The definition of the subscapular bursa （SSB） remains controversial.One researcher demonstrated that SSB was a separate pouch.l However,others believed that SSB was actually the superior ...subscapularis recess （SSR）,which is an outpouching of the glenohumeral joint capsule.4 Whether or not the SSB and SSR are two different bursae must be confirmed.Furthermore,the fluid in the SSR revealed in magnetic resonance （MR） imaging has been regarded as an indication for a diagnosis of frozen shoulder.3 Considering that the SSB and SSR are two different structures with a close spatial relationship,recognition of the MR appearance of SSB might have important diagnostic implications.The purposes of this study were to describe the anatomy of the SSB using a three-dimensional （3D） visualization technique based on the Chinese visible human （CVH） and to explore the MR appearance of the SSB.
Grain-boundary engineering is pivotal to fully utilize the mechanical, electrical, and thermal-transport properties of various materials. However, current methods in metallurgy rely almost ...exclusively on top-down approaches, making precise grain-boundary engineering, especially at nanoscale, difficult to achieve. Herein, we report a method to produce tailored grain-boundary conditions with nanoscale precision from colloidal metal nanocrystals through surface treatment followed by a pressure-sintering process. The resulting bulk grain-boundary materials (which we call “nanocrystal coins”) possess a metal-like appearance and conductivity while inheriting the original domain features of the nanocrystal building blocks. Nanoindentation measurements confirmed the superior mechanical hardness of the obtained materials. Further, we use this method to fabricate, for the first time, a single-component bulk metallic glass from amorphous palladium nanoparticles. Our discovery may spur the development of new materials whose functionality crucially depends on the domain configuration at nanoscale, such as superhard materials, thermoelectric generators, and functional electrodes.
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•Fabrication of bulk grain-boundary materials from eight kinds of metal nanoparticles•Precise nanoscale grain-boundary engineering using nanocrystals•Emerging the Hall-Petch effect to enhance mechanical hardness of the materials•The first example of a single-component bulk metallic glass
Enhancing materials’ properties through grain-boundary (GB) engineering has been broadly employed in various scenes, ranging from an ancient “striking while the iron is hot” approach to modern state-of-the-art techniques. However, precisely controlling the GB condition of bulk materials at the nanometer scale has proven to be extremely challenging. In this work, we discover a new GB engineering approach, i.e., a nanocrystal (NC)-coining process, through consolidating premade NCs into bulk GB materials under pressure. By using surface-engineered metal NCs as the building blocks of “nanograins,” free-standing metal pieces (which we call “NC coins”) with designed nanometer-sized domains can be produced. These NC coins show metallic appearance, conductivity, and enhanced mechanical hardness. Our method allows us to create the first single-component bulk metallic glass from amorphous palladium nanoparticles.
We propose a new concept, the nanocrystal (NC)-coining process, to produce bulk materials with precisely tailored nanoscale grain-boundary conditions. By consolidating surface-engineered NCs into bulk materials using pressure, we can fabricate free-standing NC coins with metallic appearance and conductivity, while preserving the original NC domain feature. The obtained NC coins show enhanced mechanical hardness due to the Hall-Petch effect. With this method, we have created the first example of a bulk single-component metallic glass from amorphous palladium nanoparticles.
This study explores the persistence and transformation of culture amidst a critical economic process in China today, known as urbanization. Based on the China Labor-force Dynamics Survey (CLDS), we ...find that the clan, a central mechanism used to sustain cooperation in China's rural society, continues to impact trust traits amidst the ongoing urbanization process. Respondents from regions with a history of high clan density report higher levels of limited trust toward families, lower levels of generalized trust toward strangers, and a significant trust gap between these two. Nevertheless, the urbanization process is gradually mitigating the effect of clans on trust traits by driving the population from villages, providing public services to citizens, and promoting cooperation among strangers.
•This study examines cultural persistence and changes during China's urbanization.•Clan system still influences trust traits during rapid urbanization process.•High clan density regions show larger trust gap between families and strangers.•Urbanization is mitigating clans' effect on trust traits.•It does so by moving populations, offering public services, and fostering stranger cooperation.
Detailed observation of the phenotypic changes in rice panicle substantially helps us to understand the yield formation. In recent studies, phenotyping of rice panicles during the heading-flowering ...stage still lacks comprehensive analysis, especially of panicle development under different nitrogen treatments. In this work, we proposed a pipeline to automatically acquire the detailed panicle traits based on time-series images by using the YOLO v5, ResNet50, and DeepSORT models. Combined with field observation data, the proposed method was used to test whether it has an ability to identify subtle differences in panicle developments under different nitrogen treatments. The result shows that panicle counting throughout the heading-flowering stage achieved high accuracy (
= 0.96 and RMSE = 1.73), and heading date was estimated with an absolute error of 0.25 days. In addition, by identical panicle tracking based on the time-series images, we analyzed detailed flowering phenotypic changes of a single panicle, such as flowering duration and individual panicle flowering time. For rice population, with an increase in the nitrogen application: panicle number increased, heading date changed little, but the duration was slightly extended; cumulative flowering panicle number increased, rice flowering initiation date arrived earlier while the ending date was later; thus, the flowering duration became longer. For a single panicle, identical panicle tracking revealed that higher nitrogen application led to earlier flowering initiation date, significantly longer flowering days, and significantly longer total duration from vigorous flowering beginning to the end (total DBE). However, the vigorous flowering beginning time showed no significant differences and there was a slight decrease in daily DBE.
Smoking, depression, and anxiety increase the risk of death in patients with COPD, but the combined effect of these factors is unknown. We assessed the interactive effects of smoking, depression, and ...anxiety on mortality in patients with COPD.
We collected and analyzed data from 7,787 subjects with COPD, in 14 rural communities, from May 2008 to May 2012, and used logistic regression to evaluate the interactions and relative excess risk due to interaction (RERI). We applied the attributable proportion of interaction and the synergy index to evaluate the additive interactions of the factors.
In our COPD subjects the interaction of current smoking and depression symptoms increased the death risk by 3.8-fold (odds ratio 3.78, 95% CI 2.51-5.05), with significant biological interactions (RERI 1.74, 95% CI 0.51-2.99, attributable proportion 0.48, 95% CI 0.13-0.85, synergy index 2.98, 95% CI 1.44-4.56). The biological interactions increased with increasing years or pack-years of smoking: for subjects with ≥ 30 years of smoking: RERI 1.80, 95% CI 1.05-2.75, attributable proportion 0.48, 95% CI 0.15-0.82, synergy index 2.85, 95% CI 1.75-3.96; for subjects with ≥ 40 pack-years of smoking: RERI 3.11, 95% CI 1.54-4.71, attributable proportion 0.60, 95% CI 0.31-0.91, synergy index 4.00, 95% CI 2.84-5.26. Similarly, the combined effect of current smoking and anxiety symptoms increased the death risk by 4.3-fold (odds ratio 4.27, 95% CI 95% CI 2.96-5.59), with significant biological interactions (RERI 1.51, 95% CI 0.31-2.74, attributable proportion 0.46, 95% CI 0.11-0.87, synergy index 2.89, 95% CI 1.31-4.51). The biological interactions also increased with increasing years or pack-years of smoking: for subjects with ≥ 30 years of smoking: RERI 1.41, 95% CI 0.45-2.43, attributable proportion 0.45, 95% CI 0.12-0.81, synergy index 2.88, 95% CI 1.24-5.98; for subjects with ≥ 40 pack-years of smoking: RERI 3.15, 95% CI 2.07-4.61, attributable proportion 0.55, 95% CI 0.21-0.94, synergy index 3.00, 95% CI 1.45-4.75.
Smoking, depression, and anxiety are associated with higher risk of death in patients with COPD. The risk of death, depression, and anxiety increases with increasing duration of smoking (years) and cigarette pack-years. Chinese Clinical Trials Registration ChiCTR-TRC-12001958.
Bcl-2 (B-cell lymphoma 2) protein is localized in the outer membrane of mitochondria, where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic ...proteins. PRDM10 is a member of the PR/SET family of epigenetic regulators and may play a role in development and cell differentiation. Here we show that human PRDM10 contributes to the transcriptional regulation of human Bcl-2 gene. We found that PRDM10-depletion in human cells reduced the expression of Bcl-2 protein and over-expression of PRDM10 promoted Bcl-2 protein expression. Furthermore, luciferase reporter activity of Bcl-2 gene P1 promoter was significantly increased in cells co-transfected with PRDM10, and PRDM10 was able to bind to the Bcl-2 P1 promoter
. Using The Cancer Genome Atlas (TCGA) data set, we found weak positive correlation between PRDM10 and Bcl-2 in several cancer types including cancers of the breast, colon, and lung tissues. These data identify a novel function for PRDM10 protein and provide insights on the transcriptional control of Bcl-2 expression.
In order to understand the yield performance and nitrogen （N） response of hybrid rice under different ecological conditions in southern China, field experiments were conducted in Huaiji County of ...Guangdong Province, Binyang of Guangxi Zhuang Autonomous Region and Changsha City of Hunan Province, southern China in 2011 and 2012. Two hybrid （Liangyoupeijiu and Y-liangyou 1） and two inbred rice cultivars （Yuxiangyouzhan and Huanghuazhan） were grown under three N treatments （N1,225 kg ha-l; N2, 112.5-176 kg ha-l; N3, 0 kg ha-1） in each location. Results showed that grain yield was higher in Changsha than in Huaiji and Binyang for both hybrid and inbred cultivars. The higher grain yield in Changsha was attribut- ed to larger panicle size （spikelets per panicle） and higher biomass production. Consistently higher grain yield in hybrid than in inbred cultivars was observed in Changsha but not in Huaiji and Binyang. Higher grain weight and higher biomass production were responsible for the higher grain yield in hybrid than in inbred cultivars in Changsha. The better crop perfor- mance of rice （especially hybrid cultivars） in Changsha was associated with its temperature conditions and indigenous soil N. N2 had higher internal N use efficiency, recovery efficiency of applied N, agronomic N use efficiency, and partial factor productivity of applied N than N1 for both hybrid and inbred cultivars, while the difference in grain yield between N1 and N2 was relatively small. Our study suggests that whether hybrid rice can outyield inbred rice to some extent depends on the ecological conditions, and N use efficiency can be increased by using improved nitrogen management such as site-specific N management in both hybrid and inbred rice production.
We introduce a new type of fuzzy preference structure, called interval-valued hesitant preference relations, to describe uncertain evaluation information in group decision making (GDM) processes. ...Moreover, it allows decision makers to offer all possible interval values that are not accounted for in current preference structure types when one compares two alternatives. We generalize the concept of hesitant fuzzy set (HFS) to that of interval-valued hesitant fuzzy set (IVHFS) in which the membership degrees of an element to a given set are not exactly defined, but denoted by several possible interval values. We give systematic aggregation operators to aggregate interval-valued hesitant fuzzy information. In addition, we develop an approach to GDM based on interval-valued hesitant preference relations in order to consider the differences of opinions between individual decision makers. Numerical examples are provided to illustrate the proposed approach.
Abstract
This study examined the effects of (−)schisandrin B (−)Sch B on MAPK and Nrf2 activation and the subsequent induction of glutathione antioxidant response and cytoprotection against apoptosis ...in AML12 hepatocytes. Pharmacological tools, such as cytochrome P-450 (CYP) inhibitor, antioxidant, MAPK inhibitors and Nrf2 RNAi, were used to delineate the signalling pathway. (−)Sch B caused a time-dependent activation of MAPK in AML12 cells, particularly the ERK1/2. The MAPK activation was followed by an enhancement in Nrf2 nuclear translocation and the eliciting of a glutathione antioxidant response. Reactive oxygen species arising from a CYP-catalysed reaction with (−)Sch B seemed to be causally related to the activation of MAPK and Nrf2. ERK inhibition by U0126 or Nrf2 suppression by Nrf2 RNAi transfection almost completely abrogated the cytoprotection against menadione-induced apoptosis in (−)Sch B-pre-treated cells. (−)Sch B pre-treatment potentiated the menadione-induced ERK activation, whereas both p38 and JNK activations were suppressed. Under the condition of ERK inhibition, Sch B treatment did not protect against carbon tetrachloride-hepatotoxicity in an in vivo mouse model. In conclusion, (−)Sch B triggers a redox-sensitive ERK/Nrf2 signalling, which then elicits a cellular glutathione antioxidant response and protects against oxidant-induced apoptosis in AML12 cells.
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