Supersymmetric Model with Higgs Triplet Diaz-Cruz, J L; Hernandez-Sanchez, J; Moretti, S ...
AIP conference proceedings,
01/2008, Letnik:
1026, Številka:
1
Journal Article
Recenzirano
We present a study of the Higgs sector within an extension of the Minimal Supersymmetric Standard Model that includes one Complex Higgs Triplet (MSSM+1CHT). The model spectrum includes three singly ...charged Higgs bosons as well as three CP-even (or scalar) and two CP-odd (or pseudoscalar) neutral Higgs bosons. We present an approximated calculation of the one-loop radiative corrections to the neutral CP-even Higgs masses (m') and the couplings H'Z0Z0(i = 1,2,3), which determine the magnitude of the Higgs-strahlung processes e+e-'Z0H'. Limits from LEP2 are then considered, in order to obtain bounds on the neutral Higgs sector. Further, we also include the experimental limits from LEP2 on e+e-'H+H- and those on BR(t'bH+) from Tevatron, to derive bounds on the mass of the two lightest charged Higgs bosons (H' and H'). Concerning the latter, we find some cases, where m'~90 GeV, that are not excluded by any experimental bound, even for large values of tanb, so that they should be looked for at the Large Hadron Collider (LHC).
The toxicokinetics of deltamethrin and its metabolite 4′-HO-deltamethrinafter single doses of 26 mg of deltamethrin/kg (oral) or 1.2 mg of deltamethrin/kg (intravenous) were studied in male Wistar ...rats. Serial blood samples were obtained after oral and intravenous administration. Brain, vas deferens, and anococcygeus tissue samples were also obtained after oral administration. Plasma, hypothalamus, cerebellum, frontal cortex, caudate putamen, hippocampus, medulla oblongata, vas deferens, and anococcygeus concentrations of deltamethrin and 4′-HO-deltamethrin were determined by a high-performance liquid chromatographic assay. The deltamethrin and 4′-HO-deltamethrin plasma profiles could be adequately described by a two-compartment open model. For deltamethrin and 4′-HO-deltamethrin, the elimination halflives (t12β) from plasma were 33.0 and 25.67 hr after iv and 38.50 and 30.13 hr after po administration of deltamethrin parent compound. The apparent volume of distribution Vd(area) and volume of distribution at steady state Vd(ss) for deltamethrin were 5.33 and 2.04 liters, respectively, after iv administration, suggesting a considerable diffusion of the pyrethroid into tissue. The total plasma clearance of deltamethrin was the saure for both the oral and the iv routes—0.11 liter/hr. After the single oral dose, deltamethrin was rapidly absorbed with a Tmax of 1.83 hr. The maximum plasma concentrations of deltamethrin and 4′-HO-deltamethrin were 0.46 and 0.26 μg/ml. The maximum plasma concentration of 4′-HO-deltamethrin was achieved at 3.29 hr. The oral bioavailability of deltamethrin was found to be 14.43%. The tissue concentration time data for deltamethrin and its metabolite 4′-HO-deltamethrin were found to fit a one-compartment open model. Considerable concentrations of deltamethrin and 4'-HO-deltamethrin were found in the hypothalamus, cerebellum, frontal cortex, caudate putamen, hippocampus, medulla oblongata, vas deferens, and anococcygeus tissues. The elimination half-lives (t12e1) for both deltamethrin and 4′-HO-deltamethrin were somewhat smaller for the cerebellum, frontal cortex, caudate putamen, medulla oblongata, vas deferens, and anococcygeus tissues (range, 18-33 hr for deltamethrin and 15-28 hr for 4′-HO-deltamethrin) than for plasma (t12e1, 38.50 and 30.13 hr, respectively). Exceptions were seen for the hypothalamus and hippocampus in which the t12e1's for deltamethrin were 40.76 and 38.50 hr, respectively. Nervous tissue accumulation of deltamethrin and its metabolite 4′-HO-deltamethrin was evidenced by the tissue/plasma area under the concentration (AUC) versus time curve ratios. The ratios of AUCtissue/AUCplasma for deltamethrin were 2.32 in medulla oblongata, 295.30 in hypothalamus, and intermediate in other tissues.
Abstract
Background
Cardiogenic shock (CS) is the most severe expression of acute heart failure. Despite the advances in therapeutic and cardiovascular care, the mortality rate remains high. Recent ...trials showed that sex plays a significant role in the etiology, presentation, treatment and in-hospital outcomes in the setting of CS.
Purpose
To evaluate sex differences in demographics, baseline characteristics, management strategies employed and the outcomes following treatment between female and male patients with CS.
Methods
In this retrospective cohort study, we analyzed data from 872 patients admitted to the Coronary Care Unit from January 2006 to December 2021. CS was defined as systolic blood pressure <90mmHg or catecholamine use, cardiac index <2.2 L/min/m2 of blood lactate ≥2 mmol/L. We evaluated baseline characteristics, prior comorbidities, laboratory parameters, treatment used and in-hospital outcomes.
Results
From the 872 patients studied, 617 (70.8%) were male and 255 (29.2%) were female.Among the baseline characteristics, the median age was 62 years for men and 66 for women, p=0.003. Current smoking was present in 29.7% of men vs 13.3% of women, p<0.001. Among prior chronic diseases, the significant differences were found in hypertension (47.7% men vs 56.9% women, p=0.013), dyslipidemia (28.9% men vs 22% women, p=0.037), AF (5.5% men vs 21.2% women, p<0.001), previous AMI >1 month (22% men vs 10.2% women, p<0.001), HF (24% men vs 33% women, p=0.006). Among clinical signs at presentation, differences were found in MAP: 71.7mmHg in men vs 62 in women, p<0.001. As for, LVEF measured by echocardiogram (30% in men vs 38% in women, p<0.001). Among laboratory parameters, the statistically different were Hb (14.6 in men vs 12.6 in women, p<0.001), Cr (1.6 in men vs 1.47 in women, p<0.001), Na (136 in men vs 135 in women, p<0.001), CPR (54 in men vs 40 in women, p=0.018) and lactate (3.9 in men vs 4.4 in women, p=0.024). Among the treatment strategies, the most common used catecholamine was norepinephrine (93.2% men vs 93.7% women, p=0.774), followed by dobutamine (71.3% men vs 63.1% women, p=0.018) and the most frequent number of catecholamines used simultaneously was 3 in both groups (39.9% men vs 40.8% women, p=0.131). Mechanical ventilation was used in 69.5% of men and 61.2% of women, p=0.017. IABP was placed in 45% of men and 19.6% of women, p<0.001. Considering the SCAI stage, the overall comparison between men and women was statistically different, p<0.001. The general mortality rate was 64.7% in men vs 74.1% in women, p=0.007; and the days to fatal outcome were 9 for men vs 5 for women, p<0.001.
Conclusion
Women were more likely to be older, with higher comorbidity, received different treatment strategy and were most importantly less likely to be treated with percutaneous LVAD. Female sex was an independent predictor of higher SCAI stage leading to a higher in-hospital mortality, which has not been described before in current studies.
Funding Acknowledgement
Type of funding sources: None.
Abstract
Background
Cardiogenic shock (CS) mortality is about 50–60%; acute myocardial infarction (AMI) remains the most common cause, representing the 81%. There are related risk factors for the ...occurrence of CS in this vulnerable population, yet, data in these patients is scarce and compels us to identify specific risk factors and treatments to improve their prognosis.
Purpose
To identify the differences in clinical and laboratory characteristics, management strategies and outcomes, by evaluating etiology and risk factors, in order to predict mortality in this setting.
Methods
255 women were included, CS was defined by: systolic blood pressure <90 mmHg, need of vasopressors, cardiac index <2.2 L/min/m2, or blood lactate ≥2 mmol/L. Categorical variables were analyzed using X2; continuum data with U-Mann-Whitney; logistic regression for in-hospital mortality was constructed and KM curves were performed against SCAI and CARDSHOCK scores.
Results
In the current cohort, we found that classic risk factors are associated with AMI-CS such as age (68 vs 60, p<0.001), BMI (26 vs 24, p=0.007), diabetes (65.58 vs 25%, p<0.001), smoking (20.78 vs 2%, p=0.015), dyslipidemia (29 vs 10.89%, p=0.001), hypertension (66.88 vs 41.58%, p<0.001) and previous stroke (3.9 vs 11.8, p<0.001). Interestingly, AF occurred more frequently in non-AMI-CS (48.51 vs 3.25, p<0.001). Initial SBP, DBP, and MAP were lower in this group (p<0.001), and LVEF was higher (45 vs 35%, p=0.015). At lab data, AMI-CS had higher glucose, leukocytes, sodium, AST, ALT, and eGFR and lower creatinine.
Regarding the management strategy, AMI-CS was associated with the simultaneous use of more vasoactive agents (p<0.001), norepinephrine (p=0.001), dobutamine (p<0.001) and levosimendan (p=0.019), as well as IABP (31.17. vs 1.98, p<0.001). No difference among groups was seen in global mortality (74.68 vs 73.27, p=0.802).
When analyzed by logistic regression, SCAI stages D and E had higher odds ratio (OR) of mortality compared to C stage. CARDSHOCK had significant differences along the tertiles, these 2 scores had substantial differences in the Kaplan-Meier curves with the 30-day mortality (p<0.001, Fig. 1A, B, and C). The number of vasoactive agents had an incremental risk when using 2 (OR=2.66) or ≥3 (OR=2.32) drugs. Mechanical ventilation was associated with an increased mortality (OR=1.86). Gasometrical derived data had significant differences in lactate (OR=1.1), pH decrease (OR=1.33), and base excess (BE, OR=1.07) (Fig. 1A)
Conclusions
Herein, we identified specific risk factors related to mortality in women, AMI-CS patients had similar risk factors than the ones seen in men populations. But some specifics factors in women management differ compared to historical mixed cohorts.
In conclusion, women-derived data must be specifically analyzed focusing in the involved risk factors and management strategies, which differ from those reported in mixed cohorts.
Funding Acknowledgement
Type of funding sources: Public Institution(s). Main funding source(s): National Institute of Cardiology in Mexico City
Abstract
Introduction
Cardiogenic shock (CS) is a spectrum of phenotypes and multiorgan failure (MOF). Recent works 1 approach the typification, but no continuous hemodynamic patterns has been ...associated with these phenotypes nor MOF.
Methods
295 AMI-CS patients (SBP ≤90 mmHg, vasopressor use, cardiac index ≤2.2 L/min/m2, or lactate ≥2 mmol/L) and pulmonary artery (PA) catheter. Cut-off values were used to divide in 3 phenotypes cardiac C0 (no organ involvement), cardiorenal CR (eGFR <45 ml/min/1.73 m2), and cardiometabolic CM (renal+hepatic AST or ALT >3 ULN) 2 SCAI definitions were used 3. MODS score defines MOF as ≥2 organs 4; AKI (rise Cr >0.3 mg/dL) and electric instability (VT/VF). Repeated measures ANOVA was used to compare 24 h hemodynamic data. 30-day mortality hazard ratios were obtained (Fig. 1E).
Results
C0 represent 64.41% (190), CR 14.91% (44) and CM 20.68% (61). SCAI C was more in C0 (24.74 vs 0, 0%), E in the CM (23.16, 38.64 vs 63.93%); SCAI D had differences in CR and CM (61.36 vs 36.07%). C0 were younger (59, vs CR 66, CM 62; p<0.001); diabetes was more common in CM (60.66) vs CR (56.82) or C0 (42.63%) (p=0.024). Hypertension predominates in CR (72.73 vs CM 57.38, C0 44.21%). GRACE score was lower in C0 (180.64, 157–206) against CR (211.07, 186.5–237), CM (218, 195–247) (p<0.001). AKI was higher in CR, CM (79.55, 86.89 vs 65.79%, p<0.001), as hemodialysis (18.18 and 34.43 vs 6.32, p<0.001) compared to C0. In CM: leukocytes, BUN, Cr, AST, ALT, and CRP were higher with lower levels of eGFR and platelets. C0 had fewer vasoactive requirements (p<0.001). IABP (p=0.741) and VT/FV (p=0.687) had no differences. MOF prevalence was C0 62.6% vs CR 86.4% and CM 96.7% (p<0.001). MODS ≥4 was C0 39.5, CR 65.9, CM 85.2% and SOFA ≥7 was C0 32.6, CR 63.6, CM 83.6%. Mortality was higher in CR (56.82%) and CM (54.1%) compared to C0 (39.47%, p=0.032) (p=0.001, Fig. 1A). RAP (p<0.001, Fig. 2A), PCWP (0.007, Fig. 2C), cardiac output (<0.001, Fig. 2B), index (0.001), power (0.001), perfusion pressure (PP = MAP-RAP, 0.028) and PAPi (0.043) discriminate the C0 phenotype.
AKI had lower survival (p<0.001, Fig. 1B) related to lower SBP (<0.001), DBP (0.003), MAP (<0.001, Fig. 2F) cardiac output (0.002), index (<0.001), power (<0.001, Fig. 2E), and PP (<0.001, Fig. 2D) and higher RAP (0.003), PADP (0.024), PAMP (0.011), PCWP (0.001). Electrical instability had lower survival (p<0.001, Fig. 1C), lower SBP (0.004), DBP (0.011), MAP (0.001, Fig. 2G), cardiac outpu t(0.036), index (0.019), power (0.003, Fig. 2I), PP (0.002, Fig. 2H) and higher PAMP (0.04). Finally, multiorgan failure had a decreased survival (p=0.016, Fig. 1D), higher heart rates (p=0.018), RAP (0.001, Fig. 2K), PCWP (<0.001), PADP (0.02) and lower SBP (0.017), DBP (0.002), MAP (<0.001) cardiac output (<0.001), index (0.004), power (<0.001), PP (<0.001, Fig. 2J), PAPi (<0.001, Fig. 2L).
Conclusions
We demonstrated associations with hemodynamic trajectories across time, which has not been reported before, could reveal AMI-CS phenotypes and related organ dysfunction patterns.
Funding Acknowledgement
Type of funding sources: None.
Highlights ► A combined universal vaccination strategy was the most effective measure. ► This strategy would help achieve the goal of global rubella eradication in the near future. ► Other strategies ...shifted the disease to susceptible groups continuing transmission.
The present research work shows an application of a mathematical algorithm based on a linear programming model, with which a solution is given to the raw material inventory management problem ...presented by the company «Kjantu Collection» in its warehouses, in the It is not known how much should be invested in a given period or how much the total merchandise is valued. The objective of the research is to apply a raw material inventory control model using linear programming that contributes to decision making within the company Kjantu Collection S.A.C using the WinQSB software. In support of the solution of the model, the WinQSB software is used, whose results managed to obtain the optimal quantities for the company Kjantu Collection S.A.C with which the downtimes in the production of the different garments of the company will be eliminated, it was also possible to determine the costs per period in the production of each garment.
Knowledge about parasites of Antarctic birds is fragmented and scarce. The aim of this work is to contribute to the knowledge of gastrointestinal parasites of the Chinstrap Penguin (
Pygoscelis ...antarctica
) from Deception Island (South Shetlands, Antarctica). Gastrointestinal tracts of 64 fresh dead individuals (61 chicks and three adults) were collected from December 2006 to February 2009 and examined for macroparasites. Three adult parasite species were found: two
Cestoda
species (
Parorchites zederi
and
Tetrabothrius pauliani
) and one
Nematoda
species (
Stegophorus macronectes
). Also, immature acanthocephalans (
Corynosoma
sp.) were found in one penguin. The low parasite richness observed could be related to the stenophagic and pelagic diet of the host species. False negatives were found in coprological studies.
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