Many urban areas experience both fluvial and pluvial floods, because locations next to rivers are preferred settlement areas and the predominantly sealed urban surface prevents infiltration and ...facilitates surface inundation. The latter problem is enhanced in cities with insufficient or non-existent sewer systems. While there are a number of approaches to analyse either a fluvial or pluvial flood hazard, studies of a combined fluvial and pluvial flood hazard are hardly available. Thus this study aims to analyse a fluvial and a pluvial flood hazard individually, but also to develop a method for the analysis of a combined pluvial and fluvial flood hazard. This combined fluvial–pluvial flood hazard analysis is performed taking Can Tho city, the largest city in the Vietnamese part of the Mekong Delta, as an example. In this tropical environment the annual monsoon triggered floods of the Mekong River, which can coincide with heavy local convective precipitation events, causing both fluvial and pluvial flooding at the same time. The fluvial flood hazard was estimated with a copula-based bivariate extreme value statistic for the gauge Kratie at the upper boundary of the Mekong Delta and a large-scale hydrodynamic model of the Mekong Delta. This provided the boundaries for 2-dimensional hydrodynamic inundation simulation for Can Tho city. The pluvial hazard was estimated by a peak-over-threshold frequency estimation based on local rain gauge data and a stochastic rainstorm generator. Inundation for all flood scenarios was simulated by a 2-dimensional hydrodynamic model implemented on a Graphics Processing Unit (GPU) for time-efficient flood propagation modelling. The combined fluvial–pluvial flood scenarios were derived by adding rainstorms to the fluvial flood events during the highest fluvial water levels. The probabilities of occurrence of the combined events were determined assuming independence of the two flood types and taking the seasonality and probability of coincidence into account. All hazards – fluvial, pluvial and combined – were accompanied by an uncertainty estimation taking into account the natural variability of the flood events. This resulted in probabilistic flood hazard maps showing the maximum inundation depths for a selected set of probabilities of occurrence, with maps showing the expectation (median) and the uncertainty by percentile maps. The results are critically discussed and their usage in flood risk management are outlined.
Floods frequently cause substantial economic and human losses, particularly in developing countries. For the development of sound flood risk management schemes that reduce flood consequences, ...detailed insights into the different components of the flood risk management cycle, such as preparedness, response, flood impact analyses and recovery, are needed. However, such detailed insights are often lacking: commonly, only (aggregated) data on direct flood damage are available. Other damage categories such as losses owing to the disruption of production processes are usually not considered, resulting in incomplete risk assessments and possibly inappropriate recommendations for risk management. In this paper, data from 858 face‐to‐face interviews among flood‐prone households and small businesses in Can Tho city in the Vietnamese Mekong Delta are presented to gain better insights into the damage caused by the 2011 flood event and its management by households and businesses.
Sixteen compounds (1-16) were isolated from Impatiens chapaensis. Chemical structures were determined by spectroscopic analyses and comparisons with previously published data. This report is the ...first to identify compounds 1, 5–7, 10, 12–14, and 16 from the genus Impatiens. Seven chosen isolates (5, 7, 10, 11, 12, 15, and 16) were submitted for α-glucosidase inhibition assays with acarbose as the positive control (IC50 = 227.14 ± 13.71 µM). Flavonoid 5 exhibited a significant inhibitory effect (IC50 = 101.00 ± 9.01 µM).
The first chemical study of the whole Impatiens parvisepala S. X. Yu & Y. T. Hou led to the isolation of a new triterpene saponin, named Iparvisepala-1 (6) along with ten known compounds, which cover ...three flavonoid glycosides (1-3), one dihydrochalcone glucoside (4), one triterpenoid saponin (5), one triterpene (7) and four miscellaneous compounds (8-11). Their structures were elucidated by MS, NMR spectroscopic analyses as well as by comparisons of spectra data with those of the related published literatures. Additionally, flavonoid glucoside 2 showed impressive effect on α-glucosidase inhibition with the IC
50
value of 12.53 ± 0.39 µM, much better than that of the positive control acabose (IC
50
= 197.53 ± 2.68 µM).
The utilization of beneficial bacteria in aquaculture is increasingly advocated due to their positive impact on fish growth and health. This study assesses the effect of dietary Lactobacillus ...plantarum L03 on the growth and disease resistance of Nile tilapia Oreochromis niloticus. Fish (19.07 ± 0.43 g) were fed with a diet supplemented with L. plantarum at 0, 2, 5, 10 g/kg (referred to as LP0, LP2, LP5, and LP10 treatments) for seven weeks. One day after the end of experiment, fish were infected with Streptococcus algalactiae at 5 × 10
5
CFU/mL and monitored for 14 days. Blood samples were collected for hematological analyses after feeding trial and bacterial challenge. The results indicated no effects of dietary L. plantarum on fish growth, while the positive effects on feed conversion ratio and protein efficiency ratio (P < .05) were found in LP2 and LP5-fed fish. The supplementation of probiotics exhibited beneficial effects on red and white blood cells, hemoglobin, hematocrit, and mortality after bacterial challenge for LP5 treatment (P < .05). In conclusion, LP5 treatment at a dietary supplementation of 5 g L. plantarum per kg resulted in positive outcomes on feed utilization, cellular immunity, and disease resistance in Nile tilapia.
Inflamm-aging is associated with the rate of aging and is significantly related to diseases such as Alzheimer's disease, Parkinson's disease, atherosclerosis, heart disease, and age-related ...degenerative diseases such as type II diabetes and osteoporosis. This study aims to evaluate the safety and efficiency of autologous adipose tissue-derived mesenchymal stem cell (AD-MSC) transplantation in aging-related low-grade inflammation patients.
This study is a single-group, open-label, phase I clinical trial in which patients treated with 2 infusions (100 million cells i.v) of autologous AD-MSCs were initially evaluated in 12 inflamm-aging patients who concurrently had highly proinflammatory cytokines and 2 of the following 3 diseases: diabetes, dyslipidemia, and obesity. The treatment effects were evaluated based on plasma cytokines.
During the study's follow-up period, no adverse effects were observed in AD-MSC injection patients. Compared to baseline (D-44), the inflammatory cytokines IL-1α, IL-1β, IL-8, IL-6, and TNF-α were significantly reduced after 180 days (D180) of MSC infusion. IL-4/IL-10 at 90 days (D90) and IL-2/IL-10 at D180 increased, reversing the imbalance between proinflammatory and inflammatory ratios in the patients.
AD-MSCs represent a potential intervention to prevent age-related inflammation in patients.
ClinicalTrials.gov number is NCT05827757, first registered on 13th Oct 2020.
Rett syndrome (RTT) is a severe neurodevelopmental disorder in children characterized by a normal neurodevelopmental process in the first 6-18 months followed by a period of motor and vocal ...deterioration with stereotypic hand movements. Incidence of RTT is mostly due to de novo mutation in the MECP2 gene (methyl-CpG-binding protein 2).
The study assessed 27 female patients presented with classical RTT phenotype age range from 18 months to 48 months. Specialist carried out the clinical evaluation and diagnosis according to RTT diagnosis criteria. Blood samples from patients were then collected for genomic DNA extraction. We next performed MECP2 gene amplification and sequencing of the whole coding region to screen for mutations.
MECP2 mutation was found in 20 patients (74%) including: 2 missense, 4 nonsense, 6 frameshift and 2 deletion mutation. The study identified 14 pathogenic mutations which we found 4 mutation, to our knowledge and extensive search, not priory reported in any mutation database or publication: c.1384-1385DelGT, c.1205insT, c.717delC and c.1132_1207del77. High percentage of C > T (70%) in CpG sites mutation was found.
Our result reveals a high percentage of C > T mutation in CpG hot spot, which is more prone to modification and more likely to be detected in RTT as a disorder is strictly due to de novo mutations. The study is the first to identify the mutation spectrum of MECP2 gene in Vietnamese patients and also an important step toward better diagnosis and care for RTT patients in Vietnam.
BACKGROUND: Drinking water quality affects directly human health. Assessment and prevention of water-borne diseases are crucial for primary prevention, especially for children. OBJECTIVE: The main ...aim of this study was to investigate the quality of drinking water from tap water in preschools and primary schools in a district area in Hanoi City, Vietnam. METHODS: A cross-sectional study was performed from August to October 2019. Water samples from tap water of 154 schools in a district area of Hanoi were collected to determine the quality of drinking water. From each school, at least 2 bottles of water samples were collected on the basis of a standard operating procedure (SOP). Each water sample was analyzed for microbial and physicochemical parameters, including Color, Taste and Odor, Turbidity, pH, Nitrite, Nitrate, Ammonium, Total Iron, Permanganate, Chloride, Hardness, Total Manganese, Sulfate, Arsenic, Coliform, and E.coli, by analytical methods. The obtained values of each parameter were compared with the standard values set by WHO and National Technical Regulation on Domestic Water Quality of Vietnam. RESULTS: All of the schools employed community water system as a main source for drinking water. The results showed that all tested samples were found to be within the standards for some physicochemical properties, including Color, Taste and Odor, Hardness, Chloride, Total Iron (Fe2+ và Fe3+), Total Manganese (Mn), Nitrate (NO3–), Sulfate (SO42–), and Total Arsenic (As). On the other hand, some samples did not meet the allowable limits of the national standard, due to pH (3.9%), Turbidity (0.6%), Nitrite (3.2%), Permanganate (6.5%), and Ammonium (5.8%). Furthermore, the microbial data revealed that the substandard water samples from municipal water systems were contaminated by Coliform (9.7%) and/or E.coli (7.8%). CONCLUSIONS AND RECOMMENDATIONS: Contaminants such as bacterial and chemical agents in to drinking water could be occurred during transport, storage and handling before using by the consumer without regular surveillance. A periodic treatment procedure and monitoring system to keep the level of microbial and chemical contamination of drinking water in schools under control should be performed.
Abstract
Semi-flexible pavement has a more notable advantage over asphalt concrete pavement in terms of rutting performance. Cement grouting and open-graded asphalt concrete are components of the ...semi-flexible pavement. In cement grouting, two commercial modifiers from Sika Vietnam were used, Sika Latex and Sika TH Latex, with different contents from 4.5% to 7.5% for Sika Latex and 7.5% to 9.5% for Sika TH Latex. 72 samples of cement mortar were fabricated in laboratory conditions from PCB40. All cement grouts were cured at the age of 7 days. The paper results focus on the flexural strength and the compressive strength of both mortars, the suggestion of Sika content to produce the stable strength of cement grout, and the viscosity of cement mortar based on the Sika contents.
Background. The optimal time to initiate antiretroviral therapy (ART) in human immunodeficiency virus (HIV)—associated tuberculous meningitis is unknown. Methods. We conducted a randomized, ...double-blind, placebo-controlled trial of immediate versus deferred ART in patients with HIV-associated tuberculous meningitis to determine whether immediate ART reduced the risk of death. Antiretroviral drugs (zidovudine, lamivudine, and efavirenz) were started either at study entry or 2 months after randomization. All patients were treated with standard antituberculosis treatment, adjunctive dexamethasone, and prophylactic co-trimoxazole and were followed up for 12 months. We conducted intention-to-treat, perprotocol, and prespecified subgroup analyses. Results. A total of 253 patients were randomized, 127 in the immediate ART group and 126 in the deferred ART group; 76 and 70 patients died within 9 months in the immediate and deferred ART groups, respectively. Immediate ART was not significantly associated with 9-month mortality (hazard ratio HR, 1.12; 95% confidence interval CI,.81-1.55; P = .50) or the time to new AIDS events or death (HR, 1.16; 95% CI,.87-1.55; P = .31). The percentage of patients with severe (grade 3 or 4) adverse events was high in both arms (90% in the immediate ART group and 89% in the deferred ART group; P = .84), but there were significantly more grade 4 adverse events in the immediate ART arm (102 in the immediate ART group vs 87 in the deferred ART group; P = .04). Conclusions. Immediate ART initiation does not improve outcome in patients presenting with HIV-associated tuberculous meningitis. There were significantly more grade 4 adverse events in the immediate ART arm, supporting delayed initiation of ART in HIV-associated tuberculous meningitis.
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