In mice, bacteria from the mouth can translocate to the pancreas and impact pancreatic cancer progression. In humans, oral bacteria associated with periodontal disease have been linked to pancreatic ...cancer risk. It is not known if DNA bacterial profiles in the pancreas and duodenum are similar within individuals.
Tissue samples were obtained from 50 subjects with pancreatic cancer or other conditions requiring foregut surgery at the Rhode Island Hospital (RIH), and from 34 organs obtained from the National Disease Research Interchange. 16S rRNA gene sequencing was performed on 189 tissue samples (pancreatic duct, duodenum, pancreas), 57 swabs (bile duct, jejunum, stomach), and 12 stool samples.
Pancreatic tissue samples from both sources (RIH and National Disease Research Interchange) had diverse bacterial DNA, including taxa typically identified in the oral cavity. Bacterial DNA across different sites in the pancreas and duodenum were highly subject specific in both cancer and noncancer subjects. Presence of genus
was significantly higher in noncancer subjects compared with cancer subjects and the relative abundance of
spp., previously associated with colorectal cancer, was higher in cancer subjects compared with noncancer subjects.
Bacterial DNA profiles in the pancreas were similar to those in the duodenum tissue of the same subjects, regardless of disease state, suggesting that bacteria may be migrating from the gut into the pancreas. Whether bacteria play a causal role in human pancreatic cancer needs to be further examined.
Identifying bacterial taxa that differ in cancer patients can provide new leads on etiologically relevant bacteria.
In order to estimate the capabilities of a computing slot with limited processing time, it is necessary to know with a rather good precision its "power". This allows for example pilot jobs to match a ...task for which the required CPU-work is known, or to define the number of events to be processed knowing the CPU-work per event. Otherwise one always has the risk that the task is aborted because it exceeds the CPU capabilities of the resource. It also allows a better accounting of the consumed resources. The traditional way the CPU power is estimated in WLCG since 2007 is using the HEP-Spec06 benchmark (HS06) suite that was verified at the time to scale properly with a set of typical HEP applications. However, the hardware architecture of processors has evolved, all WLCG experiments moved to using 64-bit applications and use different compilation flags from those advertised for running HS06. It is therefore interesting to check the scaling of HS06 with the HEP applications. For this purpose, we have been using CPU intensive massive simulation productions from the LHCb experiment and compared their event throughput to the HS06 rating of the worker nodes. We also compared it with a much faster benchmark script that is used by the DIRAC framework used by LHCb for evaluating at run time the performance of the worker nodes. This contribution reports on the finding of these comparisons: the main observation is that the scaling with HS06 is no longer fulfilled, while the fast benchmarks have a better scaling but are less precise. One can also clearly see that some hardware or software features when enabled on the worker nodes may enhance their performance beyond expectation from either benchmark, depending on external factors.
As part of the R2D2 (Rare Decays with Radial Detector) R &D, the use of a gas detector with a spherical or cylindrical cathode, equipped with a single anode and operating at high pressure, was ...studied for the search of rare phenomena such as neutrinoless double-beta decay. The presented measurements were obtained with a cylindrical detector, covering gas pressures ranging from 1 to 10 bar in argon and 1 to 6 bar in xenon, using both a point-like source of
210
Po (5.3 MeV
α
) and a diffuse source of
222
Rn (5.5 MeV
α
). Analysis and interpretation of the data were developed using the anodic current waveform. Similar detection performances were achieved with both gases, and comparable energy resolutions were measured with both sources. As long as the purity of the gas was sufficient, no significant degradation of the measured energy was observed by increasing the pressure. At the highest operating pressure, an energy resolution better than 1.5% full-width at half-maximum (FWHM) was obtained for both gaseous media, although optimal noise conditions were not reached.
Whether we consider illness, disability or aging, we are or we will be all, at some point in our lives, affected by the theme of this conference. Acting to address these problems whatever they are, ...is not only do for but first and foremost do with and let it done. To succeed we must: – porpose to support a person throughout life irrespective of his age; – proceed to this necessary change by changing practices, the use of innovations, changes in professional cultures…; Many of our systems are built on an organization where supply dictates demand. Now, the user is the common point of all economic issues. His participation should not be limited to the listening of the needs alone. It is essential to involve the person from design to experiments in a living situation and provide an economic and medico-social assessment. This doesn’t mean to be inside but take his place in order to adapt the environment to the elderly, sick and/or disabled person. For this purpose, we are one of autonomic lab partners. There is a condition for this success: Make these networks work in complementary skills including different trades care, guidance, and research from the University, the public health and the industry, public authorities, elected officials. Co build increases the chances of success and distribution of solutions and devices proposed in this process. The heart of this new industry is: to highlight the person, to prioritize and simplify the care pathway, to highlight the desired route: from the choice of the necessary complementarities between human assistance and technical aids, to not confuse resource and compensation, gateways between trades of CARE and take CARE to make a real life course, to legitimate their respective competences. Finally, the desire to improve life expectancy in good health and living together.
ABSTRACT
We present the results of an analysis aimed at probing the small-scale magnetic fields of M dwarfs observed with SPIRou, the nIR high-resolution spectro-polarimeter installed at the ...Canada–France–Hawaii Telescope, in the context of the SPIRou Legacy Survey. Our analysis relies on high-resolution median spectra built from several tens of spectra recorded between 2019 and 2022, and on synthetic spectra computed with the ZeeTurbo code for various combination of atmospheric parameters and magnetic field strengths. We pursue the efforts undertaken in a previous study and focus on 44 weakly to moderately active M dwarfs. We derive average magnetic field strengths ( ) ranging from 0.05 to 1.15 kG, in good agreement with activity estimates and rotation periods. We found that including magnetic fields in our models has virtually no impact on our derived atmospheric parameters, and that a priori assumptions on the stellar surface gravity can affect our estimated . Our results suggest that small-scale magnetic fields account for more than 70 per cent of the overall average magnetic field for most targets whose large-scale fields were previously measured. We derived low magnetic fluxes for several targets in our sample, and found no clear evidence that decreases with increasing Rossby number in the unsaturated dynamo regime. We even identified counterexamples (GJ 1289 and GJ 1286) where the small-scale field is unusually strong despite the long rotation period. Along with similar results on the large-scale fields, our findings further suggest that dynamo processes may operate in a non-conventional mode in these strongly magnetic, slowly rotating stars.
Grafting from polymerization was used to synthesize nano-titania/polyurethane (nTiO(2)/polyurethane) composite coatings, where nTiO(2) was chemically attached to the backbone of the polyurethane ...polymer matrix with a bifunctional monomer, 2,2-bis(hydroxymethyl) propionic acid (DMPA). This bifunctional monomer can coordinate to nTiO(2) through an available -COOH group, with two available hydroxyl groups that can react with diisocyanate terminated pre-polyurethane through step-growth polymerization. The coordination reaction was monitored by FTIR and TGA, with the coordination reaction found to follow first order kinetics. After step-growth polymerization, the polyurethane nanocomposites were found to be stable on standing with excellent distribution of Ti in the polymer matrix without any significant agglomeration compared to simple physical mixtures of nTiO(2) in the polyurethane coatings. The functionalized nTiO(2)-polyurethane composite coatings showed excellent antibacterial activity against gram-negative bacteria Escherichia coli; 99% of E. coli were killed within less than one hour under solar irradiation. Self-cleaning was also demonstrated using stearic acid as a model for 'dirt'.
ABSTRACT
We present near-infrared spectropolarimetric observations of a sample of 43 weakly to moderately active M dwarfs, carried with SPIRou at the Canada–France–Hawaii Telescope in the framework ...of the SPIRou Legacy Survey from early 2019 to mid-2022. We use the 6700 circularly polarised spectra collected for this sample to investigate the longitudinal magnetic field and its temporal variations for all sample stars, from which we diagnose, through quasi-periodic Gaussian process regression, the periodic modulation and longer-term fluctuations of the longitudinal field. We detect the large-scale field for 40 of our 43 sample stars, and infer a reliable or tentative rotation period for 38 of them, using a Bayesian framework to diagnose the confidence level at which each rotation period is detected. We find rotation periods ranging from 14 to over 60 d for the early-M dwarfs, and from 70 to 200 d for most mid- and late-M dwarfs (potentially up to 430 d for one of them). We also find that the strength of the detected large-scale fields does not decrease with increasing period or Rossby number for the slowly rotating dwarfs of our sample as it does for higher-mass, more active stars, suggesting that these magnetic fields may be generated through a different dynamo regime than those of more rapidly rotating stars. We also show that the large-scale fields of most sample stars evolve on long time-scales, with some of them globally switching sign as stars progress on their putative magnetic cycles.
Abstract Background Irreversible electroporation (IRE) is a novel, non-thermal form of ablation. We studied the safety and efficacy of IRE for the ablation of liver tissue around the liver hilum. We ...also studied the ability of triphenyltetrazolium chloride staining (TTC) to predict the zone of ablation after IRE. Methods Eight swine underwent 20 ablations of the liver and liver hilum. Two monopolar probes were positioned 2 cm apart. IRE was performed using 90 pulses of 2500–3000 V/cm. IRE treatments were performed from 15 min to 14 days ( n = 4) before sacrifice. Results All animals survived. No major complications were encountered. Ablation width ranged from 2.27 to 4.45 cm and ablation height ranged from 1.5 to 1.8 cm. TTC staining demonstrated the zone of ablation in all animals. Hepatocyte necrosis occurs immediately adjacent to large central veins without evidence of heat sink. Bile ducts, portal veins and hepatic arteries appear to be more resistant to the effects of IRE. Conclusions IRE appears to be safe and effective for liver tissue ablation in the liver hilum. The portal structures appear more resistant to the effects of IRE. TTC staining can predict the zone of IRE ablation as early as 15 min after treatment.
Since in hospitalized older patients delirium is associated with poor outcomes, we evaluated the effectiveness of a multicomponent strategy for the prevention of delirium.
We studied 852 patients 70 ...years of age or older who had been admitted to the general-medicine service at a teaching hospital. Patients from one intervention unit and two usual-care units were enrolled by means of a prospective matching strategy. The intervention consisted of standardized protocols for the management of six risk factors for delirium: cognitive impairment, sleep deprivation, immobility, visual impairment, hearing impairment, and dehydration. Delirium, the primary outcome, was assessed daily until discharge.
Delirium developed in 9.9 percent of the intervention group as compared with 15.0 percent of the usual-care group, (matched odds ratio, 0.60; 95 percent confidence interval, 0.39 to 0.92). The total number of days with delirium (105 vs. 161, P=0.02) and the total number of episodes (62 vs. 90, P=0.03) were significantly lower in the intervention group. However, the severity of delirium and recurrence rates were not significantly different. The overall rate of adherence to the intervention was 87 percent, and the total number of targeted risk factors per patient was significantly reduced. Intervention was associated with significant improvement in the degree of cognitive impairment among patients with cognitive impairment at admission and a reduction in the rate of use of sleep medications among all patients. Among the other risk factors per patient there were trends toward improvement in immobility, visual impairment, and hearing impairment.
The risk-factor intervention strategy that we studied resulted in significant reductions in the number and duration of episodes of delirium in hospitalized older patients. The intervention had no significant effect on the severity of delirium or on recurrence rates; this finding suggests that primary prevention of delirium is probably the most effective treatment strategy.
PDF
