Adipokines are involved in the etiology of diabetes, insulin resistance, and the development of atherosclerosis and other latent-onset complications. The objective of this meta-analysis was to ...determine the effectiveness of exercise interventions on adipokines in pediatric obesity.
A computerized search was made using three databases. The analysis was restricted to studies that examined the effect of exercise interventions on adipokines (adiponectin, leptin, resistin and visfatin) in pediatric obesity (6-18 years old). Fourteen randomized controlled trials (347 youths) were included. Weighted mean difference (WMD) and 95% confidence intervals were calculated.
Exercise was associated with a significant increase in adiponectin (WMD=0.882 μg ml
, 95% CI, 0.271-1.493) but did not alter leptin and resistin level. Likewise, exercise intensity and change in body fat; as well as total exercise program duration, duration of the sessions, and change in body fat all significantly influenced the effect of exercise on adiponectin and leptin, respectively.
Exercise seems to increase adiponectin levels in childhood obesity. Our results also suggested that exercise on its own, without the concomitant presence of changes in body composition levels, does not affect leptin levels.
In this paper, new advances concerning the link between evolution algebras and (pseudo)digraph are shown. Some important elements that can be read from the (pseudo)digraph that is associated with an ...evolution algebra are studied. Moreover, several results concerning solvability, nilpotency, and the preservation of them under the graph union operation are proved. To complement the theoretical study, an algorithmic method has been implemented. This is devoted to computing the nilpotency index of a nilpotent evolution algebra using its associated digraph.
The XMM-Newton serendipitous survey Rosen, S R; Webb, N A; Watson, M G ...
Astronomy and astrophysics (Berlin),
06/2016, Letnik:
590
Journal Article
Recenzirano
Odprti dostop
Context. Thanks to the large collecting area (3 x~1500 cm super(2) at 1.5 keV) and wide field of view (30' across in full field mode) of the X-ray cameras on board the European Space Agency X-ray ...observatory XMM-Newton, each individual pointing can result in the detection of up to several hundred X-ray sources, most of which are newly discovered objects. Since XMM-Newton has now been in orbit for more than 15 yr, hundreds of thousands of sources have been detected. Aims. Recently, many improvements in the XMM-Newton data reduction algorithms have been made. These include enhanced source characterisation and reduced spurious source detections, refined astrometric precision of sources, greater net sensitivity for source detection, and the extraction of spectra and time series for fainter sources, both with better signal-to-noise. Thanks to these enhancements, the quality of the catalogue products has been much improved over earlier catalogues. Furthermore, almost 50% more observations are in the public domain compared to 2XMMi-DR3, allowing the XMM-Newton Survey Science Centre to produce a much larger and better quality X-ray source catalogue. Methods. The XMM-Newton Survey Science Centre has developed a pipeline to reduce the XMM-Newton data automatically. Using the latest version of this pipeline, along with better calibration, a new version of the catalogue has been produced, using XMM-Newton X-ray observations made public on or before 2013 December 31. Manual screening of all of the X-ray detections ensures the highest data quality. This catalogue is known as 3XMM. Results. In the latest release of the 3XMM catalogue, 3XMM-DR5, there are 565962 X-ray detections comprising 396910 unique X-ray sources. Spectra and lightcurves are provided for the 133000 brightest sources. For all detections, the positions on the sky, a measure of the quality of the detection, and an evaluation of the X-ray variability is provided, along with the fluxes and count rates in 7 X-ray energy bands, the total 0.2-12 keV band counts, and four hardness ratios. With the aim of identifying the detections, a cross correlation with 228 catalogues of sources detected in all wavebands is also provided for each X-ray detection. Conclusions. 3XMM-DR5 is the largest X-ray source catalogue ever produced. Thanks to the large array of data products associated with each detection and each source, it is an excellent resource for finding new and extreme objects.
High activity concentrations of several man-made radionuclides (such as
131I,
132I,
132Te,
134Cs and
137Cs) have been detected along the Iberian Peninsula from March 28th to April 7th 2011. The ...analysis of back-trajectories of air masses allowed us to demonstrate that the levels of manmade radionuclide activity concentrations in the southwest of the Iberian Peninsula come from the accident produced in the nuclear power plant of Fukushima. The pathway followed by the radioactive plume from Fukushima into Huelva (southwest of the Iberian Peninsula) was deduced through back-trajectories analysis, and this fact was also verified by the activity concentrations measured of those radionuclides reported in places crossed by this radioactive cloud. In fact, activity concentrations reported by E.P.A., and by IAEA, in several places of Japan, Pacific Ocean and United States of America are according to the expected ones from the air mass trajectory arriving at Huelva province.
► Influence of Fukushima accident over Iberian Peninsula. ► High activity concentrations of several man-made radionuclides (such as
131I,
132I,
132Te,
134Cs and
137Cs). ► Back-trajectory computation for the previous 16
days. ► Relationship between air mass circulation and high activity concentrations.
HMG20A is a high mobility group (HMG) domain containing protein homologous to HMG20B, a core subunit of the Lys-specific demethylase 1/REST co-repressor 1 (LSD1-CoREST) histone demethylase complex. ...Here, we show that HMG20A can replace HMG20B and, therefore, they are mutually exclusive subunits of the complex. Both proteins interact through a coiled-coil domain with BHC80, another subunit of the LSD1-CoREST complex. To investigate the functional differences between the two proteins, we performed transcriptomic analysis of HMG20A- and HMG20B-depleted cells. Analysis of the misregulated genes in HMG20A-knockdown cells evidenced a high proportion of genes related to the epithelial-to-mesenchymal transition (EMT) process. EMT occurs during embryonic development or during the course of malignant cancer progression and consists in the dynamic and reversible transitions between epithelial and mesenchymal phenotypes. We show that HMG20A together with LSD1 are required for SNAI1-dependent repression of epithelial genes and for (transforming growth factor β) TGF-β-triggered EMT. Importantly, HMG20A-depleted cells displayed reduced binding of LSD1 to epithelial gene promoters and increased methylation of lysine 4 of histone H3, suggesting a role of HMG20A in recruiting or in stabilizing the complex at the chromatin. SNAI1 and the TGF-β-related transcription factor SMAD4 were found to be associated with the LSD1-CoREST complex containing HMG20A. Furthermore, we show that HMG20A-depleted cells displayed reduced motility and invasion activity. Finally, we show that expression of HMG20A correlates positively with mesenchymal markers and negatively with epithelial markers in human tumor samples. Taken together, our data demonstrate that HMG20A is essential for the mesenchymal phenotype.
In the 2000s, nail polish manufacturers started promoting “3-Free” products, phasing out three widely publicized toxic chemicals: toluene, formaldehyde, and dibutyl phthalate (DnBP). However, ...DnBP was sometimes replaced by another endocrine-disrupting plasticizer, triphenyl phosphate (TPHP). Many new “n-Free” labels have since appeared, without any standardization on which n chemicals are excluded. This study aimed to compare measured plasticizer content against nail polish labels. First, we summarized definitions of labels. Then, we measured 12 phthalate and 10 organophosphate plasticizers in 40 nail polishes from 12 brands selected for popularity and label variety. We found labels ranging from 3- to 13-Free; 10-Free was the most inconsistently defined (six definitions). Our samples contained TPHP and bis(2-ethylhexyl) phthalate (DEHP) at up to 7940 and 331 μg/g, respectively. The 5- to 13-Free samples had lower TPHP levels than unlabeled or 3-Free samples (median <0.002 vs 3730 μg/g, p < 0.001). The samples that did not contain TPHP had higher DEHP levels (median 68.5 vs 1.51 μg/g, p < 0.05). We measured plasticizers above 100 μg/g in five brands that did not disclose them and in two that excluded them in labels. This study highlights inconsistencies in nail polish labels and identifies TPHP and DEHP as ingredient substitutes for DnBP.
Estuarine and coastal marine sediment-water fluxes are considered to be important ecological features, but a global-scale assessment has yet to be developed. Goals of this work were to assemble a ...global-scale database of net sediment-water flux measurements, examine measurement techniques, characterize the geographic distribution and magnitude of sediment fluxes, explore the data for controls on sediment flux magnitude, and assess the importance of sediment fluxes in ecosystem-level metabolism and primary production. We examined 480 peer-reviewed sources and found sediment flux data for 167 estuarine and coastal systems. Most measurements were made in North America, Europe, and Australia. Fluxes varied widely among systems, some by several orders of magnitude. Inter-annual variability within sites was less than an order of magnitude but time series flux data to evaluate this were rare. However, limited time series data exhibited large and rapid responses to decreased external nutrient loading rates, climate change effects (possible temperature effects), and variability in trophic conditions. Comparative analyses indicated organic matter supply to sediments set the upper limits of flux magnitude, with other factors playing secondary roles. Two metrics were developed to assess ecosystem-level importance of sediment-water fluxes. Sediments represented 30% or more of depth-integrated rates of aerobic system respiration at depths of <10 m. An annual phytoplankton production data set was used to estimate N and P demand; sediments supplied an average of 15-32% of N and 17-100% of P demand and, in some cases, was as large or larger than external nutrient inputs. The percent of demand supplied by sediments was highest in temperate latitudes and lower in high and tropical latitudes.
Airborne pollen transport at micro-, meso-gamma and meso-beta scales must be studied by atmospheric models, having special relevance in complex terrain. In these cases, the accuracy of these models ...is mainly determined by the spatial resolution of the underlying meteorological dataset. This work examines how meteorological datasets determine the results obtained from atmospheric transport models used to describe pollen transport in the atmosphere. We investigate the effect of the spatial resolution when computing backward trajectories with the HYSPLIT model. We have used meteorological datasets from the WRF model with 27, 9 and 3 km resolutions and from the GDAS files with 1 ° resolution. This work allows characterizing atmospheric transport of Olea pollen in a region with complex flows. The results show that the complex terrain affects the trajectories and this effect varies with the different meteorological datasets. Overall, the change from GDAS to WRF-ARW inputs improves the analyses with the HYSPLIT model, thereby increasing the understanding the pollen episode. The results indicate that a spatial resolution of at least 9 km is needed to simulate atmospheric flows that are considerable affected by the relief of the landscape. The results suggest that the appropriate meteorological files should be considered when atmospheric models are used to characterize the atmospheric transport of pollen on micro-, meso-gamma and meso-beta scales. Furthermore, at these scales, the results are believed to be generally applicable for related areas such as the description of atmospheric transport of radionuclides or in the definition of nuclear-radioactivity emergency preparedness.
The impact of regional and local weather and of local topography on intradiurnal variations in airborne pollen levels was assessed by analysing bi-hourly holm oak (Quercus ilex subsp. ballota (Desf.) ...Samp.) pollen counts at two sampling stations located 40 km apart, in southwestern Spain (Cordoba city and El Cabril nature reserve) over the period 2010–2011. Pollen grains were captured using Hirst-type volumetric spore traps. Analysis of regional weather conditions was based on the computation of backward trajectories using the HYSPLIT model. Sampling days were selected on the basis of phenological data; rainy days were eliminated, as were days lying outside a given range of percentiles (P95–P5). Analysis of cycles for the study period, as a whole, revealed differences between sampling sites, with peak bi-hourly pollen counts at night in Cordoba and at midday in El Cabril. Differences were also noted in the influence of surface weather conditions (temperature, relative humidity and wind). Cluster analysis of diurnal holm oak pollen cycles revealed the existence of five clusters at each sampling site. Analysis of backward trajectories highlighted specific regional air-flow patterns associated with each site. Findings indicated the contribution of both nearby and distant pollen sources to diurnal cycles. The combined use of cluster analysis and meteorological analysis proved highly suitable for charting the impact of local weather conditions on airborne pollen-count patterns. This method, and the specific tools used here, could be used not only to study diurnal variations in counts for other pollen types and in other biogeographical settings, but also in a number of other research fields involving airborne particle transport modelling, e.g. radionuclide transport in emergency preparedness exercises.
Measurements of sediment–water fluxes of O
2
, NO
23
, NH
4
, and PO
4
and water column and sediment variables were conducted at 348 sites in Chesapeake Bay and Maryland Coastal Bays with most (~ ...76%) of the 1746 sets of measurements collected during warm seasons when these processes were most active. We performed a system-wide synthesis of these spatially extensive, long-term data to identify the primary controlling factors on sediment–water fluxes over seasonal and interannual time periods and assess the relative contribution of sediment–water fluxes to nutrient cycling across distinct regions of Chesapeake Bay and the Maryland Coastal Bays. Bay-wide spatial patterns revealed hotspots for sediment–water fluxes, and statistical models were able to explain 46% (O
2
), 23% (NH
4
), 25% (NO
23
), and 38% (PO
4
) of variability in fluxes, with solute-specific controlling variables including temperature, bottom water oxygen and nutrient concentration, and sediment organic matter. An analysis of long-term variations in fluxes at six locations in the Bay (12–17 year time series) exhibited only weak evidence of long-term trends, but interannual variability was related to both water column and sediment variables, depending on the solute of interest. Finally, we compared external loads of “new” total nitrogen and phosphorus (TN and TP) to system-wide sediment–water fluxes of NH
4
and PO
4
at 22 Bay tributary and Coastal Bays sites, finding that ~ 64% of sites had annual sediment recycling rates that exceeded annual external loading rates, revealing the importance of recycled nutrients in these shallow systems.
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