Land use and related pressures have reduced local terrestrial biodiversity, but it is unclear how the magnitude of change relates to the recently proposed planetary boundary ("safe limit"). We ...estimate that land use and related pressures have already reduced local biodiversity intactness–the average proportion of natural biodiversity remaining in local ecosystems–beyond its recently proposed planetary boundary across 58.1% of the world's land surface, where 71.4% of the human population live. Biodiversity intactness within most biomes (especially grassland biomes), most biodiversity hotspots, and even some wilderness areas is inferred to be beyond the boundary. Such widespread transgression of safe limits suggests that biodiversity loss, if unchecked, will undermine efforts toward long-term sustainable development.
Abundance and distribution of earthworms in agricultural fields is frequently proposed as a measure of soil quality assuming that observed patterns of abundance are in response to improved or ...degraded environmental conditions. However, it is not clear that earthworm abundances can be directly related to their edaphic environment, as noted in Darwin’s final publication, perhaps limiting or restricting their value as indicators of ecological quality in any given field. We present results from a spatially explicit intensive survey of pastures within United Kingdom farms, looking for the main drivers of earthworm density at a range of scales. When describing spatial variability of both total and ecotype-specific earthworm abundance within any given field, the best predictor was earthworm abundance itself within 20–30 m of the sampling point; there were no consistent environmental correlates with earthworm numbers, suggesting that biological factors (e.g. colonisation rate, competition, predation, parasitism) drive or at least significantly modify earthworm distributions at this spatial level. However, at the national scale, earthworm abundance is well predicted by soil nitrate levels, density, temperature and moisture content, albeit not in a simple linear fashion. This suggests that although land can be managed at the farm scale to promote earthworm abundance and the resulting soil processes that deliver ecosystem services, within a field, earthworm distributions will remain patchy. The use of earthworms as soil quality indicators must therefore be carried out with care, ensuring that sufficient samples are taken within field to take account of variability in earthworm populations that is unrelated to soil chemical and physical properties.
ObjectivePeople with post-stroke aphasia (language/communication impairment) and their supporters report mixed satisfaction with stroke and aphasia care. To date, however, their journey of care and ...the key service interactions that shape their experience have not been comprehensively explored. We aimed to investigate the lived experience of post-stroke aphasia care, across the continuum of care and by geographical location, to establish priorities for service design.DesignThis is the first stage of an experience-based co-design study. We purposively sampled people with aphasia (PWA) and significant others (SOs) across 21 hospital and health service sites, community groups and by self-referral. Participants shared experiences of care in online interviews and focus groups. Touchpoints (key moments that shape experience) and unmet needs were identified using qualitative thematic analysis. Priorities for service design were established using an adapted nominal group technique.SettingSites spanned remote, regional and metropolitan areas in Queensland, Australia.ParticipantsPWA (n=32; mild=56%; moderate=31%; severe=13%) and SOs (n=30) shared 124 experiences of acute, rehabilitation and community-based care in 23 focus groups and 13 interviews.ResultsBoth positive and negative healthcare experiences occurred most frequently in hospital settings. Negative experiences regularly related to communication with health professionals, while positive experiences related to the interpersonal qualities of healthcare providers (eg, providing hope) for PWA, or witnessing good rapport between a PWA and their health professional for SOs. To improve services, PWA prioritised communicatively accessible education and information and SOs prioritised access to psychological and peer support.ConclusionsWe identified key aspects of post-stroke aphasia care that shape experience. The needs of PWA and SOs may be better met through health professional training in supported communication, increased service availability in regional and remote areas, communication-accessible hospital environments, increased access to psychological and peer support, and meaningful involvement of SOs in rehabilitation.
Mutations in bone morphogenetic protein receptor II (BMPR-II) underlie most heritable cases of pulmonary arterial hypertension (PAH). However, less than half the individuals who harbor mutations ...develop the disease. Interestingly, heterozygous null BMPR-II mice fail to develop PAH unless an additional inflammatory insult is applied, suggesting that BMPR-II plays a fundamental role in dampening inflammatory signals in the pulmonary vasculature. Using static- and flow-based in vitro systems, we demonstrate that BMPR-II maintains the barrier function of the pulmonary artery endothelial monolayer suppressing leukocyte transmigration. Similar findings were also observed in vivo using a murine model with loss of endothelial BMPR-II expression. In vitro, the enhanced transmigration of leukocytes after tumor necrosis factor α or transforming growth factor β1 stimulation was CXCR2 dependent. Our data define how loss of BMPR-II in the endothelial layer of the pulmonary vasculature could lead to a heightened susceptibility to inflammation by promoting the extravasation of leukocytes into the pulmonary artery wall. We speculate that this may be a key mechanism involved in the initiation of the disease in heritable PAH that results from defects in BMPR-II expression.
Soils are key components of our ecosystems and provide 95%–99% of our food. This importance is reflected by an increase in participatory citizen science projects on soils. Citizen science is a ...participatory research method that actively involves and engages the public in scientific enquiry to generate new knowledge or understanding. Here, we review past and current citizen science projects on agricultural soils across Europe. We conducted a web‐based survey and described 24 reviewed European citizen science projects in the light of the 10 principles of citizen science and identified success factors for citizen science. Over 66% of the projects generated soil biodiversity data; 54% and 42% of the projects generated data on vegetation cover and soil organic carbon, respectively. Our findings show that soil citizen science projects aligned with the 10 principles of citizen science offer an unexploited resource for European soil health research. We conclude that promoting co‐creation, fostering knowledge‐sharing networks and enabling long‐term communication and commitment with citizens are success factors for further development of citizen science on soils.
Factors such as socioeconomic status, age at menarche and childbearing patterns are components that have been shown to influence mammary gland development and establish breast cancer disparity. ...Pubertal mammary gland development is selected as the focus of this review, as it is identified as a "window of susceptibility" for breast cancer risk and disparity. Here we recognize non-Hispanic White, African American, and Asian American women as the focus of breast cancer disparity, in conjunction with diets associated with changes in breast cancer risk. Diets consisting of high fat, N-3 polyunsaturated fatty acids, N-6 polyunsaturated fatty acids, as well as obesity and the Western diet have shown to lead to changes in pubertal mammary gland development in mammalian models, therefore increasing the risk of breast cancer and breast cancer disparity. While limited intervention strategies are offered to adolescents to mitigate development changes and breast cancer risk, the prominent solution to closing the disparity among the selected population is to foster lifestyle changes that avoid the deleterious effects of unhealthy diets.
Methods and approaches to advance soil macroecology White, Hannah J.; León‐Sánchez, Lupe; Burton, Victoria J. ...
Global ecology and biogeography,
October 2020, 2020-10-00, 20201001, Letnik:
29, Številka:
10
Journal Article
Recenzirano
Odprti dostop
Motivation and aim
Soil biodiversity is central to ecosystem function and services. It represents most of terrestrial biodiversity and at least a quarter of all biodiversity on Earth. Yet, research ...into broad, generalizable spatial and temporal patterns of soil biota has been limited compared to aboveground systems due to complexities of the soil system. We review the literature and identify key considerations necessary to expand soil macroecology beyond the recent surge of global maps of soil taxa, so that we can gain greater insight into the mechanisms and processes shaping soil biodiversity. We focus primarily on three groups of soil taxa (earthworms, mycorrhizal fungi and soil bacteria) that represent a range of body sizes and ecologies, and, therefore, interact with their environment at different spatial scales.
Results
The complexities of soil, including fine‐scale heterogeneity, 3‐D habitat structure, difficulties with taxonomic delimitation, and the wide‐ranging ecologies of its inhabitants, require the classical macroecological toolbox to be expanded to consider novel sampling, molecular identification, functional approaches, environmental variables, and modelling techniques.
Main conclusions
Soil provides a complex system within which to apply macroecological research, yet, it is this property that itself makes soil macroecology a field ripe for innovative methodologies and approaches. To achieve this, soil‐specific data, spatio‐temporal, biotic, and abiotic considerations are necessary at all stages of research, from sampling design to statistical analyses. Insights into whole ecosystems and new approaches to link genes, functions and diversity across spatial and temporal scales, alongside methodologies already applied in aboveground macroecology, invasion ecology and aquatic ecology, will facilitate the investigation of macroecological processes in soil biota, which is key to understanding the link between biodiversity and ecosystem functioning in terrestrial ecosystems.
Adenosine possesses potent anti‐inflammatory properties which are partly mediated by Gi‐coupled adenosine A3 receptors (A3Rs). A3R agonists have shown clinical benefit in a number of inflammatory ...conditions although some studies in A3R‐deficient mice suggest a pro‐inflammatory role. We hypothesised that, in addition to cell signalling effects, A3R compounds might inhibit neutrophil chemotaxis by disrupting the purinergic feedback loop controlling leukocyte migration. Human neutrophil activation triggered rapid upregulation of surface A3R expression which was disrupted by pre‐treatment with either agonist (Cl‐IB‐MECA) or antagonist (MRS1220). Both compounds reduced migration velocity and neutrophil transmigration capacity without impacting the response to chemokines per se. Similar effects were observed in murine neutrophils, while cells from A3R‐deficient mice displayed a constitutively impaired migratory phenotype indicating compound‐induced desensitisation and genetic ablation had the same functional outcome. In a dextran sodium sulphate‐induced colitis model, A3R‐deficient mice exhibited reduced colon pathology and decreased tissue myeloperoxidase levels at day 8 – consistent with reduced neutrophil recruitment. However, A3R‐deficient mice were unable to resolve the dextran sodium sulphate‐induced inflammation and had elevated numbers of tissue‐associated bacteria by day 21. Our data indicate that A3Rs play a role in neutrophil migration and disrupting this function has the potential to adversely affect innate immune responses.
Global change is affecting soil biodiversity and functioning across all terrestrial ecosystems. Still, much is unknown about how soil biodiversity and function will change in the future in response ...to simultaneous alterations in climate and land use, as well as other environmental drivers. It is crucial to understand the direct, indirect and interactive effects of global change drivers on soil communities and ecosystems across environmental contexts, not only today but also in the near future. This is particularly relevant for international efforts to tackle climate change like the Paris Agreement, and considering the failure to achieve the 2020 biodiversity targets, especially the target of halting soil degradation. Here, we outline the main frontiers related to soil ecology that were presented and discussed at the thematic sessions of the World Biodiversity Forum 2022 in Davos, Switzerland. We highlight multiple frontiers of knowledge associated with data integration, causal inference, soil biodiversity and function scenarios, critical soil biodiversity facets, underrepresented drivers, global collaboration, knowledge application and transdisciplinarity, as well as policy and public communication. These identified research priorities are not only of immediate interest to the scientific community but may also be considered in research priority programmes and calls for funding.
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