Summary
Background
Few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas.
Objectives
To evaluate the clinicopathological features of ...95 cases of vulvar melanoma.
Methods
p53, CD117, Ki‐67, neurofibromin, brafv600e and nrasq61r immunostains, and molecular analyses by either targeted next‐generation or direct sequencing, were performed on available archival materials.
Results
Molecular testing detected mutations in KIT (44%), BRAF (25%), NF1 (22%), TP53 (17%), NRAS (9%) and TERT promoter (9%). Co‐mutation of KIT and NF1 and of KIT and NRAS were identified in two and one cases, respectively. KIT mutations were significantly associated with better progression‐free survival in univariate analyses. In multivariate analyses CD117 expression was significantly associated with better progression‐free survival. Tumour thickness was significantly associated with worse progression‐free and overall survival, and perineural invasion significantly correlated with reduced melanoma‐specific survival and reduced overall survival. Cases were from multiple centres and only a subset of samples was available for molecular testing.
Conclusions
KIT mutations and CD117 overexpression are markers of better progression‐free survival. In addition to its prognostic value, molecular testing may identify cases that might respond to targeted agents or immunotherapeutic approaches.
What's already known about this topic?
Vulvar melanomas are rare, with poorer prognoses than conventional cutaneous melanomas.
To date, few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas.
What does this study add?
This study, involving 10 clinical institutions from the U.S.A., Spain and Poland, shows that KIT mutations and CD117 overexpression are markers of better progression‐free survival for vulvar melanoma.
What is the translational message?
CD117 immunostaining and KIT mutational analysis can potentially serve as prognostic markers of vulvar melanoma.
Targeted inhibitors may have a therapeutic role in cases harbouring actionable mutations.
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MCORD - MPD Cosmic Ray Detector a new features Bielewicz, M.; Milewicz-Zalewska, M.; Grodzicka-Kobylka, M. ...
EPJ Web of Conferences,
2019, Letnik:
204
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
The main detector system at the Nuclotron-based Ion Collider fAcility (NICA) located in Dubna, Russia is the Multi-Purpose Detector (MPD). For better calibration reason, the MPD needs an additional ...trigger system for an off-beam calibration of MPD sub-detectors and for rejection (veto) of cosmic muons. The system should also be useful for practical astrophysics observations of cosmic showers. The consortium NICA-PL group defines goals and basic assumptions for the MPD Cosmic Ray Detector (MCORD). This article describes the conceptual design and simulation plans of the MCORD detector based on plastic scintillators with SiPM photodetectors and electronic digital system based on the MicroTCA crate.
PANDA Phase One Liu, Z.; Liu, B.; Shen, X. ...
The European physical journal. A, Hadrons and nuclei,
06/2021, Letnik:
57, Številka:
6
Journal Article
Recenzirano
Odprti dostop
The Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany, provides unique possibilities for a new generation of hadron-, nuclear- and atomic physics experiments. The future ...antiProton ANnihilations at DArmstadt (PANDA or
P
¯
ANDA) experiment at FAIR will offer a broad physics programme, covering different aspects of the strong interaction. Understanding the latter in the non-perturbative regime remains one of the greatest challenges in contemporary physics. The antiproton–nucleon interaction studied with PANDA provides crucial tests in this area. Furthermore, the high-intensity, low-energy domain of PANDA allows for searches for physics beyond the Standard Model,
e.g.
through high precision symmetry tests. This paper takes into account a staged approach for the detector setup and for the delivered luminosity from the accelerator. The available detector setup at the time of the delivery of the first antiproton beams in the HESR storage ring is referred to as the
Phase One
setup. The physics programme that is achievable during Phase One is outlined in this paper.
The Nuclotron-based Ion Collider fAcility (NICA) is under construction at the Joint Institute for Nuclear Research (JINR), with commissioning of the facility expected in late 2022. The Multi-Purpose ...Detector (MPD) has been designed to operate at NICA and its components are currently in production. The detector is expected to be ready for data taking with the first beams from NICA. This document provides an overview of the landscape of the investigation of the QCD phase diagram in the region of maximum baryonic density, where NICA and MPD will be able to provide significant and unique input. It also provides a detailed description of the MPD set-up, including its various subsystems as well as its support and computing infrastructures. Selected performance studies for particular physics measurements at MPD are presented and discussed in the context of existing data and theoretical expectations.
Decays of b hadrons into final states containing a D0 meson and a muon are used to measure the bb¯ production cross-section in proton–proton collisions at a centre-of-mass energy of 7 TeV at the LHC. ...In the pseudorapidity interval 2<η<6 and integrated over all transverse momenta we find that the average cross-section to produce b-flavoured or b¯-flavoured hadrons is (75.3±5.4±13.0) μb.
The exclusive charmonium production process in p¯p annihilation with an associated π0 meson p¯p→J/ψπ0 is studied in the framework of QCD collinear factorization. The feasibility of measuring this ...reaction through the J/ψ→e+e− decay channel with the AntiProton ANnihilation at DArmstadt (P¯ANDA) experiment is investigated. Simulations on signal reconstruction efficiency as well as the background rejection from various sources including the p¯p→π+π−π0 and p¯p→J/ψπ0π0 reactions are performed with PandaRoot, the simulation and analysis software framework of the P¯ANDA experiment. It is shown that the measurement can be done at P¯ANDA with significant constraining power under the assumption of an integrated luminosity attainable in four to five months of data taking at the maximum design luminosity.
.
This paper summarises a comprehensive Monte Carlo simulation study for precision resonance energy scan measurements. Apart from the proof of principle for natural width and line shape measurements ...of very narrow resonances with PANDA, the achievable sensitivities are quantified for the concrete example of the charmonium-like
X
(3872) state discussed to be exotic, and for a larger parameter space of various assumed signal cross-sections, input widths and luminosity combinations. PANDA is the only experiment that will be able to perform precision resonance energy scans of such narrow states with quantum numbers of spin and parities that differ from
J
P
C
=
1
-
-
.
Bound nuclear systems with two units of strangeness are still poorly known despite their importance for many strong interaction phenomena. Stored antiprotons beams in the GeV range represent an ...unparalleled factory for various hyperon–antihyperon pairs. Their outstanding large production probability in antiproton collisions will open the floodgates for a series of new studies of systems which contain two or even more units of strangeness at the P‾ANDA experiment at FAIR. For the first time, high resolution γ-spectroscopy of doubly strange ΛΛ-hypernuclei will be performed, thus complementing measurements of ground state decays of ΛΛ-hypernuclei at J-PARC or possible decays of particle unstable hypernuclei in heavy ion reactions. High resolution spectroscopy of multistrange Ξ−-atoms will be feasible and even the production of Ω−-atoms will be within reach. The latter might open the door to the |S|=3 world in strangeness nuclear physics, by the study of the hadronic Ω−-nucleus interaction. For the first time it will be possible to study the behavior of Ξ‾+ in nuclear systems under well controlled conditions.
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