suppression rate among patients receiving DTG + ABC/3TC was 71.7% compared with 65.2% for RAL + ABC/3TC and 59.6% for DRV/r + ABC/3TC. The mean duration of response per patient was 116.6 months for DTG + ABC/3TC, 108.6 months for RAL + ABC/3TC, and 98.9 months for DRV/r + ABC/3TC. Total discounted costs for treatment over patient lifetime were RUB 2.89, 5.32, and 4.38million for DTG + ABC/3TC, RAL + ABC/3TC, and DRV/r + ABC/3TC, respectively. Lifetime discounted QALYs were 12.73 for patients on DTG + ABC/3TC and 12.72 each for patients on RAL + ABC/3TC and DRV/r + ABC/3TC. DTG + ABC/3TC thus dominated the other two alternatives.
With lower costs, higher response rates, and comparable QALYs, DTG + ABC/3TC can be considered as a cost-effective alternative.
SUMMARY
The resistance to mousepox is correlated with the production of type I cytokines: interleukin (IL)‐2, IL‐12, interferon (IFN)‐gamma and tumour necrosis factor (TNF)‐alpha. We intend to ...describe the modulation of generalized ectromelia virus (EV) infection with exogenous administration of mrIFN‐γ and mrTNF‐α separately and in combination using susceptible BALB/c mice. The treatment schemes presented resulted in the localization of the generalized EV infection and its development into non‐fatal sloughing of the infected limb. This was accompanied by low virus titres in the treated mice due to control of systemic virus replication and virus clearance. The balance of type I versus type II cytokines was dominated by a type I response in the treated groups. The group treated with the combination of IFN‐γ and TNF‐α exhibited the best survival with Th1‐dominant (IFN‐γ and IL‐12) cytokine profiles, whereas the TNF‐α‐treated group of mice was less successful in clearance of virus and demonstrated the lowest survival rate. The successful cytokine treatment schemes in this orthopoxvirus model system may have important implications in the treatment of viral diseases in humans and, in particular, of variola virus infection.
In 2005 huge epizooty of H5N1 HPAI occurred in Russia. It had been clear that territory of Russia becoming endemic for H5N1 HPAI. In 2006 several outbreaks have occurred. To develop new vaccines and ...antiviral therapies, animal models had to be investigated. We choose highly pathogenic strain for these studies.
A/duck/Tuva/01/06 belongs to Quinghai-like group viruses. Molecular markers-cleavage site, K627 in PB2 characterize this virus as highly pathogenic. This data was confirmed by direct pathogenic tests: IVPI = 3.0, MLD50 = 1,4Log10EID50. Also molecular analysis showed sensitivity of the virus to adamantanes and neuraminidase inhibitors. Serological analysis showed wide cross-reactivity of this virus with sera produced to H5N1 HPAI viruses isolated earlier in South-East Asia. Mean time to death of infected animals was 8,19+/-0,18 days. First time acute delayed hemorrhagic syndrome was observed in mice lethal model. Hypercytokinemia was determined by elevated sera levels of IFN-gamma, IL-6, IL-10.
Assuming all obtained data we can conclude that basic model parameters were characterized and virus A/duck/Tuva/01/06 can be used to evaluate anti-influenza vaccines and therapeutics.
STUDY OF SAFETY OF PAROTITIS VACCINE Ignatiev, G M; Kulak, M V; Otrashevskaya, E V ...
Žurnal mikrobiologii, ėpidemiologii i immunobiologii,
2015 Nov-Dec
6
Journal Article
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Monitoring of post-vaccinal complications in children immunized with a parotitis vaccine.
Observation of 198 945 children, immunized with 16 lots of parotitis vaccine with Leningrad-3 strain (L-3), ...was carried out for 3 years. Paired samples of sera and saliva were obtained from children, in whom adverse events were registered for 42 days after vaccination. Titers of specific IgM and IgG were determined in blood sera. Analysis of nucleotide sequences of genes F, SH and NH of RNA of parotitis virus was carried out from samples of blood and saliva.
Intensive parameter of vaccine-associated aseptic meningitis under the conditions of the experiments was 0 for 100 000 immunized. Frequency of occurrence of post-vaccinal parotitis was 0.06% from the number of vaccinated--18 cases of vaccine-associated parotitis were registered and laboratory confirmed. A significant difference in specific activity was detected for 3 lots of the vaccine, that were associated with cases of development of parotitis, relative to that of 13 lots of vaccine, development of parotitis was not registered after administration of those.
The study carried out confirmed low neurovirulence of the parotitis vaccine with the L-3 strain of parotitis virus, as well as a low degree of its reactogenicity. A relatively high immunization dose of the used vaccine could be one of the reasons of development of post-vaccinal complications in part of the immunized children.
The pathogenesis of a disease caused by Qinghai-like H5N1 influenza virus in BALB/c mice was studied. Clinical, morphological, and immunological characteristics of the experimental infection caused ...by highly pathogenic A/duck/Tuva/01/06/ (H5N1) virus are described.
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