The NA62 experiment at CERN reports a search for the lepton number violating decays K+→π−e+e+ and K+→π−μ+μ+ using a data sample collected in 2017. No signals are observed, and upper limits on the ...branching fractions of these decays of 2.2×10−10 and 4.2×10−11 are obtained, respectively, at 90% confidence level. These upper limits improve on previously reported measurements by factors of 3 and 2, respectively.
We demonstrate a radio-frequency potassium-vapor magnetometer operating with sensitivities of 0.3 fT/Hz at 0.5 MHz and 0.9 fT/Hz at 1.31 MHz in the absence of radio-frequency and mu-metal or magnetic ...shielding. The use of spatially separated magnetometers, two voxels within the same cell, permits for the subtraction of common mode noise and the retention of a gradient signal, as from a local source. At 0.5 MHz the common mode noise was white and measured to be 3.4 fT/Hz; upon subtraction the noise returned to the values observed when the magnetometer was shielded. At 1.31 MHz, the common mode noise was from a nearby radio station and was reduced by a factor of 33 upon subtraction, limited only by the radio signal picked up by receiver electronics. Potential applications include in-the-field low-field magnetic resonance, such as the use of nuclear quadrupole resonance for the detection of explosives.
Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Chondroitin sulfate is upregulated at injury, thus methods to promote neurite ...extension through chondroitin sulfate-rich matrices and synthetic scaffolds are needed. We describe the use of both chondroitin sulfate and a novel chondroitin sulfate-binding peptide to control the release of nerve growth factor. Interestingly, the novel chondroitin sulfate-binding peptide enhances the controlled release properties of the chondroitin sulfate gels. While introduction of chondroitin sulfate into a scaffold inhibits primary cortical outgrowth, the combination of chondroitin sulfate, chondroitin sulfate-binding peptide and nerve growth factor promotes primary cortical neurite outgrowth in chondroitin sulfate gels.
Coagulopathy reversal in intracerebral haemorrhage Sweidan, Alexander Jacob; Singh, Navneet Kaur; Conovaloff, Joseph Luke ...
Stroke and vascular neurology,
03/2020, Letnik:
5, Številka:
1
Journal Article
Recenzirano
Odprti dostop
As intracerebral hemorrahge becomes more frequent as a result of an aging population with greater comorbidities, rapid identification and reversal of precipitators becomes increasingly paramount. The ...aformentioned population will ever more likely be on some form of anticoagulant therapy. Understanding the mechanisms of these agents and means by which to reverse them early on is critical in managing the acute intracerebral hemorrhage.
The first search for ultra-rare K+ decays into the π+e+e−e+e− final state is reported, using a dataset collected by the NA62 experiment at CERN in 2017–2018. An upper limit of 1.4×10−8 at 90% CL is ...obtained for the branching ratio of the K+→π+e+e−e+e− decay, predicted in the Standard Model to be (7.2±0.7)×10−11. Upper limits at 90% CL are obtained at the level of 10−9 for the branching ratios of two prompt decay chains involving pair-production of hidden-sector mediators: K+→π+aa, a→e+e− and K+→π+S, S→A′A′, A′→e+e−.
Searches for lepton number violating K+→π−e+e+ and K+→π−π0e+e+ decays have been performed using the complete dataset collected by the NA62 experiment at CERN in 2016–2018. Upper limits of 5.3×10−11 ...and 8.5×10−10 are obtained on the decay branching fractions at 90% confidence level. The former result improves by a factor of four over the previous best limit, while the latter result represents the first limit on the K+→π−π0e+e+ decay rate.
The NA62 Experiment is a fixed-target, kaon experiment using beam from the Super Proton Synchrotron at CERN. The purpose of the experiment is to measure the branching ratio of the K+ → π+ ν ν decay ...to 10% precision. Such a measurement is theoretically very clean and could point to new physics unexplainable by the Standard Model. Data collected by the experiment in the 2015 run is used to assess background rejection via kinematics and particle identification. Total background rejection is found to be on the order of 10−11 which meets experimental design specifications. Signal reconstruction efficiency is calculated and background to the signal is also estimated and used as inputs to the Rolkes-Lopez method, used to calculate an upper bound to the K+ → π+ ν ν decay. The upper bound of the K+ → π+ ν ν decay is found to be 5.68 ×10−7 at the 90% confidence level.
A search for the K+→μ−νe+e+ decay, forbidden within the Standard Model by either lepton number or lepton flavour conservation depending on the flavour of the emitted neutrino, has been performed ...using the dataset collected by the NA62 experiment at CERN in 2016–2018. An upper limit of 8.1×10−11 is obtained for the decay branching fraction at 90% CL, improving by a factor of 250 over the previous search.
A 52-year-old man with a history of diabetes, hypertension, and obstructive sleep apnea presented to us for LVSG. ...we believe HES use is unnecessary and should be avoided in most elective bariatric ...surgery cases.
Chondroitin sulfate (CS) expression is increased in the glial scar following spinal cord injury demonstrating the importance understanding the role of CS in the central nervous system (CNS). There ...have been conflicting studies on the effects of the most abundant types of CS, chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate (C6S), found in the CNS. In this study, the effects of C4S and C6S on rat embryonic day 18 cortical neurons were investigated. C4S had no effect on neuron behavior whereas C6S inhibited neurite outgrowth at higher concentrations (>10
μg/ml). Two C6S-binding peptides (C6S-1 and C6S-2) were tested for their ability to block the inhibitory activity of C6S on neurite outgrowth. Neurons cultured with C6S and C6S-binding peptide at higher peptide concentrations had neurite lengths similar to neurons cultured without C6S. Therefore, the C6S-binding peptides were effective at blocking the inhibitory activity of C6S. The C6S-1 peptide had a higher binding affinity than the C6S-2 peptide and was consequently more effective at blocking C6S inhibition of neurite growth. To date, this is the first study to employ an alternative strategy from enzymatic digestion of CS chains to increase neurite outgrowth. These studies warrant further investigation of the use of C6S-binding peptides to increase nerve regeneration following spinal cord injury.
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