The number of B-lymphocytes was counted in 69 patients with diffuse toxic goiter (DTG) using a new method. The relative number of B-lymphocytes was investigated before therapy, one year and 2 years ...after it. The patients were divided into 2 groups (48 patients with endocrine ophthalmopathy and 39 patients without it). The investigation has shown that in the patients without endocrine ophthalmopathy the relative number of B-lymphocytes did not differ from control values, whereas in the patients with endocrine ophthalmopathy their number was elevated. These differences suggested an idea of the involvement of B-lymphocytes in the process of endocrine ophthalmopathy, that was confirmed by positive correlation (r = 0.38, p less than 0.001) between the relative number of B-lymphocytes before therapy and a degree of endocrine ophthalmopathy in one year. Thus, the relative number of B-lymphocytes before therapy can serve a marker of an outcome of endocrine ophthalmopathy.
The concentrations of vitamin E and malonic dialdehyde (MDA) were investigated in the blood serum of 146 patients with diffuse goiter of various degree of severity and in 35 controls with diffuse and ...nodular goiter without thyroid dysfunction. Vitamin E and MDA concentrations in patients with mild thyrotoxicosis did not differ from that in the controls. Vitamin E concentrations in patients with moderate and severe types of thyrotoxicosis were notably decreased and MDA concentration was elevated. The data on decreased vitamin E concentrations and increased MDA concentrations indicated vitamin E insufficiency in these patients. This fat-soluble antioxidant is recommended for multimodality therapy of thyrotoxicosis.
Altogether 93 patients with autoimmune thyroiditis were investigated. A great variability of the functional clinical symptomatology (from thyrotoxicosis up to manifest hypothyroidism) was revealed. ...Subclinical hypothyroidism was detected in a majority of patients. In some patients the clinical symptoms of thyrotoxicosis were combined with euthyroidism or subclinical hypothyroidism basing on the findings of the hormonal investigation which should be taken into account while choosing therapeutic tactics. Patients with autoimmune thyroiditis demonstrated a preserved circadian rhythm of cortisol secretion. Adrenocorticotropin-zinc-phosphate testing has shown good functional adrenocortical reserves; cortisol secretion did not depend on thyroid function nor did it differ from the indicator in the control group.
A rare case of adrenal myelolipoma Danis, Iu K; Chiaponis, I I; Gedminas, Iu A ...
Problemy ėndokrinologii,
1990 May-Jun, Letnik:
36, Številka:
3
Journal Article
The effect of pharmacopoeic human somatotropin (HS) produced by the Kaunas plant of endocrine preparations, on the proteic, lipid, carbohydrate and mineral metabolism was studied in 40 patients with ...hypothalamohypophyseal nanism (HHN). The experiments were performed before treatment on an empty stomach, 4 hs after HS administration in a dose of 4 I. U. and during the course of treatment (with 1-2 or 3-4 monthly intervals). The HS administration resulted in the increase of urea, phosphorus and alkaline phosphatase levels, decreased those of beta-lipoproteins, potassium and sodium and caused the redistribution of proteic fractions in the blood of HHN patients. Simultaneous reduction of the urea, creatinine and phosphoric excretion in lime with enhanced urinary excretion of potassium was observed. During a long-term intermittent HS therapy no changes were revealed in carbohydrate metabolism in HHN patients.
Altogether 18 female patients and one male patient with autoimmune thyroiditis aged 17 to 57 were investigated before and during thyroidin therapy. A basal raised level of immunoreactive calcitonin ...(iCT) was revealed in 4 patients, that of immunoreactive parathormone (iPTH) in 11 patients. The authors discussed the causes of the elevation of iCT and iPTH levels in patients with autoimmune thyroiditis. A transient character of a rise of the content of these hormones was noted. The authors suggested that in raised iCT and iPTH levels assessment of C-cell and parathyroid function should be repeated in patients with autoimmune thyroiditis after compensation of the main disease.
