In this experiment, a highly effective electrochemical sensor based on a molecularly imprinted polymer has been developed for ultrasensitive detection of dimetridazole. The sensor was made by ...incorporating of dimetridazole as a template molecule during the electropolymerization of poly-arginine on a glassy carbon electrode. The modified electrode GCE/P-Arg@MIP was characterized by voltammetric and microscopic techniques. Differential pulse voltammetry method was used to detect target analyte under the optimum condition. The DPV response to dimetridazole was linear at 0.1 × 10−9 to 10 × 10−6 mol L−1 (R2 = 0.996), with a method detection limit (S/N = 3) of 0.1 × 10−9 mol L−1. Moreover, the proposed sensor shows satisfactory recovery ranges for the determination dimetridazole in commercially available egg, milk and honey samples.
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•Highly effective electrochemical MIP sensor developed for ultrasensitive detection of dimetridazole.•GCE/P-Arg@MIP electrode was fabricated via electrochemical deposition technique.•The proposed sensor exhibited a wide linear detection range with an LOD of 0.1 nM.•The GCE/P-Arg@MIP sensor was applied to detect analyte in egg, milk and honey.
Last few decades, viruses are a real menace to human safety. Therefore, the rapid identification of viruses should be one of the best ways to prevent an outbreak and important implications for ...medical healthcare. The recent outbreak of coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus which belongs to the single-stranded, positive-strand RNA viruses. The pandemic dimension spread of COVID-19 poses a severe threat to the health and lives of seven billion people worldwide. There is a growing urgency worldwide to establish a point-of-care device for the rapid detection of COVID-19 to prevent subsequent secondary spread. Therefore, the need for sensitive, selective, and rapid diagnostic devices plays a vital role in selecting appropriate treatments and to prevent the epidemics. During the last decade, electrochemical biosensors have emerged as reliable analytical devices and represent a new promising tool for the detection of different pathogenic viruses. This review summarizes the state of the art of different virus detection with currently available electrochemical detection methods. Moreover, this review discusses different fabrication techniques, detection principles, and applications of various virus biosensors. Future research also looks at the use of electrochemical biosensors regarding a potential detection kit for the rapid identification of the COVID-19.
•Electrochemical biosensing platform helps to early diagnosis of pathogenic viruses.•Different electrochemical transduction system strategies are explained.•We covered more than 125 recent research articles on virus biosensors.•The advantages of each biosensor for COVID-19 detection are highlighted.•The advantages, drawbacks, and future perspectives of biosensors are discussed.
An innovative biosensor assembly relying on glassy carbon electrodes modified with nanocomposites consisting of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) as a host matrix ...with functionalized gold nanoparticles (GCE/PEDOT:PSS-AuNPs) is presented for the selective and sensitive detection of xanthine (XA). The developed sensor was successfully applied for the quantification of XA in the presence of significant interferents like hypoxanthine (HXA) and uric acid (UA). Different spectroscopy and electron microscopy analyses were done to characterize the as-prepared nanocomposite. Calibration responses for the quantification of XA was linear from 5.0 × 10
−8
to 1.0 × 10
−5
M (
R
2
= 0.994), with a detection limit as low as 3.0 × 10
−8
(S/N = 3). Finally, the proposed sensor was applied for the analyses of XA content in commercial fish and meat samples and satisfactory recovery percentage was obtained.
An innovative biosensor with glassy carbon electrodes modified with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate nanocomposites as a host matrix with functionalized gold nanoparticles for the selective and sensitive detection of xanthine.
Abstract
In this work, we have successfully synthesized core-shell structured Au-PDA@SiO
2
nanospheres and decorated on reduced graphene oxide (rGO) modified glassy carbon electrode for the ...electrochemical detection of cefotaxime. The one-pot hydrothermal method was used to synthesis core-shell nanostructures by loading Au nanoparticles on polydopamine (PDA) coated SiO
2
nanospheres. The as-prepared Au-PDA@SiO
2
nanospheres were used to fabricate electrochemically reduced graphene oxide (rGO) modified glassy carbon electrode (Au-PDA@SiO
2
/rGO/GCE) for electrochemical determination of cefotaxime. Scanning electron microscopy, powder x-ray diffraction, transmission electron microscopy, and Fourier-transform infrared spectroscopy were used to confirm the structure and morphology of the as-prepared nanospheres. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed for electrochemical characterizations different modified electrodes. It was revealed that the nanocomposite modified electrodes exhibited excellent electrochemical performances for electrooxidation of target analytes and could achieve ultra-sensitive detections. A linear relationship was observed between peak currents and concentrations in the ranges of 1.0 × 10
−9
to 5.0 × 10
−8
M (
R
2
= 0.9877), and 1.0 × 10
−7
to 5.0 × 10
−6
M (
R
2
= 0.9821) for cefotaxime with a detection limit (S/N = 3) of 1.0 × 10
−10
M. It can be deduced that the proposed sensor is suitable for the sensitive detection of cefotaxime in pharmaceutical samples.
A regioselective anti-hydrochlorination of unactivated alkynes is reported. The reaction utilizes in situ generated HCl as the source of both the Cl– and H+ and is catalyzed by palladium(II) ...acetate, with loadings as low as 25 ppm. Removable picolinamide and 8-aminoquinoline bidentate directing groups are used to control the regioselectivity of the chloropalladation step and stabilize the resulting alkenylpalladium(II) intermediate for subsequent protodepalladation. This method provides access to a broad array of substituted alkenyl chlorides in excellent yields and with high regioselectivity. The products from this transformation were successfully derivatized via Stille coupling to a variety of trisubstituted alkene products. Reaction progress kinetic analysis was performed, shedding light on a possible mechanism for this catalytic process.
Cancer is the most frequent life-threatening disease which has the highest mortality rate throughout the world. Diagnosis of cancer at the early stage can plays a critical role for its effective and ...successful treatment. Traditional diagnostic methods for cancer screening are costly, time-consuming, and not practical for repeated screenings. However, a biomarker-based cancer diagnosis is emerging as one of the most promising strategies for early diagnosis, monitoring disease progression, and subsequent cancer treatment. This review describes the recent advances and improvements in the electrochemical biosensors designed for detecting various cancer biomarkers using different signal transduction techniques and biological recognition strategies.
•Electrochemical biosensor helps to early diagnosis of cancer biomarkers.•Different electrochemical transduction system strategies are well explained.•More than 75 recent research articles on biosensors for cancer biomarker detection have been reviewed.•The advantages and future perspectives of each biosensor are highlighted.
Comparison based Analysis of Different FFT Architectures Pariyal, Priyanka S.; Koyani, Dhara M.; Gandhi, Daizy M. ...
International journal of image, graphics and signal processing,
06/2016, Letnik:
8, Številka:
6
Journal Article
Odprti dostop
A time-domain sequence is converted into an equivalent frequency-domain sequence using discrete Fourier transform. The reverse operation converts a frequency-domain sequence into an equivalent ...time-domain sequence using inverse discrete Fourier transform. Based on the discrete Fourier transform. Fast Fourier transform (FFT) is an effective algorithm with few computations. FFT is used in everything from broadband to 3G and Digital TV to radio LAN's. To improve its architecture different efficient algorithms are developed. This paper gives an overview of the work done by a different FFT processor previously. The comparison of different architecture is also discussed.
A highly sensitive electrochemical-based detector was fabricated to selectively sense methyl-parathion (MP). A Glassy carbon electrode (GCE) was functionalized with zinc oxide (ZnO) hollow spheres ...(ZnOHS) and a molecularly imprinted polymer (MIP) to form the developed sensor. Cyclic voltammetry (CV) was performed to synthesize a molecularly imprinted polymeric film on the ZnOHS modified GCE (GCE/ZnOHS) by electropolymerization of functional monomer, l-arginine (L-Arg), and template molecule, MP. The differential pulse voltammetry (DPV) was utilized to evaluate the efficiency of the electrochemical detection of MP under optimal conditions by the proposed sensor. The developed sensor recorded a good performance for detecting MP in the linear range of 5 × 10−9 to 0.1 × 10−4 mol L−1 (R2=0.985) with a detection limit (S/N = 3) of 0.5 × 10−9 mol L−1 and sensitivity of 571 nA/μmolL −1 cm −2. This electrochemical sensing system effectively detects MP in real samples with satisfactory recoveries of 90.4%, 91.9%, 118%, and 96.3% for fresh green beans, strawberry, tomato, and cabbage, respectively.
•Electrochemical biosensing platform helps to detect methyl parathion in environment.•ZnOHS arrayed MIP electrochemical sensor was developed for MP detection.•The developed GCE/ZnOHS/MIP sensor showed a sensitive and selective response to MP.•The proposed sensor showed good sensitivity, stability, and reproducibility.
In this work, we have successfully synthesized core-shell structured Au-PDA@SiO
nanospheres and decorated on reduced graphene oxide (rGO) modified glassy carbon electrode for the electrochemical ...detection of cefotaxime. The one-pot hydrothermal method was used to synthesis core-shell nanostructures by loading Au nanoparticles on polydopamine (PDA) coated SiO
nanospheres. The as-prepared Au-PDA@SiO
nanospheres were used to fabricate electrochemically reduced graphene oxide (rGO) modified glassy carbon electrode (Au-PDA@SiO
/rGO/GCE) for electrochemical determination of cefotaxime. Scanning electron microscopy, powder x-ray diffraction, transmission electron microscopy, and Fourier-transform infrared spectroscopy were used to confirm the structure and morphology of the as-prepared nanospheres. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed for electrochemical characterizations different modified electrodes. It was revealed that the nanocomposite modified electrodes exhibited excellent electrochemical performances for electrooxidation of target analytes and could achieve ultra-sensitive detections. A linear relationship was observed between peak currents and concentrations in the ranges of 1.0 × 10
to 5.0 × 10
M (R
= 0.9877), and 1.0 × 10
to 5.0 × 10
M (R
= 0.9821) for cefotaxime with a detection limit (S/N = 3) of 1.0 × 10
M. It can be deduced that the proposed sensor is suitable for the sensitive detection of cefotaxime in pharmaceutical samples.
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•Gold and silver nanoparticles are synthesized using the juice of Punica granatum.•The synthesized nanocatalysts are used in the degradation of organic dyes.•Pseudo first order ...kinetics is suggested and rate constants calculated.•Comparative study on percentage removal of dyes.•Phenolic hydroxyls play a vital role in the reduction of metal ions.
We present for the first time biogenic reduction and stabilization of gold and silver ions at room temperature using fruit juice of Punica granatum. The formation, morphology and crystalline structure of the synthesized nanoparticles are determined using UV–Visible, XRD and TEM. An attempt to reveal the partial role of phenolic hydroxyls in the reduction of Au3+ and Ag+ is done through FTIR analysis. The synthesized nanoparticles are used as potential catalysts in the degradation of a cationic phenothiazine dye, an anionic mono azo dye and a cationic fluorescent dye. The calculated values of percentage removal of dyes and the rate constants from pseudo first order kinetic data fit give a comparative study on degradation of organic dyes in presence of prepared gold and silver nanoparticles.
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