Consensus statement on bladder injuries Gomez, Reynaldo G.; Ceballos, Lily; Coburn, Michael ...
BJU international,
July 2004, Letnik:
94, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The consensus on genitourinary trauma continues this month with the statement on bladder trauma from several internationally recognised experts on the subject. They describe blunt, penetrating and ...iatrogenic injuries and their management, considering paediatric injuries separately. They underline the importance of prompt diagnosis and treatment, stressing that problems raised when the diagnosis is delayed.
•The Glulam beams increased their load capacity by up to 20 % with a section composed of 11.36 % UHPFRC.•The Glulam beams are less expansive up to 56.16 % lower than concrete beams.•The Glulam beams ...have less environmental impact than concrete beams with a reduction up to 41.90 kgCO2e.
Timber-concrete structures have been developed as sustainable solutions to face current environmental challenges. This paper aims to present a numerical method for the analysis of the mechanical behaviour of glued laminated wood beams (Glulam) reinforced with ultra-high-performance fibre-reinforced concrete (UHPFRC). For this purpose, three series of a proposed Glulam-UHPFRC (HP-Glulam) beams with different slenderness ratio values, percentage, and position reinforcement under 4-point flexural tests were simulated by the finite element software Ansys®. The orthotropic linear elastic model was assigned to the Glulam, whilst to model the tensile plastic behaviour of UHPFRC the Cast Iron Model was adopted; this last model is based on grey cast iron. The numerical model results were validated with experimental tests from the literature. The Glulam beams increased their load capacity by up to 20 % with a cross-section composed of 11.36 % UHPFRC. The Series C, reinforced with a layer of UHPFRC at the top, demonstrated a greater increase in its flexural properties; therefore, the slender beams (span/depth = 13.16) were taken for a comparative analysis with concrete and steel beams. With the goal to propose a tool for building designers, estimation of costs and embodied energy generated during the production of materials were assessed too. Results show that HP-Glulam beams is a potential substitute for frequently used concrete beams, with a production cost up to 56.16 % lower and up to 41.90 kgCO2e less embedded carbon.
Objective
To compare the perceptions of students and teachers of the “Educational Climate” (EC) in Spanish public dental schools.
Methods
A group of 1064 students and 354 teachers from six Spanish ...public dental schools responded to the DREEM questionnaire. This has 50 items grouped into five subscales: perception of learning (Learning); perception of teachers (Teachers); academic self‐perceptions (Academic); perception of the atmosphere in the faculty (Atmosphere); and social self‐perceptions (Social). The DREEM scale provides results for each item, each subscale and the overall EC.
Results
The EC scores were 123.2 (61.6%) for the students and 134.1 (67.0%) for the teachers (P<.001). The scores of the students and teachers for the subscales were, respectively: 27.9 (58.1%) and 30.2 (63.0 %) for Learning (P<.001); 26.8 (60.9%) and 32.6 (74.1%) for Teachers (P<.001); 20.7 (64.7%) and 20.5 (64.0%) for Academic (P=.333); 29.9 (62.3%) and 33.7 (70.3%) for Atmosphere (P<.001); and 17.9 (64.0%) and 16.9 (60.5%) for Social (P<.001). The students identified six problematic items (12.0 %) compared to only two (4.0 %) highlighted by the teachers.
Conclusion
The students and teachers considered the EC to be “more positive than negative” in Spanish public dental schools; and the different subscales to be “positive and acceptable.” The teachers did, however, evaluate the EC, and specifically the learning‐teaching process, more positively than their students, identifying fewer problematic educational aspects. Both groups agreed on the need to: improve support systems for students who suffer from stress and reduce teaching based on “factual learning.”
Aim
To carry out a psychometric evaluation of the Spanish‐language version of the Dundee Ready Education Environment Measure (DREEM) applied to dental students.
Methods
A total of 1,391 students from ...nine Spanish public schools of dentistry responded to the DREEM questionnaire. To analyse the reliability of the DREEM questionnaire, the internal consistency was assessed and a ‘test‐retest’ carried out. Validity was evaluated through analysis of item response rate, floor and ceiling effects, corrected item‐total and item‐subscale correlations and factor structure. A confirmatory factor analysis was performed to analyse the structure of the original DREEM scale.
Results
Cronbach's alpha coefficient for the ‘Educational Climate’ (EC) global scale was 0.92. In the subscales, the ‘observed’ Cronbach's alpha coefficients ranged between 0.57 and 0.79 and were higher than the ‘expected’ ones; except for the Social subscale. In the DREEM questionnaire, all of the corrected correlation coefficients between the items and the EC global scale, and the items and their corresponding subscales, were >0.2; except for items 50 and 17. All goodness‐of‐fit indices of confirmatory factor analysis showed acceptable values (close to one or zero, depending on the case), and there was consistency in the results.
Conclusions
The Spanish‐language version of the DREEM questionnaire is a reliable and valid instrument for analysing the EC for dental students and its factor structure is supported by the data. Although our findings indicate that the DREEM may be as culturally independent as was originally stated, more research should be directed at verifying the factor structure in various languages and cultural environments.
The goal for CMS computing is to maximise the throughput of simulated event generation while also processing event data generated by the detector as quickly and reliably as possible. To maintain this ...achievement as the quantity of events increases CMS computing has migrated at the Tier 1 level from its old production framework, ProdAgent, to a new one, WMAgent. The WMAgent framework offers improved processing efficiency and increased resource usage as well as a reduction in operational manpower. In addition to the challenges encountered during the design of the WMAgent framework, several operational issues have arisen during its commissioning. The largest operational challenges were in the usage and monitoring of resources, mainly a result of a change in the way work is allocated. Instead of work being assigned to operators, all work is centrally injected and managed in the Request Manager system and the task of the operators has changed from running individual workflows to monitoring the global workload. In this report we present how we tackled some of the operational challenges, and how we benefitted from the lessons learned in the commissioning of the WMAgent framework at the Tier 2 level in late 2011. As case studies, we will show how the WMAgent system performed during some of the large data reprocessing and Monte Carlo simulation campaigns.
File-based data flow in the CMS Filter Farm Andre, J-M; Andronidis, A; Bawej, T ...
Journal of physics. Conference series,
12/2015, Letnik:
664, Številka:
8
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
During the LHC Long Shutdown 1, the CMS Data Acquisition system underwent a partial redesign to replace obsolete network equipment, use more homogeneous switching technologies, and prepare the ground ...for future upgrades of the detector front-ends. The software and hardware infrastructure to provide input, execute the High Level Trigger (HLT) algorithms and deal with output data transport and storage has also been redesigned to be completely file- based. This approach provides additional decoupling between the HLT algorithms and the input and output data flow. All the metadata needed for bookkeeping of the data flow and the HLT process lifetimes are also generated in the form of small "documents" using the JSON encoding, by either services in the flow of the HLT execution (for rates etc.) or watchdog processes. These "files" can remain memory-resident or be written to disk if they are to be used in another part of the system (e.g. for aggregation of output data). We discuss how this redesign improves the robustness and flexibility of the CMS DAQ and the performance of the system currently being commissioned for the LHC Run 2.
Abstract
Background
A drug safety warning was published in 2021 about the risks associated with tofacitinib, which were found in the Oral-Surveillance study. The European Medicines Agency (EMA) and ...the Spanish Agency for Medicines and Medical Products (AEMPS) have recommended, due to this warning, some precautions in the prescriptions: It should not be used in patients older than 65 years of age, people who are current or past smokers, or individuals with cardiovascular or malignancy risk factors unless there are no suitable treatment alternatives. The aim fo this study was to assess the safety and treatment persistence of tofacitinib in clinical practice in three Spanish third-level hospitals.
Methods
Retrospective observational multicenter study of patients with Ulcerative Colitis (UC) treated with tofacitinib from January 2019 to October 2023. Sex, age, line of treatment, persistence, adverse events, discontinuations and risk factors associated with the warning were evaluated. Information was collected from the hospital’s information systems.
Results
A total of 56 patients, 53% women, mean age 55 (18-72) years old. Tofacitinib was the first line treatment in 2% of the patients after loss of response to the conventional treatment, second line for 57%, third line for 30% and fourth line for 11% after biological drugs (infliximab, adalimumab, vedolizumab and ustekinumab). 52% of patients needed maintenance with the higher doses (10mg dose) after induction due to the lack of response with the 5 mg dose, with an average of 52 weeks. The mean persistence was 18 months (1-56), with 19,6% discontinuations due to primary failure and secondary failure. It must be noted that one patient, who received tofacitinib for three years, underwent appendicular neoplasia and finally died due to liver metastases. There was not discontinuation due to other adverse events, which were: 3,6% herpes zoster, 46,4% increased total cholesterol level >200 mg/dl (compared with the initial measurement), of which 19% received statins.There were 27 (48%) patients with risk factors associated with the safety warning: 37% cardiovascular risk, 3,7% older than 65 years, 11,1% previous malignancy, 18,5% current or past smokers and 29,6% had several of these risks.
Conclusion
In this multicenter real-world treatment-refractory UC population cohort, tofacitinib was well tolerated in the long term, even in the patients with risk factors related to the warning.
Aim
To analyse the ‘Educational Climate’ (EC) of dental students in Spain.
Methods
The study group consisted of 1391 students from nine Spanish Public Schools of Dentistry, who responded to the ...questionnaire based on ‘Dundee Ready Education Environment Measure’ (DREEM). This questionnaire has 50 items that are grouped into five domains: Learning, Teachers, Academic, Atmosphere and Social.
Results
The global score on the EC was 123.1 (interpretation: ‘EC more positive than negative’). The scores obtained in the different domains were: 28.0 in Learning (interpretation: ‘a generally positive perception of learning’), 26.8 in Teachers (interpretation: ‘teachers are going in the right direction’), 20.8 in Academic (interpretation: ‘feeling more on the positive side’), 29.7 in Atmosphere (interpretation: ‘a generally positive atmosphere’) and 17.7 in Social (interpretation: ‘social perception acceptable’). In seven items (14%), an average of <2 was detected, showing that there are some educational problem areas. Regarding the EC in the different Schools of Dentistry, an average of >100 was achieved in all of them, although there were two centres that showed significantly higher values of EC.
Conclusions
Spanish dental students felt that their EC was more positive than negative and considered that the different domains were positive and acceptable. However, they pointed out the existence of several educational problem areas associated with the development of a traditional curriculum. Accordingly, and in parallel with the implementation of an innovative curriculum in all Spanish Dental Schools in the coming years, immediate educational goals must address the problem areas identified, thereby further promoting a more positive perception of EC.
The XMM-Newton serendipitous survey Rosen, S R; Webb, N A; Watson, M G ...
Astronomy and astrophysics (Berlin),
06/2016, Letnik:
590
Journal Article
Recenzirano
Odprti dostop
Context. Thanks to the large collecting area (3 x~1500 cm super(2) at 1.5 keV) and wide field of view (30' across in full field mode) of the X-ray cameras on board the European Space Agency X-ray ...observatory XMM-Newton, each individual pointing can result in the detection of up to several hundred X-ray sources, most of which are newly discovered objects. Since XMM-Newton has now been in orbit for more than 15 yr, hundreds of thousands of sources have been detected. Aims. Recently, many improvements in the XMM-Newton data reduction algorithms have been made. These include enhanced source characterisation and reduced spurious source detections, refined astrometric precision of sources, greater net sensitivity for source detection, and the extraction of spectra and time series for fainter sources, both with better signal-to-noise. Thanks to these enhancements, the quality of the catalogue products has been much improved over earlier catalogues. Furthermore, almost 50% more observations are in the public domain compared to 2XMMi-DR3, allowing the XMM-Newton Survey Science Centre to produce a much larger and better quality X-ray source catalogue. Methods. The XMM-Newton Survey Science Centre has developed a pipeline to reduce the XMM-Newton data automatically. Using the latest version of this pipeline, along with better calibration, a new version of the catalogue has been produced, using XMM-Newton X-ray observations made public on or before 2013 December 31. Manual screening of all of the X-ray detections ensures the highest data quality. This catalogue is known as 3XMM. Results. In the latest release of the 3XMM catalogue, 3XMM-DR5, there are 565962 X-ray detections comprising 396910 unique X-ray sources. Spectra and lightcurves are provided for the 133000 brightest sources. For all detections, the positions on the sky, a measure of the quality of the detection, and an evaluation of the X-ray variability is provided, along with the fluxes and count rates in 7 X-ray energy bands, the total 0.2-12 keV band counts, and four hardness ratios. With the aim of identifying the detections, a cross correlation with 228 catalogues of sources detected in all wavebands is also provided for each X-ray detection. Conclusions. 3XMM-DR5 is the largest X-ray source catalogue ever produced. Thanks to the large array of data products associated with each detection and each source, it is an excellent resource for finding new and extreme objects.
PDF
