We measure the branching fractions for seven D-s(+) two-body decays to pseudoscalar mesons, by analyzing data collected at root s = 4:178 similar to 4:226 GeV with the BESIII detector at the BEPCII ...collider. The branching fractions are determined to be B(D-s(+) -> K+eta ') = (2:68 +/- 0:17 +/- 0:17 +/- 0:08) x 10(-3), B(D-s(+) -> eta 'pi(+)) = (37:8 +/- 0:4 +/- 2:1 +/- 1:2) x 10(-3), B(D-s(+) -> K+eta) = (1:62 +/- 0:10 +/- 0:03 +/- 0:05) x 10(-3), B(D-s(+) -> eta pi(+)) = (17:41 +/- 0:18 +/- 0:27 +/- 0:54) x 10(-3), B(D-s(+) -> (K+Ks0)) = (15:02 +/- 0:10 +/- 0:27 +/- 0:47) x 10(-3), B(D-s(+) -> K-s(0)pi(+)) = (1:109 +/- 0:034 +/- 0:023 +/- 0:035) x 10(-3), B(D-s(+) -> K+pi(0)) = (0:748 +/- 0:049 +/- 0:018 +/- 0:023) x 10(-3), where the first uncertainties are statistical, the second are systematic, and the third are from external input branching fraction of the normalization mode D-s(+) -> K+K-pi(+). Precision of our measurements is significantly improved compared with that of the current world average values.
Background
Aortic valve sclerosis (AVS) is closely related to hypertension and is an important predictor of coronary artery disease as well as cardiovascular morbidity and mortality. However, the ...mechanisms causing AVS have not yet been clarified. Therefore, we planned to investigate the influence of atherosclerosis-related risk factors including C-reactive protein (CRP), epicardial adipose tissue (EAT), carotid intima-media thickness (CIMT), pulse wave velocity (PWV), left ventricular hypertrophy, and the conventional risk parameters as well as endothelial dysfunction in untreated hypertensive patients.
Methods and results
Our study was cross-sectional and observational, and included 107 consecutive untreated hypertensive patients. All patients underwent vascular evaluation by CIMT, PWV, flow-mediated dilation (FMD%), as well as echocardiographic examinations. Age (OR
=
1.180, p < 0.001), male sex (OR = 3.056, p = 0.019), waist circumference (OR = 1.082, p = 0.004), EAT (OR = 1.419, p = 0.001), smoking status (OR = 3.161, p = 0.014), FMD% (OR = 0.649, p < 0.001), mean CIMT (OR = 2.481, P < 0.001), and carotid plaque (OR = 4.692, P = 0.001) were associated with AVS in univariate analyses. Multivariate analyses revealed only age (OR = 1.144, P = 0.006) and FMD% (OR = 0.691, 0.001) as independent predictors of AVS. The presence of AVS had a high positive predictive value (100 %) but a low negative predictive value (51 %) for endothelial dysfunction (FMD < 12 %) in hypertensive patients.
Conclusion
Our study supports the theory that systemic endothelial dysfunction has an initial and independent effect on AVS pathogenesis. Moreover, we demonstrated that the presence of AVS in patients with hypertension predicts endothelial dysfunction, with a high positive predictive value. Thus, AVS in hypertensive patients may urge clinicians toward aggressive risk factor modification and intensive treatment.
The aim of the present study was to assess genes expressed in maternal uterine tissue and pre-implantation embryos which are presumably involved in maternal recognition and establishment of canine ...pregnancy. For this purpose, 10 pregnant bitches were ovariohysterectomized between days 10 and 12 after mating. Four non-pregnant bitches served as controls. Early pregnancy was verified by flushing the uterine horns with PBS solution. The collected embryos (n = 60) were stored deep-frozen (-80°C). Uterine tissue was excised, snaps frozen in liquid nitrogen and homogenized using TRI Reagent. All embryos from one litter were thawed together and also homogenized in TRI Reagent. RT-PCR was performed to prove mRNA expression of progesterone receptor, key enzymes of the prostaglandin synthesis pathway, selected growth factors, cytokines, immune cell receptors, major histocompatibility complex (MHC) and matrix-metalloproteinases (MMP). Only pregnant uteri revealed the presence of mRNA for interferon (IFN)-γ, IL-4 and CD-8, which resembles the milieu in humans and other mammalians. Similarly, in day 10 embryos, mRNA for transforming growth factor-β, insulin-like growth factor-1,-2, hepatocyte growth factor, leukaemia inhibitor factor, tumour necrosis factor-α, interleukin-1β,-6,-8, cyclooxygenase-2, CD4⁺ cells, and MMP-2 and -9 were detected, but not MHC-I or -II. We therefore suppose that the canine embryo, like its human counterpart, actively initiates measures to prevent attacks from the maternal immune system to prepare its own adhesion, nidation, growth and further development.
Abstract We report the first measurement of the absolute branching fraction of the inclusive decay $$\Lambda _c^+ \rightarrow K_S^0X$$ Λ c + → K S 0 X . The analysis is performed using an $$e^+e^-$$ ...e + e - collision data sample corresponding to an integrated luminosity of 567 $$\hbox {pb}^{-1}$$ pb - 1 taken at $$\sqrt{s}$$ s = 4.6 GeV with the BESIII detector. Using eleven Cabibbo-favored $${\bar{\Lambda }}_c^-$$ Λ ¯ c - decay modes and the double-tag technique, this absolute branching fraction is measured to be $${\mathcal {B}}(\Lambda _c^+ \rightarrow K_S^0X)=(9.9\pm 0.6\pm 0.4)\%$$ B ( Λ c + → K S 0 X ) = ( 9.9 ± 0.6 ± 0.4 ) % , where the first uncertainty is statistical and the second systematic. The relative deviation between the branching fractions for the inclusive decay and the observed exclusive decays is $$(18.7\pm 8.3)\%$$ ( 18.7 ± 8.3 ) % , which indicates that there may be some unobserved decay modes with a neutron or excited baryons in the final state.
Background
Macrophages in atherosclerotic plaques secrete YKL-40, a new biomarker of acute and chronic inflammation in patients with stable CAD. We hypothesized that YKL-40 may be a specific marker ...reflecting the burden of localized inflammation in myocardium and a predictor in patients with STEMI. In this study, we investigated the relationship of YKL-40 to in-hospital major adverse cardiac events (MACE), reperfusion parameters and its predictors in patients with STEMI.
Methods
In total, 80 patients with STEMI and no history of prior coronary artery disease (CAD), who underwent primary percutaneous coronary intervention (p-PCI), were enrolled consecutively. In addition, 30 patients with normal coronary arteries (NCA) were enrolled as a control group. Cardiac biomarker levels including creatinine kinase-MB fraction (CK-MB), troponin-I, admission glucose and inflammatory markers including leukocytes and YKL-40 levels were measured as admission values.
Results
In our study, YKL-40 levels correlated to high-sensitivity CRP levels (
r
= 0.333,
p
= 0.003), TIMI risk score (
r
= 0.445,
p
< 0.001), age (
r
= 0.477,
p
< 0.001), pain to balloon time (
r
= 0.432,
p
< 0.001), leukocyte and neutrophil count (
r
= 0.386,
p
< 0.001 and
r
= 0.430,
p
< 0.001, respectively), hemoglobin (
r
= − 0.345,
p
= 0.002), admission and fasting blood glucose (
r
= 0.388,
p
< 0.001 and
r
= 0.427,
p
< 0.001), creatinine levels (
r
= 0.395,
p
< 0.001) and myocardial blush grade (
r
= − 0.334,
p
= 0.004). When the patients were divided into two groups determined by presence or absence of MACE, the patients with MACE had significantly higher levels of YKL-40 in comparison to the patients without MACE and the control group (194 ± 104, 114 ± 61 and 110 ± 53 μg/L,
p
< 0.001, respectively). In multivariate logistic regression analysis in STEMI patients, only YKL-40 level (OR: 1.011, 95%CI: 1.002–1.019,
p
= 0.011) and leukocyte count (OR: 1.264, 95%CI: 1.037–1.540,
p
= 0.020) were the independent predictors for MACE. Sensitivity and specificity of YKL-40 to predict MACE, when 125 μg/l was accepted as a cut-off value, were 84% and 70%, respectively.
Conclusion
We found that serum YKL-40 is related to older age, increased admission glucose levels, leukocyte counts and decreased hemoglobin levels; YKL-40 level and leukocyte count independently predicted MACE.
Abstract Using a sample of $$1.31\times 10^{9} ~J/\psi $$ 1.31×109J/ψ events collected with the BESIII detector, we perform a study of $$J/\psi \rightarrow \gamma K{\bar{K}}\eta '$$ J/ψ→γKK¯η′ . ...X(2370) is observed in the $$K{\bar{K}}\eta '$$ KK¯η′ invariant-mass distribution with a statistical significance of $$8.3\sigma $$ 8.3σ . Its resonance parameters are measured to be $$M=2341.6\pm 6.5 \, \text {(stat.)} \pm 5.7 \, \text {(syst.)}~ \hbox {MeV}/c^{2}$$ M=2341.6±6.5(stat.)±5.7(syst.)MeV/c2 and $$\Gamma = 117\pm 10 \, \text {(stat.)}\pm 8 \, \text {(syst.)}~\hbox {MeV}$$ Γ=117±10(stat.)±8(syst.)MeV . The product branching fractions for $$J/\psi \rightarrow \gamma X(2370),X(2370)\rightarrow K^{+}K^{-}\eta '$$ J/ψ→γX(2370),X(2370)→K+K-η′ and $$J/\psi \rightarrow \gamma X(2370),X(2370)\rightarrow K_{S}^{0}K_{S}^{0}\eta '$$ J/ψ→γX(2370),X(2370)→KS0KS0η′ are determined to be $$(1.79\pm 0.23\, \text {(stat.)}\pm 0.65\,\text {(syst.)})\times 10^{-5}$$ (1.79±0.23(stat.)±0.65(syst.))×10-5 and $$(1.18\pm 0.32\, \text {(stat.)}\pm 0.39\, \text {(syst.)})\times 10^{-5}$$ (1.18±0.32(stat.)±0.39(syst.))×10-5 , respectively. No evident signal for X(2120) is observed in the $$K{\bar{K}}\eta '$$ KK¯η′ invariant-mass distribution. The upper limits for the product branching fractions of $${\mathcal {B}}(J/\psi \rightarrow \gamma X(2120)\rightarrow \gamma K^{+} K^{-} \eta ')$$ B(J/ψ→γX(2120)→γK+K-η′) and $${\mathcal {B}}(J/\psi \rightarrow \gamma X(2120)\rightarrow \gamma K_{S}^{0} K_{S}^{0} \eta ')$$ B(J/ψ→γX(2120)→γKS0KS0η′) are determined to be $$1.49\times 10^{-5}$$ 1.49×10-5 and $$6.38\times 10^{-6}$$ 6.38×10-6 at the 90% confidence level, respectively.
This study was designed to compare the effects of YC-1 (3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole), a nitric oxide (NO)-independent soluble guanylate cyclase activator, and ...diethylenetriamine-NONOate (DETA/NO), a NO donor, on spontaneous contractions and the levels of cyclic GMP (cGMP) of myometrial strips isolated from timed-pregnant rats. Myometrial strips were obtained from timed-pregnant Wistar albino rats (
n
=
10) and were mounted in organ baths and tested for changes in isometric tension in response to YC-1 and DETA/NO. We also evaluated the effect of YC-1 and DETA/NO on the levels of cGMP in myometrial strips obtained from timed-pregnant rat uterine horns (
n
=
20). YC-1 (10
−
9
–3
×
10
−
5
M) and DETA/NO (10
−
7
–10
−
4
M) concentration-dependently decreased the amplitude and frequency of spontaneous contractions of myometrial strips isolated from term-pregnant rats. The inhibitions of the amplitude and frequency of spontaneous contractions by YC-1 and DETA/NO were antagonized with methylene-blue (10
−
5
M). Antagonistic effect of methylene-blue (10
−
5
M) was more on DETA/NO responses than that of YC-1 (
P
<
0.05). In addition, YC-1-stimulated myometrial strips showed more elevation in myometrial cGMP than that of DETA/NO (
P
<
0.05). We demonstrated that YC-1 and DETA/NO induce relaxations in the amplitude and frequency of spontaneous contractions of myometrial strips with different potencies. We also found that YC-1 and DETA/NO-induced relaxations are associated with significant increases in cGMP. These results might suggest that the relaxant effects of YC-1 and DETA/NO on the rat myometrium could be due to the stimulation of the soluble guanylate cyclase and cGMP may play a role for the maintenance of uterine quiescence during pregnancy.
Introduction
Attention deficit hyperactivity (ADHD) disorder is a common childhood neurodevelopmental disorder, and Methylphenidate (MPH) is a first-line therapeutic option for treating ADHD.However, ...how brain complexity and entropy changes with methylphenidate treatment the clinical implications of possible changes in entropy and the clinical implications of possible changes in entropy have yet to be studied.
Objectives
This study aimed to reveal how the MPH treatment affects the complexity in the brain of children with ADHD by entropy-based qEEG analysis. In addition, the presence of the relationship between possible neurophysiological changes to be detected with clinical variables and how they are two other important questions of this study to be answered.
Methods
During eyes-open resting, EEG signals were recorded from 25 boys with ADHD-combined type before MPH administration and at the end of the 1st month of the treatment. Approximate entropy (ApEn), sample entropy (SampEn), permutation entropy (PermEn) were used to analyse.
Results
A statistically significant decrease in entropy level was found with MPH treatment in the F4 channel according to approximate entropy (ApEn) and sample entropy (SampEn) analysis (p<0.05). In addition, according to permutation entropy (PermEn) analysis, the decrease in entropy with MPH treatment in the regions indicated by F3, F4, P4, T3, T6, and O2 channels was found to be statistically significant (p <0.05).
Conclusions
This is the first study to investigate how MPH treatment affects the complexity in the brain of children with ADHD. Entropy-based qEEG analysis may be a new method that can be used in diagnostic, clinical and prognostic predictions in ADHD.
Disclosure
No significant relationships.
Some applications in remote sensing require estimating a field containing a discontinuity whose exact location is a priori unknown. Such fields of interest include sea surface temperature in ...oceanography and soil moisture in hydrology. For the former, oceanic fronts form a temperature discontinuity, while in the latter sharp changes exist across the interface between soil types. To complicate the estimation process, remotely sensed measurements often exhibit regions of missing observations due to occlusions such as cloud cover. Similarly, water surface and ground-based sensors usually provide only an incomplete set of measurements. Traditional methods of interpolation and smoothing for estimating the fields from such potentially sparse measurements often blur across the discontinuities in the field.
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