BACKGROUNDSpain has been one of the countries most affected by the COVID-19 pandemic. OBJECTIVETo create a registry of patients with COVID-19 hospitalized in Spain, in order to improve our knowledge ...of the clinical, diagnostic, therapeutic, and prognostic aspects of this disease. METHODSA multicentre retrospective cohort study, including consecutive patients hospitalized with confirmed COVID-19 throughout Spain. Epidemiological and clinical data, additional tests at admission and at seven days, treatments administered, and progress at 30 days of hospitalization were collected from electronic medical records. RESULTSUp to June 30th 2020, 15,111 patients from 150 hospitals were included. Their median age was 69.4 years (range: 18-102 years) and 57.2% were male. Prevalences of hypertension, dyslipidemia, and diabetes mellitus were 50.9%, 39.7%, and 19.4%, respectively. The most frequent symptoms were fever (84.2%) and cough (73.5%). High values of ferritin (73.5%), lactate dehydrogenase (73.9%), and D-dimer (63.8%), as well as lymphopenia (52.8%), were frequent. The most used antiviral drugs were hydroxychloroquine (85.6%) and lopinavir/ritonavir (61.4%); 33.1% developed respiratory distress. Overall mortality rate was 21.0%, with a marked increase with age (50-59 years: 4.7%, 60-69 years: 10.5%, 70-79 years: 26.9%, ≥80 years: 46.0%). CONCLUSIONSThe SEMI-COVID-19 Network provides data on the clinical characteristics of patients with COVID-19 hospitalized in Spain. Patients with COVID-19 hospitalized in Spain are mostly severe cases, as one in three patients developed respiratory distress and one in five patients died. These findings confirm a close relationship between advanced age and mortality.
Here we present deep (16 Jy beam−1), very high (40 mas) angular resolution 1.14 mm, polarimetric, Atacama Large Millimeter/submillimeter Array (ALMA) observations toward the massive protostar driving ...the HH 80-81 radio jet. The observations clearly resolve the disk oriented perpendicularly to the radio jet, with a radius of 0 171 (∼291 au at 1.7 kpc distance). The continuum brightness temperature, the intensity profile, and the polarization properties clearly indicate that the disk is optically thick for a radius of R 170 au. The linear polarization of the dust emission is detected almost all along the disk, and its properties suggest that dust polarization is produced mainly by self-scattering. However, the polarization pattern presents a clear differentiation between the inner (optically thick) part of the disk and the outer (optically thin) region of the disk, with a sharp transition that occurs at a radius of ∼0 1 (∼170 au). The polarization characteristics of the inner disk suggest that dust settling has not occurred yet with a maximum dust grain size between 50 and 500 m. The outer part of the disk has a clear azimuthal pattern but with a significantly higher polarization fraction compared to the inner disk. This pattern is broadly consistent with the self-scattering of a radiation field that is beamed radially outward, as expected in the optically thin outer region, although contribution from non-spherical grains aligned with respect to the radiative flux cannot be excluded.
We describe a revised collection of the number of sunspot groups from 1610 to the present. This new collection is based on the work of Hoyt and Schatten (
Solar Phys
.
179
, 189,
1998
). The main ...changes are the elimination of a considerable number of observations during the Maunder Minimum (hereafter, MM) and the inclusion of several long series of observations. Numerous minor changes are also described. Moreover, we have calculated the active-day percentage during the MM from this new collection as a reliable index of the solar activity. Thus, the level of solar activity obtained in this work is greater than the level obtained using the original Hoyt and Schatten data, although it remains compatible with a grand minimum of solar activity. The new collection is available in digital format.
Recent high angular resolution ( 40 mas) ALMA observations at 1.14 mm resolve a compact (R 200 au), flattened dust structure perpendicular to the HH 80-81 jet emanating from the GGD 27-MM1 high-mass ...protostar, making it a robust candidate for a true accretion disk. The jet-disk system (HH 80-81/GGD 27-MM1) resembles those found in association with low- and intermediate-mass protostars. We present radiative transfer models that fit the 1.14 mm ALMA dust image of this disk, which allow us to obtain its physical parameters and predict its density and temperature structure. Our results indicate that this accretion disk is compact (Rdisk 170 au) and massive ( 5 M ), at about 20% of the stellar mass of 20 M . We estimate the total dynamical mass of the star-disk system from the molecular line emission, finding a range between 21 and 30 M , which is consistent with our model. We fit the density and temperature structures found by our model with power-law functions. These results suggest that accretion disks around massive stars are more massive and hotter than their low-mass siblings, but they still are quite stable. We also compare the temperature distribution in the GGD 27-MM1 disk with that found in low- and intermediate-mass stars and discuss possible implications for the water snow line. We have also carried out a study of the distance based on Gaia DR2 data and the population of young stellar objects in this region and from the extinction maps. We conclude that the source distance is within 1.2 and 1.4 kpc, closer than what was derived in previous studies (1.7 kpc).
We report progress on the ongoing recalibration of the Wolf sunspot number (SN) and group-sunspot number (GN) following the release of version 2.0 of SN in 2015. This report constitutes both an ...update of the efforts reported in the 2016 Topical Issue of Solar Physics and a summary of work by the International Space Science Institute (ISSI) International Team formed in 2017 to develop optimal SN and GN reconstruction methods while continuing to expand the historical sunspot-number database. Significant progress has been made on the database side while more work is needed to bring the various proposed SN and (primarily) GN reconstruction methods closer to maturity, after which the new reconstructions (or combinations thereof) can be compared with (a) “benchmark” expectations for any normalization scheme (e.g., a general increase in observer normalization factors going back in time), and (b) independent proxy data series such as F10.7 and the daily range of variations of Earth’s undisturbed magnetic field. New versions of the underlying databases for SN and GN will shortly become available for years through 2022 and we anticipate the release of the next versions of these two time series in 2024.
The world requests for raw materials used in animal feed has been steadily rising in the last years driven by higher demands for livestock production. Mycotoxins are frequent toxic metabolites ...present in these raw materials. The exposure of farm animals to mycotoxins could result in undesirable residues in animal-derived food products. Thus, the potential ingestion of edible animal products (milk, meat and fish) contaminated with mycotoxins constitutes a public health concern, since they enter the food chain and may cause adverse effects upon human health. The present review summarizes the state-of-the-art on the occurrence of mycotoxins in feed, their metabolism and carry-over into animal source foodstuffs, focusing particularly on the last decade. Maximum levels (MLs) for various mycotoxins have been established for a number of raw feed materials and animal food products. Such values are sometimes exceeded, however. Aflatoxins (AFs), fumonisins (FBs), ochratoxin A (OTA), trichothecenes (TCs) and zearalenone (ZEN) are the most prevalent mycotoxins in animal feed, with aflatoxin M1 (AFM1) predominating in milk and dairy products, and OTA in meat by-products. The co-occurrence of mycotoxins in feed raw materials tends to be the rule rather than the exception, and the carry-over of mycotoxins from feed to animal source foods is more than proven.
Display omitted
•Mycotoxins can appear in the feed materials because of fungal infection of crops.•Co-occurrence of mycotoxins in animal feed is an issue that is increasingly relevant.•Feed contaminated by mycotoxins could result in the presence of some metabolites in animal derived products.•Mycotoxin carry-over into animal derived products from contaminated feed has been evidenced.
AbstractObjectiveThe AGO-OVAR16 study was designed to test the efficacy, safety, and tolerability of pazopanib maintenance after first-line chemotherapy in patients with newly diagnosed advanced ...ovarian cancer (AOC). MethodsNine hundred and forty patients with histologically confirmed AOC, International Federation of Gynecology and Obstetrics (FIGO) stage II–IV, were randomized in a 1:1 ratio to receive either 800 mg pazopanib once daily or placebo for up to 24 months, unless there was disease progression, toxicity, withdrawal of consent, or death. The primary endpoint (investigator-assessed progression-free survival PFS) was met and previously reported. The results of final analyses of overall survival (OS) are reported here. ResultsA third OS interim analysis showed futility and led to study closure and a final OS analysis after last patient last visit. At the time of the final OS analysis, 494 (89.7% of the planned 551) events had occurred. No difference was observed in OS between pazopanib and placebo. The hazard ratio (HR) was 0.960 (95% confidence interval CI: 0.805–1.145), and the median OS from randomization was 59.1 months in pazopanib and 64.0 months in placebo arms. For the East Asian patients, similar to the first three interim OS analyses, a numerical negative trend was observed favoring placebo (HR, 1.332; 95% CI: 0.863–2.054). Exploratory analyses showed a trend for a longer time to first subsequent anti-cancer therapy or death with pazopanib over placebo (HR, 0.829; 95% CI: 0.713–0.965), with a median estimate of 19.0 and 14.5 months, respectively. No new safety signals were observed. ConclusionAlthough pazopanib prolonged PFS, this was not associated with improvement in median OS. Clinical trial information.ClinicalTrials.gov: NCT00866697.
An analysis of the sunspot observations made by Hevelius during 1642-1645 is presented. These records are the only systematic sunspot observations just before the Maunder Minimum (MM). We have ...studied different phenomena meticulously recorded by Hevelius after translating the original Latin texts. We reevaluate the observations of sunspot groups by Hevelius during this period and obtain an average value 7% greater than that calculated from his observations given in the current group database. Furthermore, the average of the active day fraction obtained in this work from Hevelius's records previous to the MM is significantly greater than the solar activity level obtained from Hevelius's sunspot observations made during the MM (70% versus 30%). We also present the butterfly diagram obtained from the sunspot positions recorded by Hevelius for the period 1642-1645. It can be seen that no hemispheric asymmetry exists during this interval, in contrast with the MM. Hevelius noted a ∼3-month period that appeared to lack sunspots in early 1645 that gave the first hint of the impending MM. Recent studies claim that the MM was not a grand minimum period, speculating that astronomers of that time, due to the Aristotelian ideas, did not record all sunspots that they observed, producing thus an underestimation of the solar activity level. However, we show that the good quality of the sunspot records made by Hevelius indicates that his reports of sunspots were true to the observations.
In December 2019, the International Association of Geomagnetism and Aeronomy (IAGA) Division V Working Group (V-MOD) adopted the thirteenth generation of the International Geomagnetic Reference Field ...(IGRF). This IGRF updates the previous generation with a definitive main field model for epoch 2015.0, a main field model for epoch 2020.0, and a predictive linear secular variation for 2020.0 to 2025.0. This letter provides the equations defining the IGRF, the spherical harmonic coefficients for this thirteenth generation model, maps of magnetic declination, inclination and total field intensity for the epoch 2020.0, and maps of their predicted rate of change for the 2020.0 to 2025.0 time period.
Although there are solid findings regarding the detrimental effect of alcohol consumption, the existing evidence on the effect of other dietary factors on breast cancer (BC) risk is inconclusive. ...This study aimed to evaluate the association between dietary patterns and risk of BC in Spanish women, stratifying by menopausal status and tumour subtype, and to compare the results with those of Alternate Healthy Index (AHEI) and Alternate Mediterranean Diet Score (aMED).
We recruited 1017 incident BC cases and 1017 matched healthy controls of similar age (±5 years) without a history of BC. The association between 'a priori' and 'a posteriori' developed dietary patterns and BC in general and according to menopausal status and intrinsic tumour subtypes (ER+/PR+ and HER2-; HER2+; and ER-/PR- and HER2-) was evaluated using logistic and multinomial regression models.
Adherence to the Western dietary pattern was related to higher risk of BC (OR for the top vs the bottom quartile 1.46 (95% CI 1.06-2.01)), especially in premenopausal women (OR=1.75; 95% CI 1.14-2.67). In contrast, the Mediterranean pattern was related to a lower risk (OR for the top quartile vs the bottom quartile 0.56 (95% CI 0.40-0.79)). Although the deleterious effect of the Western pattern was similarly observed in all tumour subtypes, the protective effect of our Mediterranean pattern was stronger for triple-negative tumours (OR=0.32; 95% CI 0.15-0.66 and Pheterogeneity=0.04). No association was found between adherence to the Prudent pattern and BC risk. The associations between 'a priori' indices and BC risk were less marked (OR for the top vs the bottom quartile of AHEI=0.69; 95% CI 0.51-0.94 and aMED=0.74; 95% CI 0.46-1.18)).
Our results confirm the harmful effect of a Western diet on BC risk, and add new evidence on the benefits of a diet rich in fruits, vegetables, legumes, oily fish and vegetable oils for preventing all BC subtypes, and particularly triple-negative tumours.
PDF
