Undeclared allergens in imported packaged food for retail in Australia Sheridan, Michael John; Koeberl, Martina; Hedges, Claire Elizabeth ...
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment,
02/2020, Letnik:
37, Številka:
2
Journal Article
Recenzirano
The Australia New Zealand Food Standards Code (the Code) requires a declaration of the presence of 11 different allergens made through the label on a food product. Most food recalls in Australia are ...now due to undeclared allergens . This survey determined the extent of undeclared allergens in imported food products on the Asian retail market in Australia. A total of 50 imported packaged foods were selectively purchased from local Asian grocery retail stores in Melbourne and the presence of undeclared gluten, milk, peanut and egg determined. Analysis was performed using commercial enzyme-linked immunosorbent assay (ELISA) (R-Biopharm). Thirty-seven undeclared allergens (gluten n = 12, milk n = 12, peanut n = 6, and egg n = 7) were detected in 23 of the 50 products analysed (46%), with 18% containing multiple undeclared allergens. The high number of undeclared allergens is alarming and in line with the increasing number of food recalls and anaphylaxis recorded in Australia.
Current interferon‐based therapy for hepatitis C virus (HCV) infection is inadequate, prompting a shift toward combinations of direct‐acting antivirals (DAA) with the first protease‐targeted drugs ...licensed in 2012. Many compounds are in the pipeline yet primarily target only three viral proteins, namely, NS3/4A protease, NS5B polymerase, and NS5A. With concerns growing over resistance, broadening the repertoire for DAA targets is a major priority. Here we describe the complete structure of the HCV p7 protein as a monomeric hairpin, solved using a novel combination of chemical shift and nuclear Overhauser effect (NOE)‐based methods. This represents atomic resolution information for a full‐length virus‐coded ion channel, or “viroporin,” whose essential functions represent a clinically proven class of antiviral target exploited previously for influenza A virus therapy. Specific drug‐protein interactions validate an allosteric site on the channel periphery and its relevance is demonstrated by the selection of novel, structurally diverse inhibitory small molecules with nanomolar potency in culture. Hit compounds represent a 10,000‐fold improvement over prototypes, suppress rimantadine resistance polymorphisms at submicromolar concentrations, and show activity against other HCV genotypes. Conclusion: This proof‐of‐principle that structure‐guided design can lead to drug‐like molecules affirms p7 as a much‐needed new target in the burgeoning era of HCV DAA. (Hepatology 2014;59:408–422)
Food Allergen Management in Australia Koeberl, Martina; Clarke, Dean; Allen, Katrina J ...
Journal of AOAC International,
2018-Jan-01, 20180101, Letnik:
101, Številka:
1
Journal Article
Recenzirano
Food allergies are increasing globally, including numbers of allergens, the sensitization rate, and the prevalence rate. To protect food-allergic individuals in the community, food allergies need to ...be appropriately managed. This paper describes current Australian food allergen management practices. In Australia, the prevalence of food allergies, the anaphylaxis rate, and the fatal anaphylaxis rate are among the highest in the world. Interagency and stakeholder collaboration is facilitated and enhanced as Australia moves through past, current, and ongoing food allergen challenges. As a result, Australia has been a global leader in regulating the labeling of common allergens in packaged foods and their disclosure in foods not required to bear a label. Moreover, the food industry in Australia and New Zealand has developed a unique food allergen risk management tool, the Voluntary Incidental Trace Allergen Labelling program, which is managed by the Allergen Bureau. This paper summarizes insights and information provided by the major stakeholders involved to protect food-allergic consumers from any allergic reaction. Stakeholders include government; consumer protection, regulation, and enforcement agencies; the food industry; and food allergen testing and food allergen/allergy research bodies in Australia. The ongoing goal of all stakeholders in food allergen management in Australia is to promote best practice food allergen management procedures and provide a wide choice of foods, while enabling allergic consumers to manage their food allergies and reduce the risk of an allergic reaction.
Abstract
Food allergies are increasing globally, including numbers of allergens, the sensitization rate, and the prevalence rate. To protect food-allergic individuals in the community, food allergies ...need to be appropriately managed. This paper describes current Australian food allergen management practices. In Australia, the prevalence of food allergies, the anaphylaxis rate, and the fatal anaphylaxis rate are among the highest in the world. Interagency and stakeholder collaboration is facilitated and enhanced as Australia moves through past, current, and ongoing food allergen challenges. As a result, Australia has been a global leader in regulating the labeling of common allergens in packaged foods and their disclosure in foods not required to bear a label. Moreover, the food industry in Australia and New Zealand has developed a unique food allergen risk management tool, the Voluntary Incidental Trace Allergen Labelling program, which is managed by the Allergen Bureau. This paper summarizes insights and information provided by the major stakeholders involved to protect food-allergic consumers from any allergic reaction. Stakeholders include government; consumer protection, regulation, and enforcement agencies; the food industry; and food allergen testing and food allergen/allergy research bodies in Australia. The ongoing goal of all stakeholders in food allergen management in Australia is to promote best practice food allergen management procedures and provide a wide choice of foods, while enabling allergic consumers to manage their food allergies and reduce the risk of an allergic reaction.
Quantum technology has the potential to change the way we solve many problems in our daily lives. Perhaps the most ambitious quantum technology in development is quantum computers. In the past decade ...significant progress has been made in the number of qubits within a quantum computer, and this trend seems to be increasing. In this work we look at one particular architecture for quantum computing; the iontrap quantum computer. In this thesis we investigate the integration of this type of quantum computer with fibre tip optical cavities. We numerically analyse the effect of misalignment of these cavities and attempt to find the optimal cavity parameters for integration into the ion-trap quantum computer. This work should provide a useful framework for optimal integration of cavities, and the tolerances to misalignment. This should allow for future ion-trap quantum computer designs to be more efficient and help increase the number of qubits, paving the way to develop a useful universal quantum computer.
A dessert matrix previously used for diagnosis of food allergies was incurred with pasteurised egg white or skimmed milk powder at 3, 6, 15 and 30 mg allergen protein per kg of dessert matrix and ...evaluated as a quality control material for allergen analysis in a multi-laboratory trial. Analysis was performed by immunoassay using five kits each for egg and milk (based on casein) and six 'other' milk kits (five based on β-lactoglobulin and one total milk). All kits detected allergen protein at the 3 mg kg(-1) level. Based on ISO criteria only one egg kit accurately determined egg protein at 3 mg kg(-1) (p=0.62) and one milk (casein) kit accurately determined milk at 6 (p=0.54) and 15 mg kg(-1) (p=0.83), against the target value. The milk "other" kits performed least well of all the kits assessed, giving the least precise analyses. The incurred dessert material had the characteristics required for a quality control material for allergen analysis.
Estimates of vegetation attributes measured by sampling often inform scientific inference, management actions, and policy decisions. However, different sampling methods and sample sizes (i.e. number ...of plots) can yield significantly different estimates of vegetation attributes. This occurs because the abundance distributions and spatial distributions of species in the plant community influence their probabilities of detection and estimates of their abundances. We predicted that different sampling methods and sample sizes would produce significantly different estimates not only of vascular plant species diversity, but also of indigenous dominance (the level of indigenous influence) in mixed vegetation where indigenous and exotic floras have different abundance or spatial distributions. To test our predictions we applied three sampling methods to 24 plots in grassland and cushion vegetation in a 1058-ha scientific reserve in the Upper Waitaki (Mackenzie) Basin, New Zealand. Our methods sampled ground areas from 0.65 to 400 m², and included two variants of common ‘subsampling’ approaches, which assessed only discrete subunits within larger plots. Indigenous plant species were both less abundant on average and more spatially-clustered (i.e. less evenly dispersed across plots) than exotic species. The two subsampling methods were less likely to detect less abundant and more spatially clustered species, leading to lower ratios of indigenous to exotic species recorded, and lower estimates of indigenous dominance of composition (% of species indigenous). Numbers of indigenous species accumulated more rapidly with increasing sample size than numbers of exotic species, so that indigenous dominance also increased with the number of plots sampled. We conclude that properly measuring species diversity and indigenous dominance in mixed indigenous-exotic plant communities requires both the searching of sizeable plots and use of rarefaction rather than plot-averaging of statistics. We suggest greater use of rarefaction and more consideration of species’ detection probabilities in sampling New Zealand’s mixed indigenous–exotic plant communities should improve the reliability, transparency and comparability of measures of diversity and may also provide new ecological insights.
Factors controlling vegetation restoration of depleted short-tussock grasslands are poorly understood. We investigated effects of mouse-ear hawkweed (‘hawkweed’,Pilosella officinarum) cover and ...environmental stress associated with landform and soil type on the rate and pattern of indigenous vegetation recovery from grazing in the highly-modified 1000-ha Lake Tekapo Scientific Reserve in the north of the Upper Waitaki (‘Mackenzie’) Basin. The reserve has been destocked of sheep and under effective rabbit control since 1992. At that time, mouse-ear hawkweed dominated vegetation on three of its five major landforms (up to 42% cover), and 44–89% of soil was exposed. In 2011 we resampled 12 original vegetation monitoring plots that were established in 1993. Indigenous vegetation recovered in the 18 years following removal from grazing despite high levels of initial modification and exotic cover dominance. Exposed soil and rock decreased, and indigenous plant cover and litter increased across all landforms, while vascular and nonvascular indigenous plant cover increased at different ends of a landform-driven productivity gradient. Hawkweed invasion did not retard recovery; to the contrary, the extent and rate of recovery was higher on more productive landforms with higher initial hawkweed cover. The pattern of change across the reserve was consistent with grazing having exerted a powerful constraint on the growth and biomass of both indigenous and exotic palatable species prior to reservation. Soil moisture stress appeared to delay the timing of hawkweed invasion, and to constrain productivity and hence the rate of indigenous vegetation recovery following release from grazing. We propose a testable model of interacting influences of grazing and environment on indigenous vegetation and the niche of mouse-ear hawkweed, in which recovery outcomes depend on environmental productivity. We suggest that removal of feral grazing as well as stock, size of recovery area, limited monitoring-disturbance, and timing of grazing-release relative to hawkweed invasion may explain why our results and conclusions contrast with those from other studies of release of fescue-tussock grasslands from pastoral grazing.
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