This study attempts to solve the publication bias suggested by recent review articles in the tourism-growth literature. Publication bias is the tendency to report favourable and significant results. ...Method and data triangulation, and the Solow-Swan model are applied. A sample from 1995 to 2018 is considered with Tonga as a case study. The approach consists of multiple methods, data frequencies, exchange rates, structural breaks, and an overall tourism index developed using principal component analysis (PCA). Consistent results across these dimensions are obtained with the PCA models. Tourism has small, positive, and statistically significant economic growth effects. Theoretically consistent values of the capital share and exchange rates are obtained. The results indicate the importance of multiple methods and the overall tourism index in assessing the tourism-growth relationship and minimising publication biases. The practical implication is the provision of robust elasticity estimates and better economic policies.
Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material for the generation of cellular therapeutics requires demonstration of comparability of lines derived from ...different individuals and in different facilities. This requires agreement on the critical quality attributes of such lines and the assays that should be used. Working from established recommendations and guidance from the International Stem Cell Banking Initiative for human embryonic stem cell banking, and concentrating on those issues more relevant to iPSCs, a series of consensus workshops has made initial recommendations on the minimum dataset required to consider an iPSC line of clinical grade, which are outlined in this report. Continued evolution of this field will likely lead to revision of these guidelines on a regular basis.
Fire in the Mountains Chandra, Amit
Science (American Association for the Advancement of Science),
03/2021, Letnik:
371, Številka:
6533
Journal Article
Due to its high reactivity, monochloroacetic acid (MCA) is an essential intermediate used in the manufacturing of a wide variety of chemicals. Its industrial production process is highly energy‐ and ...capital‐intensive, requiring costly purification steps to remove dichloroacetic acid (DCA) impurities. Here, an innovative eco‐efficient process for MCA‐DCA separation is proposed based on extractive distillation in a fully thermally coupled system (a dividing‐wall column (DWC) or an equivalent side‐rectifier configuration) using a new effective solvent: diethylene glycol dipentylether. The design was optimized by performing sensitivity analyses and varying key operating and design parameters. The study proves that separating MCA‐DCA by an extractive DWC (or thermally coupled) is feasible, efficient, controllable, economic, and sustainable.
The feasibility of a novel extractive distillation process using a divided‐wall column for the separation of the close‐boiling mixture of mono‐ and dichloroacetic acid is demonstrated as a sustainable and eco‐efficient alternative to the current energy‐ and capital‐intensive hydrogenation and crystallization steps. Optimization was done by sensitivity analyses and variation of key operating and design parameters.
Large-scale manufacture of human embryonic stem cells (hESCs) is prerequisite to their widespread use in biomedical applications. However, current hESC culture strategies are labor-intensive and ...employ highly variable processes, presenting challenges for scaled production and commercial development. Here we demonstrate that passaging of the hESC lines, HUES7, and NOTT1, with trypsin in feeder-free conditions, is compatible with complete automation on the CompacT SelecT, a commercially available and industrially relevant robotic platform. Pluripotency was successfully retained, as evidenced by consistent proliferation during serial passage, expression of stem cell markers (OCT4, NANOG, TRA1-81, and SSEA-4), stable karyotype, and multi-germlayer differentiation in vitro, including to pharmacologically responsive cardiomyocytes. Automation of hESC culture will expedite cell-use in clinical, scientific, and industrial applications. Biotechnol. Bioeng. 2009;102: 1636-1644.
The global burden of thyroid disorders, especially hypothyroidism, is high and increasing. Prevalence studies of such disorders are limited in Nepal. The aim of this study was to find out the ...prevalence of hypothyroidism among patients visiting the Department of Biochemistry in the central laboratory of a tertiary care centre.
A descriptive cross-sectional study was conducted among patients visiting the Department of Biochemistry in the central laboratory from 1 August 2020 to 31 July 2021 after taking ethical approval from the Institutional Review Committee (Reference number: UCMS/IRC/054/20). Patients of all age groups and gender were considered. Hypothyroid patients were identified based on the thyroid function parameters. They were further categorized as sub-clinical and overt hypothyroid. A convenience sampling method was used. Point estimate and 95% Confidence Interval were calculated.
Among 3,010 patients, the prevalence of hypothyroidism was seen in 770 (25.58%) (24.02-27.14, 95% Confidence Interval). Out of total hypothyroid patients, 555 (72.08%) were females. Overt hypothyroidism 519 (67.40%) was the most prevalent hypothyroid disorder, followed by subclinical hypothyroidism 251 (32.60%).
The prevalence of hypothyroidism among patients visiting the Department of Biochemistry in the central laboratory of a tertiary care centre was higher than in other studies done in similar settings.
hypothyroidism; Nepal; thyroid-stimulating hormone.
Terahertz transmission of (i) pure gallium selenide, (ii) 500-ppm indium-doped gallium selenide, and (iii) 500-ppm chromium-doped gallium selenide is taken in the range 0.2-3.0 THz (6.67-100 cm -1 ) ...to identify the effect of doping on phonon modes. Fourier transform of time domain THz transmission data is fitted with a modified Drude-Smith model to derive phonon mode oscillator strength, phonon relaxation rate, plasma frequency, and momentum relaxation time of free carriers. It is observed that the effect of doping on defect states and carrier concentration rightly accounts the measured plasma frequency and momentum relaxation time. The THz absorption lines are appropriately attributed to the combination of phonon modes obtained by Raman spectroscopy.
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