•CVA decreases as executive function demands increase.•CVA changes moderate the association of changes in cognitive and prefrontal response.•A larger CVA withdrawal may be adaptive in situations ...requiring high executive demands.
Phasic cardiac vagal activity (CVA), reflecting ongoing, moment-to-moment psychophysiological adaptations to environmental changes, can serve as a predictor of individual difference in executive function, particularly executive performance. However, the relationship between phasic CVA and executive function demands requires further validation because of previous inconsistent findings. Moreover, it remains unclear what types of phasic changes of CVA may be adaptive in response to heightened executive demands. This study used the standard N-back task to induce different levels of working memory (WM) load and combined functional Near-Infrared Spectroscopy (fNIRS) with a multipurpose polygraph to investigate the variations of CVA and its interactions with cognitive and prefrontal responses as executive demands increased in fifty-two healthy young subjects. Our results showed phasic decreases in CVA as WM load increased (t (51) = -3.758, p < 0.001, Cohen's d = 0.526). Furthermore, phasic changes of CVA elicited by increased executive demands moderated the association of cognitive and cerebral hemodynamic variations in the prefrontal cortex (B = 0.038, SE = 0.014, p < 0.05). Specifically, as executive demands increased, individuals with larger phasic CVA withdrawal showed a positive relationship between cognitive and hemodynamic variations in the prefrontal cortex (β = 0.281, p = 0.031). No such significant relationship was observed in individuals with smaller phasic CVA withdrawal. The current findings demonstrate a decrease in CVA with increasing executive demands and provide empirical support for the notion that a larger phasic CVA withdrawal can be considered adaptive in situations requiring high executive function demands.
Studies show that different geometries of a Variable Cycle Engine (VCE) can be adjusted during the transient stage of the engine operation to improve the engine performance. However, this improvement ...increases the complexity of the acceleration and deceleration control schedule. In order to resolve this problem, the Transient-state Reverse Method (TRM) is established in the present study based on the Steady-state Reverse Method (SRM) and the Virtual Power Extraction Method (VPEM). The state factors in the component-based engine performance models are replaced by variable geometry parameters to establish the TRM for a double bypass VCE. Obtained results are compared with the conventional component-based model from different aspects, including the accuracy and the convergence rate. The TRM is then employed to optimize the control schedule of a VCE. Obtained results show that the accuracy and the convergence rate of the proposed method are consistent with that of the conventional model. On the other hand, it is found that the new-model-optimized control schedules reduce the acceleration and deceleration time by 45% and 54%, respectively. Meanwhile, the surge margin of compressors, fuel–air ratio and the turbine inlet temperature maintained are within the acceptable criteria. It is concluded that the proposed TRM is a powerful method to design the acceleration and deceleration control schedule of the VCE.
The mismatch negativity (MMN) implicating a comparison process between the deviant and the memory trace of the standard can be elicited by not only changes in physical features but also violations of ...abstract patterns. It is considered pre-attentive, yet the use of the passive design makes it difficult to exclude the possibility of attention leak. In contrast to how this issue has been well addressed with the MMN to physical changes, much less research directly investigated the attentional effect on the MMN to abstract relationships. Here we conducted an electroencephalography (EEG) experiment to study whether and how the MMN to abstract relationships is modulated by attention. We adapted the oddball paradigm of Kujala et al. by presenting occasional descending tone pairs among frequent ascending tone pairs, while additionally implementing a novel control of attention. Participants' attention was either directed away from the sounds (with an engaging task of visual target detection, so that the sounds were task-irrelevant) or toward the sounds (with a conventional task of auditory deviant detection, so that the sounds were task-relevant). The MMN to abstract relationships appeared regardless of attention, confirming the pre-attentive assumption. The attention-independence of the frontocentral and supratemporal components of the MMN supported the notion that attention is not required to generate the MMN. At the individual level, a relatively equal number of participants showed attention enhancement and attention suppression. It is unlike the attentional modulation on the P3b, which was robustly elicited in the attended condition only. The concurrent collection of these two neurophysiological markers in both unattended and attended conditions might be potentially suitable for testing clinical populations showing heterogeneous deficits in auditory function independent/dependent of attention.
Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells. ...Resistance to drugs and metastases are potential barriers for prostate cancer endocrine therapy. Although immunotherapy for tumors has developed rapidly in the last few decades, its effectiveness in treating prostate cancer is unsatisfactory. Prostate cancer has a high-expression level of CD47. Therefore, a novel approach for potential immunotherapy may be provided by investigating the relationship among CD47 and the infiltration of immune cells in the prostate carcinoma. Methods. The GEPIA database was utilized to compare the abundance of CD47 in malignant tissues with tissues that were normal. Furthermore, the function of CD47 in prostate carcinoma was assessed by CancerSEA. The association among CD47 and the tumor microenvironment was assessed utilizing the TISCH single cell data database. By using TIMER, the connection among CD47 and immunological invasion of prostate cancer was explored. Moreover, macrophages were cocultured with mouse prostate cancer cell RM-1 blocked by CD47 antibody to observe the changes in phagocytosis efficiency in vitro. Results. Expression level of CD47 is upregulated in prostate carcinoma, and it is closely connected with prostate cancer’s inadequate immune invasion. CD47 antibody blocking promotes macrophage phagocytosis of RM-1. Conclusion. Our research demonstrates a closely relationship among CD47 and the immunological microenvironment of prostate cancer, and blocking CD47 can promote macrophages to phagocytosis of prostate cancer cells. Therefore, CD47 may provide novel strategies for potential immunotherapy of prostate cancer.
•Children with SLI have spared fast mapping ability.•Word learning deficit in SLI lies in building a robust phonological representation.•Mandarin compound knowledge fosters word learning performance ...in preschool children.•Relationship between children's word learning and oral vocabulary is significant.
Children with SLI exhibit overall deficits in novel word learning compared to their age-matched peers. However, the manifestation of the word learning difficulty in SLI was not consistent across tasks and the factors affecting the learning performance were not yet determined. Our aim is to examine the extent of word learning difficulties in Mandarin-speaking preschool children with SLI, and to explore the potent influence of existing lexical knowledge on to the word learning process. Preschool children with SLI (n=37) and typical language development (n=33) were exposed to novel words for unfamiliar objects embedded in stories. Word learning tasks including the initial mapping and short-term repetitive learning were designed. Results revealed that Mandarin-speaking preschool children with SLI performed as well as their age-peers in the initial form-meaning mapping task. Their word learning difficulty was only evidently shown in the short-term repetitive learning task under a production demand, and their learning speed was slower than the control group. Children with SLI learned the novel words with a semantic head better in both the initial mapping and repetitive learning tasks. Moderate correlations between stand word learning performances and scores on standardized vocabulary were found after controlling for children's age and nonverbal IQ. The results suggested that the word learning difficulty in children with SLI occurred in the process of establishing a robust phonological representation at the beginning stage of word learning. Also, implicit compound knowledge is applied to aid word learning process for children with and without SLI. We also provide the empirical data to validate the relationship between preschool children's word learning performance and their existing receptive vocabulary ability.
Due to the cellular heterogeneity in multidrug resistance (MDR) cell populations, positive drug effects on the modulation of MDR can be obscured in conventional methods, especially when only a small ...number of cells are available. To address cellular variations among different MDR cells, we report a new microfluidic approach to study drug effect on MDR modulation, by investigating drug accumulation of daunorubicin in MDR leukemia cells. We have demonstrated that the new approach of same-single-cell analysis by accumulation (denoted as SASCA-A) is not only superior to different-single-cell analysis, but also has key advantages over our previous approach of same-single-cell analysis. First, SASCA-A is much simpler as it does not require multiple cycles of drug uptake and drug efflux. Second, it is faster, only taking about one fourth of the time used in the previous approach. Third, it provides a more 'identical' and reliable control because it compares the time points just before MDR modulator tests. To help understand the dynamics of drug accumulation in MDR cells, we also developed a mathematical model to describe the kinetics of drug accumulation conducted in individual cells. The SASCA-A method will benefit drug resistance research in minor cell subpopulations (e.g., cancer "stem" cells) because this method requires only a small number of cells in identifying the MDR reversal effect.
The purpose of this study was to use mismatch responses (MMRs) to explore the dynamic changes of Mandarin speech perception abilities from early to middle childhood. Twenty preschoolers, 18 ...school-aged children, and 26 adults participated in this study. Two sets of synthesized speech stimuli varying in Mandarin consonant (alveolo-palatal affricate vs. fricative) and lexical tone features (rising vs. contour tone) were used to examine the developmental course of speech perception abilities. The results indicated that only the adult group demonstrated typical early mismatch negativity (MMN) responses, suggesting that the ability to discriminate specific speech cues in Mandarin consonant and lexical tone is a continuing process in preschool- and school-aged children. Additionally, distinct MMR patterns provided evidence indicating diverse developmental courses to different speech characteristics. By incorporating data from the two speech conditions, we propose using MMR profiles consisting of mismatch negativity (MMN), positive mismatch response (p-MMR), and late discriminative negativity (LDN) as possible brain indices to investigate speech perception development.
The properties of faba bean (
L.) protein isolate (FPI) gels depend on their starting protein material and can be modulated by the addition of polysaccharides. In order to investigate the interplay ...between these two factors, commercial FPI (FPI
) and FPI prepared in-house (FPI
) were used to fabricate glucono-delta-lactone-induced gels, with or without dextran (DX) addition. FPI
exhibited lower solubility in water and a larger mean particle size, likely because it experienced extensive degradation due to the intense conditions involved in its preparation. The FPI
gel showed a similar water-holding capacity as the FPI
gel; however, its hardness was lower and viscoelasticity was higher. After DX addition, the hardness of both FPI gels decreased, while their water-holding capacity increased. Interestingly, DX addition decreased the viscoelasticity of the FPI
gel but enhanced the viscoelasticity of the FPI
gel. The microstructural analysis demonstrated that the density of the aggregation network decreased in the FPI
gel after DX addition but increased in the FPI
gel. This was consistent with the changes observed in the dominant protein interaction forces in these gels after DX addition. Overall, these findings have the potential to guide ingredient selection for the tailored preparation of FPI gels.
The plateaus of Tibet have a unique climate that poses a great challenge for local agriculture. To promote sustainable development in Tibet, an elite tea variety has been introduced. However, the ...modifications of tea flavors in response to the climate of the plateaus are unknown. In this study, volatile organic compounds (VOCs) and other taste substances of tea planted in its original location (OOT) and in Tibet (TOT) were systematically analyzed and compared. The volatile components in TOT and OOT showed a slight difference, and principal component analysis revealed that the characteristic aroma compounds distinguishing tea grown in Tibet from tea grown in Guangdong were hotrienol and benzyl alcohol. In terms of taste substances, TOT exhibited higher levels of water extractable compounds, including polyphenols and amino acids, but lower levels of caffeine than OOT, which implies that TOT may taste better than OOT. To our knowledge, this is the first study to describe the changes in aroma and flavor profiles of tea induced by high altitude systematically, which will provide a basis for reference during the introduction and cultivation of tea crops to the plateaus of Tibet.
Particulate air pollution in Lanzhou China Chu, Peter C.; Chen, Yuchun; Lu, Shihua ...
Environment international,
07/2008, Letnik:
34, Številka:
5
Journal Article, Conference Proceeding
Recenzirano
Concentrations of total suspended particles (TSP) and PM
10 in Lanzhou China have been kept high for the past two decades. Data collected during the intensive observational period from October 1999 ...to April 2001 show high TSP and PM
10 concentrations. Starting from November, the PM
10 pollution intensifies, and reaches mid to high alert level of air pollution, continues until April next year, and is at low alert level in the summer. In the winter and spring, the TSP concentration is 2–10 times higher than the third-level criterion of air quality (severe pollution). Effects of intrinsic factors (sources of pollution) and remote preconditions (propagation of dust storms) for severe PM
10 and TSP pollution in Lanzhou are analyzed.
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