Context.
Herbig Ae/Be stars (HAeBes) have so far been studied based on relatively small samples that are scattered throughout the sky. Their fundamental stellar and circumstellar parameters and ...statistical properties were derived with heterogeneous approaches before
Gaia
.
Aims.
Our main goal is to contribute to the study of HAeBes from the largest sample of such sources to date, for which stellar and circumstellar properties have been determined homogeneously from the analysis of the spectral energy distributions (SEDs) and
Gaia
EDR3 parallaxes and photometry.
Methods.
Multiwavelength photometry was compiled for 209 bona fide HAeBes for which
Gaia
EDR3 distances were estimated. Using the Virtual Observatory SED Analyser (VOSA), photospheric models were fit to the optical SEDs to derive stellar parameters, and the excesses at infrared (IR) and longer wavelengths were characterized to derive several circumstellar properties. A statistical analysis was carried out to show the potential use of such a large dataset.
Results.
The stellar temperature, luminosity, radius, mass, and age were derived for each star based on optical photometry. In addition, their IR SEDs were classified according to two different schemes, and their mass accretion rates, disk masses, and the sizes of the inner dust holes were also estimated uniformly. The initial mass function fits the stellar mass distribution of the sample within 2 <
M
*
∕
M
⊙
< 12. In this aspect, the sample is therefore representative of the HAeBe regime and can be used for statistical purposes when it is taken into account that the boundaries are not well probed. Our statistical study does not reveal any connection between the SED shape from the Meeus et al. (2001, A&A, 365, 476) classification and the presence of transitional disks, which are identified here based on the SEDs that show an IR excess starting at the K band or longer wavelengths. In contrast, only ~28% of the HAeBes have transitional disks, and the related dust disk holes are more frequent in HBes than in HAes (~34% vs. 15%). The relatively small inner disk holes and old stellar ages estimated for most transitional HAes indicate that photoevaporation cannot be the main mechanism driving disk dissipation in these sources. In contrast, the inner disk holes and ages of most transitional HBes are consistent with the photoevaporation scenario, although these results alone do not unambiguously discard other disk dissipation mechanisms.
Conclusions.
The complete dataset is available online through a Virtual Observatory-compliant archive, representing the most recent reference for statistical studies on the HAeBe regime. VOSA is a complementary tool for the future characterization of newly identified HAeBes.
Maize is one of the most important crops for human and animal consumption and contains a chemical arsenal essential for survival: flavonoids. Moreover, flavonoids are well known for their beneficial ...effects on human health. In this review, we decided to organize the information about maize flavonoids into three sections. In the first section, we include updated information about the enzymatic pathway of maize flavonoids. We describe a total of twenty-one genes for the flavonoid pathway of maize. The first three genes participate in the general phenylpropanoid pathway. Four genes are common biosynthetic early genes for flavonoids, and fourteen are specific genes for the flavonoid subgroups, the anthocyanins, and flavone C-glycosides. The second section explains the tissue accumulation and regulation of flavonoids by environmental factors affecting the expression of the MYB-bHLH-WD40 (MBW) transcriptional complex. The study of transcription factors of the MBW complex is fundamental for understanding how the flavonoid profiles generate a palette of colors in the plant tissues. Finally, we also include an update of the biological activities of C3G, the major maize anthocyanin, including anticancer, antidiabetic, and antioxidant effects, among others. This review intends to disclose and integrate the existing knowledge regarding maize flavonoid pigmentation and its relevance in the human health sector.
Experimental animal models of diabetes can be useful for identifying novel targets related to disease, for understanding its physiopathology, and for evaluating emerging antidiabetic treatments. This ...study aimed to characterize two rat diabetes models: HFD + STZ, a high-fat diet (60% fat) combined with streptozotocin administration (STZ, 35 mg/kg BW), and a model with a single STZ dose (65 mg/kg BW) in comparison with healthy rats. HFD + STZ- induced animals demonstrated a stable hyperglycemia range (350-450 mg/dL), whereas in the STZ-induced rats, we found glucose concentration values with a greater dispersion, ranging from 270 to 510 mg/dL. Moreover, in the HFD + STZ group, the AUC value of the insulin tolerance test (ITT) was found to be remarkably augmented by 6.2-fold higher than in healthy animals (33,687.0 ± 1705.7 mg/dL/min vs. 5469.0 ± 267.6, respectively), indicating insulin resistance (IR). In contrast, a more moderate AUC value was observed in the STZ group (19,059.0 ± 3037.4 mg/dL/min) resulting in a value 2.5-fold higher than the average exhibited by the control group. After microarray experiments on liver tissue from all animals, we analyzed genes exhibiting a fold change value in gene expression <-2 or >2 (
-value <0.05). We found 27,686 differentially expressed genes (DEG), identified the top 10 DEGs and detected 849 coding genes that exhibited opposite expression patterns between both diabetes models (491 upregulated genes in the STZ model and 358 upregulated genes in HFD + STZ animals). Finally, we performed an enrichment analysis of the 849 selected genes. Whereas in the STZ model we found cellular pathways related to lipid biosynthesis and metabolism, in the HFD + STZ model we identified pathways related to immunometabolism. Some phenotypic differences observed in the models could be explained by transcriptomic results; however, further studies are needed to corroborate these findings. Our data confirm that the STZ and the HFD + STZ models are reliable experimental models for human T1D and T2D, respectively. These results also provide insight into alterations in the expression of specific liver genes and could be utilized in future studies focusing on diabetes complications associated with impaired liver function.
Context.
It has been hypothesized that the location of Herbig Ae/Be stars (HAeBes) within the empirical relation between the inner disk radius (
r
in
), inferred from
K
-band interferometry, and the ...stellar luminosity (
L
*
), is related to the presence of the innermost gas, the disk-to-star accretion mechanism, the dust disk properties inferred from the spectral energy distributions (SEDs), or a combination of these effects. However, no general observational confirmation has been provided to date.
Aims.
This work aims to test whether the previously proposed hypotheses do, in fact, serve as a general explanation for the distribution of HAeBes in the size–luminosity diagram.
Methods.
GRAVITY/VLTI spectro-interferometric observations at ~2.2 μm have been obtained for five HBes representing two extreme cases concerning the presence of innermost gas and accretion modes. V590 Mon, PDS 281, and HD 94509 show no excess in the near-ultraviolet, Balmer region of the spectra (Δ
D
B
), indicative of a negligible amount of inner gas and disk-to-star accretion, whereas DG Cir and HD 141926 show such strong Δ
D
B
values that cannot be reproduced from magnetospheric accretion, but probably come from the alternative boundary layer mechanism. In turn, the sample includes three Group I and two Group II stars based on the Meeus et al. SED classification scheme. Additional data for these and all HAeBes resolved through
K
-band interferometry have been compiled from the literature and updated using
Gaia
EDR3 distances, almost doubling previous samples used to analyze the size–luminosity relation.
Results.
We find no general trend linking the presence of gas inside the dust destruction radius or the accretion mechanism with the location of HAeBes in the size–luminosity diagram. Similarly, our data do not support the more recent hypothesis linking such a location and the SED groups. Underlying trends are present and must be taken into account when interpreting the size–luminosity correlation. In particular, it cannot be statistically ruled out that this correlation is affected by dependencies of both
L
*
and
r
in
on the wide range of distances to the sources. Still, it is argued that the size–luminosity correlation is most likely to be physically relevant in spite of the previous statistical warning concerning dependencies on distance.
Conclusions.
Different observational approaches have been used to test the main scenarios proposed to explain the scatter of locations of HAeBes in the size–luminosity diagram. However, none of these scenarios have been confirmed as a fitting general explanation and this issue remains an open question.
In this work, we demonstrate, analytically and numerically, that degenerate states of a beam with free ends, with anti-symmetrical transverse mode shape and occurring in the first-degeneracy points ...above the cutoff frequency, tend asymptotically to the thickness-shear mode in the infinitely long beam limit, which has not been previously reported. We compare our numerical results, obtained using a Timoshenko–Ehrenfest beam theory of second order, with those obtained with the Finite Element method and plane stress elastodynamics theory, obtaining an excellent agreement. We show that anti-symmetric states within the vicinity of these first-degeneracy states are very similar and closely resemble the so-called thickness-shear mode but for a finite beam with free ends under flexural vibrations.
•Mode shapes of degenerate states are studied in Timoshenko–Ehrenfest beams.•First-degeneracy asymmetric states turn out very similar to the thickness-shear mode.•Instead, it is shown that transverse oscillations of the cutoff states are non-negligible.•Results for a beam with free ends are corroborated with the Finite Element method.•It is demonstrated that analogs to the thickness-shear mode exist for finite beams.
Background and purpose
The existence of contraindications to intravenous thrombolysis (IVT) is considered a criterion for direct transfer of patients with suspected acute stroke to ...thrombectomy‐capable centers in the prehospital setting. Our aim was to assess the utility of this criterion in a setting where routing protocols are defined by the Madrid – Direct Referral to Endovascular Center (M‐DIRECT) prehospital scale.
Methods
This was a post hoc analysis of the M‐DIRECT study. Reported contraindications to IVT were retrospectively collected from emergency medical services reports and categorized into late window, anticoagulant treatment and other contraindications. Final diagnosis and treatment rates were compared between patients with and without reported IVT contraindications and according to anticoagulant treatment or late window categories.
Results
The M‐DIRECT study included 541 patients. Reported IVT contraindications were present in 227 (42.0%) patients. Regarding final diagnosis no significant differences were found between patients with or without reported IVT contraindications: ischaemic stroke (any) 65.6% vs. 62.1%, ischaemic stroke with large vessel occlusion (LVO) 32.2% vs. 28.3%, hemorrhagic stroke 15.4% vs. 15.6%, stroke mimic 18.9% vs. 22.3% respectively. Amongst patients with LVO, endovascular thrombectomy (EVT) was performed less often in the presence of IVT contraindications (56.2% vs. 74.2%). M‐DIRECT‐positive patients had higher rates of LVO and EVT compared with M‐DIRECT‐negative patients independent of reported IVT contraindications.
Conclusions
Reported IVT contraindications alone do not increase EVT likelihood and should not be considered to determine routing in urban stroke networks.
Abstract An over-activation of the mechanistic target of rapamycin (mTOR) pathway promotes senescence and age-related diseases like type 2 diabetes. Besides, the regenerative potential of pancreatic ...islets deteriorates with aging. Nevertheless, the role of mTOR on senescence promoted by metabolic stress in islet cells as well as its relevance for electrophysiological aspects is not yet known. Here, we investigated whether parameters suggested to be indicative for senescence are induced in vitro in mouse islet cells by glucotoxicity and if mTOR inhibition plays a protective role against this. Islet cells exhibit a significant increase (~ 76%) in senescence-associated beta-galactosidase (SA-beta-gal) activity after exposure to glucotoxicity for 72 h. Glucotoxicity does not markedly influence p16 INK4a protein within 72 h, but p16 INK4a levels increase significantly after a 7-days incubation period. mTOR inhibition with a low rapamycin concentration (1 nM) entirely prevents the glucotoxicity-mediated increase of SA-beta-gal and p16 INK4a . At the functional level, reactive oxygen species, calcium homeostasis, and electrical activity are disturbed by glucotoxicity, and rapamycin fails to prevent this. In contrast, rapamycin significantly attenuates the insulin hypersecretion promoted by glucotoxicity by modifying the mRNA levels of Vamp2 and Snap25 genes, related to insulin exocytosis. Our data indicate an influence of glucotoxicity on pancreatic islet-cell senescence and a reduction of the senescence markers by mTOR inhibition, which is relevant to preserve the regenerative potential of the islets. Decreasing the influence of mTOR on islet cells exposed to glucotoxicity attenuates insulin hypersecretion, but is not sufficient to prevent electrophysiological disturbances, indicating the involvement of mTOR-independent mechanisms.
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•Acute lupin β-conglutin treatment improves glycaemia response in normal rats.•Chronic β-conglutin treatment prevents glycaemia deterioration in STZ-induced rats.•β-conglutin ...treatment elicits a cholesterol lowering effect in STZ-induced rats.•β-conglutin effects may involve antioxidant, antiinflammatory and estrogenic activity.
Constituents of lupin seeds, like γ-conglutin and lupanine, have gained attention as potential complementary treatments for dysglycaemia management. Notwithstanding, the effect of other lupin components on carbohydrate metabolism, including β-conglutin protein, has received little attention. Here, we investigated the influence of the acute and chronic administration of β-conglutin on glycaemia modulation in normal and streptozotocin induced-to-diabetes rats. We analysed the liver transcriptome modulation exerted by β-conglutin in diabetes-induced rats using DNA microarrays to scout for potential molecular targets and pathways involved in this biological response. The acute administration of β-conglutin reduced the incremental area under the curve of glycaemia in normal and diabetes-induced animals. In a seven-day study with diabetic animals, glycaemia increased significantly in non-treated animals but remained unchanged in animals treated with a daily dose of β-conglutin. Total cholesterol was significantly lower at the end of the experimental period (−21.8 %, p = 0.039). The microarray and gene ontology analyses revealed several targets and pathways potentially modulated by β-conglutin treatment, including a possible down-regulation of Jun kinase activity. Moreover, our data indicate that targets related to oxidative stress, inflammation, and estrogenic activity might orchestrate these metabolic effects. In conclusion, our findings show that β-conglutin may help manage postprandial glycaemia and reduce cholesterol levels under the dysglycaemia stage. We identified and proposed new potential molecular targets for further research related to the mechanism of action of β-conglutin.
Previous studies have individually shown the antidiabetic potential of gamma conglutin (Cγ) and lupanine from lupins. Until now, the influence of combining both compounds and the effective dose of ...the combination have not been assessed. Moreover, the resulting gene expression profile from this novel combination remains to be explored. Therefore, we aimed to evaluate different dose combinations of Cγ and lupanine by the oral glucose tolerance test (OGTT) to identify the higher antidiabetic effect on a T2D rat model. Later, we administered the selected dose combination during a week. Lastly, we evaluated biochemical parameters and liver gene expression profile using DNA microarrays and bioinformatic analysis. We found that the combination of 28 mg/kg BW Cγ + 20 mg/kg BW lupanine significantly reduced glycemia and lipid levels. Moreover, this treatment positively influenced the expression of
,
,
,
,
,
,
,
,
, and
genes. The biological processes associated with these genes are oxidative stress, apoptosis regulation, and glucose and fatty-acid homeostasis. For the first time, we report the beneficial in vivo effect of the combination of two functional lupin compounds. Nevertheless, further studies are needed to investigate the pharmacokinetics and pharmacodynamics of the Cγ + lupanine combined treatment.
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