Global Monitoring for Environment and Security (GMES) is the European programme to establish a European capacity for Earth Observation. GMES is designed to provide European policy makers and public ...authorities with accurate and timely information to better manage the environment, understand and mitigate the effects of climate change and ensure civil security. Sentinel-3 is an Earth observation satellite mission specifically designed for GMES to ensure the long-term collection and operational delivery of high-quality measurements to GMES ocean, land, and atmospheric services, while contributing to the GMES, emergency and security services. Key Sentinel-3 measurement requirements, corresponding to identified GMES user needs, have been derived as follows:•Sea surface topography (SSH), significant wave height (Hs) and surface wind speed derived over the global ocean to an equivalent accuracy and precision as that presently achieved by ENVISAT Radar Altimeter-2 (RA-2) but with enhanced surface topography measurements in the coastal zone, sea ice regions and over inland rivers, their tributaries and lakes.•Sea surface temperature (SST) determined for oceanic and coastal waters globally to an equivalent accuracy and precision as that presently achieved by the ENVISAT Advanced Along Track Scanning Radiometer (AATSR) over the ocean (i.e. <0.3K), at a spatial resolution of 1km.•Visible, and Short-Wave Infrared radiances for oceanic, inland and coastal waters at a spatial resolution of 0.3km (simultaneously and co-registered with SST measurements), determined to an equivalent level of accuracy and precision as ENVISAT Medium Resolution Imaging Spectrometer with complete ocean coverage in 2–3days.•Visible and infrared radiances over global land-surfaces in 1–2days, sea-ice and ice-sheets equivalent to those currently provided from ENVISAT MERIS, AATSR and Système Probatoire d'Observation de la Terre (SPOT) Vegetation.
The Sentinel-3 mission addresses these requirements by implementing and operating:•A dual frequency, Synthetic Aperture Radar Altimeter (SRAL) instrument supported by a dual frequency passive microwave radiometer (MWR) for wet-tropospheric correction, a Precise Orbit Determination package including a GPS receiver, a DORIS instrument and a laser retro-reflector.•A highly sensitive Ocean and Land Colour Imager (OLCI) delivering multi-channel wide-swath optical measurements for ocean and land surfaces.•A dual-view Sea and Land Surface Temperature Radiometer (SLSTR) delivering accurate surface ocean, land, and ice temperature.•A collaborative ground segment providing management of the mission, management, development, production and access to core data products in an operational near real time delivery context.
The mission foresees a series of satellites, each having 7-year lifetime, over a 20-year period starting with the launch of Sentinel-3A in late 2013 and of Sentinel-3B in late 2014. During full operations two identical satellites will be maintained in the same orbit with a phase delay of 180°.
This paper provides an overview of the GMES Sentinel-3 mission including the mission background and user requirements, a technical description of the space segment, a brief overview of the ground segment concept, and a summary description of Sentinel-3 data products and their anticipated performance.
► A new satellite mission called Sentinel-3 dedicated to oceanography is described. ► A technical overview of the Sentinel-3 instrument payload is presented. ► A summary of the Sentinel-3 ground segment and operations concept is presented. ► A summary of products derived from Sentinel-3 payload instruments is presented.
We present photometric redshifts and spectral energy distribution (SED) classifications for a sample of 1542 optically identified sources detected with XMM in the COSMOS field. Our template fitting ...classifies 46 sources as stars and 464 as nonactive galaxies, while the remaining 1032 require templates with an active galactic nucleus (AGN) contribution. High accuracy in the derived photometric redshifts was accomplished as the result of (1) photometry in up to 30 bands with high-significance detections, (2) a new set of SED templates, including 18 hybrids covering the far-UV to mid-infrared, which have been constructed by the combination of AGNs and nonactive galaxies templates, and (3) multiepoch observations that have been used to correct for variability (most important for type 1 AGNs). The reliability of the photometric redshifts is evaluated using the subsample of 442 sources with measured spectroscopic redshifts. We achieved an accuracy of for i* AB < 22.5 ( for i* AB < 24.5). The high accuracies were accomplished for both type 2 (where the SED is often dominated by the host galaxy) and type 1 AGNs and QSOs out to z = 4.5. The number of outliers is a large improvement over previous photometric redshift estimates for X-ray-selected sources (4.0% and 4.8% outliers for i* AB < 22.5 and i* AB < 24.5, respectively). We show that the intermediate band photometry is vital to achieving accurate photometric redshifts for AGNs, whereas the broad SED coverage provided by mid-infrared (Spitzer/IRAC) bands is important to reduce the number of outliers for normal galaxies.
Abstract Objectives First bite syndrome (FBS) is an early postoperative pain syndrome characterized by the sudden onset of pain in the parotid region at the first bite of each meal. The etiology is ...not certain, hence a standardized therapy does not exist. Methods A 50-year old woman referred to us complaining of a swelling in the right parotid region. Fine-needle aspiration biopsy (FNAB) was diagnostic for pleomorphus adenoma of the deep lobe of the parotid gland. A 50-year old man presented with a mass in the right side of the neck, FNAB was diagnostic for parapharyngeal space neurinoma. The first patient was submitted to total parotidectomy with facial nerve preservation, the second to extracapsular dissection of the tumor. A week after surgery both patients developed FBS. A qualitative/quantitative description of pain was obtained by means of a self-coded questionnaire. The score ranges from 8 to 44, corresponding to the lowest and the highest discomfort possible, respectively. Acupuncture was used to treat these 2 patients. The treatment protocol comprised 6 sessions, one per week, lasting 30 minutes each. Results Our questionnaire was administered before and after treatment and the score dropped from 33 to 25 in the female, from 30 to 15 in the male patient. Conclusion FBS is a complication of upper cervical surgery with a high morbidity rate. We describe the first two cases of FBS that were successfully treated with acupuncture in our ENT department. We believe that this procedure may represent a valid therapeutic alternative in the future.
The Global Forest Products Model Joseph Buongiorno, Shushuai Zhu, Dali Zhang, James Turner, David Tomberlin
2003, 2003-04-24
eBook
The Global Forest Products Model (GFPM) book provides a complete introduction to this widely applied computer model. The GFPM is a dynamic economic equilibrium model that is used to predict ...production, consumption, trade, and prices of 14 major forest products in 180 interacting countries. The book thoroughly documents the methods, data, and computer software of the model, and demonstrates the model's usefulness in addressing international economic and environmental issues. The Global Forest Products Model is written by an international multi- disciplinary team and is ideal for graduate students and professionals in forestry, natural resource economics, and related fields. It explains trends in world forest industries in the simplest terms by explaining the economic theory underlying the model. It describes six applications of the GFPM, three of which were commissioned by the Food Agriculture of the United Nations, the USDA Forest Service, and New Zealand Research. The authors show how to apply the model to real issues such as the effects of the Asian economic crisis on the forest sector, the effects of eliminating tariffs on international trade and production, and the international effects of national environmental policies. They provide complete explanations on how to use the GFPM software, prepare the data, make the forecasts, and summarize the results with tables and graphs. * Comprehensive, and rigorous description of the world forestry sector * Written by an international multi-disciplinary team * Thorough description of data and methods * In-depth applications to modern economic and policy issues * Detailed documentation of the computer software * Suitable for students, researchers, and decision makers
Advanced glycation end products (AGE) increase as a consequence of diabetic hyperglycemia and, in nephropathic patients, following renal function loss. Protein-bound AGE behave as immunogens, ...inducing formation of specific antibodies (Ab-AGE). In this work AGE immunogenicity was studied in 42 diabetic patients, 26 nephropathic patients on hemodialysis and 26 patients with end-stage renal disease who underwent kidney transplantation and in 20 normal subjects. Non-oxidation-derived AGE (nox-AGE), oxidation-derived AGE (ox-AGE) and Ab-AGE were measured by competitive or direct enzyme-linked immunosorbent assay (ELISA) and circulating immune complexes (CIC) by C1q ELISA. Nox-AGE increased significantly in all patient groups (
p
≤0.05 to ≤0.0001) except in patients on hemodialysis for less than 6 yr. Ox-AGE were only significantly increased in patients transplanted more than 3 yr previously (
p
<0.05). Ab-AGE were significantly lower than controls in both diabetic groups and in patients on hemodialysis for more than 6 yr (
p
<0.005 to <0.0001) and not unlike controls in the other groups. These results demonstrate that hemodialysis or renal tranplantation can, initially, reduce either nox- or ox-AGE levels, which however go back to being high in time. Renal transplantation fails to normalize nox-AGE. More importantly, plasma Ab-AGE levels are reduced or unchanged in all patient groups in comparison with controls, despite higher circulating AGE levels. This suggests the importance of tissue-bound AGE as Ab-AGE targets. Additional interventions are needed to control AGE levels in treated nephropathic patients. The search and quantification of specific Ab-AGE would give more meaningful results if performed over specific tissue specimens.
The flare-up effect of GnRH analogues may cause transient uterine bleeding in girls affected with idiopathic central precocious puberty (ICPP).
To assess the incidence of endometrial bleeding and ...verify whether pretreatment with cyproterone acetate could counteract it.
Fifty-four girls affected by ICPP were divided into 2 groups. The first group (30 girls) was treated with triptorelin (3.75 mg, i.m. injection) every 28 days. The second group (24 girls) was treated with cyproterone acetate and triptorelin: cyproterone acetate (50 mg/m(2)) was administered every day for 8 weeks, and triptorelin (3.75 mg) was commenced 4 weeks after starting the cyproterone, then the intramuscular injection of triptorelin was repeated every 28 days.
Eight of 54 girls (15%) had mild withdrawal bleeding. There were no differences in incidence between groups 1 and 2. Girls with pubertal uterus at pelvic ultrasound had a higher incidence of uterine bleeding than girls with infantile uterus (25 vs. 7%), but this difference was not significant.
Co-administration of cyproterone acetate and GnRH analogues does not significantly decrease the incidence of uterine bleeding.
PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome is the most common autoinflammatory syndrome in pediatrics, accepted as an hyperimmune condition. Pidotimod is ...a molecule with immunomodulatory activity on both innate and adaptive immune responses; it also has the capacity to modulate the function of the respiratory epithelial cells through the activation of a NK-KB pathway which would involve the host-virus interaction. Moreover, the proven beneficial effect of Pidotimod in enhancing the immune response during vaccination, and its benefits in the prevention of respiratory tract infections, should be noted.
A joint combination of Pidotimod and bacterial lysates was used to treat 37 children with a clinical diagnosis of PFAPA; within the end of the first year of therapy, the healing rate of PFAPA symptoms was 67.5% (25 children), with a 10.8% (4 cases) still in complete remission within the end of the second year of follow-up.
It is important to highlight that 29 children (78.3%) had benefitted from this therapy, in terms of healing, with a marked decrease in the incidence of fever from a total of 360 to 106 episodes, and episodes of periodic fever occurring almost 4 times less frequently. The use of Pidotimod determined a significant reduction of surgical tonsillectomy's treatment.
This approach had a strong impact on the children's quality of life; a significant decrement in the use of antipyretic drugs, as well as a lower rate of antibiotic prescription, were also noted. It also had a dramatic impact on families' lives, because the treatment lowers the number of absences of family members from work or school/kindergarten.
In the present study we measured PC-1 content, tumour necrosis factor (TNF)-alpha gene expression, and insulin stimulation of insulin receptor tyrosine-kinase activity in adipose tissue from ...non-obese, non-diabetic subjects. These parameters were correlated with in vivo insulin action as measured by the intravenous insulin tolerance test (Kitt values). PC-1 content was negatively correlated with Kitt values (r = -0.5, p = 0.04) and positively with plasma insulin levels both fasting (r = 0.58, p = 0.009) and after 120 min during oral glucose tolerance test (OGTT) (r = 0.67, p = 0.002). Moreover, adipose tissue PC-1 content was higher in relatively insulin-resistant subjects (Kitt values lower than 6) than in relatively insulin-sensitive subjects (Kitt values higher than 6) (525 +/- 49 ng/mg protein vs 336 +/- 45, respectively, p = 0.012). Adipose tissue insulin receptor tyrosine-kinase activity in response to insulin was significantly lower at all insulin concentrations tested (p = 0.017, by two-way analysis of variance test) in insulin-resistant than in insulin-sensitive subjects (Kitt values lower or higher than 6, respectively). In contrast to PC-1, no significant correlation was observed between adipose tissue TNF-alpha mRNA content and Kitt values, and plasma insulin levels, both fasting and at after 120 min during OGTT. Also, no difference was observed in TNF-alpha mRNA content between subjects with Kitt values higher or lower than 6. These studies in adipose tissue, together with our previous studies in skeletal muscle raise the possibility that PC-1, by regulating insulin receptor function, may play a role in the degree of insulin sensitivity in non-obese, non-diabetic subjects.
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