Background: The minichromosome maintenance protein-2 (MCM-2) is a more sensitive proliferation marker than Ki-67. This study aimed to evaluate the relationship between MCM-2 and Oncotype DX ...recurrence score (ODX-RS) and determine an MCM-2 cutoff value in high-risk patients according to TAILORx risk categorization. Methods: Hormone receptor (HR) positive HER-2 negative early-stage breast cancer patients (pT1-2, pN0-N1, M0) who had ODXRS were included in the study. According to the TAILORx trial, patients were divided into two groups with high (ODX- RS greater than or equal to 26) and low risk (ODX-RS <26) in terms of ODX-RS. Formalin-fixed-paraffin-embedded tissues of patients were re-evaluated, and 3 microm sections were prepared for MCM-2 immuno-histochemical staining. The relationship between ODX-RS and the percentage of MCM-2 staining was evaluated in two groups. The ROC curve analysis was performed to determine the MCM-2 cut-off value for the TAILORx high-risk group (ODX-RS greater than or equal to 26). Results: The mean MCM-2 value was significantly higher in the high-risk group (60.2 + or - 11.2 vs 34.4 + or - 13.8, p < 0.001). In the multivariate analysis, MCM-2 (OR: 1.27, 95% CI: 1.08-1.49, p = 0.003) and progesterone receptor (PR) levels less than or equal to 10% (OR: 60.9, 95% CI: 4.1-89.7, p = 0.003) were found to be independent factors indicating a high- risk group. A one-unit increase in MCM-2 level increased the likelihood of being in the high-risk group by 1.27 times. In the ROC curve analysis, the optimal MCM-2 cut-off level was 50 (AUC: 0.921, sensitivity: 86.7%, specificity: 96.0%, p < 0.001). Conclusion: Our study is the first study in the literature to investigate the relationship between ODX-RS and MCM- 2 levels in HR-positive HER-2 negative early breast-cancer patients. In this study, MCM-2 was an independent risk factor in identifying high-risk patients according to TAILORx risk classification. MCM 2 cut-off value (50) may help the decision on adjuvant chemotherapy in patients where the Oncotype DX test cannot be performed. Keywords: breast cancer, MCM-2, Oncotype DX recurrence score, TAILORx risk categorization
Abstract We measured the Born cross sections for the process e + e − → ωη′ at 22 center-of-mass energies from 2.000 to 3.080 GeV with the BESIII detector at the BEPCII collider. We observed a ...resonant structure with a statistical significance of 9.6σ. A Breit-Wigner fit determines its mass to be M R = (2153 ± 30 ± 31) MeV/c 2 and its width to be Γ R = (167 ± 77 ± 7) MeV, where the first uncertainties are statistical and the second are systematic.
Conventionally, structural topology is used for spatial normalization during the pre-processing of fMRI. The co-existence of multiple intrinsic networks which can be detected in the resting brain are ...well-studied. Also, these networks exhibit temporal and spatial modulation during cognitive task vs. rest which shows the existence of common spatial excitation patterns between these identified networks. Previous work (Khullar et al., 2011) has shown that structural and functional data may not have direct one-to-one correspondence and functional activation patterns in a well-defined structural region can vary across subjects even for a well-defined functional task. The results of this study and the existence of the neural activity patterns in multiple networks motivates us to investigate multiple resting-state networks as a single fusion template for functional normalization for multi groups of subjects. We extend the previous approach (Khullar et al., 2011) by co-registering multi group of subjects (healthy control and schizophrenia patients) and by utilizing multiple resting-state networks (instead of just one) as a single fusion template for functional normalization. In this paper we describe the initial steps toward using multiple resting-state networks as a single fusion template for functional normalization. A simple wavelet-based image fusion approach is presented in order to evaluate the feasibility of combining multiple functional networks. Our results showed improvements in both the significance of group statistics (healthy control and schizophrenia patients) and the spatial extent of activation when a multiple resting-state network applied as a single fusion template for functional normalization after the conventional structural normalization. Also, our results provided evidence that the improvement in significance of group statistics lead to better accuracy results for classification of healthy controls and schizophrenia patients.
The IAXO Helioscope Ribas, E Ferrer; Armengaud, E; Avignone, F T. ...
Journal of physics. Conference series,
11/2015, Letnik:
650, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The IAXO (International Axion Experiment) is a fourth generation helioscope with a sensitivity, in terms of detectable signal counts, at least 104 better than CAST phase-I, resulting in sensitivity ...on gaγ one order of magnitude better. To achieve this performance IAXO will count on a 8-coil toroidal magnet with 60 cm diameter bores and equipped with X-ray focusing optics into 0.20 cm2 spots coupled to ultra-low background Micromegas X-ray detectors. The magnet will be on a platform that will allow solar tracking for 12 hours per day. The next short term objectives are to prepare a Technical Design Report and to construct the first prototypes of the hardware main ingredients: demonstration coil, X-ray optics and low background detector while refining the physics case and studying the feasibility studies for Dark Matter axions.
Abstract Using (10087 ± 44) × 106 J/ψ events collected with the BESIII detector at the BEPCII e + e − storage ring at the center-of-mass energy of s $$ \sqrt{s} $$ = 3.097 GeV, we present a search ...for the rare semi-muonic charmonium decay J/ψ → D − μ + ν μ + c.c.. Since no significant signal is observed, we set an upper limit of the branching fraction to be B $$ \mathcal{B} $$ (J/ψ → D − μ + ν μ + c.c.) < 5.6 × 10 −7 at 90% confidence level. This is the first search for the weak decay of charmonium with a muon in the final state.
Abstract Using e + e − collision datasets corresponding to a total integrated luminosity of 21.7 fb −1 collected with the BESIII detector at the BEPCII collider at center-of-mass energies ranging ...from 4.009 GeV to 4.951 GeV, the energy-dependent cross sections of e + e − → p K − Λ ¯ + c . c . $$ {e}^{+}{e}^{-}\to p{K}^{-}\overline{\Lambda}+c.c. $$ are measured for the first time. By fitting these energy-dependent cross sections, we search for the excited ψ states ψ(4160) and ψ(4415), and the vector charmonium-like states ψ(4230), ψ(4360), and ψ(4660). No evidence for these is observed and the upper limits on the branching fractions of these states decaying into p K − Λ ¯ + c . c . $$ p{K}^{-}\overline{\Lambda}+c.c. $$ are set at the 90% confidence level.
Abstract The D s + → K + K − μ + ν μ $$ {D}_s^{+}\to {K}^{+}{K}^{-}{\mu}^{+}{\nu}_{\mu } $$ decay is studied based on 7.33 fb −1 of e + e − collision data collected with the BESIII detector at ...center-of-mass energies in the range from 4.128 to 4.226 GeV. The absolute branching fraction is measured as B D s + → ϕ μ + ν μ = 2.25 ± 0.09 ± 0.07 × 10 − 2 $$ \mathcal{B}\left({D}_s^{+}\to \phi {\mu}^{+}{\nu}_{\mu}\right)=\left(2.25\pm 0.09\pm 0.07\right)\times {10}^{-2} $$ , the most precise measurement to date. Combining with the world average of B D s + → ϕ e + ν e $$ \mathcal{B}\left({D}_s^{+}\to \phi {e}^{+}{\nu}_e\right) $$ , the ratio of the branching fractions obtained is B D s + → ϕ μ + ν μ B D s + → ϕ e + ν e = 0.94 ± 0.08 $$ \frac{\mathcal{B}\left({D}_s^{+}\to \phi {\mu}^{+}{\nu}_{\mu}\right)}{\mathcal{B}\left({D}_s^{+}\to \phi {e}^{+}{\nu}_e\right)}=0.94\pm 0.08 $$ , in agreement with lepton universality. By performing a partial wave analysis, the hadronic form factor ratios at q 2 = 0 are extracted, finding r V = V 0 A 1 0 = 1.58 ± 0.17 ± 0.02 $$ {r}_V=\frac{V(0)}{A_1(0)}=1.58\pm 0.17\pm 0.02 $$ and r 2 = A 2 0 A 1 0 = 0.71 ± 0.14 ± 0.02 $$ {r}_2=\frac{A_2(0)}{A_1(0)}=0.71\pm 0.14\pm 0.02 $$ , where the first uncertainties are statistical and the second are systematic. No significant S-wave contribution from f 0(980) → K + K − is found. The upper limit B D s + → f 0 980 μ + ν μ ⋅ B f 0 980 → K + K − < 5.45 × 10 − 4 $$ \mathcal{B}\left({D}_s^{+}\to {f}_0(980){\mu}^{+}{\nu}_{\mu}\right)\cdot \mathcal{B}\left({f}_0(980)\to {K}^{+}{K}^{-}\right)<5.45\times {10}^{-4} $$ is set at 90% credibility level.
The antibiotic restriction policy has been validated nationwide since February 2003 by the Ministry of Health because the excessive consumption of antimicrobials causes a high cost. The aim of this ...study was to evaluate the therapeutic use of antibiotics in Aegean Region hospitals and to assess the impact of this nationwide antibiotic restriction policy. This new policy is based on justification that the infectious disease (ID) physicians should be primarily responsible for the prescription of antimicrobials.
Eight university and government hospitals were included in the study. The criteria of the Council for Appropriate and Rational Antibiotic Therapy (CARAT) were considered. Both patient-based and antibiotic-based analyses were performed. For the analysis of inappropriate use, logistic regression was modeled.
Therapeutic use was determined in 540 patients by a total of 29 ID physicians.In the study, 30.2% of the patients were given antimicrobials and empirically started antibiotics accounted for 79% cases of therapeutic antibiotic use, and 60% of those were inappropriate (P = 0.001). The appropriate use of ID level antibiotics (P = 0.000) were very compatible with other antimicrobial groups.
The study shows that the Turkish government's new intervention policy on antimicrobial prescribing has been effective.
Abstract Based on 4.5 fb −1 e + e − collision data collected with BESIII detector at seven energy points between 4.600 and 4.699 GeV, the branching fractions for Λ c + → pη $$ {\Lambda}_c^{+}\to ...p\eta $$ and Λ c + → pω $$ {\Lambda}_c^{+}\to p\omega $$ were measured by means of single-tag method. The branching fractions of Λ c + → pη $$ {\Lambda}_c^{+}\to p\eta $$ and Λ c + → pω $$ {\Lambda}_c^{+}\to p\omega $$ are determined to be (1.57 ± 0.11stat ± 0.04syst) × 10 −3 and (1.11 ± 0.20stat ± 0.07syst) × 10 −3, with a statistical significance of greater than 10σ and 5.7σ, respectively. These results are consistent with the previous measurements by BESIII, LHCb and Belle, and the result of Λ c + → pη $$ {\Lambda}_c^{+}\to p\eta $$ is the most precise to date.
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