Nonlinear optics plays a central role in the advancement of optical science and laser‐based technologies. The second‐order rogue‐wave solutions and modulation instability for the coherently coupled ...nonlinear Schrödinger equations with the positive coherent coupling in nonlinear optics are reported in this paper. Generalized Darboux transformations for such coupled equations are derived, with which the second‐order rational solutions for the purpose of modelling the rogue waves are obtained. With respect to the slowly‐varying complex amplitudes of two interacting optical modes, it is observed that 1) number of valleys of the second‐order rogue waves increases and peak value of the second‐order rogue wave decreases first and then increases; 2) single‐hump second‐order rogue wave turns into the double‐hump second‐order rogue wave; 3) single‐hump bright second‐order rogue wave turns into the dark second‐order rogue wave and finally becomes the three‐hump bright second‐order rogue wave. Meanwhile, baseband modulation instability through the linear stability analysis is seen.
The second‐order rogue‐wave solutions and modulation instability for the coherently coupled nonlinear Schrödinger equations with the positive coherent coupling are reported. With respect to the slowly‐varying complex amplitudes of two interacting optical modes, different types of rogue structures are presented and properties of the rogue‐wave solutions are discussed.
The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, ...intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled the role of DDX3X in tumorigenesis and tumour progression. In fact, DDX3X possesses numerous functions in cancer biology and is closely related to many well-known molecules. In this review, we describe the function of DDX3X in RNA metabolism, cellular stress response, innate immune response, metabolic stress response in pancreatic β cells and embryo development. Then, we focused on the role of DDX3X in cancer biology and systematically demonstrated its functions in various aspects of tumorigenesis and development. To provide a more intuitive understanding of the role of DDX3X in cancer, we summarized its functions and specific mechanisms in various types of cancer and presented its involvement in cancer-related signalling pathways.
Solid oxide fuel cells with proton conducting electrolytes (H–SOFCs) show great potential for more efficient energy conversion over their oxygen ionic conducting counterparts at temperatures below ...650 °C, providing a comparably high performance cathode material can be available. A brief review of current development of cathode materials shows that materials with triple (oxygen ionic, protonic, and electronic) conducting properties are most promising for H–SOFCs. In this work, a triple-conducting LiNi0.8Co0.2O2 (LNCO) with layered structure, allowing simultaneous conduction of intrinsic oxygen ion and electron as well as the extrinsic proton, is proposed as a cathode material for H–SOFC. The electrochemical impedance spectroscopy analysis of LNCO shows the good oxygen reduction reaction (ORR) activity with a considerably low activation energy of 0.88 eV, and an evident water uptake capability those facilitate the cathode reaction process. Fuel cells using LNCO cathode on a BaZr0.1Ce0.7Y0.2O3 proton-conducting electrolyte render a peak power density of 410 mW cm−2 at 650 °C under H2/air condition, which is higher than most of the typical cathode materials reported with similar cell configurations. This work also demonstrated a new series of simple and low cost cathode materials simultaneously possessing interesting triple-conduction and good ORR activities for low temperature H–SOFCs.
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•LiNi0.8Co0.2O2 (LNCO) shows typical layered structure by solid state reaction.•LNCO presents good ORR activity with low activation energy on BZCY electrolyte.•Proton conduction in LNCO is proven by EIS study in various moisture contents.•Fuel cell with LNCO cathode gives excellent performances, outperform typical cathodes.•A new series of cathode materials with similar structure is indicated.
Context
The flipped classroom (FC), reversing lecture and homework elements of a course, is popular in medical education. The FC uses technology‐enhanced pre‐class learning to transmit knowledge, ...incorporating in‐class interaction to enhance higher cognitive learning. However, the FC model is expensive and research on its effectiveness remains inconclusive. The aim of this study was to compare the efficacy of the FC model over traditional lecture‐based (LB) learning by meta‐analysis.
Methods
We systematically searched MEDLINE, PubMed, ERIC, CINAHL, EMBASE, reference lists and Association for Medical Education in Europe (AMEE) conference books. Controlled trials comparing academic outcomes between the FC and LB approaches in higher education were considered eligible. The main findings were pooled using a random‐effects model when appropriate.
Results
Forty‐six studies (9026 participants) were included, comprising four randomised controlled trials (RCTs), 19 quasi‐experimental studies and 23 cohort studies. Study populations were health science (n = 32) and non health science (n = 14) students. The risk of bias was high (36/37 articles). Meta‐analyses revealed that the FC had significantly better outcomes than the LB method in examination scores (post‐intervention and pre–post change) and course grades, but not in objective structured clinical examination scores. Subgroup analyses showed the advantage of the FC was not observed in RCTs, non‐USA countries, nursing and other health science disciplines and earlier publication years (2013 and 2014). Cumulative analysis and meta‐regression suggested a tendency for progressively better outcomes by year. Outcome assessments rarely focused on behaviour change.
Conclusions
The FC method is associated with greater academic achievement than the LB approach for higher‐level learning outcomes, which has become more obvious in recent years. However, results should be interpreted with caution because of the high methodological diversity, statistical heterogeneity and risk of bias in the studies used. Future studies should have high methodological rigour, a standardised FC format and utilise assessment tools evaluating higher cognitive learning and behaviour change to further examine differences between FC and LB learning.
The authors’ meta‐analysis (46 studies, >9000 participants, health and non‐health science education) found flipped classrooms generally have significantly better learning outcomes than lecture learning, with a tendency for better outcomes for more recent studies.
•A deep long short-term memory (LSTM) network is developed for nonlinear structural response modeling.•Two input-output schemes (LSTM-s and LSTM-f) are presented.•The deep learning model is capable ...of modeling both elastic and inelastic response of buildings.•An unsupervised learning algorithm is used to cluster the seismic inputs for training enhancement.•The approach was successfully verified by both numerical and experimental examples.
This paper presents a comprehensive study on developing advanced deep learning approaches for nonlinear structural response modeling and prediction. Two schemes of the long short-term memory (LSTM) network are proposed for data-driven structural seismic response modeling. The proposed deep learning model, trained on available datasets, is capable of accurately predicting both elastic and inelastic response of building structures in a data-driven fashion as opposed to the classical physics-based nonlinear time history analysis using numerical methods. In addition, an unsupervised learning algorithm based on a proposed dynamic K-means clustering approach is established to cluster the seismic inputs in order to (1) generate the least but the most informative datasets for training the LSTM and (2) improve the prediction accuracy and robustness of the model trained with limited data. The performance of the proposed approach is successfully demonstrated through three proof-of-concept studies that include a nonlinear hysteretic system, a real-world building with field sensing data, and a steel moment resisting frame. The results show that the proposed LSTM network is a promising, reliable and computationally efficient approach for nonlinear structural response prediction, and offers significant potential in seismic fragility analysis of buildings for reliability assessment.
Background
This study examines the predictive value of a novel systemic immune‐inflammation index (SII, platelet × neutrophil/lymphocyte ratio) in coronary artery disease (CAD) patients.
Methods
A ...total of 5602 CAD patients who had undergone a percutaneous coronary intervention (PCI) were enrolled. They were divided into two groups by baseline SII score (high SII vs low SII) to analyse the relationship between SII groups and the long‐term outcome. The primary outcomes were major cardiovascular events (MACE) which includes nonfatal myocardial infarction (MI), nonfatal stroke and cardiac death. Secondary outcomes included a composite of MACE and hospitalization for congestive heart failure.
Results
An optimal SII cut‐off point of 694.3 × 109 was identified for MACE in the CAD training cohort (n = 373) and then verified in the second larger CAD cohort (n = 5602). Univariate and multivariate analyses showed that a higher SII score (≥694.3) was independently associated with increased risk of developing cardiac death (HR: 2.02; 95% CI: 1.43‐2.86), nonfatal MI (HR: 1.42; 95% CI: 1.09‐1.85), nonfatal stroke (HR: 1.96; 95% CI: 1.28‐2.99), MACE (HR: 1.65; 95% CI: 1.36‐2.01) and total major events (HR: 1.53; 95% CI: 1.32‐1.77). In addition, the SII significantly improved risk stratification of MI, cardiac death, heart failure, MACE and total major events than conventional risk factors in CAD patients by the significant increase in the C‐index (P < .001) and reclassification risk categories by significant NRI (P < .05) and IDI (P < .05).
Conclusions
SII had a better prediction of major cardiovascular events than traditional risk factors in CAD patients after coronary intervention.
Solid oxide fuel cells (SOFCs) show considerable promise for meeting the current ever-increasing energy demand and environmental sustainability requirements because of their high efficiency, low ...environmental impact, and distinct fuel diversity. In the past few decades, extensive R&D efforts have been focused on lowering operational temperatures in order to decrease the system (stack and balance-of-plant) cost and improve the longevity of operationally useful devices of commercial relevance. Nanomaterials and related nanotechnologies have the potential to improve SOFC performance because of their advantageous functionalities, namely, their enlarged surface area and unique surface and interface properties compared to their microscale analogs. Recently, the use of nanomaterials has increased rapidly, as reflected by the exponential growth in the number of publications since 2002. In this work, we present a comprehensive summary of nanoparticles, nano-thin films and nanocomposites with different crystal phases, morphologies, microstructures, electronic properties, and electrochemical performances for low temperature SOFCs (LT-SOFCs), with focus on efforts to enhance electrical efficiency, to induce novel fundamental properties that are inaccessible in microcrystalline materials, and to promote the commercialization of LT-SOFCs. Recent progress in the applications of many classically or newly chemical and physical nanomaterials and nanofabrication techniques, such as thin film vacuum deposition, impregnation, electrospinning, spark plasma sintering, hard- and soft-template methods, and in-situ nanoparticle surface exsolution are also thoroughly described. The technological and scientific advantages and limitations related to the use of nanomaterials and nanotechnologies are highlighted, along with our expectations for future research within this emerging field.
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•Recent progress on the deployment of nanomaterials and nanotechnologies in SOFCs.•Low temperature operation of SOFCs enables nanomaterials applicability.•Nanomaterials and nanotechnologies richens SOFC study and understanding.•Nanothin film, nanograin and nanocomposite enhanced the capability of SOFCs.•Challenges & opportunities of nano application in SOFCs are analyzed and suggested.
Long non-coding RNA (lncRNA), which is a kind of noncoding RNA, is generally characterized as being more than 200 nucleotide transcripts in length. LncRNAs exhibit many biological activities, ...including, but not limited to, cancer development. In this review, a search of the PubMed database was performed to identify relevant studies published in English. The term "lncRNA or long non-coding RNA" was combined with a range of search terms related to the core focus of the review: mechanism, structure, regulation, and cancer. The eligibility of the retrieved studies was mainly based on the abstract. The decision as to whether or not the study was included in this review was made after a careful assessment of its content. The reference lists were also checked to identify any other study that could be relevant to this review. We first summarized the molecular mechanisms of lncRNAs in tumorigenesis, including competing endogenous RNA (ceRNA) mechanisms, epigenetic regulation, decoy and scaffold mechanisms, mRNA and protein stability regulation, transcriptional and translational regulation, miRNA processing regulation, and the architectural role of lncRNAs, which will help a broad audience better understand how lncRNAs work in cancer. Second, we introduced recent studies to elucidate the structure of lncRNAs, as there is a link between lncRNA structure and function and visualizing the architectural domains of lncRNAs is vital to understanding their function. Third, we explored emerging evidence for regulators of lncRNA expression, lncRNA turnover, and lncRNA modifications (including 5-methylcytidine, N6-methyladenosine, and adenosine to inosine editing), highlighting the dynamics of lncRNAs. Finally, we used autophagy in cancer as an example to interpret the diverse mechanisms of lncRNAs and introduced clinical trials of lncRNA-based cancer therapies.
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