Football is, arguably, the most globalized sport in the world. Since the official date of its foundation, back in 1863, it has spread around the planet, reaching almost every country. Over time, ...Football roots grew so attached to society that it is a valid indicator to understand how the social order responds to general crises. In 1911 in the IFA Shield tournament when Mohun Bagan defeated the British side, East Yorkshire Regiment, and took home the shield. This was Indian football's 'Lagaan' moment. Even during the period between 1950 and 1962 is often considered to be the 'Golden Era' of Indian football, so much so that India was often referred to as the 'Brazil of Asia'. But where are we now? The latest FIFA rankings places India at the 105th position. We are a country of 1.3 billion people failing to produce a well-built set of players, who can challenge European, South American, or even our South Asian counterparts consistently. So, it certainly begs the question: Where are we going wrong?
This work introduces Symbiotic Organism Search (SOS) for solving stability related problems. SOS is a new and robust approach in met heuristic fields and never been used to solve discrete problems. A ...sophisticated method to deal with stability related problem that is applied using the basic Symbiotic Organism Search (SOS) framework. The performance of the algorithm was evaluated on a set of benchmark instances and compared results with best known solution. The results show that the proposed algorithm can produce good solution. These results indicated that the proposed SOS can be applied as an alternative to solve the stability related issue. SOS algorithm is an effective met heuristic developed in 2014, which mimics the symbiotic relationship among the living beings, such as mutualism, commensalism, and parasitism, to survive in the ecosystem. In this study, three modified versions of the SOS algorithm are proposed by introducing adaptive benefit factors in the basic SOS algorithm to improve its efficiency.
In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis. ...Platelets' hemostatic and non‐hemostatic functions are mediated by the expression of various membrane receptors and the release of proteins, ions and other mediators. Therefore, specific activities of platelets responsible for the non‐hemostatic disease are to be inhibited while leaving the platelet's hemostatic function unaffected. Platelets' anti‐aggregatory property has been used as a primary criterion for antiplatelet drugs/bioactives; however, their non‐hemostatic activities are not well known. This review describes the hemostatic and non‐hemostatic function of human blood platelets and the modulatory effects of bioactive food components.
Practical applications
In this review, we have discussed the antiplatelet effects of several food components. These bioactive compounds inhibit both hemostatic and non‐hemostatic pathways involving blood platelet. Platelets have emerged as critical biological factors of normal and pathologic vascular healing and other diseases such as cancers and inflammatory and immune disorders. The challenge for therapeutic intervention in these disorders will be to find drugs and bioactive compounds that preferentially block specific sites implicated in emerging roles of platelets' complicated contribution to inflammation, tumour growth, or other disorders while leaving at least some of their hemostatic function intact.
A comprehensive overview of platelet multifunctional roles in CVD and other diseases and the effects of food components' modulatory effects are described.
