GaSb film growth by liquid phase epitaxy García-Cruz, M. L.; Martínez-Juárez, J.; López-Salazar, P. ...
Physica status solidi. C,
April 2010, Letnik:
7, Številka:
3-4
Journal Article
Pharmacokinetics and residues of enrofloxacin in chickens Anadon, A. (Universidad Complutense de Madrid, Madrid, Spain.); Martinez-Larranaga, M.R; Diaz, M.J ...
American journal of veterinary research,
04/1995, Letnik:
56, Številka:
4
Journal Article
Recenzirano
Odprti dostop
The pharmacokinetic properties of enrofloxacin were determined in broiler chickens after single IV and orally administered doses of 10 mg/kg of body weight. After IV and oral administrations, the ...plasma concentration-time graph was characteristic of a two-compartment open model. The elimination half-life and the mean +/- SEM residence time of enrofloxacin for plasma were 10.29 +/- 0.45 and 9.65 +/- 0.48 hours, respectively, after IV administration and 14.23 +/- 0.46 and 15.30 +/- 0.53 hours, respectively, after oral administration. After single oral administration, enrofloxacin was absorbed slowly, with time to reach maximal plasma concentration of 1.64 +/- 0.04 hours. Maximal plasma concentration was 2.44 +/- 0.06 micrograms/ml. Oral bioavailability was found to be 64.0 +/- 0.9%. Statistically significant differences between the routes of administration were found for the pharmacokinetic variables-half-lives of the distribution and elimination phase and apparent volume of distribution and volume of distribution at steady state. In chickens, enrofloxacin was extensively metabolized into ciprofloxacin. Residues of enrofloxacin and the major metabolite ciprofloxacin in fat, kidney, liver, lungs, muscles, and skin were measured in chickens that received an orally administered dose of 10 mg/kg once daily for 4 days. The results indicate that enrofloxacin and ciprofloxacin residues were cleared slowly. Mean muscle, liver, and kidney concentrations of the metabolite ciprofloxacin ranging between 0.020 and 0.075 micrograms/g persisted on day 12 in chickens after dosing. However, at the time of slaughter (12 days), enrofloxacin residues were only detected in liver and mean +/- SEM concentration was 0.025 +/- 0.003 micrograms/g
Rare top decay as a probe of new physics Díaz-Cruz, J. L.; Diaz-Furlong, A.; Gaitán-Lozano, R. ...
The European physical journal. C, Particles and fields,
08/2012, Letnik:
72, Številka:
8
Journal Article
Recenzirano
Odprti dostop
The rare top decay
, which involves flavor violation, is studied as a possible probe of new physics. This decay is analyzed with one of the simplest Standard Model extensions with additional gauge ...symmetry formalism. The considered extension is the Left–Right Symmetric Model, including a new neutral gauge boson
Z
′ that allows one to obtain the decay at tree level through Flavor-Changing Neutral Currents (FCNC) couplings. The neutral gauge boson couplings are considered diagonal but family non-universal in order to induce these FCNC. We find
for the range 1 TeV≤
M
Z
′
≤3 TeV.
Higgs-flavon fields appear as a part of the Froggatt–Nielsen (FN) mechanism, which attempts to explain the hierarchy of Yukawa couplings. We explore the possibility that the 750 GeV diphoton ...resonance recently reported at the LHC13 could be identified with a low-scale Higgs-flavon field HF and find the region of the parameter space consistent with CMS and ATLAS data. It is found that the extra vector-like fermions of the ultraviolet completion of the FN mechanism are necessary in order to reproduce the observed signal. We consider a standard model (SM) extension that contains two Higgs doublets (a standard one and an inert one) and one complex FN singlet. The inert doublet includes a stable neutral boson, which provides a viable dark matter candidate, while the mixing of the standard doublet and the FN singlet induces flavor violation in the Higgs sector at the tree-level. Constraints on the parameters of the model are derived from the LHC Higgs data, which include the search for the lepton flavor violating decay of the SM Higgs boson h→μ¯τ. It is also found that in some region of the parameter space the model may give rise to a large branching ratio for the HF→hh decay, of the order of 0.1, which could be searched for at the LHC.
The squark mass-matrix from the soft supersymmetry (SUSY) breaking sector contains a rich flavor-mixing structure that allows O(1) mixings among top- and charm-squarks while being consistent with all ...the existing theoretical and experimental bounds. We formulate a minimal flavor-changing-neutral current scheme in which the squark mixings arise from the non-diagonal scalar trilinear interactions. This feature can be realized in a class of new models with a horizontal U(1)H symmetry which generates realistic quark-mass matrices and provides a solution to the SUSY μ-problem. Finally, without using the mass-insertion approximation, we analyze SUSY radiative corrections to the H±bc and h0tc couplings, and show that these couplings can reveal exciting new discovery channels for the Higgs boson signals at the Tevatron and the LHC.
We discuss a scenario consisting of an effective 4D theory containing fundamental and composite fields. The strong dynamics sector responsible for the compositeness is assumed to be of extra ...dimensional origin. In the 4D effective theory the SM fermion and gauge fields are taken as fundamental fields. The scalar sector of the theory resembles a bosonic topcolor in the sense there are two scalar Higgs fields, a composite scalar field and a fundamental gauge-Higgs unification scalar. A detailed analysis of the scalar spectrum is presented in order to explore the parameter space consistent with experiment. It is found that, under the model assumptions, the acceptable parameter space is quite constrained. As a part of our phenomenological study of the model, we evaluate the branching ratio of the lightest Higgs boson and find that our model predicts a large FCNC mode h→tc, which can be as large as O(10−3). Similarly, a large BR for the top FCNC decay is obtained, namely BR(t→c+H)≃10−4.
4-nitroquinoline-1-oxide (4-NQO) is a pro-oxidant carcinogen bioactivated by xenobiotic metabolism (XM). We investigated if antioxidants lycopene 0.45, 0.9, 1.8 μM, resveratrol 11, 43, 172 μM, and ...vitamin C 5.6 mM added or not with FeSO
0.06 mM, modulate the genotoxicity of 4-NQO 2 mM with the Drosophila wing spot test standard (ST) and high bioactivation (HB) crosses, with inducible and high levels of cytochromes P450, respectively. The genotoxicity of 4-NQO was higher when dissolved in an ethanol - acetone mixture. The antioxidants did not protect against 4-NQO in any of both crosses. In the ST cross, resveratrol 11 μM, vitamin C and FeSO
resulted in genotoxicity; the three antioxidants and FeSO
increased the damage of 4-NQO. In the HB cross, none of the antioxidants, neither FeSO
, were genotoxic. Only resveratrol 172 μM + 4-NQO increased the genotoxic activity in both crosses. We concluded that the effects of the antioxidants, FeSO
and the modulation of 4-NQO were the result of the difference of Cyp450s levels, between the ST and HB crosses. We propose that the basal levels of the XM's enzymes in the ST cross interacted with a putative pro-oxidant activity of the compounds added to the pro-oxidant effects of 4-NQO.
Introduction: Malanga is a stem with a high content of available nutrients such as carbohydrates and protein, as well as being highly digestible; probiotic foods are taking off because of their ...health benefits. Objectives: The objective of this work was to develop a food supplement with functional characteristics, adding lactic acid bacteria (Lactobacillos casei) (BAL), using malanga starch (Xanthosoma sagittifolium) as an encapsulating agent. Methods: The amount of malanga starch used was 1 and 2 %; for every 100 ml of liquid supplement a proportion of 80 % of sweet whey was used (pH 6.0), 1% malanga starch, 2% active BAL, 17 % cooked fruit pulp (mango and apple), which were mixed in constant agitation at a temperature ≤40°C until the desired consistency was achieved; it was then dehydrated at 150°C at an airflow of 20 ml/min, using a spray dryer (SD 18A, LABFREEZ®, China). Results: The yield was 12%, with a viability after seven days of vacuum storage of more than 1x106 UFC/g, according to NOM 181 SCFI/SAGARPA- 2018. It is an innocuous product, since microbiological tests were performed according to NOM -112- SSA1- 1994 and NOM 114-SSA1-1994, finding negative results. The nutritional composition of the supplement is 2.03 g of carbohydrates, 7.65 g of proteins and 0.61 g of lipids. Conclusions: A 12% yield was achieved, indicating its potential for processing. The food supplement presented a high nutritional content, and the viability of the LAB present was maintained, allowing it to be considered as a functional food, which can be used in different age groups. Drying (spraying) conditions allowed encapsulation and maintenance of viability of LAB strains.
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