Neoadjuvant strategies for non-small cell lung cancer De Marinis, Filippo; Migliorino, Maria Rita; Mancuso, Andrea ...
I supplementi di Tumori : official journal of Societa italiana di cancerologia ... et al.,
2004 Mar-Apr, Letnik:
3, Številka:
2
Journal Article
The peristaltic activity of the guinea‐pig ileum was studied in the absence and in the presence of the blockade of GABA
A
receptors.
Bicuculline (1–30 μ
m
), improved at the highest concentrations ...the efficiency of peristalsis by enhancing the frequency of propulsive contractions and the amount of fluid ejected per unit of time.
Neither SR 95531 (0.3–10 μ
m
), a novel GABA
A
receptor antagonist, which competitively antagonized 3‐aminopropane sulphonic acid induced contractions in myenteric plexus‐longitudinal muscle preparations (pA
2
value: 6.47), nor picrotoxinin (1–30 μ
m
) modified peristaltic parameters or influenced the potentiating effect of bicuculline on peristaltic activity.
In myenteric plexus‐longitudinal muscle preparations, bicuculline (1–30 μ
m
) enhanced the amplitude of electrically‐induced cholinergic contractions without modifying submaximal contractions to applied acetylcholine. SR 95531 and picrotoxinin had no effect on twitch amplitude. In the presence of each of these compounds, bicuculline retained its potentiating effect.
The results obtained with SR 95531 and picrotoxinin question the view that GABA
A
receptors may exert a critical role in intestinal propulsion by modulating the activity of nerve pathways subserving peristalsis. Bicuculline potentiates the peristaltic activity of the ileum probably via a facilitatory effect on enteric cholinergic transmission that is independent of GABA
A
receptor blockade.
1
The peristaltic activity of the guinea‐pig ileum was studied in the absence and in the presence of the blockade of GABAA receptors.
2
Bicuculline (1–30 μm), improved at the highest concentrations ...the efficiency of peristalsis by enhancing the frequency of propulsive contractions and the amount of fluid ejected per unit of time.
3
Neither SR 95531 (0.3–10 μm), a novel GABAA receptor antagonist, which competitively antagonized 3‐aminopropane sulphonic acid induced contractions in myenteric plexus‐longitudinal muscle preparations (pA2 value: 6.47), nor picrotoxinin (1–30 μm) modified peristaltic parameters or influenced the potentiating effect of bicuculline on peristaltic activity.
4
In myenteric plexus‐longitudinal muscle preparations, bicuculline (1–30 μm) enhanced the amplitude of electrically‐induced cholinergic contractions without modifying submaximal contractions to applied acetylcholine. SR 95531 and picrotoxinin had no effect on twitch amplitude. In the presence of each of these compounds, bicuculline retained its potentiating effect.
5
The results obtained with SR 95531 and picrotoxinin question the view that GABAA receptors may exert a critical role in intestinal propulsion by modulating the activity of nerve pathways subserving peristalsis. Bicuculline potentiates the peristaltic activity of the ileum probably via a facilitatory effect on enteric cholinergic transmission that is independent of GABAA receptor blockade.
PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to ESA in May 2013 as a large-class mission for investigating within the framework of the ESA Cosmic Vision program a set of ...important scientific questions that require high resolution, high sensitivity, full-sky observations of the sky emission at wavelengths ranging from millimeter-wave to the far-infrared. PRISM's main objective is to explore the distant universe, probing cosmic history from very early times until now as well as the structures, distribution of matter, and velocity flows throughout our Hubble volume. PRISM will survey the full sky in a large number of frequency bands in both intensity and polarization and will measure the absolute spectrum of sky emission more than three orders of magnitude better than COBE FIRAS. The aim of this Extended White Paper is to provide a more detailed overview of the highlights of the new science that will be made possible by PRISM
Blends of natural and synthetic polymers were studied for potential applications in the biomedical field. Collagen and hyaluronic acid were mixed in aqueous solution with poly(vinyl alcohol) and ...poly(acrylic acid). The properties of the blends were studied by differential scanning calorimetry and dynamic mechanical thermal analysis. Some methods were also investigated to enhance the miscibility of the polymers in these blends.
PRISM (Polarized Radiation Imaging and Spectroscopy Mission) was proposed to ESA in response to the Call for White Papers for the definition of the L2 and L3 Missions in the ESA Science Programme. ...PRISM would have two instruments: (1) an imager with a 3.5m mirror (cooled to 4K for high performance in the far-infrared---that is, in the Wien part of the CMB blackbody spectrum), and (2) an Fourier Transform Spectrometer (FTS) somewhat like the COBE FIRAS instrument but over three orders of magnitude more sensitive. Highlights of the new science (beyond the obvious target of B-modes from gravity waves generated during inflation) made possible by these two instruments working in tandem include: (1) the ultimate galaxy cluster survey gathering 10e6 clusters extending to large redshift and measuring their peculiar velocities and temperatures (through the kSZ effect and relativistic corrections to the classic y-distortion spectrum, respectively) (2) a detailed investigation into the nature of the cosmic infrared background (CIB) consisting of at present unresolved dusty high-z galaxies, where most of the star formation in the universe took place, (3) searching for distortions from the perfect CMB blackbody spectrum, which will probe a large number of otherwise inaccessible effects (e.g., energy release through decaying dark matter, the primordial power spectrum on very small scales where measurements today are impossible due to erasure from Silk damping and contamination from non-linear cascading of power from larger length scales). These are but a few of the highlights of the new science that will be made possible with PRISM.
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