Approaching the end of the second decade of the 21st century, almost the whole demand of vanillin is met by the synthetic product obtained either via a petrochemical process starting from phenol and ...glyoxylic acid or from energy intensive alkaline oxidative depolymerization of lignin. Only a minor fraction is comprised of natural vanillin obtained from ferulic acid fermentation, and even less of highly valued Vanilla planifolia extracts. Are there alternative green production methods? And, if yes, are they suitable to find practical application?
Vanilla green! Only a minor fraction of commercial vanillin is comprised of natural vanillin obtained from ferulic acid fermentation, and even less of highly valued Vanilla planifolia extracts. Are there alternative green production methods? And, if yes, are they suitable to find practical application?
Rheological and mechanical comparative tests of the new AquaSun antifouling sol-gel coating coated on shipbuilding steel compared to a commercial silyl acrylate antifouling top coat containing ...cuprous oxide and copper pyrithione show further evidence of the practical viability of this multifunctional coating for the protection of the immersed surfaces from biofouling. AquaSun is a less rigid or less viscous material than commercial top coat but more adherent to the steel substrate. These results support further investigation of this multifunctional sol-gel coating as an eco-friendly antifouling paint.
Tested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful protective, antioxidant and antiproliferative agent. The strong antioxidant properties of this new citrus ...pectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make it an attractive therapeutic and preventive agent for the treatment of oxidative stress-associated brain disorders. Similarly, the ability of this pectic polymer rich in RG-I regions, as well as in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface, to inhibit cell proliferation or even kill, at high doses, neoplastic cells may have opened up new therapeutic strategies in cancer research. In order to take full advantage of its vast therapeutic and preventive potential, detailed studies of the molecular mechanism involved in the antiproliferative and neuroprotective of this IntegroPectin are urgently needed.
Regardless of multiple efforts carried out across many countries to disseminate the ideas and the practice of open science, most scholars in the early 2020s do not self-archive their research ...articles and do not publish research papers in preprint form. Having received no education and training on open science, researchers are often puzzled on what to do, in practice, to start reaping the benefits of open science. This study offers a succinct vademecum on how to benefit from the open science approach to scholarly communication, no matter whether in natural or in humanistic and social sciences.
Open science, Open access, Preprint, Self-archiving, Scholarly publishing.
Reproducibility in chemistry research Ciriminna, Rosaria; Angellotti, Giuseppe; Petri, Giovanna Li ...
Heliyon,
07/2024, Letnik:
10, Številka:
14
Journal Article
Recenzirano
Odprti dostop
Chemistry is a reproducible science whose pillars - synthesis and analysis - actually comprise a huge collection of highly reproducible experimental methods to synthesize and analyze substances. The ...historical development of chemistry, furthermore, shows that reproducibility of methods has been the companion of novelty and creative innovation. The “publish or perish” principle dominating global academia since over two decades, however, intrinsically contributes to the publication of non-reproducible research outcomes also in chemistry. A study on reproducibility of chemistry research seems therefore timely, especially now that chemists are slowly but inevitably adopting open science and its tools such as the preprint, open access, and data sharing. We conclude presenting three simple guidelines for enhanced publication of research findings in chemistry.
The identification of biomarkers for predicting inter-individual sorafenib response variability could allow hepatocellular carcinoma (HCC) patient stratification. SNPs in angiogenesis- and drug ...absorption, distribution, metabolism, and excretion (ADME)-related genes were evaluated to identify new potential predictive biomarkers of sorafenib response in HCC patients. Five known SNPs in angiogenesis-related genes, including
,
,
,
, and
, were investigated in 34 HCC patients (9 sorafenib responders and 25 non-responders). A subgroup of 23 patients was genotyped for SNPs in ADME genes. A machine learning classifier method was used to discover classification rules for our dataset. We found that only the
(rs2010963) C allele and CC genotype were significantly associated with sorafenib response. ADME-related gene analysis identified 10 polymorphic variants in
(rs6811453),
(rs10008281),
(rs11401),
(rs7905939),
(rs2297595 and rs1801265),
(rs2020863), and
(rs149738, rs171248, and rs183574) significantly associated with sorafenib response. We have identified a genetic signature of predictive response that could permit non-responder/responder patient stratification. Angiogenesis- and ADME-related genes correlation was confirmed by cumulative genetic risk score and network and pathway enrichment analysis. Our findings provide a proof of concept that needs further validation in follow-up studies for HCC patient stratification for sorafenib prescription.
Endowed with exceptional chemical and physical properties that make it potentially useful in a wide array of industrial sectors, nanocellulose remains a niche industrial product chiefly manufactured ...in the form of microfibrillated cellulose for low value utilization in paper and cardboard products. This study first shows that the case of nanocellulose adds to many other cases of overpromising typical of the nanosciences. Hence, it suggests that fulfilling the industrial potential of nanocellulose may benefit from the main lessons learned during the hype technology cycle (attention trigger, peak of inflated expectations, disappointment). Renewed management and research efforts aimed at large-scale production of this bionanomaterial will rather focus on the interdisciplinary approach to green chemistry required to make economically viable the green extraction routes with which to replace current energy-intensive and wasteful fibrillation processes.
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DRIFT, HPLC-MS, and SPME-GC/MS analyses were used to unveil the structure and the main functional compounds of red (blood) orange (
) and bitter orange (
). The IntegroPectin samples show evidence ...that these new citrus pectins are comprised of pectin rich in RG-I hairy regions functionalized with citrus biophenols, chiefly flavonoids and volatile molecules, mostly terpenes. Remarkably, IntegroPectin from the peel of fresh bitter oranges is the first high methoxyl citrus pectin extracted via hydrodynamic cavitation, whereas the red orange IntegroPectin is a low methoxyl pectin.
IntegroPectin has a uniquely high concentration of adsorbed flavonoids, especially the flavanone glycosides hesperidin, naringin, and eriocitrin.
We analyze the main nanochemistry factors affecting photovoltaic performance in TiO(2) employed as wide bandgap semiconductor in dye-sensitized solar cells (DSCs). What is the best morphology of the ...oxide? Which processes yield the required structures? Finally, putting the discussion in the context of the rapid evolution of photovoltaic technologies, we argue that new titania nanostructures will form the basic component of second-generation solar modules based on dye solar cells.
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