The molybdenum (Mo) isotope system is a powerful tool for tracing recycled crustal components in volcanic rocks. Existing Mo isotope data show that intraplate basalts have highly variable Mo ...isotopes. However, the heterogeneity of Mo isotopes in intraplate basalts was interpreted to be inherited from recycling of different slab components, and its origin remains unclear. Here we synthesize Mo isotope and other geochemical data for global intraplate basalts, which provide insights into Mo recycling in Earth's deep mantle. Global intraplate basalts display highly variable δ98Mo values of −0.84‰ to 0.10‰, suggesting mantle Mo isotopic heterogeneity. Most of the basalts have low δ98Mo values and high Ce/Mo ratios that are similar to those of the oceanic eclogites, indicating that recycled dehydrated oceanic crustal components were involved in their mantle sources. However, some intraplate basalts have heavy Mo isotopes. This reveals that slab components at shallow depths were dragged by the downgoing slab and have carried heavy Mo isotopes into the deep mantle. Significantly, high δ98Mo values of these basalts are also associated with low Ce/Mo ratios, high fluid-mobile element contents, and depleted radiogenic SrNd isotopes. Given that recycled basaltic oceanic crust and sediment are generally efficiently dehydrated during subduction and sequester light Mo isotopes, subducted serpentinised lithospheric mantle is a plausible candidate to transfer heavy Mo isotopes into the deep mantle. Thus, Mo isotope systematics of intraplate basalts record complex geochemical fluxes from subducting slab to the deep mantle, in which subducted serpentinites play an important role in the Mo isotope recycling. Our study highlights the effectiveness of Mo isotopes as indicators for geochemical heterogeneity of Earth's deep mantle.
Quantum‐dot light‐emitting diodes (QLEDs) may combine superior properties of colloidal quantum dots (QDs) and advantages of solution‐based fabrication techniques to realize high‐performance, ...large‐area, and low‐cost electroluminescence devices. In the state‐of‐the‐art red QLED, an ultrathin insulating layer inserted between the QD layer and the oxide electron‐transporting layer (ETL) is crucial for both optimizing charge balance and preserving the QDs' emissive properties. However, this key insulating layer demands very accurate and precise control over thicknesses at sub‐10 nm level, causing substantial difficulties for industrial production. Here, it is reported that interfacial exciton quenching and charge balance can be independently controlled and optimized, leading to devices with efficiency and lifetime comparable to those of state‐of‐the‐art devices. Suppressing exciton quenching at the ETL–QD interface, which is identified as being obligatory for high‐performance devices, is achieved by adopting Zn0.9Mg0.1O nanocrystals, instead of ZnO nanocrystals, as ETLs. Optimizing charge balance is readily addressed by other device engineering approaches, such as controlling the oxide ETL/cathode interface and adjusting the thickness of the oxide ETL. These findings are extended to fabrication of high‐efficiency green QLEDs without ultrathin insulating layers. The work may rationalize the design and fabrication of high‐performance QLEDs without ultrathin insulating layers, representing a step forward to large‐scale production and commercialization.
Interfacial exciton quenching and charge balance are independently controlled and optimized in quantum‐dot light‐emitting diodes without ultrathin insulating layers, leading to red devices with efficiency (peak external quantum efficiency: 18.2%) and lifetime (T50 at an initial brightness of 100 cd m−2: ≈190 000 h) comparable to those of state‐of‐the‐art devices.
Photonic quantum information requires high-purity, easily accessible, and scalable single-photon sources. Here, we report an electrically driven single-photon source based on colloidal quantum dots. ...Our solution-processed devices consist of isolated CdSe/CdS core/shell quantum dots sparsely buried in an insulating layer that is sandwiched between electron-transport and hole-transport layers. The devices generate single photons with near-optimal antibunching at room temperature, i.e., with a second-order temporal correlation function at zero delay (g
(0)) being <0.05 for the best devices without any spectral filtering or background correction. The optimal g
(0) from single-dot electroluminescence breaks the lower g
(0) limit of the corresponding single-dot photoluminescence. Such highly suppressed multi-photon-emission probability is attributed to both novel device design and carrier injection/recombination dynamics. The device structure prevents background electroluminescence while offering efficient single-dot electroluminescence. A quantitative model is developed to illustrate the carrier injection/recombination dynamics of single-dot electroluminescence.
Objective
Homeless persons are at high risk for poor oral health. Supportive housing can improve housing stability for persons with behavioural health conditions, but its impact on dental service use ...has been little studied.
Methods
Data for this evaluation come from matched public service records for eligible applicants to a New York City supportive housing program (NY III) targeting chronic homelessness. NY III tenants (N = 5678) were compared with applicants not placed in housing (N = 6536) and applicants placed in other supportive housing programmes (N = 4823). Regression analysis was used to assess the association between supportive housing, primary care use, clinical severity and the likelihood of dental visits.
Results
Over four observation years, 71% of applicants had at least one dental visit for any cause and 57% for preventive dental care. Incidence of dental visits was lower for persons with physical disability (IRR = 0.91; 95% CI = 0.85, 0.97, P = .003), psychiatric hospital stays (IRR = 0.78; 95% CI = 0.68, 0.88, P < .001) and age over 54. Persons engaged in primary care (IRR = 1.26; 95% CI = 1.21, 1.31, P < .001) and outpatient mental health care (IRR = 1.16; 95% CI = 1.12, 1.21, P < .001) had greater incidence of dental visits.
Conclusions
Supportive housing was associated with greater dental service use. The positive association between primary care, mental health care and dental care suggests important points of entry for dental care. Oral health education and service referrals in supportive housing and primary care settings may improve oral health service delivery to persons experiencing social exclusion due to homelessness, mental illness and poor oral health.
Skin substitutes with existing vascularization are in great demand for the repair of full-thickness skin defects. In the present study, we hypothesized that a pre-vascularized skin substitute can ...potentially promote wound healing. Novel three-dimensional (3D) skin substitutes were prepared by seeding a mixture of human endothelial progenitor cells (EPCs) and fibroblasts into a human plasma/calcium chloride formed gel scaffold, and seeding keratinocytes onto the surface of the plasma gel. The capacity of the EPCs to differentiate into a vascular-like tubular structure was evaluated using immunohistochemistry analysis and WST-8 assay. Experimental studies in mouse full-thickness skin wound models showed that the pre-vascularized gel scaffold significantly accelerated wound healing 7 days after surgery, and resembled normal skin structures after 14 days post-surgery. Histological analysis revealed that pre-vascularized gel scaffolds were well integrated in the host skin, resulting in the vascularization of both the epidermis and dermis in the wound area. Moreover, mechanical strength analysis demonstrated that the healed wound following the implantation of the pre-vascularized gel scaffolds exhibited good tensile strength. Taken together, this novel pre-vascularized human plasma gel scaffold has great potential in skin tissue engineering.
Elevated levels of interleukin 1β (IL‐1β) have been identified in patients with chronic viral hepatitis and have been associated with depressive symptoms. Given the high prevalence of depression in ...this patient population, this study sought to explore the potential influence of IL‐1β genetic variations on the severity of depressive symptoms. In a cohort of 181 Taiwanese patients with chronic viral hepatitis, we investigated the impact of five common IL‐1β single nucleotide polymorphisms (SNPs), including rs16944, rs1143627, rs1143630, rs1143643, and rs3136558, on depressive symptoms using the Beck's Depression Inventory‐II. Additionally, we analyzed the primary domains of IL‐1β‐related depressive symptoms according to Beck's six symptom categories of depression. Our analysis revealed significant associations between depressive symptoms and three intronic IL‐1β SNPs. After controlling for age, sex, marital status, and education level, patients with the rs1143630 GG, rs1143643 CC, and rs3136558 AA genotypes demonstrated higher severity of depressive symptoms in the domains of indecision (p = 0.004), agitation (p = 0.001), and feelings of punishment (p = 0.005), respectively, compared to rs1143630 GA+AA, rs1143643 CT, and rs3136558 AG+GG genotypes. According to Beck's categorization, these symptoms can be classified into three dimensions: disturbances in emotion regulation, energy, and cognition. Our findings demonstrate the association between IL‐1β polymorphisms and depressive symptoms and suggest a potential underlying mechanism for specific depressive symptoms within the chronic viral hepatitis population. These insights could improve our understanding and treatment of depressive symptoms in individuals with viral hepatitis.
Highly variable molybdenum (Mo) isotope compositions are common in mafic arc magmas above oceanic subduction zones, but Mo isotopes of mafic magmas related to continental deep subduction have not yet ...been documented. Here, we report for the first time the Mo isotope composition of mafic igneous rocks above a typical continental subduction zone in east-central China, where the North China Block was subducted by the South China Block in the Triassic. Continental basalts of Early Cretaceous age show negative δ98Mo values of −0.98 to −0.16 ‰, significantly lower than the normal mantle value of −0.20 ± 0.01 ‰. These basalts also exhibit arc-like trace element compositions, high (87Sr/86Sr)i ratios of 0.7050 to 0.7058, negative εNd(t) values of −15.2 to −10.4, and negative εHf(t) values of −18.7 to −7.9. The light Mo isotope signatures are associated with enrichments in not only radiogenic Sr-Nd-Hf isotopes but also melt-mobile incompatible elements in the basalts. This indicates that the mantle source of these basalts would be generated by metasomatic reaction of the mantle wedge peridotite with felsic melts derived from partial melting of the deeply subducted continental crust. Given that continental crust usually exhibits heavy Mo isotope compositions, it would be dehydrated during its subduction to subarc depths. While the dehydration would have released isotopically heavy Mo fluids from the subducting crust, it leaves isotopically light Mo in the residual crust. The dehydrated continental crust underwent partial melting at subarc depths to produce felsic melts with low δ98Mo values, transferring the light Mo isotope signature into the mantle source of the basalts. Therefore, Mo isotopes in mafic igneous rocks are a powerful means to decipher the recycling of crustal components at convergent plate margins. Our study provides the first insight into Mo isotope recycling in continental subduction zones.
Background
Systemic lupus erythematosus (SLE) is a complex autoimmune connective tissue disease (CTD) that is an important cause of devastating pulmonary arterial hypertension (PAH), and persistent ...progression of PAH can lead to right heart failure, predicting a poor prognosis for SLE patients. Right ventricular-pulmonary arterial (RV-PA) coupling with echocardiography has been demonstrated to be a noninvasive alternative method for evaluating PAH patients' predictive outcomes. Whether the ratio of right ventricular stroke volume (RVSV) to right ventricular end-systolic volume (RVESV) measured by three-dimensional echocardiography (3DE) is a new index of RV-PA coupling has not been discussed as a new predictor for the clinical outcome of systemic lupus erythematosus-associated pulmonary arterial hypertension (SLE-PAH).
Methods
From June 2019 to February 2023, 46 consecutive patients with SLE-PAH were enrolled prospectively, and their clinical data and echocardiographs were studied and analyzed. The control group consisted of 30 healthy subjects matched for age, sex, and body surface area (BSA). The main endpoints of this study were a composite of all-cause mortality and adverse clinical events. Baseline clinical characteristics and echocardiographic assessments were analyzed.
Results
During a median of 24 months (IQR 18–31), 16 of 46 SLE-PAH patients (34.7%) experienced endpoint-related events. At baseline, patients who experienced mortality or adverse events had a worse WHO functional class (WHO FC) and lower anti-double-stranded DNA (dsDNA) antibody levels. The right ventricular (RV) systolic dysfunction in SLE-PAH subjects was significantly worse than that in the healthy control group, especially in SLE-PAH patients in the endpoint event group. Compared to controls, patients with SLE-PAH had a lower RVSV/RVESV ratio. In the group comparison, patients who had experienced an endpoint event had a sequentially worse ratio (1.86 (1.65–2.3) versus 1.30 (1.09–1.46) versus 0.64 (0.59-0.67), p < .001). There were statistically significant associations between the RVSV/RVESV ratio to routine RV systolic function and clinical parameters. The RVSV/RVESV ratio was negatively correlated with the WHO FC (r = −0.621, p < .001) and positively correlated with the anti-dsDNA level. The ROC curve showed that the optimal cutoff for RVSV/RVESV < 0.712 determined a higher risk of poor prognosis. Kaplan‒Meier survival curves showed that an RVSV/RVESV ratio >0.712 was associated with more favorable long-term outcomes.
Conclusions
The 3DE-derived SV/ESV ratio as a noninvasive alternative surrogate of RV-PA coupling was an eximious indicator for identifying endpoint events in SLE-PAH patients and can provide a diagnostic basis for clinical intervention.
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Transition metal chalcogenides (TMCs) have demonstrated great potential in energy storage devices due to their versatile structures and composite functionalities. However, the ...application of TMCs in potassium-ion batteries (PIBs) suffers from the issues of large volume expansion, polysulfide dissolution, and sluggish kinetics. To overcome these challenges, this work develops nano-flower-like MnS-Co3S4 confined in poly-pyrrole (PPY) carbon nanotube (denoted as MS-CS-PPY) as an excellent anode in PIBs. The nitrogen-doped PPY framework facilitates the interface electron transfer, confines active materials MS-CS effectively, and mitigates the volume change, thus resulting in boosted reaction kinetics and exceptional cycling stability. TMCs induce the surface capacitance and enable the chemical anchoring of the charge/discharge products during the potassium/de-potassium process. Moreover, this work reveals the potassium/de-potassium reaction mechanism, redox kinetics, and solid electrolyte interphase formation of MS-CS-PPY in different electrolytes through theoretical calculations and experimental studies. The solvation ability of electrolytes plays a vital role in manipulating the redox kinetics of the MS-CS-PPY anode material. This study offers feasible strategies for electrode design and electrolyte selection for developing TMCs negative electrodes in future PIBs.
Serpentinite-derived components play an important role in chemical cycling in subduction zones. However, it is difficult to identify recycled serpentinite in subarc mantle due to the overprinting of ...other slab components, and how serpentinite contributes to arc magmatism is poorly understood. Here we report Mo and Mg isotopic compositions of Early Paleozoic Qushiang arc mafic rocks in the East Kunlun orogen. The Qushiang mafic rocks have variable δ98Mo values of −0.50‰ to 0.78% and δ26Mg values of −0.31‰ to −0.05‰. These features, combining with arc-type trace element distribution patterns, enriched SrNd isotopes, and variable zircon HfO isotopes, suggest the incorporation of different subducting components in their mantle source. Some mafic rocks show high δ98Mo values together with low Mo/Ce ratios and enriched SrNd isotopes, suggesting the contribution of subducted sediment (SSD)-derived melts. Additionally, light Mo isotopes are also identified in mafic rocks, which are closely related to depleted SrNd isotopes. These features are mainly inherited from the subducted dehydrated altered oceanic crust (SAOC)-derived melts. More importantly, the coexisting and significantly high δ26Mg and δ98Mo values of these rocks could not be explained by the SSD or SAOC components, but require serpentinite components in the subarc mantle source. Our study reveals that combined Mo and Mg isotopic studies are potential tools for tracing serpentinite recycling, and provides new insight into the mechanisms by which different subducting components contribute to arc magmatism.
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