Background
Several associations between microsatellite instability (MSI) and other clinicopathological factors have been reported in gastric cancer, but the results have been ambiguous. This ...systematic review and meta‐analysis investigated the relationship between MSI and overall survival and clinicopathological characteristics of patients with gastric cancer.
Methods
A systematic literature search of the PubMed, Cochrane and Ovid databases until 31 January 2016 was performed in accordance with the PRISMA statement. The articles were screened independently according to PICO (population, intervention, comparator, outcome) eligibility criteria. All eligible articles were evaluated independently by two reviewers for risk of bias according to the Quality In Prognosis Study tool.
Results
Overall, 48 studies with a total of 18 612 patients were included. MSI was found in 9·2 per cent of patients (1718 of 18 612), and was associated with female sex (odds ratio (OR) 1·57, 95 per cent c.i. 1·31 to 1·89; P < 0·001), older age (OR 1·58, 2·20 to 1·13; P < 0·001), intestinal Laurén histological type (OR 2·23, 1·94 to 2·57; P < 0·001), mid/lower gastric location (OR 0·38, 0·32 to 0·44; P < 0·001), lack of lymph node metastases (OR 0·70, 0·57 to 0·86, P < 0·001) and TNM stage I–II (OR 1·77, 1·47 to 2·13; P < 0·001). The pooled hazard ratio for overall survival of patients with MSI versus those with non‐MSI gastric cancer from 21 studies was 0·69 (95 per cent c.i. 0·56 to 0·86; P < 0·001).
Conclusion
MSI in gastric cancer was associated with good overall survival, reflected in several favourable clinicopathological tumour characteristics.
Microsatellite instabililty subgroup does better
Bounces of a marble and Zeno’s paradox Luca, R De; Mauro, M Di; Naddeo, A
Journal of physics. Conference series,
05/2021, Letnik:
1929, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Abstract
The coefficient of restitution of the bounces of a marble on a table is here studied and measured in terms of the total bouncing time. Interesting links arise with mathematics (geometric ...series) as well as philosophy (Zeno’s paradox), which make our proposal appealing for an interdisciplinary teaching-learning sequence. The relevance of this work for high school and undergraduate students is discussed with emphasis on students’ misconceptions when dealing with infinite processes.
Research is required to monitor changes in the nature of neurobehavioral deficits in extremely preterm (EP) or extremely low birth weight (ELBW) survivors. This study examines cognitive, academic, ...and behavioral outcomes at age 8 years for a regional cohort of EP/ELBW children born in 1997.
The EP/ELBW cohort comprised all live births with a gestational age <28 weeks (EP) or birth weight <1000 g (ELBW) born in the state of Victoria, Australia, in 1997. Of 317 live births, 201 (63.4%) survived to 2 years of age.A term/normal birth weight (T/NBW) cohort was recruited comprising 199 infants with birthweights ≥2500 g or gestational age ≥37 weeks corrected. Measures of intellectual ability, educational achievement, and behavior were administered at age 8.
Retention was 94% for the EP/ELBW group and 87% for the T/NBW group. The EP/ELBW group performed poorer than the T/NBW group on measures of IQ, educational achievement, and certain behavioral domains, even after adjustment for sociodemographic factors and exclusion of children with neurosensory impairment. The rate of any neurobehavioral impairment was elevated in the EP/ELBW group (71% vs 42%), and one-half of subjects had multiple impairments. The outcomes for those with <750 g birth weight or <26 weeks' gestational age were similar to those with a birth weight of 750 to 999 g or a gestational age of 26 to 27 weeks, respectively.
Despite ongoing improvements in the management of EP/ELBW infants, the rate of neurobehavioral impairment at school-age remains too high relative to controls.
•A mathematical model for fluid dynamics in a rotating bidispersive porous medium, horizontally isotropic, is introduced.•Linear and nonlinear stability analyses for thermal convection are ...performed.•The coincidence between linear instability and non-linear stability thresholds has been proved.•The influence of a uniform rotation on the onset of convection has been examined.
Linear and nonlinear stability analyses for thermal convection in a rotating bidispersive porous medium, horizontally isotropic, is performed. Since the coincidence between linear instability and non-linear stability thresholds has been proved, the linear theory captures completely the physics of the problem at stake.
This study examined fatigue in patients treated for childhood acute lymphoblastic leukemia (ALL) over a 2-year period (3- to 27-months post-treatment completion), from the perspective of children and ...parent caregivers, compared to a healthy comparison group.
Eighty-three patients (4-16 years at enrolment) and their parents, reported on the child's fatigue using the Pediatric Quality of Life Inventory- Multidimensional Fatigue Scale (PedsQL-MFS), at 3- 15- and 27-months post-treatment completion, and 53 healthy children and their parents reported on fatigue across the same timepoints.
Parent proxy-reporting showed that parents of ALL patients reported more total fatigue than parents of the comparison group at all time points, with all subscales elevated (general, cognitive, and sleep/rest fatigue). In contrast, patient self-report of fatigue over this period differed from the comparison children for the general fatigue subscale only. Self-reported total fatigue was worse than the comparison group at the 27-month timepoint, with cognitive and sleep/rest fatigue symptoms contributing to this difference. Expected improvements in fatigue over time were not evident in either patient or parent report and no demographic risk factors were identified. Parents and children from both groups reported significantly more fatigue at all time points compared to commonly utilised normative population data.
Patients treated for childhood ALL are impacted by fatigue symptoms in the post-treatment and early survivorship period. These findings highlight that patients in the 2-years following treatment require increased symptom surveillance and may benefit particularly from interventions that target cognitive and sleep/rest fatigue.
ABSTRACT
Two meteorite pieces have been recovered in Italy, near the town of Cavezzo (Modena), on 2020 January 4th. The associated fireball was observed on the evening of New Year’s Day 2020 by eight ...all-sky cameras of the PRISMA fireball network, a partner of FRIPON. The computed trajectory had an inclination angle of approximately 68° and a velocity at infinity of 12.8 km s−1. Together with the relatively low terminal height, estimated as 21.5 km, those values were indicating the significant possibility of a meteorite dropping event, as additionally confirmed by the non-zero residual total mass. The strewn-field was computed taking into account the presence of two bright light flashes, revealing that the meteoroid had been very likely subject to fragmentation. Three days after the event, two samples, weighing 3.1 and 52.2 g, were collected as a result of a dedicated field search and thanks to the involvement of the local people. The two pieces were immediately recognized as freshly fallen fragments of meteorite. The computed orbital elements, compared with the ones of known Near-Earth Asteroids from the NEODyS database, are compatible with one asteroid only; 2013 VC10. The estimated original mass of the meteoroid, 3.5 kg, and size, approximately 13 cm, is so far the smallest among the current 35 cases in which meteorites were recovered from precise strewn-field computation thanks to observational data. This result demonstrates the effectiveness of accurate processing of fireball network data even on challenging events generated by small size meteoroids.
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