Ferroptosis is a newly discovered form of regulated cell death that is the nexus between metabolism, redox biology, and human health. Emerging evidence shows the potential of triggering ferroptosis ...for cancer therapy, particularly for eradicating aggressive malignancies that are resistant to traditional therapies. Recently, there has been a great deal of effort to design and develop anticancer drugs based on ferroptosis induction. Recent advances of ferroptosis‐inducing agents at the intersection of chemistry, materials science, and cancer biology are presented. The basis of ferroptosis is summarized first to highlight the feasibility and characteristics of triggering ferroptosis for cancer therapy. A literature review of ferroptosis inducers (including small molecules and nanomaterials) is then presented to delineate their design, action mechanisms, and anticancer applications. Finally, some considerations for research on ferroptosis inducers are spotlighted, followed by a discussion on the challenges and future development directions of this burgeoning field.
Emerging evidence shows the therapeutic potential of ferroptosis inducers in cancer therapy, particularly for eradicating intractable malignancies that are resistant to traditional therapies. Recent advancements in ferroptosis inducers for cancer treatment are presented, including small molecules and nanomaterials. The remaining challenges and future development directions of this emerging field are also discussed.
Solar energy is abundant and offers significant potential for future climate change mitigation. This study investigates the impacts of climate change on surface solar radiation in the United States ...using a set of climate projections from global and regional climate models (GCMs and RCMs). Multi-model ensemble mean of GCMs in the fifth phase of the Coupled Model Intercomparison Project (CMIP5) show a significant increase in annual mean surface solar radiation over the eastern and southern US. The projected solar brightening is consistent among different future periods and pathways. However, RCMs in North American Coordinated Regional Climate Downscaling Experiment (NA-CORDEX) and convection-permitting simulations of the climate of North America exhibit a significant decrease in surface solar radiation over large areas of the US. Those conflicting responses between the GCMs and RCMs are evident throughout the year with the greatest disagreement during fall. When scrutinizing the mechanism of solar radiation changes, we find that cloud behavior alone cannot adequately explain the contrasting changes in solar radiation. Instead, if a climate model considers transient aerosols is the key for solar brightening or dimming. Future solar brightening is mainly associated with the declining aerosols that have been implemented in most of the CMIP5 GCMs. In contrast, solar dimming becomes evident because of the greenhouse gas effects in those GCMs and RCMs without considering the aerosol effects. This study highlights the importance of the aerosol effects in solar energy-related climate assessment, and it is necessary to implement the aerosol forcing in regional climate downscaling.
Sarcopenia, a newly recognized geriatric syndrome, is characterized by age-related decline of skeletal muscle plus low muscle strength and/or physical performance. Previous studies have confirmed the ...association of sarcopenia and adverse health outcomes, such as falls, disability, hospital admission, long term care placement, poorer quality of life, and mortality, which denotes the importance of sarcopenia in the health care for older people. Despite the clinical significance of sarcopenia, the operational definition of sarcopenia and standardized intervention programs are still lacking. It is generally agreed by the different working groups for sarcopenia in the world that sarcopenia should be defined through a combined approach of muscle mass and muscle quality, however, selecting appropriate diagnostic cutoff values for all the measurements in Asian populations is challenging. Asia is a rapidly aging region with a huge population, so the impact of sarcopenia to this region is estimated to be huge as well. Asian Working Group for Sarcopenia (AWGS) aimed to promote sarcopenia research in Asia, and we collected the best available evidences of sarcopenia researches from Asian countries to establish the consensus for sarcopenia diagnosis. AWGS has agreed with the previous reports that sarcopenia should be described as low muscle mass plus low muscle strength and/or low physical performance, and we also recommend outcome indicators for further researches, as well as the conditions that sarcopenia should be assessed. In addition to sarcopenia screening for community-dwelling older people, AWGS recommends sarcopenia assessment in certain clinical conditions and healthcare settings to facilitate implementing sarcopenia in clinical practice. Moreover, we also recommend cutoff values for muscle mass measurements (7.0 kg/m(2) for men and 5.4 kg/m(2) for women by using dual X-ray absorptiometry, and 7.0 kg/m(2) for men and 5.7 kg/m(2) for women by using bioimpedance analysis), handgrip strength (<26 kg for men and <18 kg for women), and usual gait speed (<0.8 m/s). However, a number of challenges remained to be solved in the future. Asia is made up of a great number of ethnicities. The majority of currently available studies have been published from eastern Asia, therefore, more studies of sarcopenia in south, southeastern, and western Asia should be promoted. On the other hand, most Asian studies have been conducted in a cross-sectional design and few longitudinal studies have not necessarily collected the commonly used outcome indicators as other reports from Western countries. Nevertheless, the AWGS consensus report is believed to promote more Asian sarcopenia research, and most important of all, to focus on sarcopenia intervention studies and the implementation of sarcopenia in clinical practice to improve health care outcomes of older people in the communities and the healthcare settings in Asia.
In this work we address the task of semantic image segmentation with Deep Learning and make three main contributions that are experimentally shown to have substantial practical merit. First, we ...highlight convolution with upsampled filters, or `atrous convolution', as a powerful tool in dense prediction tasks. Atrous convolution allows us to explicitly control the resolution at which feature responses are computed within Deep Convolutional Neural Networks. It also allows us to effectively enlarge the field of view of filters to incorporate larger context without increasing the number of parameters or the amount of computation. Second, we propose atrous spatial pyramid pooling (ASPP) to robustly segment objects at multiple scales. ASPP probes an incoming convolutional feature layer with filters at multiple sampling rates and effective fields-of-views, thus capturing objects as well as image context at multiple scales. Third, we improve the localization of object boundaries by combining methods from DCNNs and probabilistic graphical models. The commonly deployed combination of max-pooling and downsampling in DCNNs achieves invariance but has a toll on localization accuracy. We overcome this by combining the responses at the final DCNN layer with a fully connected Conditional Random Field (CRF), which is shown both qualitatively and quantitatively to improve localization performance. Our proposed "DeepLab" system sets the new state-of-art at the PASCAL VOC-2012 semantic image segmentation task, reaching 79.7 percent mIOU in the test set, and advances the results on three other datasets: PASCAL-Context, PASCAL-Person-Part, and Cityscapes. All of our code is made publicly available online.
Many modern object detectors demonstrate outstanding performances by using the mechanism of looking and thinking twice. In this paper, we explore this mechanism in the backbone design for object ...detection. At the macro level, we propose Recursive Feature Pyramid, which incorporates extra feedback connections from Feature Pyramid Networks into the bottom-up backbone layers. At the micro level, we propose Switchable Atrous Convolution, which convolves the features with different atrous rates and gathers the results using switch functions. Combining them results in DetectoRS, which significantly improves the performances of object detection. On COCO test-dev, DetectoRS achieves state-of-the-art 55.7% box AP for object detection, 48.5% mask AP for instance segmentation, and 50.0% PQ for panoptic segmentation. The code is made publicly available 1 .
Association of frailty with adverse clinical outcomes has been reported in Western countries, but data from the Asian population are scarce. This study aimed to evaluate the epidemiology of frailty ...among community-dwelling middle-aged and elderly population and to explore its association with musculoskeletal health in Taiwan.
I-Lan Longitudinal Aging Study (ILAS) data were retrieved for this study. Frailty was defined by the Fried's criteria; a comparison of demographic characteristics, physical performance, and body composition, including skeletal muscle mass and bone mineral density (BMD), as well as recent falls, history of hip fractures and the functional status of subjects with different frailty statuses were accomplished.
Overall, the data of 1,839 participants (mean age: 63.9±9.3 years, male 47.5%) were obtained for analysis. The prevalence of pre-frailty was 42.3% in men and 38.8% in women, whereas the prevalence of frailty was 6.9% and 6.7% in men and women, respectively. Frailty was significantly associated with older age, the male gender, larger waist circumference, lower skeletal muscle index, lower hip BMD, poorer physical function, poorer nutritional status, and poorer cognitive function. Also, frailty was significantly associated with osteoporosis (OR: 7.73, 95% CI: 5.01-11.90, p<0.001), history of hip fractures (OR: 8.66, 95% CI: 2.47-30.40, p = 0.001), and recent falls (O.R: 2.53, 95% CI: 1.35-4.76, p = 0.004).
Frailty and pre-frailty, in Taiwan, was closely associated with recent falls, history of hip fractures and osteoporosis among community-dwelling people 50 years of age and older. Furthermore, frailty intervention programs should take an integrated approach towards strengthening both and muscle mass, as well as prevention of falls.
Lattice structures, which are also known as architected cellular structures, have been applied in various industrial sectors, owing to their fascinated performances, such as low elastic modulus, high ...stiffness-to-weight ratio, low thermal expansion coefficient, and large specific surface area. The lattice structures fabricated by conventional manufacturing technologies always involve complicated process control, additional assembly steps, or other uncontrollable factors. Furthermore, limited types of unit cells can be used to construct lattice structures when using conventional processes. Fortunately, additive manufacturing technology, based on a layer-by-layer process from computer-aided design models, demonstrates the unique capability and flexibility and provides an ideal platform in manufacturing complex components like lattice structures, resulting in an effective reduction in the processing time to actual application and minimum of material waste. Therefore, additive manufacturing relieves the constraint of structure design and provides accurate fabrication for lattice structures with good quality. This work systematically presents an overview of conventional manufacturing methods and novel additive manufacturing technologies for metallic lattice structures. Afterward, the design, optimization, a variety of properties, and applications of metallic lattice structures produced by additive manufacturing are elaborated. By summarizing state-of-the-art progress of the additively manufactured metallic lattice structures, limitations and future perspectives are also discussed.
In this paper, a duty-varied voltage pulse-charge strategy (DVVPCS), that can detect and dynamically track the suitable duty of the charge pulse, is proposed to improve the battery-charge ...performance. To assess the system performance, a prototype of the duty-varied voltage pulse charger (DVVPC) is designed and implemented. Comparing with the standard constant-current and constant-voltage (CC-CV) charge strategy, the charge speed of the proposed DVVPCS is improved by about 14%, while the proposed DVVPCS is improved by about 5% in comparison with the conventional duty-fixed voltage pulse-charge strategy (DFVPCS). The charge efficiency of the proposed DVVPC has been improved by about 3.4% as compared with that of the general CC-CV. In comparison with conventional DFVPCS with D = 50%, the charge efficiency of the proposed DVVPCS is improved by about 1.5%. The results indicate that the DVVPCS can actually provide pulse with suitable duty to charge the battery, and the charge performance is improved.
Aim
Skeletal muscle loss is a common feature of aging, and is associated with unfavorable outcomes. Although several indexes of skeletal muscle mass measurement have been developed, the most optimal ...index for sarcopenia diagnosis among Asian populations has remained unclear. The present study aimed to evaluate the relationship between skeletal muscle mass and physical performance among community‐dwelling people in Taiwan.
Methods
Data of the I‐Lan Longitudinal Aging Study (ILAS) were retrieved for study. Comparisons between demographic profiles, physical performance and skeletal muscle mass (measured by dual‐energy X‐ray absorptiometry) were carried out. Skeletal muscle mass expressed by lean body mass divided by squared height (LBM/ht2), appendicular muscle mass divided by squared height (ASM/ht2) and percent skeletal muscle index (SMI%) were compared between measurements of physical performance.
Results
Overall, the data of 532 participants (mean age 64.6 ± 9.5 years, male 53.0%) were retrieved for analysis. Age was associated with poorer physical performance, and decreased ASM/ht2 and LBM/ht2, but not SMI%. Skeletal muscle mass (SMI%) was less significantly related to slow walking speed than ASM/ht2 in men. In women, all three muscle indexes showed no significant association between slow walking speed. In contrast, low handgrip strength was strongly associated with decreased skeletal muscle mass (measured by ASM/ht2 and LBM/ht2, but not SMI%) in both men and women.
Conclusions
Skeletal muscle mass was significantly associated with handgrip strength along with aging, but the association of skeletal muscle mass and walking speed was less significant. In sarcopenia diagnosis among Asian populations, ASM/ht2 should be the most suitable index for skeletal muscle mass measurements, and physical performance should be measured universally beyond measurements of skeletal muscle mass. Geriatr Gerontol Int 2013; 13: 964–971.
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