While green innovation has a positive impact on firms' performance, some established firms that initiate green innovation activities (referring to diversifying green entrants) could suffer from ...insufficient new green knowledge and skills. Since adopting a sustainability orientation helps firms commit to the creation of superior sustainable practices, and efficiently invest resources necessary to develop appropriate new green products, leading to superior green innovation performance, sustainability orientation offers an alternative approach for diversifying green entrants to achieve green innovation success. Building on resource-based, knowledge-based, and capabilities theories, this study aims to identify key factors that enable sustainability orientation of diversifying green entrants and enhance its effect on green innovation performance. As sustainability issues frequently occur upstream at the supplier level, and since supplier involvement effectively determines new product success, this study theorizes that diversifying green entrants that adopt sustainability orientation require two types of green supplier involvement (as a knowledge source and a co-creator) to enhance the effect of sustainability orientation on green innovation performance. Green knowledge-processing capability and green R&D capability complement green supplier involvement as a knowledge source and green supplier involvement as a co-creator, respectively, to further enhance the amount of green innovation performance. Based on a longitudinal dataset of 336 diversifying green entrants, the results support all our hypotheses. Interestingly, an additional analysis suggests that when diversifying green entrants implement green supplier involvement as a co-creator, they achieve greater green innovation performance than those who implement green supplier involvement as a knowledge source. These findings provide important theoretical implications and practical guidance for established firms to pursue green innovation.
Various scholars have accomplished a great deal to better understand open innovation effectiveness. Case studies have detailed its performance effects, while other studies showed the effectiveness of ...an aspect of open innovation, such as collaboration with third parties, external technology commercialization, and cocreation. Though most studies report a positive relation between open innovation and innovation performance, some studies indicate possible negative effects. This has resulted in a call for research on what kind of organizational context suits open innovation best.
This study therefore addresses two questions: (1) does performing open innovation activities lead to increased innovation performance, and to which aspects of innovation performance is open innovation most strongly related? (2) what is the moderating impact of various kinds of strategic orientation on the relation between open innovation and innovation performance? In this study, we investigate three types of strategic orientations: entrepreneurial orientation, market orientation, and resource orientation.
In a survey among 223 Asian service firms, we first develop and test a comprehensive measurement scale for open innovation that captures the entire range of open innovation activities, including outside‐in activities, inside‐out activities, and coupled activities. The final scale comprises of 10 items and indicates to what extent a firm has implemented open innovation activities.
Next, we study the relation between open innovation and innovation performance. The results indicate that performing open innovation activities is significantly and positively related to all four dimensions of innovation performance: new product/service innovativeness, new product/service success, customer performance, and financial performance. The impact of open innovation is not limited to a particular aspect of innovation performance; it positively affects a broad range of innovation performance indicators. Though open innovation is positively related to all four dimensions of innovation performance, the effect sizes are not equal. The impact on new service innovativeness and financial performance is relatively stronger.
Regarding the influence of a firm's strategic orientation, we find that all significant moderation effects are positive. This suggests that, in general, having a more explicit strategic orientation enhances the effectiveness of open innovation. When comparing the three strategic orientations, entrepreneurial orientation strengthens the positive performance effects of open innovation significantly more than market orientation and resource orientation do. In turn, market orientation has a significantly stronger moderation effect than resource orientation. These findings provide empirical evidence of the context dependency of open innovation. Especially an entrepreneurial orientation, which is associated with proactive and entrepreneurial processes, seems to create a fertile setting for open innovation.
`A hopeful but nonetheless hard-hitting analysis of alternative economic spaces proliferating in the belly of the capitalist beast. In this book Leyshon, Lee and Williams convene fascinating studies ...of exchange, enterprise, credit and community. They invite us onto a new and promising discursive terrain where we can analyze, criticize and above all recognize actually existing economies of diversity in the wealthy countries of the West? - J K Gibson-Graham, Australian National University and University of Massachusetts, Amherst In the context of problems in the `new economy? - from dot.com start-ups, high-technology, and telecoms - Alternative Economic Spaces presents a critical evaluation of alternatives to the global economic mainstream. It focuses on the emergence of alternative economic geographies within developed economies and analyzes the emergence of alternative economic practices within industrialized countries. These include the creation of institutions like Local Exchange and Trading Systems, Credit Unions, and other social economy initiatives; and the development of alternative practices from informal work to the invention of consumption sites that act as alternatives to the monoply of the `big-box?, multi-chain retail outlets. Alternative Economic Spaces is a reconsideration of what is meant by the `economic? in economic geography; its objective is to bring together some of the ways in which this is being undertaken. The volume shows how the `economic? is being rethought in economic geography by detailing new economic geographies as they are emerging in practice.
Microsatellite instability (MSI), the spontaneous loss or gain of nucleotides from repetitive DNA tracts, is a diagnostic phenotype for gastrointestinal, endometrial, and colorectal tumors, yet the ...landscape of instability events across a wider variety of cancer types remains poorly understood. To explore MSI across malignancies, we examined 5,930 cancer exomes from 18 cancer types at more than 200,000 microsatellite loci and constructed a genomic classifier for MSI. We identified MSI-positive tumors in 14 of the 18 cancer types. We also identified loci that were more likely to be unstable in particular cancer types, resulting in specific instability signatures that involved cancer-associated genes, suggesting that instability patterns reflect selective pressures and can potentially identify novel cancer drivers. We also observed a correlation between survival outcomes and the overall burden of unstable microsatellites, suggesting that MSI may be a continuous, rather than discrete, phenotype that is informative across cancer types. These analyses offer insight into conserved and cancer-specific properties of MSI and reveal opportunities for improved methods of clinical MSI diagnosis and cancer gene discovery.
MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate the expression of thousands of genes in a broad range of organisms in both normal physiological contexts and in disease ...contexts. miRNA expression profiling is gaining popularity because miRNAs, as key regulators in gene expression networks, can influence many biological processes and also show promise as biomarkers for disease. Technological advances have spawned a multitude of platforms for miRNA profiling, and an understanding of the strengths and pitfalls of different approaches can aid in their effective use. Here, we review the major considerations for carrying out and interpreting results of miRNA-profiling studies.
Abstract
Motivation
Historically, gene expression has been shown to be the most informative data for drug response prediction. Recent evidence suggests that integrating additional omics can improve ...the prediction accuracy which raises the question of how to integrate the additional omics. Regardless of the integration strategy, clinical utility and translatability are crucial. Thus, we reasoned a multi-omics approach combined with clinical datasets would improve drug response prediction and clinical relevance.
Results
We propose MOLI, a multi-omics late integration method based on deep neural networks. MOLI takes somatic mutation, copy number aberration and gene expression data as input, and integrates them for drug response prediction. MOLI uses type-specific encoding sub-networks to learn features for each omics type, concatenates them into one representation and optimizes this representation via a combined cost function consisting of a triplet loss and a binary cross-entropy loss. The former makes the representations of responder samples more similar to each other and different from the non-responders, and the latter makes this representation predictive of the response values. We validate MOLI on in vitro and in vivo datasets for five chemotherapy agents and two targeted therapeutics. Compared to state-of-the-art single-omics and early integration multi-omics methods, MOLI achieves higher prediction accuracy in external validations. Moreover, a significant improvement in MOLI’s performance is observed for targeted drugs when training on a pan-drug input, i.e. using all the drugs with the same target compared to training only on drug-specific inputs. MOLI’s high predictive power suggests it may have utility in precision oncology.
Availability and implementation
https://github.com/hosseinshn/MOLI.
Supplementary information
Supplementary data are available at Bioinformatics online.
The Coronavirus pandemic has led to restrictions on movement and workplace closures, resulting in governments offering temporary financial support to enterprises and workers. This paper evaluates a ...group unable to access this financial support, namely those in the undeclared economy, and possible policy responses. To identify the service industries and workers involved, a late 2019 Eurobarometer survey of undeclared work in Europe is reported. This reveals that undeclared work is particularly prevalent in the hospitality, retail and personal services sectors and identifies the population groups over-represented. Given that this undeclared workforce is now largely unable to work, it will be argued that providing access to temporary financial support, through a voluntary disclosure initiative, would be a useful initiative not only to provide the income support these enterprises and workers need but also to bring them out of the shadows and put them on the radar of the state authorities.
Selective laser melting (SLM) is a rapid manufacturing process that enables the buildup of very complex parts in short delays directly from powder beds. Due to the high laser beam energy during very ...short interaction times and the high solidification rates of the melting pool, the resulting microstructure is out-of-equilibrium and particularly textured. This type of as-fabricated microstructure may not satisfy the aeronautical criterion and requires post heat treatments. Optimized heat treatments are developed, in one side, to homogenize and form the stable phases
α
and
β
while preventing exaggerated grain growth. In the other side, heat treatment is investigated to relieve the thermal stresses appearing during cooling. This study is aimed at presenting the various types of microstructure of the Ti-6Al-4V alloy after postfabrication heat treatments below or above the
β
transus. Tensile tests are then carried out at room temperature in order to assess the effect of the microstructures on the mechanical properties. The fine as-fabricated microstructure presents high yield and ultimate strengths, whereas the ductility is well below the standard. A strong anisotropy of fracture between the two loading directions is noted, which is attributed to the manufacturing defects. Conventional and optimized heat treatments exhibit high yield and ultimate strengths while the ductility is significantly improved. This is due to a new optimization of the process parameters allowing drastic reduction of the number of defects. These two heat treatments enable now a choice of the morphology of the grains between columnar or equiaxial as a function of the type of loading.
...they are also associated with an increased risk of prostate and pancreatic cancer, among others. Because this is not widely understood, testing is not being done for the right people at the right ...time. In previous decades, people had described hereditary breast cancer and hereditary ovarian cancer as distinct entities, on the basis that such cancers cluster in families. ...some investigators have suggested renaming the gene PALB2 as BRCA3. MARY-CLAIRE KING Cancer - genetics pioneer In the mid-1970s, Mary-Claire King (pictured) was the first to recognize that hereditary breast and ovarian cancer could be accounted for by a single gene; in 1990, she and her group at the University of California, Berkeley, identified the location of the BRCA1 gene13,14.
The biogenesis of the RNA payload of mature sperm is of great interest, because RNAs delivered to the zygote at fertilization can affect early development. Here, we tested the hypothesis that small ...RNAs are trafficked to mammalian sperm during the process of post-testicular maturation in the epididymis. By characterizing small RNA dynamics during germ cell maturation in mice, we confirm and extend prior observations that sperm undergo a dramatic switch in the RNA payload from piRNAs to tRNA fragments (tRFs) upon exiting the testis and entering the epididymis. Small RNA delivery to sperm could be recapitulated in vitro by incubating testicular spermatozoa with caput epididymosomes. Finally, tissue-specific metabolic labeling of RNAs in intact mice definitively shows that mature sperm carry RNAs that were originally synthesized in the epididymal epithelium. These data demonstrate that soma-germline RNA transfer occurs in male mammals, most likely via vesicular transport from the epididymis to maturing sperm.
•Detailed characterization of small RNA dynamics in mammalian sperm maturation•Caput epididymosomes can deliver small RNAs to testicular spermatozoa in vitro•Metabolic labeling of RNAs in intact animals tracks RNAs from epididymis to sperm
Recent studies suggest that sperm carry RNAs first synthesized in epididymal somatic cells. Sharma et al. test this hypothesis, characterizing small RNA population dynamics during sperm maturation. They show that caput epididymosomes can deliver RNAs to immature sperm in vitro and track RNAs in vivo from the epididymis to sperm using metabolic labeling.
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