People typically use verbal probability phrases when discussing risks ("It is likely that this treatment will work"), both in written and spoken communication. When speakers are uncertain about ...risks, they can nonverbally signal this uncertainty by using prosodic cues, such as a rising, question-like intonation or a filled pause ("uh"). We experimentally studied the effects of these two prosodic cues on the listener's perceived speaker certainty and numerical interpretation of spoken verbal probability phrases. Participants (N = 115) listened to various verbal probability phrases that were uttered with a rising or falling global intonation and with or without a filled pause before the probability phrase. For each phrase, they gave a point estimate of their numerical interpretation in percentages and indicated how certain they thought the speaker was about the correctness of the probability phrase. Speakers were perceived as least certain when the verbal probability phrases were spoken with both prosodic uncertainty cues. Interpretation of verbal probability phrases varied widely across participants, especially when rising intonation was produced by the speaker. Overall, high probability phrases (e.g., "very likely") were estimated as lower (and low probability phrases, such as "unlikely," as higher) when they were uttered with a rising intonation. The effects of filled pauses were less pronounced, as were the uncertainty effects for medium probability phrases (e.g., "probable"). These results stress the importance of nonverbal communication when verbally communicating risks and probabilities to people, for example, in the context of doctor-patient communication.
Inverted CCAAT box-binding protein of 90 kDa (ICBP90) is over-expressed in several types of cancer, including breast, prostate and lung cancers. In search for proteins that interact with the set and ...ring-associated (SRA) domain of ICBP90, we used the two-hybrid system and screened a placental cDNA library. Several clones coding for a new domain of DNMT1 were found. The interaction, between the ICBP90 SRA domain and the DNMT1 domain, has been confirmed with purified proteins by glutathione-S-transferase pull-down experiments. We checked whether ICBP90 and DNMT1 are present in the same macro-molecular complexes in Jurkat cells and immortalized human vascular smooth muscle cells (HVTs-SM1). Co-immunoprecipitation experiments showed that ICBP90 and DNMT1 are present in the same molecular complex, which was further confirmed by co-localization experiments as assessed by immunocytochemistry. Downregulation of ICBP90 and DNMT1 decreased VEGF gene expression, a major pro-angiogenic factor, whereas those of p16(INK4A) gene and RB1 gene were significantly enhanced. Together, these results indicate that DNMT1 and ICBP90 are involved in VEGF gene expression, possibly via an interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 and an upregulation of p16(INK4A). They further suggest a new role of ICBP90 in the relationship between histone ubiquitination and DNA methylation in the context of tumoral angiogenesis and tumour suppressor genes silencing.
Electron reconstruction in CMS Baffioni, S.; Charlot, C.; Ferri, F. ...
The European physical journal. C, Particles and fields,
03/2007, Letnik:
49, Številka:
4
Journal Article
Recenzirano
Odprti dostop
The reconstruction of the energy and momentum of isolated electrons in CMS combining tracking and electromagnetic calorimetry information is described. The emphasis is put on primary electrons with ...transverse momentum below 50 GeV/c. The energy deposited in the electromagnetic calorimeter is measured in clusters of clusters (superclusters) which collect bremsstrahlung photons emitted along the electron trajectory in the tracker volume. The electron tracks are built from seeds in the pixel detector found via a cluster-driven pixel hit matching algorithm, followed by a reconstruction of trajectories in the silicon strip tracker with a Gaussian sum filter. Electrons are classified using observables sensitive to the pattern of bremsstrahlung emission and electromagnetic showering in the tracker material. Energy scale corrections depending on the electron class are applied to the supercluster and estimates of associated errors are obtained. The electron energy is deduced from a weighted combination of the corrected supercluster energy and tracker momentum measurements. The electron direction is that of the reconstructed electron track at interaction vertex. The pre-selection of isolated electron candidates for physics analysis is described. Class-dependent observables combining tracking and calorimetry information are discussed for electron identification.
CMS software and computing Charlot, C.
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2003, Letnik:
502, Številka:
2
Journal Article
Recenzirano
CMS is one of the two general-purpose HEP experiments currently under construction for the Large Hadron Collider at CERN. The handling of multi-petabyte data samples in a worldwide context requires ...computing and software systems with unprecedented scale and complexity. We describe how CMS is meeting the many data analysis challenges in the LHC area. We cover in particular our system of globally distributed regional centers, the status of our object-oriented software, and our strategies for Grid-enriched data analysis.
AbstractThis work summarizes the studies for the Higgs boson searches in CMS at the LHC collider. The main discovery channels are presented and the potential is given for the discovery of the SM ...Higgs boson and the Higgs bosons of the MSSM. The phenomenology, detector, trigger and reconstruction issues are briefly discussed.
La directiva europea de 2010 sobre eficiencia energética en los edificios exige un análisis económico y social con el objetivo de preservar la equidad social, promover la innovación y reforzar la ...productividad en la construcción. Esto es posible con el análisis del coste global ampliado y especialmente con el modelo SEC. El análisis “bottom up” realizado con la SEC se basa en una tipología de edificio/usuario y en el análisis de edificios representativos: la identificación del óptimo técnico-económico y elaboración de escenarios antes de hacer una extrapolación al conjunto del parque. SEC es una herramienta de ayuda a la decisión para desarrollar estrategias territoriales o patrimoniales de rehabilitación energética. Existen diversas versiones del modelo: para edificios residenciales (unifamiliares y plurifamiliares, públicos y privados) y para edificios terciarios.
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