The YSOVAR (Young Stellar Object VARiability) Spitzer Space Telescope observing program obtained the first extensive mid-infrared time series photometry of the Orion Nebula Cluster plus smaller ...footprints in 11 other star-forming cores. We present the data collection and reduction for the Spitzer and ancillary data, and define the "standard sample" on which we calculate statistics, consisting of fast cadence data, with epochs roughly twice per day for ~40 days. We also define a "standard sample of members" consisting of all the IR-selected members and X-ray-selected members. We characterize the standard sample in terms of other properties, such as spectral energy distribution shape. We use three mechanisms to identify variables in the fast cadence data - the Stetson index, a xsup 2 fit to a flat light curve, and significant periodicity. We do not find any evidence for variability that causes excesses to appear or vanish within our data set; out of members and field objects combined, at most 0.02% may have transient IR excesses.
Forest managers need a comprehensive scientific understanding of natural stand development processes when designing silvicultural systems that integrate ecological and economic objectives, including ...a better appreciation of the nature of disturbance regimes and the biological legacies, such as live trees, snags, and logs, that they leave behind. Most conceptual forest development models do not incorporate current knowledge of the: (1) complexity of structures (including spatial patterns) and developmental processes; (2) duration of development in long-lived forests; (3) complex spatial patterns of stands that develop in later stages of seres; and particularly (4) the role of disturbances in creating structural legacies that become key elements of the post-disturbance stands. We elaborate on existing models for stand structural development using natural stand development of the Douglas-fir—western hemlock sere in the Pacific Northwest as our primary example; most of the principles are broadly applicable while some processes (e.g. role of epicormic branches) are related to specific species. We discuss the use of principles from disturbance ecology and natural stand development to create silvicultural approaches that are more aligned with natural processes. Such approaches provide for a greater abundance of standing dead and down wood and large old trees, perhaps reducing short-term commercial productivity but ultimately enhancing wildlife habitat, biodiversity, and ecosystem function, including soil protection and nutrient retention.
Purpose
Ensuring and measuring adherence to prescribed exercise regimens are fundamental challenges in intervention studies to promote exercise in adults with cancer. This study reports exercise ...adherence in women who were asked to walk 150 min/week throughout chemotherapy treatment for early breast cancer. Participants were asked to wear a Fitbit
TM
throughout their waking hours, and Fitbit steps were uploaded directly into study computers.
Methods
Descriptive statistics are reported, and both unadjusted and multivariable linear regression models were used to assess associations between participant characteristics, breast cancer diagnosis, treatment, chemotherapy toxicities, and patient-reported symptoms with average Fitbit steps/week.
Results
Of 127 women consented to the study, 100 had analyzable Fitbit data (79%); mean age was 48 and 31% were non-white. Mean walking steps were 3956 per day. Nineteen percent were fully adherent with the target of 6686 steps/day and an additional 24% were moderately adherent. In unadjusted analysis, baseline variables associated with
fewer
Fitbit steps were: non-white race (
p
= 0.012), high school education or less (
p
= 0.0005), higher body mass index (
p
= 0.0024), and never/almost never drinking alcohol (
p
= 0.0048). Physical activity variables associated with
greater
Fitbit steps were: pre-chemotherapy history of vigorous physical activity (
p
= 0.0091) and higher self-reported walking minutes/week (
p
< 0.001), and higher outcome expectations from exercise (
p
= 0.014). Higher baseline anxiety (
p
= 0.03) and higher number of chemotherapy-related symptoms rates “severe/very severe” (
p
= 0.012) were associated with fewer steps. In multivariable analysis, white race was associated with 12,146 greater Fitbit steps per week (
p
= 0.004), as was self-reported walking minutes prior to start of chemotherapy (
p
< 0.0001).
Conclusions
Inexpensive commercial-grade activity trackers, with data uploaded directly into research computers, enable objective monitoring of home-based exercise interventions in adults diagnosed with cancer. Analysis of the association of walking steps with participant characteristics at baseline and toxicities during chemotherapy can identify reasons for low/non-adherence with prescribed exercise regimens.
By many metrics, the tornado outbreak on 27 April 2011 was the most significant tornado outbreak since 1950, exceeding the super outbreak of 3–4 April 1974. The number of tornadoes over a 24-h period ...(midnight to midnight) was 199; the tornado fatalities and injuries were 316 and more than 2,700, respectively; and the insurable loss exceeded $4 billion (U.S. dollars). In this paper, we provide a meteorological overview of this outbreak and illustrate that the event was composed of three mesoscale events: a large early morning quasi-linear convective system (QLCS), a midday QLCS, and numerous afternoon supercell storms. The main data sources include NWS and research radars, profilers, surface measurements, and photos and videos of the tornadoes. The primary motivation for this preliminary research is to document the diverse characteristics (e.g., tornado characteristics and mesoscale organization of deep convection) of this outbreak and summarize preliminary analyses that are worthy of additional research on this case.
Purpose
It is not known whether chemotherapy-related symptom experiences differ between Black and White women with early breast cancer (Stage I–III) receiving current chemotherapy regimens and, in ...turn, influences dose delay, dose reduction, early treatment discontinuation, or hospitalization.
Methods
Patients self-reported their race and provided symptom reports for 17 major side effects throughout chemotherapy. Toxicity and adverse events were analyzed separately for anthracycline and non-anthracycline regimens. Fisher’s exact tests and two-sample t-tests compared baseline patient characteristics. Modified Poisson regression estimated relative risks of moderate, severe, or very severe (MSVS) symptom severity, and chemotherapy-related adverse events.Please check and confirm that the authors and their respective affiliations have been correctly identified and amend if necessary.no changes
Results
In 294 patients accrued between 2014 and 2020, mean age was 58 (SD13) and 23% were Black. For anthracycline-based regimens, the only significant difference in MSVS symptoms was in lymphedema (41% Black vs 20% White,
p
= .04) after controlling for axillary surgery. For non-anthracycline regimens, the only significant difference was MSVS peripheral neuropathy (41% Blacks vs. 23% White) after controlling for taxane type (
p
= .05) and diabetes (
p
= .05). For all other symptoms, severity scores were similar. Dose reduction differed significantly for non-anthracycline regimens (49% Black vs. 25% White,
p
= .01), but not for anthracycline regimens or in dose delay, early treatment discontinuation, or hospitalization for either regimen.
Conclusion
Except for lymphedema and peripheral neuropathy, Black and White patients reported similar symptom severity during adjuvant chemotherapy. Dose reductions in Black patients were more common for non-anthracycline regimens. In this sample, there were minimal differences in patient-reported symptoms and other adverse outcomes in Black versus White patients.
The MuCap experiment at the Paul Scherrer Institute has measured the rate Λ(S) of muon capture from the singlet state of the muonic hydrogen atom to a precision of 1%. A muon beam was stopped in a ...time projection chamber filled with 10-bar, ultrapure hydrogen gas. Cylindrical wire chambers and a segmented scintillator barrel detected electrons from muon decay. Λ(S) is determined from the difference between the μ(-) disappearance rate in hydrogen and the free muon decay rate. The result is based on the analysis of 1.2 × 10(10) μ(-) decays, from which we extract the capture rate Λ(S) = (714.9 ± 5.4(stat) ± 5.1(syst)) s(-1) and derive the proton's pseudoscalar coupling g(P)(q(0)(2) = -0.88 m(μ)(2)) = 8.06 ± 0.55.
Effective maintenance of plant iron (Fe) homoeostasis relies on a network of transcription factors (TFs) that respond to environmental conditions and regulate Fe uptake, translocation, and storage. ...The iron-related transcription factor 3 (IRO3), as well as haemerythrin motif-containing really interesting new gene (RING) protein and zinc finger protein (HRZ), are major regulators of Fe homeostasis in diploid species like
(
) and rice (
L.), but remain uncharacterised in hexaploid bread wheat (
L.). In this study, we have identified, annotated, and characterised three
homoeologs and six
and
homoeologs in the bread wheat genome. Protein analysis revealed that TaIRO3 and TaHRZ proteins contain functionally conserved domains for DNA-binding, dimerisation, Fe binding, or polyubiquitination, and phylogenetic analysis revealed clustering of TaIRO3 and TaHRZ proteins with other monocot IRO3 and HRZ proteins, respectively. Quantitative reverse-transcription PCR analysis revealed that all
and
homoeologs have unique tissue expression profiles and are upregulated in shoot tissues in response to Fe deficiency. After 24 h of Fe deficiency, the expression of
homoeologs was upregulated, while the expression of
homoeologs was unchanged, suggesting that TaHRZ functions upstream of TaIRO3 in the wheat Fe homeostasis TF network.
Little is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for ...later lung function.
To investigate the role of expression patterns of well-defined asthma susceptibility genes during human and murine lung development. We hypothesized that genes influencing normal airways development would be over-represented by genes associated with asthma.
Asthma genes were first identified via comprehensive search of the current literature. Next, we analyzed their expression patterns in the developing human lung during the pseudoglandular (gestational age, 7-16 weeks) and canalicular (17-26 weeks) stages of development, and in the complete developing lung time series of 3 mouse strains: A/J, SW, C57BL6.
In total, 96 genes with association to asthma in at least two human populations were identified in the literature. Overall, there was no significant over-representation of the asthma genes among genes differentially expressed during lung development, although trends were seen in the human (Odds ratio, OR 1.22, confidence interval, CI 0.90-1.62) and C57BL6 mouse (OR 1.41, CI 0.92-2.11) data. However, differential expression of some asthma genes was consistent in both developing human and murine lung, e.g. NOD1, EDN1, CCL5, RORA and HLA-G. Among the asthma genes identified in genome wide association studies, ROBO1, RORA, HLA-DQB1, IL2RB and PDE10A were differentially expressed during human lung development.
Our data provide insight about the role of asthma susceptibility genes during lung development and suggest common mechanisms underlying lung morphogenesis and pathogenesis of respiratory diseases.
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