Kidney transplant recipients receive maintenance immunosuppressive therapy to avoid allograft rejection resulting in increased risk of infections and infection-related morbidity and mortality. ...Approximately 98% of adults are infected with varicella zoster virus, which upon reactivation causes herpes zoster. The incidence of herpes zoster is higher in kidney transplant recipients than in immunocompetent individuals, and kidney transplant recipients are at increased risk of severe herpes zoster-associated disease. Vaccination with adjuvanted recombinant glycoprotein E subunit herpes zoster vaccine (RZV) prevents herpes zoster in older adults with excellent efficacy (90%), and vaccination of kidney transplant candidates is recommended in Danish and international guidelines. However, the robustness and duration of immune responses after RZV vaccination, as well as the optimal timing of vaccination in relation to transplantation remain unanswered questions. Thus, the aim of this study is to characterize the immune response to RZV vaccination in kidney transplant candidates and recipients at different timepoints before and after transplantation. The Herpes Virus Infections in Kidney Transplant Patients (HINT) study is a prospective observational cohort study. The study will include kidney transplant candidates on the waiting list for transplantation (n = 375) and kidney transplant recipients transplanted since January 1, 2019 (n = 500) from all Danish kidney transplant centers who are offered a RZV vaccine as routine care. Participants are followed with repeated blood sampling until 12 months after inclusion. In the case of transplantation or herpes zoster disease, additional blood samples will be collected until 12 months after transplantation. The immune response will be characterized by immunophenotyping and functional characterization of varicella zoster virus-specific T cells, by detection of anti-glycoprotein E antibodies, and by measuring cytokine profiles. The study will provide new knowledge on the immune response to RZV vaccination in kidney transplant candidates and recipients and the robustness and duration of the response, potentially enhancing preventive strategies against herpes zoster in a population at increased risk.
Intercultural Communication, Negotiation, and Interpreting Kondo, Masaomi; Tebble, Helen; Alexieva, Bistra ...
CONFERENCE INTERPRETING: CURRENT TRENDS IN RESEARCH: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON INTERPRETING: WHAT DO WE KNOW AND HOW? (TURKU, AUGUST 25-27, 1994), Gambier, Yves, Gile, Daniel, & Taylor, Christopher Eds, Amsterdam: John Benjamins, 1997, pp 149-166,
1997, 19970801
Book Chapter
Elements of a panel discussion on the role of the interpreter in intercultural communication are reported. Levels of culture are discussed, & it is noted that, strictly speaking, all communications ...are intercultural. Various barriers in effective communication flow created by intercultural noise are listed; educational, professional, & popular aspects of cultural differences are distinguished. A set of scales describing prototypical characteristics of intercultural situations (ie, mode of delivery, elements of communicative situation, & use of language & nonlanguage codes) is described. It is argued that the interpreter ideally serves as linguistic & cultural mediator; however, a warning is issued against copying cultural mediation ideas from the separate discipline of translation studies. Mediation or equivalence problems on levels of text-structure & context embedding are noted. Strategies to enhance the interpreter's image as intercultural mediator in corporate environments are described. It is concluded that the desirable level of cultural mediation is situation-dependent & that intercultural awareness is especially important when interpreting from a culturally dominant language. 3 Figures. S. Paul
Getting Started in Interpreting Research Dimitrova, Birgitta Englund; Dam, Helle V; Dubslaff, Friedel ...
Across Languages and Cultures,
01/2002, Letnik:
3, Številka:
2
Book Review
