Structured light Forbes, Andrew; de Oliveira, Michael; Dennis, Mark R.
Nature photonics,
04/2021, Letnik:
15, Številka:
4
Journal Article
Recenzirano
All light has structure, but only recently has it been possible to control it in all its degrees of freedom and dimensions, fuelling fundamental advances and applications alike. Here we review the ...recent advances in ‘pushing the limits’ with structured light, from traditional two-dimensional transverse fields towards four-dimensional spatiotemporal structured light and multidimensional quantum states, beyond orbital angular momentum towards control of all degrees of freedom, and beyond a linear toolkit to include nonlinear interactions, particularly for high-harmonic structured light. Using a simple interference argument, centuries old, we weave a story that highlights the common nature of seemingly diverse structures, presenting a modern viewpoint on the classes of structured light, and outline the possible future trends and open challenges.Recent effort in controlling the structure of light in all its degrees of freedom and dimensions has pushed the limits of structured light and broadened its potential beyond orbital angular momentum, two-dimensional fields, qubits and biphotons, and linear optical manipulation.
Structured light has revolutionized optical particle manipulation, nano-scaled material processing, and high-resolution imaging. In particular, propagation-invariant light fields such as Bessel, ...Airy, or Mathieu beams show high robustness and have a self-healing nature. To generalize such beneficial features, these light fields can be understood in terms of caustics. However, only simple caustics have found applications in material processing, optical trapping, or cell microscopy. Thus, these technologies would greatly benefit from methods to engineer arbitrary intensity shapes well beyond the standard families of caustics. We introduce a general approach to arbitrarily shape propagation-invariant beams by smart beam design based on caustics. We develop two complementary methods, and demonstrate various propagation-invariant beams experimentally, ranging from simple geometric shapes to complex image configurations such as words. Our approach generalizes caustic light from the currently known small subset to a complete set of tailored propagation-invariant caustics with intensities concentrated around any desired curve.
Knots are topological structures describing how a looped thread can be arranged in space. Although most familiar as knotted material filaments, it is also possible to create knots in singular ...structures within three-dimensional physical fields such as fluid vortices1 and the nulls of optical fields2–4. Here we produce, in the transverse polarization profile of optical beams, knotted lines of circular transverse polarization. We generate and observe both simple torus knots and links as well as the topologically more complicated figure-eight knot. The presence of these knotted polarization singularities endows a nontrivial topological structure on the entire three-dimensional propagating wavefield. In particular, the contours of constant polarization azimuth form Seifert surfaces of high genus5, which we are able to resolve experimentally in a process we call seifertometry. This analysis reveals a level of topological complexity, present in all experimentally generated polarization fields, that goes beyond the conventional reconstruction of polarization singularity lines.
Purpose To update the ASCO guideline for antiemetics in oncology. Methods ASCO convened an Expert Panel and conducted a systematic review of the medical literature for the period of November 2009 to ...June 2016. Results Forty-one publications were included in this systematic review. A phase III randomized controlled trial demonstrated that adding olanzapine to antiemetic prophylaxis reduces the likelihood of nausea among adult patients who are treated with high emetic risk antineoplastic agents. Randomized controlled trials also support an expanded role for neurokinin 1 receptor antagonists in patients who are treated with chemotherapy. Recommendation Key updates include the addition of olanzapine to antiemetic regimens for adults who receive high-emetic-risk antineoplastic agents or who experience breakthrough nausea and vomiting; a recommendation to administer dexamethasone on day 1 only for adults who receive anthracycline and cyclophosphamide chemotherapy; and the addition of a neurokinin 1 receptor antagonist for adults who receive carboplatin area under the curve ≥ 4 mg/mL per minute or high-dose chemotherapy, and for pediatric patients who receive high-emetic-risk antineoplastic agents. For radiation-induced nausea and vomiting, adjustments were made to anatomic regions, risk levels, and antiemetic administration schedules. Rescue therapy alone is now recommended for low-emetic-risk radiation therapy. The Expert Panel reiterated the importance of using the most effective antiemetic regimens that are appropriate for antineoplastic agents or radiotherapy being administered. Such regimens should be used with initial treatment, rather than first assessing the patient's emetic response with less-effective treatment. Additional information is available at www.asco.org/supportive-care-guidelines and www.asco.org/guidelineswiki .
Three-dimensional (3D) topological states resemble truly localised, particle-like objects in physical space. Among the richest such structures are 3D skyrmions and hopfions, that realise integer ...topological numbers in their configuration via homotopic mappings from real space to the hypersphere (sphere in 4D space) or the 2D sphere. They have received tremendous attention as exotic textures in particle physics, cosmology, superfluids, and many other systems. Here we experimentally create and measure a topological 3D skyrmionic hopfion in fully structured light. By simultaneously tailoring the polarisation and phase profile, our beam establishes the skyrmionic mapping by realising every possible optical state in the propagation volume. The resulting light field's Stokes parameters and phase are synthesised into a Hopf fibration texture. We perform volumetric full-field reconstruction of the Formula: see text mapping, measuring a quantised topological charge, or Skyrme number, of 0.945. Such topological state control opens avenues for 3D optical data encoding and metrology. The Hopf characterisation of the optical hypersphere endows a fresh perspective to topological optics, offering experimentally-accessible photonic analogues to the gamut of particle-like 3D topological textures, from condensed matter to high-energy physics.
Angelman syndrome (AS) is a neurodevelopment disorder characterized by severe cognitive impairment and a high rate of autism. AS is caused by disrupted neuronal expression of the maternally inherited ...Ube3A ubiquitin protein ligase, required for the proteasomal degradation of proteins implicated in synaptic plasticity, such as the activity-regulated cytoskeletal-associated protein (Arc/Arg3.1). Mice deficient in maternal Ube3A express elevated levels of Arc in response to synaptic activity, which coincides with severely impaired long-term potentiation (LTP) in the hippocampus and deficits in learning behaviors. In this study, we sought to test whether elevated levels of Arc interfere with brain-derived neurotrophic factor (BDNF) TrkB receptor signaling, which is known to be essential for both the induction and maintenance of LTP. We report that TrkB signaling in the AS mouse is defective, and show that reduction of Arc expression to control levels rescues the signaling deficits. Moreover, the association of the postsynaptic density protein PSD-95 with TrkB is critical for intact BDNF signaling, and elevated levels of Arc were found to impede PSD-95/TrkB association. In Ube3A deficient mice, the BDNF-induced recruitment of PSD-95, as well as PLCγ and Grb2-associated binder 1 (Gab1) with TrkB receptors was attenuated, resulting in reduced activation of PLCγ-α-calcium/calmodulin-dependent protein kinase II (CaMKII) and PI3K-Akt, but leaving the extracellular signal-regulated kinase (Erk) pathway intact. A bridged cyclic peptide (CN2097), shown by nuclear magnetic resonance (NMR) studies to uniquely bind the PDZ1 domain of PSD-95 with high affinity, decreased the interaction of Arc with PSD-95 to restore BDNF-induced TrkB/PSD-95 complex formation, signaling, and facilitate the induction of LTP in AS mice. We propose that the failure of TrkB receptor signaling at synapses in AS is directly linked to elevated levels of Arc associated with PSD-95 and PSD-95 PDZ-ligands may represent a promising approach to reverse cognitive dysfunction.
Motivated by the recent discovery of electron vortex beams carrying orbital angular momentum (AM), we construct exact Bessel-beam solutions of the Dirac equation. They describe relativistic and ...nonparaxial corrections to the scalar electron beams. We describe the spin and orbital AM of the electron with Berry-phase corrections and predict the intrinsic spin-orbit coupling in free space. This can be observed as a spin-dependent probability distribution of the focused electron vortex beams. Moreover, the magnetic moment is calculated, which shows different g factors for spin and orbital AM and also contains the Berry-phase correction.
Type II DNA topoisomerases are ubiquitous enzymes with essential functions in DNA replication, recombination and transcription. They change DNA topology by forming a transient covalent cleavage ...complex with a gate-DNA duplex that allows transport of a second duplex though the gate. Despite its biological importance and targeting by anticancer and antibacterial drugs, cleavage complex formation and reversal is not understood for any type II enzyme. To address the mechanism, we have used X-ray crystallography to study sequential states in the formation and reversal of a DNA cleavage complex by topoisomerase IV from Streptococcus pneumoniae, the bacterial type II enzyme involved in chromosome segregation. A high resolution structure of the complex captured by a novel antibacterial dione reveals two drug molecules intercalated at a cleaved B-form DNA gate and anchored by drug-specific protein contacts. Dione release generated drug-free cleaved and resealed DNA complexes in which the DNA gate instead adopts an unusual A/B-form helical conformation with a Mg(2+) ion repositioned to coordinate each scissile phosphodiester group and promote reversible cleavage by active-site tyrosines. These structures, the first for putative reaction intermediates of a type II topoisomerase, suggest how a type II enzyme reseals DNA during its normal reaction cycle and illuminate aspects of drug arrest important for the development of new topoisomerase-targeting therapeutics.
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