Using 25 years of data from uninterrupted monitoring of stellar orbits in the Galactic Center, we present an update of the main results from this unique data set: a measurement of mass and distance ...to Sgr A*. Our progress is not only due to the eight-year increase in time base, but also to the improved definition of the coordinate system. The star S2 continues to yield the best constraints on the mass of and distance to Sgr A*; the statistical errors of 0.13 × 10 6 M and 0.12 kpc have halved compared to the previous study. The S2 orbit fit is robust and does not need any prior information. Using coordinate system priors, the star S1 also yields tight constraints on mass and distance. For a combined orbit fit, we use 17 stars, which yields our current best estimates for mass and distance: M = 4.28 0.10 stat . 0.21 sys × 10 6 M and R 0 = 8.32 0.07 stat . 0.14 sys kpc . These numbers are in agreement with the recent determination of R0 from the statistical cluster parallax. The positions of the mass, of the near-infrared flares from Sgr A*, and of the radio source Sgr A* agree to within 1 mas. In total, we have determined orbits for 40 stars so far, a sample which consists of 32 stars with randomly oriented orbits and a thermal eccentricity distribution, plus eight stars that we can explicitly show are members of the clockwise disk of young stars, and which have lower-eccentricity orbits.
Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is triggered by ...increases in matrix levels of Ca2+ and reactive oxygen species. This form of cell death has been implicated in ischemic injuries of the heart and brain as well as numerous degenerative diseases in the brain and skeletal muscle. This review focuses on the molecular triggers and regulators of mPTP-dependent necrosis in the context of myocardial ischemia reperfusion injury. Research over the past 50 years has led to the identity of regulators and putative pore-forming components of the mPTP. Finally, downstream consequences of activation of the mPTP as well as ongoing questions and areas of research are discussed. These questions pose a particular interest as targeting the mPTP could potentially represent an efficacious therapeutic strategy to reduce infarct size following an ischemic event.
•Ischemia reperfusion injury is a consequence of mPTP-dependent necrosis•Prolonged mPTP opening leads to mitochondrial dysfunction•mPTP opening is triggered by calcium and reactive oxygen species•The mPTP may consist of multiple pore-forming entities•Outer mitochondrial membrane permeability through the Bcl-2 family alters mPTP sensitivity to calcium
ABSTRACT Sagittarius A* (Sgr A*), the supermassive black hole at the centre of the Milky Way, undergoes large-amplitude near-infrared (NIR) flares that can coincide with the continuous rotation of ...the NIR emission region. One promising explanation for this observed NIR behaviour is a magnetic flux eruption, which occurs in three-dimensional General Relativistic Magneto-Hydrodynamic (3D GRMHD) simulations of magnetically arrested accretion flows. After running two-temperature 3D GRMHD simulations, where the electron temperature is evolved self-consistently along with the gas temperature, it is possible to calculate ray-traced images of the synchotron emission from thermal electrons in the accretion flow. Changes in the gas-dominated (σ = b2/2ρ < 1) regions of the accretion flow during a magnetic flux eruption reproduce the NIR flaring and NIR emission region rotation of Sgr A* with durations consistent with observation. In this paper, we demonstrate that these models also predict that large (1.5x – 2x) size increases of the sub-millimeter (sub-mm) and millimeter (mm) emission region follow most NIR flares by 20–50 min. These size increases occur across a wide parameter space of black hole spin (a = 0.3, 0.5, −0.5, and 0.9375) and initial tilt angle between the accretion flow and black hole spin axes θ0 (θ0 = 0°, 16°, and 30°). We also calculate the sub-mm polarization angle rotation and the shift of the sub-mm spectral index from zero to –0.8 during a prominent NIR flare in our high spin (a = 0.9375) simulation. We show that, during a magnetic flux eruption, a large (∼10rg), magnetically dominated (σ > 1), low-density, and high-temperature ‘bubble’ forms in the accretion flow. The drop in density inside the bubble and additional electron heating in accretion flow between 15rg and 25rg leads to a sub-mm size increase in corresponding images.
Most supermassive black holes (SMBHs) are accreting at very low levels and are difficult to distinguish from the galaxy centers where they reside. Our own Galaxy's SMBH provides an instructive ...exception, and we present a close-up view of its quiescent x-ray emission based on 3 megaseconds of Chandra observations. Although the x-ray emission is elongated and aligns well with a surrounding disk of massive stars, we can rule out a concentration of low-mass coronally active stars as the origin of the emission on the basis of the lack of predicted iron (Fe) Kα emission. The extremely weak hydrogen (H)—like Fe Kα line further suggests the presence of an outflow from the accretion flow onto the SMBH. These results provide important constraints for models of the prevalent radiatively inefficient accretion state.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, was first identified after a cluster of cases in Wuhan, China in December 2019. Whether vertical transmission or ...placental pathology might occur following maternal infection during pregnancy remains unknown. This review aimed to summarise all studies that examined the placenta or neonates following infection with SARS-CoV-2, or closely related highly pathogenic coronavirus (SARS-CoV-1, or the Middle East respiratory syndrome coronavirus (MERS-CoV)). Structured literature searches found 50 studies that met the inclusion criteria.
Twenty studies reported placental histopathology findings in third trimester placentas following maternal SARS-CoV-2 infection. Using the Amsterdam Consensus criteria to categorise the histopathology results, evidence of both fetal vascular malperfusion (35.3% of cases; 95% Confidence Interval (CI) 27.7–43.0%) and maternal vascular malperfusion (46% of cases; 95% CI 38.0–54.0%) were reported, along with evidence of inflammation in the placentas (villitis 8.7% cases, intervillositis 5.3% of cases, chorioamnionitis 6% of cases). The placental pathologies observed in SARS-CoV-2 were consistent with findings following maternal SARS-CoV-1 infection. Of those tested, a minority of neonates (2%) and placental samples tested positive for SARS-CoV-2 infection (21%).
Limited conclusions can be drawn about the effect of maternal SARS-CoV-2 infection on placental pathology as most lack control groups and the majority of reports followed third trimester infection. Collaboration to maximise the number of samples examined will increase the reliability and generalisability of findings. A better understanding of the association between maternal SARS-CoV-2 infection and placental pathology will inform maternity care during the coronavirus pandemic.
•Placental findings following maternal COVID-19, SARS or MERS were reviewed.•Minority of infants (2%) and placentas (21%) tested were positive for COVID-19.•Fetal and maternal vascular malperfusion were most frequently noted following COVID-19.•Minority of placentas demonstrated inflammatory lesions.•The association between maternal COVID infection and placental pathology is unclear.
Arabinoxylans and mixed linkage (1
→
3)(1
→
4)-β-
d-glucans are the major non-starch polysaccharides present in various tissues of barley. Depending on the genotypic or cellular origin, both polymers ...exhibit variations in their molecular structures. The molecular features of β-glucans and arabinoxylans are important determinants of their physical properties, such as water solubility, viscosity, and gelation properties as well as of their physiological functions in the gastro-intestinal tract. Barley β-glucans have been associated with lowering plasma cholesterol, reducing glycaemic index, and reducing risk of colon cancer. The potential application of β-glucans as food hydrocolloids has been also proposed based on their rheological characteristics. In addition to solution viscosity enhancement, β-glucans have been shown to gel under certain conditions. Arabinoxylans have been shown to significantly affect cereal-based processes such as milling, brewing, and breadmaking. Furthermore, arabinoxylans offer nutritional benefits of soluble and insoluble fibre, and, because of the presence of phenolic moieties in their molecular structures, they may also have some antioxidant properties.
Abstract
We present the first fully simultaneous fits to the near-infrared (NIR) and X-ray spectral slope (and its evolution) during a very bright flare from Sgr A*, the supermassive black hole at ...the Milky Way's centre. Our study arises from ambitious multiwavelength monitoring campaigns with XMM–Newton, NuSTAR and SINFONI. The average multiwavelength spectrum is well reproduced by a broken power law with ΓNIR = 1.7 ± 0.1 and ΓX = 2.27 ± 0.12. The difference in spectral slopes (ΔΓ = 0.57 ± 0.09) strongly supports synchrotron emission with a cooling break. The flare starts first in the NIR with a flat and bright NIR spectrum, while X-ray radiation is detected only after about 103 s, when a very steep X-ray spectrum (ΔΓ = 1.8 ± 0.4) is observed. These measurements are consistent with synchrotron emission with a cooling break and they suggest that the high-energy cut-off in the electron distribution (γmax) induces an initial cut-off in the optical–UV band that evolves slowly into the X-ray band. The temporal and spectral evolution observed in all bright X-ray flares are also in line with a slow evolution of γmax. We also observe hints for a variation of the cooling break that might be induced by an evolution of the magnetic field (from B ∼ 30 ± 8 G to B ∼ 4.8 ± 1.7 G at the X-ray peak). Such drop of the magnetic field at the flare peak would be expected if the acceleration mechanism is tapping energy from the magnetic field, such as in magnetic reconnection. We conclude that synchrotron emission with a cooling break is a viable process for Sgr A*'s flaring emission.
Although exempt, many pregnant Muslim women partake in the daily fast during daylight hours during the month of Ramadan. In other contexts an impoverished diet during pregnancy impacts on birth ...weight. The aim of this systematic review was to determine whether Ramadan fasting by pregnant women affects perinatal outcomes. Primary outcomes investigated were perinatal mortality, preterm birth and small for gestational age (SGA) infants. Secondary outcomes investigated were stillbirth, neonatal death, maternal death, hypertensive disorders of pregnancy, gestational diabetes, congenital abnormalities, serious neonatal morbidity, birth weight, preterm birth and placental weight.
Systematic review and meta-analysis of observational studies and randomised controlled trials was conducted in EMBASE, MEDLINE, CINAHL, Web of Science, Google Scholar, the Health Management Information Consortium and Applied Social Sciences Index and Abstracts. Studies from any year were eligible. Studies reporting predefined perinatal outcomes in pregnancies exposed to Ramadan fasting were included. Cohort studies with no comparator group or that considered fasting outside pregnancy were excluded, as were studies assuming fasting practice based solely upon family name. Quality of included studies was assessed using the ROBINS-I tool for assessing risk of bias in non-randomised studies. Analyses were performed in STATA.
From 375 records, 22 studies of 31,374 pregnancies were included, of which 18,920 pregnancies were exposed to Ramadan fasting. Birth weight was reported in 21 studies and was not affected by maternal fasting (standardised mean difference SMD 0.03, 95% CI 0.00 to 0.05). Placental weight was significantly lower in fasting mothers (SMD -0.94, 95% CI -0.97 to -0.90), although this observation was dominated by a single large study. No data were presented for perinatal mortality. Ramadan fasting had no effect on preterm delivery (odds ratio 0.99, 95% CI 0.72 to 1.37) based on 5600 pregnancies (1193 exposed to Ramadan fasting).
Ramadan fasting does not adversely affect birth weight although there is insufficient evidence regarding potential effects on other perinatal outcomes. Further studies are needed to accurately determine whether Ramadan fasting is associated with adverse maternal or neonatal outcome.
Antepartum fetal monitoring aims to assess fetal development and wellbeing throughout pregnancy. Current methods utilised in clinical practice are intermittent and only provide a 'snapshot' of fetal ...wellbeing, thus key signs of fetal demise could be missed. Continuous fetal monitoring (CFM) offers the potential to alleviate these issues by providing an objective and longitudinal overview of fetal status. Various CFM devices exist within literature; this review planned to provide a systematic overview of these devices, and specifically aimed to map the devices' design, performance and factors which affect this, whilst determining any gaps in development.
A systematic search was conducted using MEDLINE, EMBASE, CINAHL, EMCARE, BNI, Cochrane Library, Web of Science and Pubmed databases. Following the deletion of duplicates, the articles' titles and abstracts were screened and suitable papers underwent a full-text assessment prior to inclusion in the review by two independent assessors.
The literature searches generated 4,885 hits from which 43 studies were included in the review. Twenty-four different devices were identified utilising four suitable CFM technologies: fetal electrocardiography, fetal phonocardiography, accelerometry and fetal vectorcardiography. The devices adopted various designs and signal processing methods. There was no common means of device performance assessment between different devices, which limited comparison. The device performance of fetal electrocardiography was reduced between 28 to 36 weeks' gestation and during high levels of maternal movement, and increased during night-time rest. Other factors, including maternal body mass index, fetal position, recording location, uterine activity, amniotic fluid index, number of fetuses and smoking status, as well as factors which affected alternative technologies had equivocal effects and require further investigation.
A variety of CFM devices have been developed, however no specific approach or design appears to be advantageous due to high levels of inter-device and intra-device variability.
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