Au lieu-dit Château-Bas, sur la commune de Vernègues, le temple gallo-romain, dont une partie de l’élévation et de l’ordre corinthien subsistent encore in situ, a longtemps été le seul édifice ...visible. Les prospections, les fouilles programmées et différents diagnostics menés depuis la fin des années 1990, en plusieurs points du vallon de Cazan, et en particulier à proximité du temple, permettent de restituer l’occupation antique de cette zone sise en limite nord-ouest du territoire d’Aquae Sextiae. Notre vision du site se trouve désormais entièrement renouvelée. Cet article propose un bilan de l’ensemble de ces découvertes, qui conduisent à identifier le site à une agglomération rurale contemporaine du temple au moment de sa construction, entre extrême fin de la République et tout début du Principat d’Auguste. Nous en connaissons désormais les voies d’accès et les limites, qui dessinent une airée habitée d’au moins 8 hectares. Outre un vaste sanctuaire augustéen établi sur deux terrasses au pied de la colline et de nombreuses installations hydrauliques, le site comprenait un quartier à vocation artisanale et/ ou commerciale (verre, textile…), divers habitats (murs, tesselles de mosaïque, enduits peints…), des thermes ( ?) et une grande villa ou une grande domus à vocation mixte, vinicole et oléicole. Ce site fut occupé au moins jusqu’à la fin du Ve s. de n. è.
The Gallo-Roman temple at Château-Bas (Vernègues), where part of the elevation and Corinthian order still remain in situ, was the only visible building for a long time. Surveys, excavations and various diagnoses carried out since the end of the 1990s, in several points of the Cazan valley, and in particular near the temple, make it possible to restore the ancient occupation of this area situated on the north-western border of the territory of Aquae Sextiae. Our vision of the site is now completely renewed. This article presents an assessment of all these discoveries, which lead to the identification of the site with a rural agglomération, which was contemporary of the temple at the time of its construction, between the end of the Roman Republic and the beginning of the Principate of Augustus. We now know the access routes and boundaries, which draw an inhabited air of at least 8 hectares. In addition to a vast Augustan sanctuary established on two terraces at the foot of the hill and numerous hydraulic installations, the site included a district with an economic and/ or commercial vocation (glass, textile...), various habitats (walls, mosaic tesserae, painted plasters...), thermal baths ( ?) and a large villa or a big domus with mixed vocation, wine and olive oil. This site was occupied at least until the end of the 5th century.
Mitochondrial (mt) DNA-associated NARP (neurogenic muscle weakness, ataxia, and retinitis pigmentosa) syndrome is due to mutation in the MT-ATP6 gene.
We report the case of a 18-year-old man who ...presented with deafness, a myoclonic epilepsy, muscle weakness since the age of 10 and further developed a retinitis pigmentosa and ataxia. The whole mtDNA analysis by next-generation sequencing revealed the presence of the 2 bp microdeletion m.9127–9128 del AT in the ATP6 gene at 82% heteroplasmy in muscle and to a lower load in blood (10–20%) and fibroblasts (50%). Using the patient's fibroblasts, we demonstrated a 60% reduction of the oligomycin-sensitive ATPase hydrolytic activity, a 40% decrease in the ATP synthesis and determination of the mitochondrial membrane potential using the fluorescent probe tetramethylrhodamine, ethyl ester indicated a significant reduction in oligomycin sensitivity.
In conclusion, we demonstrated that this novel AT deletion in the ATP6 gene is pathogenic and responsible for the NARP syndrome.
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•A 2 bp deletion of the ATP6 gene causes a truncated a subunit.•The truncated a subunit is responsible for a decrease of complex V activity.•A 2 bp deletion of the ATP6 gene causes a NARP syndrome.
$Microbacterium$ $oleivorans$ A9 is a uranium-tolerant actinobacteria isolated from the trench T22 located near the Chernobyl nuclear power plant. This site is contaminated with different ...radionuclides including uranium. To observe the molecular changes at the proteome level occurring in this strain upon uranyl exposure and understand molecular mechanisms explaining its uranium tolerance, we established its draft genome and used this raw information to perform an in-depth proteogenomics study. High-throughput proteomics were performed on cells exposed or not to 10$\mu$M uranyl nitrate sampled at three previously identified phases of uranyl tolerance. We experimentally detected and annotated 1532 proteins and highlighted a total of 591 proteins for which abundances were significantly differing between conditions. Notably, proteins involved in phosphate and iron metabolisms show high dynamics. A large ratio of proteins more abundant upon uranyl stress, are distant from functionally-annotated known proteins, highlighting the lack of fundamental knowledge regarding numerous key molecular players from soil bacteria.
As a high school teacher for 20 years, I feel concerned by educational performance and school violence which is, indeed, a topical issue. I wonder to what extent school management has an impact upon ...internal organization. Does the way schools are managed help to exacerbate the phenomenon of violence, or, on the contrary, does it contribute to bring solutions to it ? My final objective is to look for preventive measures so as to complement the governmental and political ones. PUB ABSTRACT
We present a study that combines polarized and unpolarized neutrons to derive the magnetic structure of the swedenborgite compound CaBa(Co3Fe)O7. Integrated intensities from a standard neutron ...diffraction experiment and polarization matrices from spherical neutron polarimetry have been simultaneously analyzed revealing a complex order, which differs from the usual spin configurations on a kagome lattice. We find that the magnetic structure is well described by a combination of two one-dimensional representations corresponding to the magnetic superspace symmetry P21′, and it consists of spins rotating around an axis close to the 110 direction. Due to the propagation vector q=(1300), this modulation has cycloidal and helicoidal character rendering this system a potential multiferroic. The resulting spin configuration can be mapped onto the classical 3×3 structure of a kagome lattice, and it indicates an important interplay between the kagome and the triangular layers of the crystal structure.
The structure of the α-quartz-type form of germanium dioxide was refined at room temperature and up to 1344 K by the Rietveld method using time-of-flight neutron powder diffraction data. The ...intertetrahedral bridging angle θ and the tilt angle δ exhibit thermal stabilities that are among the highest observed in α-quartz homeotypes. The temperature dependence of these angles is found to be a function of the structural distortion in these materials. Structure–property relationships predict that due to its highly distorted structure, germanium dioxide is potentially a high-performance piezoelectric material. The high stability of the above structural parameters as a function of temperature infers that the corresponding piezoelectric properties should also be retained under these conditions. At the present time, problems related to phase stability and crystal growth need to be resolved before the α-quartz-type form of ger-manium dioxide can be used as a piezoelectric material.
Chemical characterization at buried interfaces is a real challenge, as the physico-chemical processes operating at the interface govern the properties of many systems and devices. We have developed a ...methodology based on the combined use of pulsed RF GD-OES (pulsed Radio Frequency Glow Discharge Optical Emission Spectrometry) and XPS (X-ray Photoelectron Spectroscopy) to facilitate the access to deeply buried locations (taking advantage of the high profiling rate of the GD-OES) and perform an accurate chemical diagnosis using XPS directly inside the GD crater. The reliability of the chemical information is, however, influenced by a perturbed layer present at the surface of the crater, hindering traditional XPS examination due to a relatively short sampling depth. Sampling below the perturbed layer may, however, can be achieved using a higher energy excitation source with an increased sampling depth, and is enabled here by a new laboratory-based HAXPES (Hard X-ray PhotoElectron Spectroscopy) (Ga-Kα, 9.25 keV). This new approach combining HAXPES with pulsed RF GD-OES requires benchmarking and is here demonstrated and evaluated on InP. The perturbed depth is estimated and the consistency of the chemical information measured is demonstrated, offering a new route for advanced chemical depth profiling through coatings and heterostructures.
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