This work aims at presenting an alternative approach to the long standing problem of the B(E2) values in Sn isotopes in the vicinity of the N=Z double-magic nucleus 100Sn, until now predominantly ...measured with relativistic and intermediate-energy Coulomb excitation reactions. The direct measurement of the lifetime of low-lying excited states in odd-even Sn isotopes provides a new and precise guidance for the theoretical description of the nuclear structure in this region. Lifetime measurements have been performed in 105Sn for the first time with the coincidence Recoil Distance Doppler Shift technique. The lifetime results for the 7/21+ first excited state and the 11/21+ state, 2+(104Sn) ⊗ν1g7/2 multiplet member, are discussed in comparison with state-of-the-art shell model and mean field calculations, highlighting the crucial contribution of proton excitation across the core of 100Sn. The reduced transition probability B(E2) of the 11/21+ core-coupled state points out an enhanced staggering with respect to the B(E2; 21+→01+) in the even-mass 104Sn and 106Sn isotopes.
The 4He(4He,4He)4He* inelastic scattering was investigated at the MAGNEX facility of INFN - LNS, aiming at shedding light on the characteristics of the isoscalar monopole resonance of 4He which lies ...at an energy slightly higher than the proton emission threshold and slightly lower than the neutron emission threshold. A complementary elastic scattering measurement was also performed to study the initial state interaction and set accurate coupled channel calculations. Here, the experimental setup, the data reduction and the theoretical interpretation strategy are briefly described.
The 32S(3He,d)33Cl one-proton transfer reaction is a powerful tool to investigate the spectroscopy of low-lying states in the proton-rich 33Cl nucleus. However, the extraction of firm differential ...cross-section data at various angles to benchmark and constrain theoretical models is made challenging by the presence of competitive reactions on target contaminants. In this paper we report on a recent measurement using a new generation hodoscope of silicon detectors, capable to detect and identify emitted deuterons down to energies of the order of 2 MeV. The high angular segmentation of our hodoscope combined with a suitable target to control possible contaminants, allowed to unambiguously disentangle the contribution of various states in 33Cl, in particular the 2.352 MeV state lying just few tens of keV above the proton separation energy.
The FAZIA apparatus is a new detector designed for the Fermi energy domain for charged particles based on three stages telescopes: Silicon detector (300 μm thick), Silicon detector (500 μm thick) and ...CsI(Tl) (10 cm). Using the ΔE-E technique and the Pulse Shape Analysis (PSA) it permits the charge and mass discrimination up to more than Z=20. In the following, some details about the FAZIA detectors and electronics, their performance and the frst experimental campaigns already performed will be discussed.
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking
. Here we identify the innate immune ...kinase TANK-binding kinase 1 (TBK1)
as a candidate immune-evasion gene in a pooled genetic screen
. Using a suite of genetic and pharmacological tools across multiple experimental model systems, we confirm a role for TBK1 as an immune-evasion gene. Targeting TBK1 enhances responses to PD-1 blockade by decreasing the cytotoxicity threshold to effector cytokines (TNF and IFNγ). TBK1 inhibition in combination with PD-1 blockade also demonstrated efficacy using patient-derived tumour models, with concordant findings in matched patient-derived organotypic tumour spheroids and matched patient-derived organoids. Tumour cells lacking TBK1 are primed to undergo RIPK- and caspase-dependent cell death in response to TNF and IFNγ in a JAK-STAT-dependent manner. Taken together, our results demonstrate that targeting TBK1 is an effective strategy to overcome resistance to cancer immunotherapy.
Proton energy calibration and identification efficiency of few Thallium activated Cesium Iodide (CsI(Tl)) crystals of the FAZIA detection system, have been studied in the range 59-180 MeV by using ...the proton beam delivered by the cyclotron of the CCB (Cyclotron Center Bronowice) facility. We observe that the light output versus energy is linear in the lower investigated energy range while showing a deviation from linearity above 140 MeV. The effects of proton induced nuclear reactions and multiple scattering causing incomplete energy deposition (IED) events have been identified and estimated via Pulse Shape Analysis in CsI(Tl) crystals. The measured experimental efficiency for proton identification in the examined energy range is then compared with GEANT4 simulations. For a centered collimated irradiation on the crystal, and at the highest measured energy, the resulting experimental efficiency value is about 70%.
The 4He(4He,4He)4He* inelastic scattering was revisited in a new coincidence measurement at the MAGNEX facility of Istituto Nazionale di Fisica Nucleare – Laboratori Nazionali del Sud. The 4He + 4He ...→ 4He + 4He* → 4He + 3H + 1H and 4He + 4He → 4He + 4He* → 4He + 3He + n reactions were measured simultaneously by detecting the 4He particles at the MAGNEX magnetic spectrometer in coincidence with the 3H and 3He at the OSCAR silicon telescope. The main concept of the experiment is described and the data reduction strategy is reported.
PDF
