Abnormalities in plasma amino acid levels have been noted in patients with various epilepsies, and sometimes also in their first degree relatives. We sought to study plasma amino acid levels in ...children with epileptic encephalopathies and their parents, relating findings to the pattern of cortical glucose metabolism as determined by
18fluorodeoxyglucose (FDG) positron emission tomography (PET). Twenty-eight children with cryptogenic epileptic encephalopathies were studied prospectively. Cortical glucose metabolism was evaluated by FDG PET with combined visual and semiquantitative analysis used to detect focal cortical defects. The plasma concentration of 21 amino acids in the children and their parents was measured by ion exchange chromatography and compared with control values using non-parametric statistical methods. Multivariate analysis was used to assess antiepileptic drug effects. Children were classified as: Lennox–Gastaut syndrome following infantile spasms (six patients); de-novo Lennox–Gastaut syndrome (eight); severe myoclonic epilepsy in infancy (eight) and myoclonic-astatic epilepsy (two). Four patients remained unclassified. Fourteen patients had focal/multifocal abnormalities on PET scans. The plasma level of aspartate was significantly lower in both the children with epileptic encephalopathies and in their parents (
P<0.005). The lowered aspartate levels could not be accounted for by the antiepileptic drug medication taken by the children. Further analysis showed the lowered aspartate levels to be confined to children and their parents who lacked focal PET abnormalities. These findings suggest a possible genetic abnormality in the aspartate neurotransmitter systems in the pathogenesis of seizures in the childhood epileptic encephalopathies.
This paper documents the sixteenth data release (DR16) from the Sloan Digital Sky Surveys; the fourth and penultimate from the fourth phase (SDSS-IV). This is the first release of data from the ...southern hemisphere survey of the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2); new data from APOGEE-2 North are also included. DR16 is also notable as the final data release for the main cosmological program of the Extended Baryon Oscillation Spectroscopic Survey (eBOSS), and all raw and reduced spectra from that project are released here. DR16 also includes all the data from the Time Domain Spectroscopic Survey (TDSS) and new data from the SPectroscopic IDentification of ERosita Survey (SPIDERS) programs, both of which were co-observed on eBOSS plates. DR16 has no new data from the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey (or the MaNGA Stellar Library "MaStar"). We also preview future SDSS-V operations (due to start in 2020), and summarize plans for the final SDSS-IV data release (DR17).
We present the results of a search in ital bar p ital p collisions at radicalital s =1.8 TeV for the top quark decaying to a charged Higgs bosson (ital Hsup plus minus). We search for dilepton final ...states from the decay chain ital t ital bar tr arrowital HH (or ital HW, or ital WW)+ital b ital bar br arrowital ll+ital X. In a sample of 19.3 pbsup minus1 collected during 1992--93 with the Collider Detector at Fermilab, we observe 2 events with a background estimation of 3.0plus minus1.0 events. Limits at 95% C.L. in the (Msub top,Msub ital Hsup plus minus) plane are presented. For the case ital Msub topltital Msub ital W+ital Msub ital b, we exclude at 95% C.L. the entire (ital Msub top,ital Msub Hplus minus) plane for the branching ratio ital B(ital Hr arrowtaunu) larger than 75%. We also interpret the results in terms of the parameter tanbeta of two-Higgs-doublet models.
We report limits on anomalous ital ZZgamma and ital Zgammagamma couplings derived from an analysis of ital Z+photon production based upon approximately 20pbsup minus1 of the bar p collision data ...recorded by the Collider Detector at Fermilab. We observe good agreement with the standard model expectation that all ital Zgamma couplings are zero. Confidence level intervals for individual couplings and contours for pairs of ital CP-conserving/violating ital ZZgamma and ital Zgammagamma couplings are presented.
We report on a study of ital W+ photon production in approximately 20 pbsup minus1 of ital pminusital bar p collisions at radicalital s=1.8 TeV recorded with the Collider Detector at Fermilab. Our ...results are in good agreement with standard model expectations and are used to obtain limits on anomalous ital CP-conserving ital WWgamma couplings of minus2.3ltDeltakappalt2.2 for lambda=0 and minus0.7ltlambdalt0.7 for Deltakappa=0 at 95% C.L. We obtain the same limits for ital CP-violating couplings. These results provide limits on the higher-order electromagnetic moments of the ital W boson of 0.8ltital gsub ital Wlt3.1 for ital qsup ital esub ital W=1 and minus0.6ltital qsup ital esub ital Wlt2.7 for ital gsub ital W=2 at 95% C.L.
Charge asymmetry has been measured using 19 039 ital W decays recorded by the Collider Detector at Fermilab during the 1992--93 run of the Tevatron Collider. The asymmetry is sensitive to the ratio ...of ital d and ital u quark distributions to ital xlt0.01 at ital Qsup 2approxital Msup 2sub ital W, where nonperturbative effects are minimal. It is found that of the two current sets of parton distributions, those of Martin, Roberts, and Stirling are favored over the sets most recently produced by the CTEQ Collaboration. The ital W asymmetry data provide stronger constraints on ital d/ital u ratio than the recent measurements of ital Fsub 2sup muital n/ital Fsub 2sup muital p, which are limited by uncertainties originating from deuteron corrections.
This Letter describes a direct measurement of the ital W boson decay width, Gamma(ital W), using the high-mass tail of the transverse mass spectrum of ital Wr arrowital enu decays recorded by the ...Collider Detector at Fermilab. We find Gamma(ital W)=2.11plus minus0.28(stat) plus minus 0.16(syst) GeV and compare this direct measurement with indirect means of obtaining the width.
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