The light output of the 324 CsI(Tl) scintillators of INDRA has been measured over large ranges in energy: 1–
80
AMeV
and in atomic number of incident ions:
Z=1–60. An analytical expression for the ...non-linear total light response as a function of the energy and the identity of the ion is developed. It depends on four parameters. For three of them, connected to CsI(Tl) intrinsic characteristics, fixed values are proposed. Two applications are presented: energy calibration and fragment identification in telescopes using a CsI(Tl) crystal as residual energy detector.
Nicotinic acetylcholine receptors (nAChRs) of parasitic nematodes are required for body movement and are targets of important "classical" anthelmintics like levamisole and pyrantel, as well as ..."novel" anthelmintics like tribendimidine and derquantel. Four biophysical subtypes of nAChR have been observed electrophysiologically in body muscle of the nematode parasite Oesophagostomum dentatum, but their molecular basis was not understood. Additionally, loss of one of these subtypes (G 35 pS) was found to be associated with levamisole resistance. In the present study, we identified and expressed in Xenopus oocytes, four O. dentatum nAChR subunit genes, Ode-unc-38, Ode-unc-63, Ode-unc-29 and Ode-acr-8, to explore the origin of the receptor diversity. When different combinations of subunits were injected in Xenopus oocytes, we reconstituted and characterized four pharmacologically different types of nAChRs with different sensitivities to the cholinergic anthelmintics. Moreover, we demonstrate that the receptor diversity may be affected by the stoichiometric arrangement of the subunits. We show, for the first time, different combinations of subunits from a parasitic nematode that make up receptors sensitive to tribendimidine and derquantel. In addition, we report that the recombinant levamisole-sensitive receptor made up of Ode-UNC-29, Ode-UNC-63, Ode-UNC-38 and Ode-ACR-8 subunits has the same single-channel conductance, 35 pS and 2.4 ms mean open-time properties, as the levamisole-AChR (G35) subtype previously identified in vivo. These data highlight the flexible arrangements of the receptor subunits and their effects on sensitivity and resistance to the cholinergic anthelmintics; pyrantel, tribendimidine and/or derquantel may still be effective on levamisole-resistant worms.
Here, we measured direct photons for pT < 5GeV/c in minimum bias and 0%–40% most-central events at midrapidity for Cu+Cu collisions at √sNN = 200GeV. The e+e– contribution from quasireal direct ...virtual photons has been determined as an excess over the known hadronic contributions in the e+e– mass distribution. A clear enhancement of photons over the binary scaled p + p fit is observed for pT < 4GeV/c in Cu+Cu data. The pT spectra are consistent with the Au + Au data covering a similar number of participants. The inverse slopes of the exponential fits to the excess after subtraction of the p + p baseline are 285 ± 53(stat) ± 57(syst) MeV/c and 333 ± 72(stat) ± 45(syst) MeV/c for minimum bias and 0%–40% most-central events, respectively. The rapidity density, dN/dy, of photons demonstrates the same power law as a function of dNch/dη observed in Au + Au at the same collision energy.
Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p–Pb collisions at a nucleon–nucleon centre-of-mass energy of ...5.02 TeV. The transverse-momentum range 0.7 < p T,assoc < p T,trig < 5.0 GeV/c is examined, to include correlations induced by jets originating from low momentum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range |η| < 0.9. The near-side long-range pseudorapidity correlations observed in high-multiplicity p–Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the non-jet-like components. The yields in the jet-like peaks are found to be invariant with event multiplicity with the exception of events with low multiplicity. This invariance is consistent with the particles being produced via the incoherent fragmentation of multiple parton–parton scatterings, while the yield related to the previously observed ridge structures is not jet-related. The number of uncorrelated sources of particle production is found to increase linearly with multiplicity, suggesting no saturation of the number of multi-parton interactions even in the highest multiplicity p–Pb collisions. Further, the number scales only in the intermediate multiplicity region with the number of binary nucleon–nucleon collisions estimated with a Glauber Monte-Carlo simulation. (creativecommons.org/licenses/by/3.0/). Funded by SCOAP 3 .
We report on the production of inclusive Υ (1S) and Υ (2S) in p–Pb collisions at √ s NN = 5.02 TeV at the LHC. The measurement is performed with the ALICE detector at backward (−4.46 < y cms < −2.96) ...and forward (2.03 < y cms < 3.53) rapidity down to zero transverse momentum. The production cross sections of the Υ (1S) and Υ (2S) are presented, as well as the nuclear modification factor and the ratio of the forward to backward yields of Υ (1S). A suppression of the inclusive Υ (1S) yield in p–Pb collisions with respect to the yield from pp collisions scaled by the number of binary nucleon–nucleon collisions is observed at forward rapidity but not at backward rapidity. The results are compared to theoretical model calculations including nuclear shadowing or partonic energy loss effects. (creativecommons.org/licenses/by/3.0/). Funded by SCOAP 3 .
This paper reports new results on the petrology, geochronology and geochemistry of two km-scale high-pressure granulite exposures, namely the Weiya and the Yushugou granulites, that occur in the ...central and southern Tianshan Paleozoic sub-belts, respectively. Petrological and geochemical results suggest that the Weiya and the Yushugou granulites are different in both the rock types and geological structures. The protolith of the Weiya granulite is basic to intermediate rocks, and that of the Yushugou granulite is basic rocks; the former is distributed as fault-bounded blocks within the Precambrian schist-gneiss, and the latter occurs as thrust slabs in the allochthonous ophiolitic mélange. Observation of deformation structures provides some evidence for two-phase ductile deformation of the Tianshan granulites, characterized by deformed garnet-pyroxene and deformed feldspar-quartz microstructures, corresponding to rheological conditions of the lower crustal level and of the middle crustal level, respectively. The deformation structures also indicate that the Weiya granulite was involved in the late stage retrograde metamorphism forming new amphibole, following a thrusting movement toward the north and ductile deformation of feldspar-quartz grains. The Yushugou granulite underwent strong ductile shearing during the Silurian–Devonian interval. Three stages of metamorphism are recorded by mineral assemblages of the Weiya granulite: M1=Pl+Qtz+Bt, M2=Cpx+Grt+Pl+Qtz+Atp±Opx, and M3=Amp+Ep+Pl+Bt+Qtz, in contrast to a two-stage metamorphic history of the Yushugou granulite: M1=Cpx+Grt+Pl±Hyp, M2=Amp+Pl+Qtz±Bt. The P–T condition estimates suggest that the Weiya granulite was formed between 910–1025 °C and 1.08–1.12 GPa, and underwent retrograde metamorphism at 650–670 °C, while the peak metamorphism of the Yushugou granulite took place between 800–870 °C and 0.88–1.13 GPa. Geochemical characteristics (major, REE and incompatible elements) of the Weiya and Yushugou granulites indicate that their protoliths were formed in a volcanic arc setting, implying that a late Precambrian active continental margin may have existed in the study area. The Sm–Nd isochron dating for the Weiya granulite suggests that the peak metamorphism occurred at 538±24 Ma, which was likely related to the ancient plate subduction. The 40Ar/39Ar dating on amphibole grains separated from the Weiya granulite yielded a plateau age of 432±1 Ma for the retrograde metamorphism, which represents an exhumation age, suggesting a significant early Paleozoic tectonothermal event.
The INDRA multidetector has been used to study multifragmentation processes in central collisions for the Xe + Sn reaction at 50
A MeV. A single isotropic source formed at an excitation energy of 12
...A MeV exhausting most of the emitted charged products has been isolated in such collisions. The fragment kinetic energy spectra indicate a fast disintegration of the system with a radial collective motion of about 2
A MeV. The light charged particle characteristics within this scenario are also discussed.
In the absence of efficient alternative strategies, the control of parasitic nematodes, impacting human and animal health, mainly relies on the use of broad-spectrum anthelmintic compounds. ...Unfortunately, most of these drugs have a limited single-dose efficacy against infections caused by the whipworm, Trichuris. These infections are of both human and veterinary importance. However, in contrast to a wide range of parasitic nematode species, the narrow-spectrum anthelmintic oxantel has a high efficacy on Trichuris spp. Despite this knowledge, the molecular target(s) of oxantel within Trichuris is still unknown. In the distantly related pig roundworm, Ascaris suum, oxantel has a small, but significant effect on the recombinant homomeric Nicotine-sensitive ionotropic acetylcholine receptor (N-AChR) made up of five ACR-16 subunits. Therefore, we hypothesized that in whipworms, a putative homolog of an ACR-16 subunit, can form a functional oxantel-sensitive receptor. Using the pig whipworm T. suis as a model, we identified and cloned a novel ACR-16-like subunit and successfully expressed the corresponding homomeric channel in Xenopus laevis oocytes. Electrophysiological experiments revealed this receptor to have distinctive pharmacological properties with oxantel acting as a full agonist, hence we refer to the receptor as an O-AChR subtype. Pyrantel activated this novel O-AChR subtype moderately, whereas classic nicotinic agonists surprisingly resulted in only minor responses. We observed that the expression of the ACR-16-like subunit in the free-living nematode Caenorhabditis elegans conferred an increased sensitivity to oxantel of recombinant worms. We demonstrated that the novel Tsu-ACR-16-like receptor is indeed a target for oxantel, although other receptors may be involved. These finding brings new insight into the understanding of the high sensitivity of whipworms to oxantel, and highlights the importance of the discovery of additional distinct receptor subunit types within Trichuris that can be used as screening tools to evaluate the effect of new synthetic or natural anthelmintic compounds.
The Tianshan range could have been built by both late Early Paleozoic accretion and Late Paleozoic collision events. The late Early Paleozoic Aqqikkudug-Weiya suture is marked by Ordovician ...ophiolitic mélange and a Silurian flysch sequence, high-pressure metamorphic relics, and mylonitized rocks. The Central Tianshan belt could principally be an Ordovician volcanic arc; whereas the South Tianshan belt, a back-arc basin. Macro- and microstructures, along with unconformities, provide some kinematic and chronological constraints on 2-phase ductile deformation. The earlier ductile deformation occurring at ca. 400 Ma was marked by north-verging ductile shearing, yielding granulite-bearing ophiolitic mélange blocks and garnet-pyroxene-facies ductile deformation, and the later deformation, a dextral strike-slip tectonic process, occurred during the Late Carboniferous(Early Permian. Early Carboniferous molasses were deposited unconformably on pre-Carboniferous metamorphic and ductilely sheared rocks, implying the end of the early orogeny. The large-scale ductile strike-slip along the Aqqikkudug-Weiya zone was possibly caused by the second tectonic event, the Hercynian collision between the northern Tarim block and the southern Siberian block. Late Paleozoic granitic magmatism and superimposed structures overprinted this Early Paleozoic deformation belt. Results of geometric and kinematic studies suggest that the primary framework of the Southern-Central Tianshan belt, at least the eastern part of the Tianshan belt, was built by these two phases of accretion events.
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