Cancer patients are regarded as a highly vulnerable group in the current Coronavirus Disease 2019 (COVID-19) pandemic. To date, the clinical characteristics of COVID-19-infected cancer patients ...remain largely unknown.
In this retrospective cohort study, we included cancer patients with laboratory-confirmed COVID-19 from three designated hospitals in Wuhan, China. Clinical data were collected from medical records from 13 January 2020 to 26 February 2020. Univariate and multivariate analyses were carried out to assess the risk factors associated with severe events defined as a condition requiring admission to an intensive care unit, the use of mechanical ventilation, or death.
A total of 28 COVID-19-infected cancer patients were included; 17 (60.7%) patients were male. Median (interquartile range) age was 65.0 (56.0–70.0) years. Lung cancer was the most frequent cancer type (n = 7; 25.0%). Eight (28.6%) patients were suspected to have hospital-associated transmission. The following clinical features were shown in our cohort: fever (n = 23, 82.1%), dry cough (n = 22, 81%), and dyspnoea (n = 14, 50.0%), along with lymphopaenia (n = 23, 82.1%), high level of high-sensitivity C-reactive protein (n = 23, 82.1%), anaemia (n = 21, 75.0%), and hypoproteinaemia (n = 25, 89.3%). The common chest computed tomography (CT) findings were ground-glass opacity (n = 21, 75.0%) and patchy consolidation (n = 13, 46.3%). A total of 15 (53.6%) patients had severe events and the mortality rate was 28.6%. If the last antitumour treatment was within 14 days, it significantly increased the risk of developing severe events hazard ratio (HR) = 4.079, 95% confidence interval (CI) 1.086–15.322, P = 0.037. Furthermore, patchy consolidation on CT on admission was associated with a higher risk of developing severe events (HR = 5.438, 95% CI 1.498–19.748, P = 0.010).
Cancer patients show deteriorating conditions and poor outcomes from the COVID-19 infection. It is recommended that cancer patients receiving antitumour treatments should have vigorous screening for COVID-19 infection and should avoid treatments causing immunosuppression or have their dosages decreased in case of COVID-19 coinfection.
•We retrospectively studied clinical features of 28 severe Coronavirus Disease 2019 (COVID-19)-infected cancer patients from three hospitals in Wuhan, China.•We analysed risk factors associated with occurrence of admission to an intensive care unit, usage of mechanical ventilation, or death.•COVID-19-infected cancer patients presented poor outcomes with high occurrence of clinically severe event and mortality.•Antitumour treatment within 14 days of COVID-19 diagnosis increased the risk of developing severe events.
Great discrepancies exist in the reported prevalence of altered energy metabolism (hypo- or hypermetabolism) in cancer patients, which is likely due to the vast array of phenomena that can affect ...energy expenditure in these patients. The purpose of this review was to critically evaluate key determinants of energy expenditure in cancer and the relevance for clinical practice. Resting energy expenditure (REE) is the largest and most commonly measured component of total energy expenditure. In addition to the energetic demand of the tumor itself, REE may be increased due to changes in inflammation, body composition and brown adipose tissue activation. Energy expenditure from physical activity is often lower in cancer compared with healthy populations, and there is evidence to suggest that the thermic effect of food might also be blunted and affected by cancer therapy. Although accurate assessment of energy metabolism is a cornerstone of adequate nutritional therapy, prediction methods often do not capture the true energy expenditure of most cancer patients. In fact, limits of agreement of prediction equations may range from 40% below to 30% above measured REE. Such variability highlights the need for a more comprehensive understanding of energy expenditure in cancer and the value of accurately assessing the energy needs of these patients.
This paper investigates the average torque separation in permanent magnet (PM) synchronous machines. In order to accurately separate the PM and armature fields, and, hence, the torque components ...accounting for the magnetic saturation and crosscoupling, the frozen permeability (FP) method is often employed, while the torque can be calculated by different methods, such as Maxwell stress tensor and virtual work principle. Although these two methods result in identical torques in normal finite element (FE) analyses when appropriate FE meshes are used, the average torques calculated by these two methods are found to be different when the FP method is employed due to the influence of equivalent rotational magnetic saliency in the stator, which causes a part of PM torque being improperly attributed to the reluctance torque when Maxwell stress tensor method is employed. However, by using the virtual work principle, this is eliminated, and, hence, the average torque components can still be appropriately separated and analyzed.
Aims: This study aimed to search for a novel quorum‐sensing inhibitor from some fungi and analyse its inhibitory activity.
Methods and Results: Chromobacterium violaceum CV026, a double mini‐Tn5 ...mutant, was used as an indicator to monitor quorum‐sensing inhibition. Auricularia auricular pigments from fruiting bodies were extracted using hydrochloric acid as an infusion, dissolved in alkaline dimethylsulfoxide (DMSO), sterilized by filtration through a 0·22‐μm membrane filter and added to C. violaceum CV026 cultures. Inhibitory activity was measured by quantifying violacein production using a microplate reader. The results have revealed that the alkaline DMSO‐soluble pigments significantly reduced violacein production in a concentration‐dependent manner, a quorum‐sensing‐regulated behaviour in C. violaceum.
Conclusions: Auricularia auricular pigments can inhibit bacterial quorum sensing.
Significance and Impact of the Study: The results suggest the bioactive constituents from edible and medicinal fungi could interfere with bacterial quorum‐sensing system, regulate its associate functions and prevent bacterial pathogenesis. Further studies were in process in our laboratory to isolate specific compounds from A. auricular pigments, evaluate them as quorum‐sensing inhibitors and analyse the exact mechanism of action.
Aim To determine the efficacy and safety of caesarean section combined with temporary aortic balloon occlusion followed by uterine artery embolisation (UAE) for the treatment of patients with ...placenta accreta. Materials and methods This retrospective study involved 42 patients with placenta accreta. All patients underwent caesarean section combined with temporary aortic balloon occlusion followed by UAE through the right femoral approach. Results All patients were confirmed to have placenta praevia and accreta, including five patients with placenta percreta, at the time of delivery. The technical success rate of the combined treatment was 97.6% (41/42). Forty-one patients underwent successful caesarean section with conservation of the uterus. Hysterectomy was required in one (3.1%) patient. The amount of blood loss and blood transfusion, and the operation time were was 586 ± 355 ml, 422 ± 83 ml and 65.5 ± 10.6 minutes, respectively. The mean postoperative hospital stay, occlusion time and fetal radiation dose were 5.5 ± 2.6 days, 22.4 ± 7.2 minutes and 4.2 ± 2.9 mGy, respectively. There were no significant changes before and 7 days after the endovascular procedure in creatinine levels (56.8 ± 13.8 μmol/l versus 63.4 ± 16.7 μmol/l, p = 0.09) or urea nitrogen (6.3 ± 2.5 μmol/l versus 7.4 ± 3.8 μmol/l, p = 0.17). There were no access-site complications after the endovascular procedure and no complications related to the intervention during follow-up. Conclusion Temporary aortic balloon occlusion followed by UAE can effectively control postpartum haemorrhage during placental dissection, and reduce transfusion requirements, hysterectomy rate, and operation time in patients with placenta accreta.
Our previous study reported that Epstein-Barr virus(EBV)-encoded latent membrane protein 1 (LMP1) could induce development of CD44(+/High) stem-like cells in nasopharyngeal carcinoma (NPC). However, ...the molecular mechanisms that underlie modulation of cancer stem cells (CSCs) in NPC remain unclear. Here, we show that LMP1 induced CSC-like properties through promotion of the expression of epithelial-mesenchymal transition-like cellular markers and through alterations in differentiation markers. Furthermore, LMP1 activated and triggered phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway, which subsequently stimulated expression of CSC markers, development of side population and tumor sphere formation. This suggests that PI3K/AKT pathway has an important role in the induction and maintenance of CSC properties in NPC. Similarly, PI3K/AKT pathway was also activated by phosphorylase in LMP1-induced CD44(+/High) cells. In addition, LMP1 greatly increased expression of miR-21 and downregulated expression of the miR-21 target, PTEN. Overexpression of miR-21 by transfection of miR-21 mimics into LMP1-transformed cells led to phosphorylase-mediated activation of the PI3K/AKT pathway and induction of CSCs. On the contrary, phosphorylation of the PI3K/AKT pathway and the expression of CSC were reversed by an miR-21 inhibitor. The specific inhibitor (Ly294002) of PI3K/AKT pathway significantly decreased expression of miR-21 and CSC markers and upregulated the expression of PTEN, which indicates that miR-21 and PTEN are the downstream effectors of PI3K/AKT and that expression of these two effectors are related to the development of NPC CSCs. Taken together, our novel findings indicate that LMP1, PI3K/AKT, miR-21 and PTEN constitute a positive feedback loop and have a key role in LMP1-induced CSCs in NPC.
We investigate the prospects for joint low-latency gravitational wave (GW) detection and prompt electromagnetic (EM) follow-up observations of coalescing binary neutron stars (BNSs). For BNS mergers ...associated with short duration gamma-ray bursts (SGRBs), we for the first time evaluate the feasibility of rapid EM follow-ups to capture the prompt emission, early engine activity, or reveal any potential by-products such as magnetars or fast radio bursts. To achieve our goal, we first simulate a population of coalescing BNSs using realistic distributions of source parameters and estimate the detectability and localization efficiency at different times before merger. We then use a selection of facilities with GW follow-up agreements in place, from low-frequency radio to high-energy γ-ray to assess the prospects of prompt follow-up. We quantify our assessment using observational SGRB flux data extrapolated to be within the horizon distances of the advanced GW interferometric detectors LIGO and Virgo and to the prompt phase immediately following the binary merger. Our results illustrate that while challenging, breakthrough multimessenger science is possible with EM follow-up facilities with fast responses and wide fields-of-view. We demonstrate that the opportunity to catch the prompt stage (<5 s) of SGRBs can be enhanced by speeding up the detection pipelines of both GW observatories and EM follow-up facilities. We further show that the addition of an Australian instrument to the optimal detector network could possibly improve the angular resolution by a factor of 2 and thereby contribute significantly to GW–EM multimessenger astronomy.
Bobbin tool friction stir welding (BT-FSW) is a promising solid-state welding process for fabricating closed or hollow profiles due to its self-supporting nature, which is achieved using a combined ...tool consisting of two shoulders and a penetrating pin, releasing the backing plate. The joint reliability is mainly affected by its macro-/micro-features including geometric defects and non-uniform grains. However, the underlying thermo-physical process has not been fully understood to clarify how the defects form and grains evolve during welding and how to control them. In this paper, a 3D thermo-mechanically coupled Eulerian-Lagrangian model was developed to analyze the material flow behavior and help understand the defect forming mechanism and recrystallization behavior during BT-FSW of aluminum alloy, wherein tracing particles were specially embedded. The calculated results revealed a complex material migration in the domain driven by the rotating tool. The flow behavior in horizontal/vertical directions at local regions was asynchronous, and eventually converged on the advancing side (AS) to normally form a sound joint, where the combined effects of shearing and squeezing of the material flow throughout thickness affected the morphology of S-line defect. In addition, the non-uniform thermo-mechanical cycling caused an abrupt change in grain structure near the TMAZ/SZ-AS transition region due to the combined continuous and discontinuous dynamic recrystallization, and geometrical effect of strain. The final joint failure was the result of competition between the two softening regions, S-line defect and TMAZ/SZ-AS. These can be applied for further fundamental investigation of parameter optimization or welding structure design, and promote the exploration of post-processing methods to improve the joint performance.
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•Grain refinement was dominant by CDRX, together with geometrized requirement of strain and discontinuous recrystallization.•The flow behavior was non-simultaneous throughout the joint, with preferential movement near shoulders.•The convergence of multiple material flow strands seriously affected the macrostructural features and crystal orientation.•The incompatibility of plastic deformation exacerbated local stress concentration to boost fracture initiation.
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