Abstract The use of reclaimed water is expected to increase in the coming years, mainly in water-scarce areas. In the European Union (EU), an increase in the use of reclaimed water is expected to ...play a significant role within the European circular economy strategy and climate change adaptation policies with the aim to enhance overall sustainability of water resource management. While several institutions have offered estimations of the potential of reclaimed water reuse in the EU context, these estimations tend to overestimate potential reuse volumes since they fail to fully consider the following important issues: (a) the role of return flows in basins where cascade reuse is crucial in maintaining downstream uses (including ecological flows); (b) the availability of abundant (and cheaper) conventional resources; and (c) the economic productivity of water as an indicator of users’ willingness to pay for reclaimed water. This study focuses on the Spanish case since this is currently the EU member state with the highest potential for reclaimed water reuse. Findings show that previous estimations of reusable water volumes in Spain may have overestimated potential volumes. The proposed analysis can be extrapolated to other EU regions, where realistic estimations of the potential of reclaimed water might be much needed.
Hepatoblastoma is the most frequent hepatic tumor in children, and its initial presentation will affect treatment and prognosis. The aim of this study is to evaluate long-term results of liver ...transplantation in children with unresectable hepatoblastoma.
This is a retrospective review of patients with hepatoblastoma who underwent liver transplantation, analyzing risk factors, tumor presentation, treatment, and long-term survival to identify prognostic factors.
Thirty-one patients underwent liver transplantation in the context of unresectable hepatoblastoma, mainly males (67%) and with risk factors such as prematurity (12.9%), maternal smoking (6.5%), and familial adenomatous polyposis (3.2%). Most frequent presentation was multifocal PRETEXT III (51.6%) and PRETEXT IV (45.2%), with metastasis at diagnosis in 12.9% and vascular involvement in 54.8%.Twenty-one patients received a living-donor (67.7%) and 10 a cadaveric graft (32.2%), at 31.7 months of age (5-125). Most transplants were primary, and only two were performed as rescue therapy after an attempt of surgical resection of the tumor.Overall survival 1 and 5 years after transplantation were 93.3% ± 4.6% and 86.4% ± 6.3%, respectively. We could not find any statistically significant differences between risk factors, tumor presentation, type of graft, or type of transplant.
Liver transplantation has increased hepatoblastoma survival in unresectable tumors. Probably due to these good results, we have not been able to find significant prognostic factors in this cohort.
This study aimed to investigate the variations of parasites in the feces of brown bears Ursus arctos inhabiting the Cantabrian Mountains (NW Spain). A total of 248 bear fecal samples were collected ...throughout one year, spanning from August 2018 to September 2019, at an approximate frequency of 20 samples per month. The results were analyzed in relation to both the season and the biological activity of the brown bears, i.e., hibernation, mating and hyperphagia. Among the examined samples, eggs of Dicrocoelium dendriticum (32.2%; 95% Confidence Interval: 26.4–38.1), Baylisascaris sp. (44.8%; 38.5–50.9), ancylostomatids (probably belonging to Uncinaria spp.) (16.5%; 11.9–21.1) and Trichuris sp. (1.2%; 0–2.6) were observed. Significant seasonal differences were noted for Baylisascaris and ancylostomatids (χ2 = 21.02, P = 0.001 and χ2 = 34.41, P = 0.001, respectively). Furthermore, the presence of helminth eggs was correlated with the activity phase of the brown bears. Dicrocoelium attained the highest prevalence during the mating phase, while Baylisascaris and ancylostomatids were more frequent during hyperphagia. Notably, the highest egg-output counts for Dicrocoelium and Baylisascaris sp. were recorded during the mating phase and hibernation, respectively, whereas ancylostomatids eggs peaked during hyperphagia. Additionally, variations in egg-output counts were significant for all helminths concerning the season, with the exception of Trichuris sp., and for Dicrocoelium and Baylisascaris sp. According to bear activity. It is concluded that infection by gastrointestinal helminths depends on the season and the biological activity of the bears from the Cantabrian Mountains, and their health status could result influenced.
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•Cantabrian brown bears are infected by liver trematodes and gastrointestinal nematodes.•The lowest helminth prevalences were observed in spring and the highest in autumn.•The presence of helminth eggs correlated with the activity phase of the brown bears.
Prevention and avoidance of deadlocks in sensor networks that use the wormhole routing algorithm is an active research domain. There are diverse control policies that will address this problem being ...our approach a new method. In this paper we present a virtual control policy for the new specialized Petri net subclass called Binary Ordered Resources Petri Net (BORPN). Essentially, it is an ordinary class constructed from various state machines that share unitary resources in a complex form, which allows branching and joining of processes. The reduced structure of this new class gives advantages that allow analysis of the entire system's behavior, which is a prohibitive task for large systems because of the complexity and routing algorithms.
In recent years, the integration of new elements to the electric grid, such as electric vehicles and renewable energies, requires the evolution of the electric grid as we know it, making it necessary ...to optimize the processes of production, distribution, and storage of energy. This situation gives rise to introducing the so-called Smart Grids (SG), which would allow a balance between energy supply and demand, thus enabling a system in which the consumer will also become a producer of its surplus energy. Under this scenario, this work proposes an architecture whose technological components, such as the internet of things (IoT), artificial intelligence (AI), cloud computing, and mobile applications, allow users to address the problem of consumption and production of electricity. In the experiments conducted, results were obtained from the components that support the functionality of the proposed platform.
The ejaculate is a heterogeneous pool of spermatozoa containing only a small physiologically adequate subpopulation for fertilization. As there is no method to isolate this subpopulation, its ...specific characteristics are unknown. This is one of the main reasons why we lack effective tools to identify male infertility and for the low efficiency of assisted reproductive technologies. The aim of this study was to improve ICSI outcome by sperm selection through thermotaxis. Here we show that a specific subpopulation of mouse and human spermatozoa can be selected in vitro by thermotaxis and that this subpopulation is the one that enters the fallopian tube in mice. Further, we confirm that these selected spermatozoa in mice and humans show a much higher DNA integrity and lower chromatin compaction than unselected sperm, and in mice, they give rise to more and better embryos through intracytoplasmic sperm injection, doubling the number of successful pregnancies. Collectively, our results indicate that a high quality sperm subpopulation is selected in vitro by thermotaxis and that this subpopulation is also selected in vivo within the fallopian tube possibly by thermotaxis.
This paper presents a study that evaluates the usability and user experience of a mobile application interface for residential energy management, adopting a hybrid approach that integrates ...quantitative and qualitative methods within a user-centered design framework. For the evaluation, metrics and tools such as the User Experience Questionnaire Short (UEQ-S) and the System Usability Scale (SUS) were used, in addition to the implementation of a fuzzy logic model to interpret and contrast the data obtained through these metrics, allowing a more accurate assessment of usability and user experience, reflecting the variability and trends in the responses. Three aspects evaluated stand out: satisfaction with the interface, ease of use, and efficiency. These are fundamental to understanding how users perceive the system. The results indicate a high likelihood of user recommendation of the system and a high overall quality of user experience. This study significantly contributes to mobile application usability, especially in residential energy management, offering valuable insights for designing more intuitive and effective user interfaces on mobile devices.
The paper presents a proposed queuing model based on Kendall’s notation for the intersection of two streets in Panama City (53 East and 56 East). The proposed model is based on a set of traffic ...lights that controls the flow of vehicles at the intersection according to a predetermined schedule. The model analyzes the stability of the system and simulations are performed to evaluate its performance. The main objective of the paper is to optimize the vehicle flow by minimizing the waiting time for passage. In the study, it was observed that the current traffic light system on Calle 50 (50th Street) is unstable and oversaturated during weekdays, which generates large vehicle queues with no estimated exit times. It was proposed to increase the system capacity to 1300 vehicles per hour to achieve reasonable stability and provide a solution to improve traffic signal timing on 50th Street. The need to increase the system capacity has been demonstrated and an optimal value has been suggested. The evaluation of other models and the use of AI can further strengthen the system and improve the prediction accuracy in different traffic scenarios.
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