There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly ...publishers-have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals. This Comment is the first formal publication of the FAIR Principles, and includes the rationale behind them, and some exemplar implementations in the community.
Objective: This study evaluated health care worker exposure to antineoplastic drugs. Methods: A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary ...documented tasks involving those drugs. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay. Results: Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay. Conclusions: Despite following recommended safehandling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations.
Abstract
Previous Juno mission event studies revealed powerful electron and ion acceleration, to 100s of kiloelectron volts and higher, at low altitudes over Jupiter's main aurora and polar cap (PC; ...poleward of the main aurora). Here we examine 30–1200 keV JEDI‐instrument particle data from the first 16 Juno orbits to determine how common, persistent, repeatable, and ordered these processes are. For the PC regions, we find (1) upward electron angle beams, sometimes extending to megaelectron volt energies, are persistently present in essentially all portions of the polar cap but are generated by two distinct and spatially separable processes. (2) Particle evidence for megavolt downward electrostatic potentials are observable for 80% of the polar cap crossings and over substantial fractions of the PC area. For the main aurora, with the orbit favoring the duskside, we find that (1) three distinct zones are observed that are generally arranged from lower to higher latitudes but sometimes mixed. They are designated here as the diffuse aurora (DifA), Zone‐I (ZI(D)) showing primarily downward electron acceleration, and Zone‐II (ZII(B)) showing bidirectional acceleration with the upward intensities often greater than downward intensities. (2) ZI(D) and ZII(B) sometimes (but not always) contain, respectively, downward electron inverted Vs and downward proton inverted Vs, (potentials up to 400 kV) but, otherwise, have broadband distributions. (3) Surprisingly, both ZI(D) and ZII(B) can generate equally powerful auroral emissions. It is suggested but demonstrated for intense portions of only one auroral crossing, that ZI(D) and ZII(B) are associated, respectively, with upward and downward electric currents.
Plain Language Summary
The science objectives of the Juno mission, with its spacecraft now orbiting Jupiter in a polar orbit, include understanding the space environments of Jupiter's polar regions and generation of Jupiter's uniquely powerful aurora. In Jupiter's polar cap regions (poleward of the main auroral oval encircling the northern and southern poles), we find here that (1) beams of electrons aligned with the upward magnetic field direction are ever‐present with energies extended to the 100s to 1,000s of kilo electron volts and (2) downward magnetic field‐aligned electrostatic potentials reaching greater than a million volts occur over broad regions for 80% of the polar cap crossings. For the main auroral oval, we find three distinct zones: designated here as diffuse aurora (DifA), Zone‐I (ZI(D)) showing downward electron acceleration to 100s of kiloelectron volts, and Zone‐II (ZII(B)) showing bidirectional acceleration with the upward intensities often greater than downward intensities. ZI(D) sometimes shows upward electrostatic potentials reaching 100s of kilovolts and is associated with upward magnetic field‐aligned electric currents. ZII(B) sometimes shows downward electrostatic potentials reaching 100s of kilovolts and is associated with downward electric currents. Unexpectedly from Earth studies, ZI(D) and ZII(B) are just as likely to generate the most intense auroral emissions.
Key Points
Jupiter's polar caps have upward electron beams essentially everywhere (100s of kiloelectron volts) and often downward megavolt electric potentials
Energetic particles reveal three main auroral acceleration zones: diffuse aurora (DifA), Zone‐I (downward), and Zone‐II (bidirectional)
ZI(D) and ZII(B) sometimes (but not always) contain, respectively, downward electron inverted Vs and downward proton inverted Vs
Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An internet-based protocol was ...used to collect clinical information and biological specimens from patients with these diseases. High-throughput DNA resequencing identified a recurrent somatic missense mutation
JAK2V617F in granulocyte DNA samples of 121 of 164 PV patients, of which 41 had homozygous and 80 had heterozygous mutations. Molecular and cytogenetic analyses demonstrated that homozygous mutations were due to duplication of the mutant allele.
JAK2V617F was also identified in granulocyte DNA samples from 37 of 115 ET and 16 of 46 MMM patients, but was not observed in 269 normal individuals. In vitro analysis demonstrated that JAK2V617F is a constitutively active tyrosine kinase.
The G305 H ii complex (G305.4+0.1) is one of the most massive star-forming structures yet identified within the Galaxy. It is host to many massive stars at all stages of formation and evolution, from ...embedded molecular cores to post-main-sequence stars. Here, we present a detailed near-infrared analysis of the two central star clusters Danks 1 and Danks 2, using Hubble Space Telescope+NICMOS imaging and Very Large Telescope+ISAAC spectroscopy. We find that the spectrophotometric distance to the clusters is consistent with the kinematic distance to the G305 complex, an average of all measurements giving a distance of 3.8 ± 0.6 kpc. From analysis of the stellar populations and the pre-main-sequence stars, we find that Danks 2 is the elder of the two clusters, with an age of 3+3
− 1 Myr. Danks 1 is clearly younger with an age of 1.5+1.5
− 0.5 Myr, and is dominated by three very luminous H-rich Wolf-Rayet stars which may have masses ≳100 M⊙. The two clusters have mass functions consistent with the Salpeter slope, and total cluster masses of 8000 ± 1500 and 3000 ± 800 M⊙ for Danks 1 and Danks 2, respectively. Danks 1 is significantly the more compact cluster of the two, and is one of the densest clusters in the Galaxy with log (ρ/M⊙ pc−3) = 5.5+0.5
− 0.4. In addition to the clusters, there is a population of apparently isolated Wolf-Rayet stars within the molecular cloud's cavity. Our results suggest that the star-forming history of G305 began with the formation of Danks 2, and subsequently Danks 1, with the origin of the diffuse evolved population currently uncertain. Together, the massive stars at the centre of the G305 region appear to be clearing away what is left of the natal cloud, triggering a further generation of star formation at the cloud's periphery.
Race and ethnicity classification systems have considerable implications for public health, including the potential to reveal or mask inequities. Given increasing "super-diversity" and multiple ...racial/ethnic identities in many global settings, especially among younger generations, different ethnicity classification systems can underrepresent population heterogeneity and can misallocate and render invisible Indigenous people and ethnic minorities. We investigated three ethnicity classification methods and their relationship to sample size, socio-demographics and sexual health indicators.
We examined data from New Zealand's HIV behavioural surveillance programme for men who have sex with men (MSM) in 2006, 2008, 2011, and 2014. Participation was voluntary, anonymous and self-completed; recruitment was via community venues and online. Ethnicity allowed for multiple responses; we investigated three methods of dealing with these: Prioritisation, Single/Combination, and Total Response. Major ethnic groups included Asian, European, indigenous Māori, and Pacific. For each classification method, statistically significant associations with ethnicity for demographic and eight sexual health indicators were assessed using multivariable logistic regression.
Overall, 10,525 MSM provided ethnicity data. Classification methods produced different sample sizes, and there were ethnic disparities for every sexual health indicator. In multivariable analysis, when compared with European MSM, ethnic differences were inconsistent across classification systems for two of the eight sexual health outcomes: Māori MSM were less likely to report regular partner condomless anal intercourse using Prioritisation or Total Response but not Single/Combination, and Pacific MSM were more likely to report an STI diagnosis when using Total Response but not Prioritisation or Single/Combination.
Different classification approaches alter sample sizes and identification of health inequities. Future research should strive for equal explanatory power of Indigenous and ethnic minority groups and examine additional measures such as socially-assigned ethnicity and experiences of discrimination and racism. These findings have broad implications for surveillance and research that is used to inform public health responses.
Large millennial-scale fluctuations of the southern margin of the North American Laurentide Ice Sheet occurred during the last deglaciation, when the margin was located between about 43° and 49°N. ...Fluctuations of the ice margin triggered episodic increases in the flux of freshwater to the North Atlantic by rerouting continental runoff from the Mississippi River drainage to the Hudson or St. Lawrence Rivers. We found that periods of increased freshwater flow to the North Atlantic occurred at the same time as reductions in the formation of North Atlantic Deep Water, thus providing a mechanism for observed climate variability that may be generally characteristic of times of intermediate global ice volume.
Abstract The functional significance of newly formed granule neurons in the adult mammalian hippocampus remains a mystery. Recently, it was demonstrated that wheel running increases new neuron ...survival and c-Fos expression in new and pre-existing granule cells in an activity-dependent manner. It is currently unknown whether other immediate early genes (IEGs) become expressed in granule neurons from running. Further, it is unknown whether locomotor activity in home cages without wheels can influence neurogenesis and IEG expression similar to running. The purpose of this study was three-fold: (1) to determine if Arc and Zif268 expression are also induced from wheel running in both pre-existing and newly formed neurons (2) to determine if neurogenesis and IEG induction is related to horizontal distance traveled in home cages without wheels, and (3) to determine whether IEG induction is related to acute bouts of running or chronic effects. Adult C57BL/6J female mice were placed in cages with or without running wheels for 31 days. The first 10 days, mice received daily injections of 5-Bromo-2′-deoxyuridine (BrdU) to label dividing cells. On day 1, running and non-running animals were euthanized either 2 h after peak activity, or during a period of relative inactivity. Immunohistochemistry was performed on hippocampal sections with antibodies against BrdU, mature neuron marker NeuN, c-Fos, Arc, and Zif268. Results demonstrate that Arc, Zif268, and c-Fos are induced from wheel running but not movement in cages without wheels. All IEGs were expressed in new neurons from running. Further, IEGs were induced acutely by running, as increased expression did not continue into the light cycle, a period of relative inactivity. The results suggest that robust movements, like running, are necessary to stimulate IEG expression and neurogenesis. Moreover, results suggest new neurons from running may be processing information about running behavior itself.
We present SN2018kzr, the fastest declining supernova-like transient, second only to the kilonova, AT2017gfo. SN2018kzr is characterized by a peak magnitude of Mr = −17.98, a peak bolometric ...luminosity of ∼1.4 × 1043 erg s−1, and a rapid decline rate of 0.48 0.03 mag day−1 in the r band. The bolometric luminosity evolves too quickly to be explained by pure 56Ni heating, necessitating the inclusion of an alternative powering source. Incorporating the spin-down of a magnetized neutron star adequately describes the lightcurve and we estimate a small ejecta mass of Mej = 0.10 0.05 M . Our spectral modeling suggests the ejecta is composed of intermediate mass elements including O, Si, and Mg and trace amounts of Fe-peak elements, which disfavors a binary neutron star merger. We discuss three explosion scenarios for SN2018kzr, given the low ejecta mass, intermediate mass element composition, and high likelihood of additional powering-the core collapse of an ultra-stripped progenitor, the accretion induced collapse (AIC) of a white dwarf, and the merger of a white dwarf and neutron star. The requirement for an alternative input energy source favors either the AIC with magnetar powering or a white dwarf-neutron star merger with energy from disk wind shocks.
We have previously described critical and nonredundant roles for the phosphoinositide 3-kinase p110δ during the activation and differentiation of naive T cells, and p110δ inhibitors are currently ...being developed for clinical use. However, to effectively treat established inflammatory or autoimmune diseases, it is important to be able to inhibit previously activated or memory T cells. In this study, using the isoform-selective inhibitor IC87114, we show that sustained p110δ activity is required for interferon-γ production. Moreover, acute inhibition of p110δ inhibits cytokine production and reduces hypersensitivity responses in mice. Whether p110δ played a similar role in human T cells was unknown. Here we show that IC87114 potently blocked T-cell receptor–induced phosphoinositide 3-kinase signaling by both naive and effector/memory human T cells. Importantly, IC87114 reduced cytokine production by memory T cells from healthy and allergic donors and from inflammatory arthritis patients. These studies establish that previously activated memory T cells are at least as sensitive to p110δ inhibition as naive T cells and show that mouse models accurately predict p110δ function in human T cells. There is therefore a strong rationale for p110δ inhibitors to be considered for therapeutic use in T-cell–mediated autoimmune and inflammatory diseases.
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