•359 NPC patients were involved from 2011 to 2014 and were followed up to March 2019.•CNI was constructed to reflect integrated nutrition status and was appropriate in NPC patients.•ETORC QLQ-C30 and ...QLQ-H&N35 was combined to assess the QoL detailed at three points.•Lower CNI correlated worse QoL and OS, CNI was an independent prognostic factor of OS.
The aim of this study was to investigate the relationship between a comprehensive nutritional index (CNI) and QoL in patients with NPC who undergo IMRT and to explore the relationship between CNI and survival.
359 patients with newly diagnosed NPC were enrolled. QoL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 and Quality of Life Questionnaire Head and Neck Cancer Module at three time points: before, immediately after, and 3 months after IMRT. The CNI comprised five values including body mass index, usual body weight percentage, hemoglobin, albumin, and total lymphocyte count, and was evaluated before and immediately after IMRT. The correlation between the CNI and QoL and the effect of CNI on prognosis were analysed.
QoL and CNI scores decreased remarkably after IMRT (P < 0.05). The CNI was quite low in patients with III–IV clinical tumor stage and those undergoing induction chemotherapy plus concurrent chemotherapy. After IMRT, lower CNI score correlated worse QoL (P < 0.05). The Kaplan-Meier curve indicated that patients with lower CNI had significantly poorer survival outcomes (P = 0.02). In multivariate analysis, CNI remained an independent prognostic factor of overall survival (P = 0.046).
CNI can be recommended as an appropriate indicator reflecting the integrated nutrition status of NPC patients. Low CNI was associated with poor QoL and predicted a poor survival outcome. More interventions should be taken to improve the nutrition status of NPC patients to improve QoL and enhance survival outcomes.
Solvent molecules, especially coordinated solvent molecules, vastly affect the energetic properties of energetic coordination polymers (ECPs). Therefore, an effective strategy to maintain energetic ...properties is to reduce solvent molecules. In this paper, a nitrogen-rich energetic coordination polymer Cu(HBTT)(H2O)n (ECP 1) was synthesized and prepared by integrating the coordination mode. Its properties were adequately investigated, including crystal structure, thermal stability, energetic properties, and sensitivity. In terms of application, it was researched as catalysts for the thermal decomposition of AP and as a primary explosive for laser initiation. As revealed by single-crystal X-ray diffraction results, it crystallizes in and belongs to monoclinic space group P21/n with a 2D layer-like structure. Meanwhile, it has outstanding thermal stability (Tp = 357.2 °C, Ek = 201.78 kJ mol-1) according to differential scanning calorimetry (DSC) curves and thermogravimetric curves (TG). The detonation velocity and detonation pressure of ECP 1 (8.63 km s-1, 36.73 GPa) can bear comparison with RDX and HMX. The catalytic pyrolysis experiment indicates that AP/ECP 1 (10 wt%) can accelerate the thermal decomposition of AP, with the high temperature for decomposition decreasing to nearly 80 °C. The activation energy (Ek) of AP decreased from 217.36 kJ mol-1 to 185.96 kJ mol-1 by adding ECP 1. Meanwhile, ECP 1 has a preliminary response to laser initiation. These results are conducive to the quick development of ECPs.
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•ECP 1(Cu(HBTT)(H2O)n·nH2O) crystallizes in monoclinic and belongs to space group P21/n with 2D layer-like structure.•The ECP 1featured high-resistance (Tp = 357.2 °C, Ek = 201.78 kJ mol-1).•The addition of ECP 1promoted the thermal decomposition of AP and the HTD decomposition of AP was reduced to approximately 80 °C.•The detonation of ECP 1 occurred corresponding to 1.7 J initiation threshold.
Forest Stock Volume (FSV) is one of the key indicators in forestry resource investigation and management on local, regional, and national scales. Limited by the saturation problems of optical ...satellite remote-sensing imagery in the retrieving of stock volume, and the high cost of Light Detection And Ranging (LiDAR) data, it is still challenging to estimate FSV in a large area using single-sensor remote-sensing data. In this paper, a method integrated multispectral satellite imagery and LiDAR data was developed to map stock volume in a large area. A random forest model was adopted to estimate the stock volume of larch forest in China based on the training samples from the Airborne Laser Scanning (ALS)-derived stock volume and corresponding Sentinel-2 imagery. Validation using National Forest Inventory (NFI) data, ALS-derived stock volume and ground investigation data demonstrated that the estimated stock volume had a high accuracy (R
2
= 0.59, RMSE = 59.69 m
3
/ha, MD = 39.96 m
3
/ha when validated with NFI data; R
2
ranged from 0.77 to 0.85, RMSE ranged from 38.68 m
3
/ha to 67.38 m
3
/ha, MD ranged from 24.90 m
3
/ha to 37.27 m
3
/ha when validated with ALS stock volume; R
2
= 0.42, RMSE = 79.10 m
3
/ha, MD = 62.06 m
3
/ha when validated with field investigation data). Results of this paper indicated the applicability of estimating stock volume of larch forest in a large area by combining Sentinel-2 data and airborne LiDAR data.
In this paper, we establish the stable results for a system of simultaneous generalized vector quasi-equilibrium problems (SSGVQEP) by using its bounded rationality model. Under the abstract frame, a ...unified well-posedness on Hadamard types and Tikhonov types well-posedness for SSGVQEP is introduced. Moreover, sufficient condition for the well-posedness of SSGVQEP is given. Finally, we prove that the majority (in Baire category sense) of SSGVQEP is structural stability.
SATB2 (Special AT-rich sequence-binding protein 2) has recently been shown to be a specific biomarker of colorectal cancer (CRC). The aim of this study was to investigate the diagnostic potential of ...SATB2 as a means of detecting a CRC origin for liver metastases. SATB2 expression was examined in a resection cohort of 101 CRC and 273 non-CRC adenocarcinoma samples using immunohistochemistry (IHC). The diagnostic accuracy of CRC origins of liver metastases based on SATB2 and a three marker panel of SATB2, CK20 and CDX2 was evaluated using an independent cohort of 192 liver biopsies. IHC showed 97 of the 101 (96.0%) primary CRC samples were SATB2 positive, compared to only 6 of the 273 (2.1%) samples of other cancer types. The sensitivity, specificity and AUC values of SATB2 expression in resection samples were 97%, 97.1% and 0.977, respectively. Meanwhile, for the liver biopsy samples, the sensitivity, specificity and AUC values of a CRC liver metastases was 92.2%, 97.8% and 0.948 for SATB2, 95.1%, 91.0% and 0.959 for CK20, and 100%, 85.4% and 0.976 for CDX2, respectively. Further analysis demonstrated that all three-marker positivity was detected in 92/103 (89.3%) CRC and 2/89 (2.2%) non-CRC liver metastases sampled by biopsy. Our findings suggest that SATB2, as measured by IHC, could serve as a promising diagnostic biomarker of CRC metastases. Combining evaluation of SATB2 with CK20 and CDX2 to form a three marker panel further improved the detection of metastatic CRCs in liver biopsy tissues.
•SATB2 protein could serve as a promising diagnostic biomarker of CRC.•SATB2 expression can distinguish liver metastases with CRC origins from other forms of adenocarcinoma.•A three marker panel of SATB2, CK20 and CDX2 used on liver biopsy samples is valuable when assessing g a CRC origin.
Liver metastasis is the leading cause of cancer-related morbidity and mortality in colorectal cancer (CRC) patients. Since histological diagnosis from liver needle biopsy is based solely on tiny fragments of tissue, it can sometimes be quite difficult to distinguish CRC from non-CRCs. Thus, there is a current need for searching and identifying of specific biomarkers that can improve the accuracy of diagnosis. Our results indicate that SATB2 could serve as a promising diagnostic biomarker of CRC metastases; and that a three marker panel of SATB2, CK20 and CDX2 used on liver biopsy samples is valuable.
Necrotizing enterocolitis (NEC) is a devastating intestinal complication that occurs mainly in very-low-birth-weight infants (VLBWI). The study's aim was to investigate the possibility of early ...prediction of NEC on postnatal day 1 based on superior mesenteric artery (SMA) doppler ultrasonograpy.
A prospective, observational, nested case control study (ChiCTR1900026197) was conducted to enroll VLBWIs (birth weight <1,500 grams) between October 2019 and September 2021. Doppler ultrasound measurement was done during the first 12 h of life and before first feeding. Infants developing NEC (stage II or III) subsequently were included in NEC group and infants spare of NEC were included in control group.
370 VLBWIs were enrolled (30 NEC cases). Among the ultrasound parameters, S/D was significantly higher in the NEC group (OR: 2.081, 95% CI: 1.411-3.069,
= 0.000). The area under the receiver operating curve (AUROC) following the Logistic regression was 0.704 (95% CI: 0.566-0.842,
= 0.001). The sensitivity of S/D for predicting NEC was 52.2% and the specificity was 92.7%. The critical value of S/D was 6.944 and Youden index was 0.449. Preplanned subgroup analysis confirmed that NEC infants of different stages were characterized by different SMA bloodstream. Small for gestational age (SGA) might be a confounding factor affecting intestinal bloodflow. And infants with delayed initiation or slow advancement of feeding exhibited characteristic intestinal perfusion.
In VLBWI, early SMA ultrasound shows the potential to predict NEC. It is reasonable to speculate that SMA bloodstream is related to intestinal structural and functional integrity.
Several studies have implicated estrogen and the estrogen receptor (ER) in the pathogenesis of benign prostatic hyperplasia (BPH); however, the mechanism underlying this effect remains elusive. In ...the present study, we demonstrated that estrogen (17β-estradiol, or E2)-induced activation of the G protein-coupled receptor 30 (GPR30) triggered Ca2+ release from the endoplasmic reticulum, increased the mitochondrial Ca2+ concentration, and thus induced prostate epithelial cell (PEC) apoptosis. Both E2 and the GPR30-specific agonist G1 induced a transient intracellular Ca2+ release in PECs via the phospholipase C (PLC)-inositol 1, 4, 5-triphosphate (IP3) pathway, and this was abolished by treatment with the GPR30 antagonist G15. The release of cytochrome c and activation of caspase-3 in response to GPR30 activation were observed. Data generated from the analysis of animal models and human clinical samples indicate that treatment with the GPR30 agonist relieves testosterone propionate (TP)-induced prostatic epithelial hyperplasia, and that the abundance of GPR30 is negatively associated with prostate volume. On the basis of these results, we propose a novel regulatory mechanism whereby estrogen induces the apoptosis of PECs via GPR30 activation. Inhibition of this activation is predicted to lead to abnormal PEC accumulation, and to thereby contribute to BPH pathogenesis.
•GPR30 activation mediates the apoptosis of prostate epithelial cells (PECs).•GPR30-mediated PEC apoptosis is calcium-dependent.•Treatment with a GPR30 agonist rescues TP-induced prostatic epithelial hyperplasia.•GPR30 abundance is negatively associated with prostate volume.•The GPR30-induced abnormal accumulation of PECs contributes to BPH pathogenesis.
Levosimendan, a calcium sensitizer and potassium channel opener, has been demonstrated to improve myocardial function without increasing oxygen consumption and to show protective effects in other ...organs. Recently, a prospective, randomized controlled trial (RCT) revealed an association between levosimendan use and a possible increased risk of bleeding postoperatively. Levosimendan's anti-platelet effects have been shown in in vitro studies. Current studies do not provide sufficient data to support a relation between perioperative levosimendan administration and increased bleeding risk.
Our goal was to investigate the relation between perioperative levosimendan administration and increased bleeding risk using a meta-analysis study design.
The PubMed, Ovid, EMBASE and Cochrane Library databases were searched for relevant RCTs before July 1, 2019. The outcome parameters included reoperation secondary to increased bleeding in the postoperative period, the amount of postoperative recorded blood loss, and the need for transfusion of packed red blood cells (RBCs) and other blood products.
A total of 1160 patients in nine RCTs (576 in the levosimendan group and 584 in the control group) were included according to our inclusion criteria. Analysis showed that perioperative levosimendan administration neither increased the rate of reoperation secondary to bleeding nor increased the amount of postoperative chest tube drainage when compared with the control group. In terms of blood product transfusion, levosimendan did not influence the requirement for RBC transfusion, platelet transfusion nor fresh frozen plasma (FFP) transfusion. Levosimendan also did not shorten or prolong the aortic cross-clamp time or the cardiopulmonary bypass time.
The analyzed parameters, including reoperations due to bleeding, postoperative chest drainage and the requirement for blood products, revealed that levosimendan did not increase postoperative bleeding risk. More studies with a larger sample size are needed to address a more reliable conclusion due to study limitations.
Objective
To observe the clinical efficacy of Tuina (Chinese therapeutic massage) manipulation for pediatric adenoid hypertrophy (AH).
Methods
A total of 60 children with AH were randomized into an ...observation group and a medication group, with 30 cases in each group. The observation group was treated with pediatric Tuina treatment, and the medication group was treated with 0.05% mometasone furoate nasal spray. The changes of main clinical symptom score, quality of life (QOL) score and X-ray nasopharynx lateral film were observed, and the clinical efficacy was evaluated.
Results
The total effective rate of the observation group was 90.0%, and that of the medication group was 66.7%. The difference between the two groups was statistically significant (
P
<0.05). After treatment, the A/N value ratio of adenoid thickness (A) and nasopharyngeal cavity width (N) of posterior nasopharyngeal lateral film did not show significant change in either group (
P
>0.05). After treatment, the clinical symptom scores in both groups decreased, and the intra-group differences were statistically significant (
P
<0.001), but there was no statistical difference between the two groups (
P
>0.05). After treatment, the QOL scores of children in both groups decreased, and the intra-group differences were statistically significant (
P
<0.001), and the difference between the two groups was statistically significant (
P
<0.001).
Conclusion
Tuina manipulation is effective in treating pediatric AH, and produces a better effect in improving traditional Chinese medicine symptoms and QOL than 0.05% mometasone furoate nasal spray.
To explore the effect of green channel for stroke patients on the treatment of severe aneurysmal subarachnoid hemorrhage.
This is a retrospective case-control study. The clinical data of patients ...with severe aneurysmal subarachnoid hemorrhage admitted to the emergency department of our hospital from January 2015 to June 2022 were retrospectively analyzed. Patients diagnosed with subarachnoid hemorrhage, confirmed intracranial aneurysm by preoperative CT angiography or digital subtraction, graded Hunt-Hess grade III, IV, and V, < 72 h from the onset to the time of consultation received surgical treatment in our hospital were included in this study. Patients with serious underlying diseases, such as heart, liver, kidney diseases, or malignant tumors, traumatic subarachnoid hemorrhage, previous history of cerebral hemorrhage, and incomplete data were excluded. The control group included patients with severe aneurysmal subarachnoid hemorrhage admitted from January 2015 to December 2018 before the establishment of the green channel for stroke patients, and the observation group included patients with severe aneurysmal subarachnoid hemorrhage admitted from January 2019 to June 2022 after the establishment of the green channel. The control group received routine treatment in the emergency department; the observation group received improved treatment of green channel for stroke patients. Gender, age, Hunt-Hess grade on admission, modified Rankin scale (mRS) on admission, aneurysm location, aneurysm size and whether accompanied by intracerebral hemorrhage, the time from onset to emergency department, the time from emergency department to vascular diagnostic examination, the time from onset to surgery, the time from emergency department to surgery, the time from hospital admission to surgery, length of hospital stay, complications, treatment effect were analyzed and compared between the 2 groups. SPSS 23.0 software was utilized to conduct comparisons between the 2 groups. The t-test, Chi-square test, or Mann-Whitney U test was chosen based on the data type. Statistical significance was established when p < 0.05.
A total of 71 patients were included in this study, of whom 37 were in the control group and 34 were in the observation group. There were no statistical differences in age, gender, Hunt-Hess grade, mRS scores, aneurysm location, aneurysm size, intracerebral hemorrhage, the time from onset to emergency department, length of hospital stay, complications between the observation group and the control group (all p > 0.05). The time (min) from visit to vascular diagnostic test (60.50 vs. 120.00, p = 0.027), the time (min) from onset to surgery (1792.00 vs. 2868.00, p = 0.023), the time (min) from emergency department to surgery (1568.50 vs. 2778.00, p = 0.016), the time (min) from hospital admission to surgery (1188.50 vs. 2708.00, p = 0.043), all of them were shorter in the observation group than those in the control group. The relative values of admission and 7-day postoperative mRS scores and the relative values of admission and discharge mRS scores ≥ 2 were used as the criteria for determining better efficacy, and the treatment effect was better than that in the control group, and the differences were statistically significant (admission to 7 days postoperative mRS score ≥ 2, 17 (50.0 %) vs. 8 (21.6 %), p = 0.012; admission to discharge mRS score ≥ 2, 19 (55.9 %) vs. 11 (29.7 %), p = 0.026).
The green channel for stroke patients with severe aneurysmal subarachnoid hemorrhage can effectively shorten the time from arrival at the emergency department to vascular diagnostic examination and the time from the emergency department to surgery, and achieve a better therapeutic effect, which is worth popularizing and applying.
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