The Mu2e experiment at Fermilab will search for the charged lepton flavor violating neutrino-less conversion of a negative muon into an electron in the field of an aluminum nucleus <xref ...ref-type="bibr" rid="ref1">1 , <xref ref-type="bibr" rid="ref2">2 . The Mu2e detector is comprised of a tracker, an electromagnetic calorimeter, and an external veto for cosmic rays. The calorimeter plays an important role in providing excellent particle identification capabilities, a fast and online trigger filter while aiding the track reconstruction capabilities. The calorimeter requirements are to provide a large acceptance for 100-MeV electrons and reach: 1) a time resolution better than 0.5 ns at 100 MeV; 2) an energy resolution O(10%) at 100 MeV; and 3) a position resolution of about 1 cm. The calorimeter consists of two disks, each one made of 674 pure CsI crystals readout by two large-area <inline-formula> <tex-math notation="LaTeX">2 \times 3 </tex-math></inline-formula> array of UV-extended silicon photomultipliers (Mu2e SiPMs) of <inline-formula> <tex-math notation="LaTeX">6\,\,\times6 </tex-math></inline-formula> mm 2 dimensions. A large-scale prototype has been constructed with 51 preproduction crystals readout by 102 Mu2e SiPMs. It has been tested at the beam test facility in Frascati, demonstrating satisfying results compared to the Mu2e requirements. At the moment of writing, the crystals production phase is halfway through the work, while the SiPM production has been completed. An overview of the characterization tests is also reported, together with a description of the final calorimeter design.
Among the genes involved in obesity, the Fat mass and obesity-associated gene (FTO) is certainly one of the most known and the relation between FTO rs9939609 and BMI is highly discussed; ...nevertheless, data about its influence on body composition are limited.
We carried out a study on a sample of 1066 Italian subjects, whose body composition and FTO rs9939609 were analyzed.
We found significant relations between FTO with arm (p=0.01), abdomen (p=0.00), and trunk circumferences (p=0.00), BMI (p=0.01), FM% (p=0.00), and android FM% (p=0.01), whereas no relations were found between FTO and both gynoid fat and lean mass.
To conclude, the relation between FTO and BMI is confirmed and is related specifically with android FM%. These results indicated that FTO rs9939609 may be a genetic etiological factor for obesity. Indeed, the specificity for the android FM% would indicate FTO as an etiological factor in the development of cardiovascular diseases.
In recent years, the advanced knowledge of clinical, biological and molecular features of prostate cancer have led to the introduction of new drugs and have allowed the relocation of old drugs in ...different settings. In this way, the new concepts of systemic disease arise: high risk or high volume vs. low risk and low volume disease castration sensitive prostate cancer (CSPC), diversifying the use of previously approved drugs (CRPC) and opening new scenarios for sequence therapy. The aim of this review is to integrate new developments into the medical management of systemic prostate cancer.
The Mu2e experiment at Fermilab searches for the charged-lepton flavor violating (CLFV) conversion of a negative muon into an electron in the field of an aluminum nucleus, with a distinctive ...signature of a monoenergetic electron of energy slightly below the muon rest mass (104.967 MeV). The Mu2e goal is to improve by four orders of magnitude the search sensitivity with respect to the previous experiments. Any observation of a CLFV signal will be a clear indication of new physics. The Mu2e detector is composed of a tracker, an electromagnetic calorimeter, and an external veto for cosmic rays surrounding the solenoid. The calorimeter plays an important role in providing particle identification capabilities, a fast online trigger filter, a seed for track reconstruction while working in vacuum, in the presence of 1-T axial magnetic field and in a harsh radiation environment. The calorimeter requirements are to provide a large acceptance for 100-MeV electrons and reach at these energies: 1) a time resolution better than 0.5 ns; 2) an energy resolution <10%; and 3) a position resolution of 1 cm. The calorimeter design consists of two disks, each one made of 674-undoped cesium iodine crystals read by two large area arrays of UV-extended silicon photomultipliers (SiPMs). We report here the construction and the test of the Module-0 prototype. The Module-0 has been exposed to an electron beam in the energy range around 100 MeV at the Beam Test Facility in Frascati. Preliminary results of timing and energy resolution at normal incidence are shown. A discussion of the technical aspects of the calorimeter engineering is also reported in this paper.
The Mu2e experiment at Fermilab searches for the charged-lepton flavor violating neutrino-less conversion of a negative muon into an electron in the field of an aluminum nucleus. The dynamics of such ...a process is well modeled by a two-body decay, resulting in a monoenergetic electron with an energy slightly below the muon rest mass (104.967 MeV). The calorimeter of this experiment plays an important role to provide excellent particle identification capabilities and an online trigger filter while aiding the track reconstruction capabilities. The baseline calorimeter configuration consists of two disks each made with ∼ 700 undoped CsI crystals read out by two large area UV-extended Silicon Photomultipliers. These crystals match the requirements for stability of response, high resolution and radiation hardness. In this paper we present the final calorimeter design.
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