Abstract
Tiger milk mushroom (TMM;
Lignosus rhinocerus
) have been used for a long time by indigenous communities in South East Asia regions as traditional medicine for different ailments, including ...respiratory disorders. The beneficial effects of TMM have been proven through in vivo and in vitro models, but these effects have yet to be validated in a clinical study. In this study, the beneficial effects of TMM supplementation were investigated in 50 voluntary participants. Participants were required to take 300 mg of TMM twice daily for three months. Level of interleukin 1β (IL-1β), interleukin 8 (IL-8), immunoglobulin A (IgA), total antioxidant capacity, malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHdG), pulmonary function and respiratory symptoms were assessed during baseline and monthly follow-up visits. Results demonstrated that supplementation of TMM significantly (
p
< 0.05) suppressed the level of IL-1β, IL-8, MDA, as well as respiratory symptoms. In additional to that, TMM also significantly (
p
< 0.05) induced the level of IgA, total antioxidant capacity, as well as pulmonary function. Analyses of data indicated that gender and BMI were factors influencing the outcomes of antioxidant status. Collectively, our findings suggested that TMM supplementation effectively improves respiratory health, immunity and antioxidant status.
Arginine plays diverse roles in cellular physiology. As a semi-essential amino acid, arginine deprivation has been used to target cancers with arginine synthesis deficiency. Arginine-deprived cancer ...cells exhibit mitochondrial dysfunction, transcriptional reprogramming and eventual cell death. In this study, we show in prostate cancer cells that arginine acts as an epigenetic regulator to modulate histone acetylation, leading to global upregulation of nuclear-encoded oxidative phosphorylation (OXPHOS) genes. TEAD4 is retained in the nucleus by arginine, enhancing its recruitment to the promoter/enhancer regions of OXPHOS genes and mediating coordinated upregulation in a YAP1-independent but mTOR-dependent manner. Arginine also activates the expression of lysine acetyl-transferases and increases overall levels of acetylated histones and acetyl-CoA, facilitating TEAD4 recruitment. Silencing of TEAD4 suppresses OXPHOS functions and prostate cancer cell growth in vitro and in vivo. Given the strong correlation of TEAD4 expression and prostate carcinogenesis, targeting TEAD4 may be beneficially used to enhance arginine-deprivation therapy and prostate cancer therapy.
We discuss scattering in a conformal field theory (CFT) via the conformal partial-wave analysis and the Regge limit. The focus of this paper is on understanding an operator product expansion (OPE) ...with Minkowski conformal blocks. Starting with a t-channel OPE, it leads to an expansion for an s-channel scattering amplitude in terms of t-channel exchanges. By contrasting with Euclidean conformal blocks we see a precise relationship between conformal blocks in the two limits without preforming an explicit analytic continuation. We discuss a generic feature for a CFT correlation function having singular F(M)(u,v)?u??, ?>0, in the limit u?0 and v?1. Here, ?=(?eff?1)/2, with ?eff serving as an effective spin and it can be determined through an OPE. In particular, it is bounded from above, ?eff?2, for all CFTs with a gravity dual, and it can be associated with string modes interpolating the graviton in AdS. This singularity is historically referred to as the Pomeron. This bound is nearly saturated by SYK-like effective d=1 CFT, and its stringy and thermal corrections have piqued current interests. Our analysis has been facilitated by dealing with Wightman functions. We provide a direct treatment in diagonalizing dynamical equations via harmonic analysis over physical scattering regions. As an example these methods are applied to the SYK model.
Inclusive production through AdS/CFT Nally, Richard; Raben, Timothy; Tan, Chung-I
The journal of high energy physics,
11/2017, Letnik:
2017, Številka:
11
Journal Article
Recenzirano
Odprti dostop
A
bstract
It has been shown that AdS/CFT calculations can reproduce certain exclusive 2→2 cross sections in QCD at high energy, both for near-forward and for fixed-angle scattering. In this paper, we ...extend prior treatments by using AdS/CFT to calculate the inclusive single-particle production cross section in QCD at high center-of-mass energy. We find that conformal invariance in the UV restricts the cross section to have a characteristic power-law falloff in the transverse momentum of the produced particle, with the exponent given by twice the conformal dimension of the produced particle, independent of incoming particle types. We conclude by comparing our findings to recent LHC experimental data from ATLAS and ALICE, and find good agreement.
Shape of proton and the pion cloud Jenkovszky, László; Szanyi, István; Tan, Chung-I
The European physical journal. A, Hadrons and nuclei,
07/2018, Letnik:
54, Številka:
7
Journal Article
Recenzirano
Odprti dostop
.
Proton-proton differential and total cross sections provide information on the energy dependence of proton shape and size. We show that the deviation from exponential behavior of the diffraction ...cone observed near
t
= -0.1 GeV
2
the so-called break) both at the ISR and the LHC follows from the
t
-channel two-pion loop contributions, imposed by unitarity. By using a simple Regge pole model, we extrapolate the “break” from the ISR energy region to that of the LHC. This allows us to answer two important questions: 1) To what extent is the “break” observed recently at the LHC a “recurrence” of that seen at the ISR (universality)? 2) What is the relative weight of two-pion effect to the vertex coupling (Regge residue) compared to expanding size (pomeron propagator) in producing the “break”? We find that the effect comes both from the Regge residue (proton-pomeron coupling) and from the Regge propagator. A detailed analysis of their balance, including the correlation between the relevant parameters is presented.
Holographic conformal field theories (CFTs) are usually studied in a limit where the gravity description is weakly coupled. By contrast, lattice quantum field theory can be used as a tool for doing ...computations in a wider class of holographic CFTs where nongravitational interactions in AdS become strong, and gravity is decoupled. We take preliminary steps for studying such theories on the lattice by constructing the discretized theory of a scalar field in AdS2 and investigating its approach to the continuum limit in the free and perturbative regimes. Our main focus is on finite sublattices of maximally symmetric tilings of hyperbolic space. Up to boundary effects, these tilings preserve the triangle group as a large discrete subgroup of AdS2, but have a minimum lattice spacing that is comparable to the radius of curvature of the underlying spacetime. We quantify the effects of the lattice spacing as well as the boundary effects, and find that they can be accurately modeled by modifications within the framework of the continuum limit description. We also show how to do refinements of the lattice that shrink the lattice spacing at the cost of breaking the triangle group symmetry of the maximally symmetric tilings.
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•Rh-Pt/Vulcan XC-72 effectively hydrogenated polyethylene terephthalate (PET).•PET can be dissolved in 1,1,1,3,3,3-hexafluro-2-propanol (HFIP).•100 % selective hydrogenation attained ...at 6.89 MPa H2 pressure and 50 °C in 60 min.•Compressed CO2 anti-solvent technique could fully recover hydrogenated PET.•Energy savings by direct hydrogenation was achieved at mild reaction conditions.
This study demonstrates the direct hydrogenation of polyethylene terephthalate (PET) dissolved in 1,1,1,3,3,3-hexafluro-2-propanol to environmentally friendly polyester polyethylene-1,4-cyclohexanedicarboxylate (PECHD) using a Vulcan XC-72 supported Rh-Pt bimetallic catalyst synthesized via a polyol method. The hydrogenation of PET was promoted by RhOx species present on the catalyst support surface which was generated using the polyol synthesis method. As compared to the monometallic Rh catalyst, the Rh-Pt bimetallic catalyst was found to be superior for hydrogenation of PET. This superiority was attributed to the strong aromatic ring adsorption ability of Rh working in synergy with an increased H2 spillover by Pt. At a H2 pressure of 6.89 MPa and 50 °C for 60 min, complete hydrogenation of PET to PECHD was achieved over the Rh-Pt bimetallic catalyst possessing theoretical Rh and Pt metal loadings of 2.5 wt% each. PECHD was found to be recovered to a very high extent using the compressed CO2 anti-solvent technique after hydrogenation of PET.
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