Background Zip codes classified by the Food Insecurity Index with moderate and high food insecurity (FI) risk can be a threat to the health and well-being of children during the first 1,000 days ...(from pregnancy to 2 years). The presence of nurturing care assets (i.e., stable environments that promote health and nutrition, learning opportunities, security and safety, and responsive relationships) can contribute to supporting families and their communities, and ultimately reduce systemic barriers to food security. We aimed to identify and characterize nurturing care assets in under-resourced communities with moderate and high FI risk. Methods Four steps were used to conduct a Community Asset Mapping (CAM): (1) review of community documents across five zip codes in Clark County, Nevada (2), engagement of community members in identifying community assets (3), definition of the assets providing nurturing care services, and (4) classification of assets to nurturing care components, i.e., good health, adequate nutrition, safety and security, opportunities for early learning, and responsive caregiving. The Food Insecurity Index was used to determine FI risk in each zip code. Analyses explored whether disparities in nurturing care assets across zip codes with moderate and high FI exist. Results We identified 353 nurturing care assets across zip codes. A more significant number of nurturing care assets were present in zip codes with high FI risk. The adequate nutrition component had the most assets overall (n = 218, 61.8%), while the responsive caregiving category had the least (n = 26, 7.4%). Most of the adequate nutrition resources consisted of convenience stores (n = 96), food pantries (n = 33), and grocery stores (n = 33). Disparities in the number and type of good health, early learning, and security and safety assets were identified within zip codes with high FI risk compared to moderate FI risk. Conclusions The quantity and type of nurturing care assets can exacerbate existing demographic disparities across zip codes, which are tied to barriers to access to food in under-resourced communities in Clark County, Nevada. Co-creating a nurturing care asset-based zip code strategy to address high FI risk will require strengthening systems across existing nurturing care assets. Keywords: Community asset mapping, Food security, Maternal-child health, Nutrition
Thoracic endometriosis syndrome (TES) is a rare disorder presenting with catamenial pneumothorax, hemothorax, hemoptysis or pulmonary nodules. Bilateral involvement is uncommon, and only a very few ...cases have been reported in the literature. We report a case of bilateral catamenial hemothorax in a patient with recurrent thoracic endometriosis. Despite multiple surgical interventions, the patient continued to develop hemopneumothorax coinciding with menses. Remission was finally achieved with the addition of gonadotropin-releasing hormone agonist, highlighting the effectiveness of postoperative adjuvant hormone therapy and supporting a combined surgical and medical approach in the treatment of TES in patients who desire future fertility.
A Quasi experimental study was conducted to assess the effectiveness of PTP on knowledge and practices of endotracheal suctioning among (46) nursing students posted in intensive care units with ...purposive sampling techniques. The objectives of the study were to assess the existing knowledge and practice of endotracheal tube suctioning, to evaluate effectiveness of PTP, to find association of pretest knowledge and practice score with selected variables. The major findings revealed that mean post knowledge score was higher than pre-test knowledge t value i.e. 2nd yearGNM had 12.2, 3rd year GNM had 12.1, and basic BSc had 7.8.With regards to practice, the pre-test and post-test analysis revealed that the mean post practice score was higher than pre-test t- value i.e. 2nd year GNM 16.8, 3rd year GNM 12.9, 2nd Basic BSc 10.2. Thus, the paired t- test result showed significant gain in knowledge (p<0.05)Statistical analysis using ANOVA test reveals that no demographic variable have significant association with pre-test knowledge and practice among nursing students regarding Endotracheal tube suctioning .Thus the study proved, planned teaching programme on knowledge and practice of Endotracheal tube suctioning was scientific, logical and effective strategy.
Abstract This retrospective cohort analysis examined the effects of maternal age on the incidence of factors associated with embryo–endometrium asynchrony in fresh autologous blastocyst transfer. The ...study included 1169 routine fresh autologous blastocyst transfers. The main outcome measure was asynchronous transfer defined by delayed (day 6) blastocyst transfer or elevated pre-ovulatory serum progesterone level. Compared with patients younger than 35 years, patients 35 years or older had increased risk of having at least one risk factor for asynchronous transfer, including premature progesterone elevation or delayed blastocyst transfer (RR 1.36; 95% CI 1.24 to 1.50). The older group had increased risk of simultaneously having both risk factors (RR 1.61, 95% CI 1.17 to 2.21) compared with the younger group. In patients younger than 35 years, live birth rate per transfer was 62.9% with day 5 transfer and low profesterone, declining to 27.9% for day 6 transfer combined with elevated progesterone. In patients 35 years or older, live birth rate per transfer was 38.0% with day 5 transfer and low progesterone, declining to 18.1% for day 6 transfer combined with elevated progesterone. Indicators of embryo–endometrium asynchrony increase in prevalence as women age and asynchrony disproportionately decreases birth rates in older patients.
Alternative methods to whole liver transplantation require a suitable cell that can be expanded to obtain sufficient numbers required for successful transplantation while maintaining the ability to ...differentiate into hepatocytes. Mesenchymal stem cells (MSCs) possess several advantageous characteristics for cell‐based therapy and have been shown to be able to differentiate into hepatocytes. Thus, we investigated whether the intrahepatic delivery of human MSCs is a safe and effective method for generating human hepatocytes and whether the route of administration influences the levels of donor‐derived hepatocytes and their pattern of distribution throughout the parenchyma of the recipient's liver. Human clonally derived MSCs were transplanted by an intraperitoneal (n = 6) or intrahepatic (n = 6) route into preimmune fetal sheep. The animals were analyzed 56–70 days after transplantation by immunohistochemistry, enzyme‐linked immunosorbent assay, and flow cytometry. The intrahepatic injection of human MSCs was safe and resulted in more efficient generation of hepatocytes (12.5% ± 3.5% versus 2.6% ± 0.4%). The animals that received an intrahepatic injection exhibited a widespread distribution of hepatocytes throughout the liver parenchyma, whereas an intraperitoneal injection resulted in a preferential periportal distribution of human hepatocytes that produced higher amounts of albumin. Furthermore, hepatocytes were generated from MSCs without the need to first migrate/lodge to the bone marrow and give rise to hematopoietic cells. Conclusion: Our studies provide evidence that MSCs are a valuable source of cells for liver repair and regeneration and that, by the alteration of the site of injection, the generation of hepatocytes occurs in different hepatic zones, suggesting that a combined transplantation approach may be necessary to successfully repopulate the liver with these cells. (HEPATOLOGY 2007.)
One of the buzzwords in the advanced information technology is IoT, which will transform the real world objects into intelligent virtual objects. IoT needs to support Device heterogeneity, ...Scalability, Ubiquitous data exchange through proximity wireless sensor technologies, Energy optimized solutions, Localization and tracking capabilities, Self-organization capabilities, Semantic interoperability and data management, Embedded security and privacy preserving mechanisms and hence challenging. Clustering plays an important role in the IoT architecture with the idea of creating collaborative, multi-hop and dynamic interactions among the heterogeneous objects. In this paper, our work focuses on providing an efficient means of communication between homogeneous devices through an efficient clustering mechanism and how efficiently clusters can be formed in a mobile and dynamic homogeneous wireless networks. In this work, we proposed a modification in the prominent wireless sensor network's routing protocol i.e. LEACH and Modified-LEACH(M-LEACH) and named as ACHs-LEACH technique which out performs as indicated in the performance metrics such as energy consumption, throughput, packet loss, packet delivery ratio. The work focuses on electing the Cluster- Head(CH) and Assistant Cluster Heads(ACHs) to reduce the energy consumption of the network so as to prolong the lifetime of the network. We also tried implementing the malicious nodes elimination which may cause problem for the integrity of the data and re-clustering of the entire network when a mobile node moves into another cluster.
Hemophilia A, or Factor VIII (FVIII) deficiency, is the most common severe hereditary coagulation disorder, affecting 1 in 5000 male live births. Animal models in dog, mouse, and rabbit have been ...developed and used to study FVIII function and to evaluate new methods of treatment and prevention of inhibitor formation. Unfortunately, for unknown reasons, results obtained using these models didn't always result in successful therapies when applied to humans. For new treatments to be safely and successfully translated from surrogate models to clinical trials, it is critical to develop an animal model that simultaneously and accurately parallels normal human physiology while mimicking human hemophilia's physiopathological process. Due to its striking physiological and anatomical similarities to humans, sheep are considered an ideal model to study a vast array of pathologies. The aim of these studies was to re-establish, study, and characterize an extinct line of sheep with a spontaneous bleeding disorder that closely recapitulated human hemophilia A (ThrombHaemost 68:618, 1992). Thus, we used frozen semen from an affected male to generate hemophilia A carriers. We obtained 20 females that when compared to pooled control sheep plasma, exhibited slightly increased PTT levels (38.1±1.1; N=30s), normal PT and platelet number, and slightly decreased FVIII:C (70±3%). Levels of Fibrinogen, FIX, vWF activity and vWF:ag were also normal. A second round of reproductive manipulations using the carriers' oocytes and the affected semen produced 23 more animals, 16 of which were obligate carriers with a similar phenotype. The other 8 animals exhibited prolonged bleeding from the umbilical cord that promptly stopped upon administration of purified human FVIII concentrate using recommended dosing. Due to the unfeasibility of clamping the umbilical cord, therapy with human FVIII was continued each 12 hours until the umbilical cord dropped off. Blood collected prior to the administration of FVIII showed that these animals had almost non-existent levels of FVIIIc, and an extremely prolonged PTT (91.5±2.9, N=30.3) with normal levels of platelets, fibrinogen, FVII, FIX, and vWF. 2 of the animals died shortly after birth due to extensive hematomas related to lambing trauma. The other 6 animals, now 5 months old (maturity 6–9 months), developed clinical symptomatology closely mimicking that of human patients with severe hemophilia A. Each of these animals had between 2–6 episodes of severe bleeding including hemarthroses of the elbow, shoulder, hip, and knee, multiple muscle hematomas, including 1 hematoma of the tongue and 1 episode of mild hematuria. All of the bleeding episodes resolved upon administration of 1–2 treatments with human FVIII. Animals have thus far received between 964-4546U of human FVIII. Of interest is that low-titer inhibitors (1.3; 2.6; 3 BU) were detected in 3 of the animals showing that the nature of the mutation present in these sheep renders them prone to inhibitor development. Characterization of the mutation is currently underway. We hope that this large animal model will contribute to a better understanding of hemophilia and the development of novel treatments that can directly translate to human patients, such as stem cell transplantation and gene therapy-based approaches.
We have previously reported the isolation of Stro-1+, CD45-, GlyA-human MSC from human bone marrow (BM), liver (LV), and brain (BR). Despite their similar morphology and phenotype, these cells, upon ...in vivo transplantation into the pre-immune fetal sheep model, seemed to differentiate more efficiently into cells of their tissue of origin. For instance, all 3 sources of MSC gave rise to blood, with average levels of human CD45+ cells in chimeric animals of 8.7% for LVMSC, 3.3% for BRMSC, and 4.5%for BMMSC. Human neural cells were also detected in the brain of transplanted animals with the highest levels obtained with BRMSC (1.33%) and lowest with LVMSC (0.4%). However, BRMSC generated very few human hepatocytes (2–10 hepatocytes/section), while both LVMSC and BMMSC gave rise to much higher levels of hepatocytes. This led us to hypothesize that despite the similar phenotype, the proteome makeup of MSC from different tissues may be distinct. To test this hypothesis, we examined the commonalities and differences in the protein repertoire of cultured MSC from these 3 different sources. The eighty most prominent protein spots from the 2-D gel of each cell population were removed and identified by MOLDI-TOF/TOF mass spectroscopy after Trypsin digestion. Our results demonstrate that there are a large number of common proteins between the LV, BM and BR MSC (> 75%). Besides the cytoskeletal and associative proteins such as Vimentin, β-actin, cofilin, Tropomyosin and Lamin A/C, the cells contained a large quantity of proteins for protein processing such as Cyclophilin A, Endoplasmic reticulum protein ERp29, Disulfide-isomerase ER60 and Glucose-regulated proteins 75 and 78, which may be important for the broad differentiative potential of MSC. Despite these similarities, forty percent of the identified proteins showed significantly different expression levels between the three types of cells (> 300%), the majority of which were not proteins previously shown to be BM-, Liver or Brain-specific. Interestingly, however, LV-derived cells contained a 5-fold greater concentration of Albumin than BM or Brain cells, which may explain their greater tendency to form liver tissue in vivo. Likewise, since BMMSC were enriched in smooth muscle associated proteins, potentially they may constitute a better source to be used for muscle repair. Thus, the definition of the different MSC proteomes can lead not only to the discover of critical differences involved in differentiation/plasticit into different cell fates, but may also help us to identify distinct cell populations that are ideally suited for cell therapies for specific organs.
Since 1995, DHRUVA, an associate organization of BAIF Development Research Foundation, has been implementing an integrated development program, known as the "Comprehensive Tribal Development Program" ...or Wadi program. The core activity is to turn each participant's 0.40 ha plot of wasteland into a mango and cashew orchard, with forest trees around the boundary. The ultimate objective of this program is to enable tribal farmers to achieve maximum yields by using timely and effective inputs. As commercial organic fertilizers are too expensive, it was decided to produce organic manure locally. There was plenty of forest litter, agri-waste and weeds lying around, so this became the raw material for composting. Vermicomposting allows use of hard substances with high cellulose content, and it has the potential to become a backyard income generation activity on a large-scale.
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